Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:nintedanib
go back to main search page
Accession:CHEBI:85164 term browser browse the term
Definition:A member of the class of oxindoles that is a kinase inhibitor used (in the form of its ethylsulfonate salt) for the treatment of idiopathic pulmonary fibrosis and cancer.
Synonyms:exact_synonym: methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
 related_synonym: BIBF 1120;   BIBF1120;   Formula=C31H33N5O4;   InChI=1S/C31H33N5O4/c1-34-15-17-36(18-16-34)20-27(37)35(2)24-12-10-23(11-13-24)32-29(21-7-5-4-6-8-21)28-25-14-9-22(31(39)40-3)19-26(25)33-30(28)38/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,38)/b29-28-;   InChIKey=XZXHXSATPCNXJR-ZIADKAODSA-N;   SMILES=COC(=O)c1ccc2\\C(=C(\\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
 xref: CAS:656247-17-5;   Drug_Central:4903;   KEGG:D10481
 xref_mesh: MESH:C530716
 xref: PDBeChem:XIN;   PMID:24657398;   PMID:25299232;   PMID:25338318;   PMID:25430078;   PMID:25474320;   PMID:25478720;   PMID:25527450;   PMID:25534294;   PMID:25571784;   PMID:25745043;   Reaxys:12016593;   Wikipedia:Nintedanib
 cyclic_relationship: is_conjugate_base_of CHEBI:85172



show annotations for term's descendants           Sort by:
 
nintedanib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tuba1a tubulin, alpha 1A decreases expression ISO nintedanib results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19741
    role 19714
      application 19547
        fuel 11288
          methanol 3916
            methyl ester 3882
              nintedanib 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19741
    subatomic particle 19739
      composite particle 19739
        hadron 19739
          baryon 19739
            nucleon 19739
              atomic nucleus 19739
                atom 19739
                  main group element atom 19687
                    p-block element atom 19687
                      carbon group element atom 19633
                        carbon atom 19629
                          organic molecular entity 19629
                            organic group 18837
                              organic divalent group 18822
                                organodiyl group 18822
                                  carbonyl group 18786
                                    carbonyl compound 18786
                                      carboxylic acid 18507
                                        carboacyl group 17646
                                          univalent carboacyl group 17646
                                            carbamoyl group 17486
                                              carboxamide 17486
                                                lactam 8348
                                                  gamma-lactam 6614
                                                    oxindoles 5866
                                                      nintedanib 1
paths to the root