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Accession:CHEBI:85155 term browser browse the term
Definition:A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2-[3,5-bis(trifluoromethyl)phenyl]-2-methylpropanoic acid with the secondary amino group of N-methyl-4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-amine; an antiemetic used in combination with palonosetron hydrochloride (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.
Synonyms:exact_synonym: 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide
 related_synonym: Formula=C30H32F6N4O;   InChI=1S/C30H32F6N4O/c1-19-8-6-7-9-23(19)24-17-26(40-12-10-38(4)11-13-40)37-18-25(24)39(5)27(41)28(2,3)20-14-21(29(31,32)33)16-22(15-20)30(34,35)36/h6-9,14-18H,10-13H2,1-5H3;   InChIKey=WAXQNWCZJDTGBU-UHFFFAOYSA-N;   SMILES=CN(C(=O)C(C)(C)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1cnc(cc1-c1ccccc1C)N1CCN(C)CC1
 xref: CAS:290297-26-6 "ChemIDplus";   CAS:290297-26-6 "KEGG DRUG";   Drug_Central:4898 "DrugCentral";   KEGG:D05152;   PMID:22732666 "Europe PMC";   PMID:23729226 "Europe PMC";   PMID:23748441 "Europe PMC";   PMID:23765630 "Europe PMC";   PMID:24122871 "Europe PMC";   PMID:24468892 "Europe PMC";   PMID:24603643 "Europe PMC";   PMID:24608196 "Europe PMC";   PMID:24631949 "Europe PMC";   PMID:24942276 "Europe PMC";   PMID:24969614 "Europe PMC";   PMID:25077526 "Europe PMC";   PMID:25105088 "Europe PMC";   PMID:25227565 "Europe PMC";   PMID:25360998 "Europe PMC";   PMID:25404586 "Europe PMC";   PMID:25552904 "Europe PMC";   PMID:25687374 "Europe PMC";   Reaxys:10314678 "Reaxys"

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  CHEBI ontology 19662
    role 19606
      application 19232
        pharmaceutical 19094
          drug 19094
            antiemetic 5087
              netupitant 0
                Akynzeo 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        carboacyl group 16944
                                          univalent carboacyl group 16944
                                            carbamoyl group 16623
                                              carboxamide 16623
                                                monocarboxylic acid amide 13187
                                                  netupitant 0
                                                    Akynzeo 0
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