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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor
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Accession:CHEBI:85113 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cGMP-dependent protein kinase (EC 2.7.11.12).
Synonyms:related_synonym: 3':5'-cyclic GMP-dependent protein kinase inhibitor;   3':5'-cyclic GMP-dependent protein kinase inhibitors;   ATP:protein phosphotransferase (cGMP-dependent) inhibitor;   ATP:protein phosphotransferase (cGMP-dependent) inhibitors;   EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitors;   EC 2.7.11.12 inhibitor;   EC 2.7.11.12 inhibitors;   PKG 1alpha inhibitor;   PKG 1alpha inhibitors;   PKG 1beta inhibitor;   PKG 1beta inhibitors;   PKG II inhibitor;   PKG II inhibitors;   PKG inhibitor;   PKG inhibitors;   STK23 inhibitor;   STK23 inhibitors;   cGMP-dependent protein kinase Ibeta inhibitor;   cGMP-dependent protein kinase Ibeta inhibitors;   cGMP-dependent protein kinase inhibitor;   cGMP-dependent protein kinase inhibitors;   guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitor;   guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitors
 xref: Wikipedia:CGMP-dependent_protein_kinase


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KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858
JBrowse link
G Arhgef17 Rho guanine nucleotide exchange factor 17 multiple interactions ISO KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]] CTD PMID:23195829 Ensembl chr 1:165,911,718...165,967,069 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP
ISO
KT 5823 inhibits the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of BDNF protein]]
CTD PMID:19428112 PMID:22850435 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Casp3 caspase 3 multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:10860942 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]] CTD PMID:22850435 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12184995 PMID:16389725 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Edn3 endothelin 3 multiple interactions EXP KT 5823 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr 3:172,856,730...172,879,276
Ensembl chr 3:172,856,733...172,880,450
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]] CTD PMID:23274518 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP KT 5823 inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17110411 PMID:17290048 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 protein] CTD PMID:23274518 NCBI chr12:17,309,122...17,315,267
Ensembl chr12:17,309,834...17,311,112
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO KT 5823 results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK1 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]]
CTD PMID:16389725 PMID:17828804 PMID:22850435 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK3 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]]
CTD PMID:16389725 PMID:17828804 PMID:22850435 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 decreases activity ISO KT 5823 results in decreased activity of MAPKAPK5 protein CTD PMID:12534346 NCBI chr12:40,510,378...40,529,332
Ensembl chr12:40,510,378...40,529,338
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MYC protein] CTD PMID:17828804 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:27774770 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein] CTD PMID:15733978 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]]; KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP KT 5823 inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] CTD PMID:20453393 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO
EXP
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]; KT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein]
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]]; KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]
CTD PMID:20177073 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] CTD PMID:20453393 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19775
    role 19722
      biological role 19722
        inhibitor 18469
          enzyme inhibitor 18261
            EC 2.* (transferase) inhibitor 13903
              EC 2.7.* (P-containing group transferase) inhibitor 13540
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8194
                  EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor 27
                    KT 5823 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 19775
    role 19722
      biological role 19722
        inhibitor 18469
          enzyme inhibitor 18261
            EC 2.* (transferase) inhibitor 13903
              EC 2.7.* (P-containing group transferase) inhibitor 13540
                protein kinase inhibitor 13068
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8194
                    EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor 27
                      KT 5823 27
paths to the root