Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor
go back to main search page
Accession:CHEBI:85113 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cGMP-dependent protein kinase (EC 2.7.11.12).
Synonyms:related_synonym: 3':5'-cyclic GMP-dependent protein kinase inhibitor;   3':5'-cyclic GMP-dependent protein kinase inhibitors;   ATP:protein phosphotransferase (cGMP-dependent) inhibitor;   ATP:protein phosphotransferase (cGMP-dependent) inhibitors;   EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitors;   EC 2.7.11.12 inhibitor;   EC 2.7.11.12 inhibitors;   PKG 1alpha inhibitor;   PKG 1alpha inhibitors;   PKG 1beta inhibitor;   PKG 1beta inhibitors;   PKG II inhibitor;   PKG II inhibitors;   PKG inhibitor;   PKG inhibitors;   STK23 inhibitor;   STK23 inhibitors;   cGMP-dependent protein kinase Ibeta inhibitor;   cGMP-dependent protein kinase Ibeta inhibitors;   cGMP-dependent protein kinase inhibitor;   cGMP-dependent protein kinase inhibitors;   guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitor;   guanosine 3':5'-cyclic monophosphate-dependent protein kinase inhibitors
 xref: Wikipedia:CGMP-dependent_protein_kinase



show annotations for term's descendants           Sort by:
KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arhgef17 Rho guanine nucleotide exchange factor 17 multiple interactions ISO KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]] CTD PMID:23195829 NCBI chr 1:155,230,607...155,290,163
Ensembl chr 1:155,233,168...155,290,498
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP
ISO
KT 5823 inhibits the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of BDNF protein]]
CTD PMID:19428112 PMID:22850435 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:10860942 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]] CTD PMID:22850435 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12184995 PMID:16389725 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn3 endothelin 3 multiple interactions EXP KT 5823 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]] CTD PMID:23274518 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP KT 5823 inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17110411 PMID:17290048 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 protein] CTD PMID:23274518 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO KT 5823 results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO KT 5823 inhibits the reaction [Cadmium Chloride results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:35122928 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK1 protein]; KT 5823 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]
CTD PMID:16389725 PMID:17828804 PMID:22850435 PMID:35122928 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK3 protein]; KT 5823 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]
CTD PMID:16389725 PMID:17828804 PMID:22850435 PMID:35122928 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO KT 5823 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:35122928 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO KT 5823 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:35122928 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 decreases activity ISO KT 5823 results in decreased activity of MAPKAPK5 protein CTD PMID:12534346 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MYC protein] CTD PMID:17828804 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:27774770 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO KT 5823 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of NFKBIA protein] CTD PMID:35122928 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein] CTD PMID:15733978 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]]; KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO KT 5823 inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RELA protein] CTD PMID:35122928 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP KT 5823 inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] CTD PMID:20453393 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO
EXP
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]; KT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein]
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]]; KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]
CTD PMID:20177073 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] CTD PMID:20453393 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      biological role 19806
        inhibitor 18896
          enzyme inhibitor 18725
            EC 2.* (transferase) inhibitor 14851
              EC 2.7.* (P-containing group transferase) inhibitor 14366
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10120
                  EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor 32
                    KT 5823 32
Path 2
Term Annotations click to browse term
  CHEBI ontology 19803
    role 19779
      biological role 19806
        inhibitor 18896
          enzyme inhibitor 18725
            EC 2.* (transferase) inhibitor 14851
              EC 2.7.* (P-containing group transferase) inhibitor 14366
                protein kinase inhibitor 13961
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 10120
                    EC 2.7.11.12 (cGMP-dependent protein kinase) inhibitor 32
                      KT 5823 32
paths to the root