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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:KT 5823
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Accession:CHEBI:85102 term browser browse the term
Definition:An organic heterooctacyclic compound that is 1H,1'H-2,2'-biindole in which the nitrogens have undergone formal oxidative coupling to positions 2 and 5 of methyl (3R)-3-methoxy-2-methyltetrahydrofuran-3-carboxylate (the 2S,3R,5R product), and in which the 3 and 3' positions of the biindole moiety have also undergone formal oxidative coupling to positions 3 and 4 of 1-methyl-1,5-dihydro-2H-pyrrol-2-one.
Synonyms:exact_synonym: methyl (5S,6R,8R)-6-methoxy-5,14-dimethyl-13-oxo-5,6,7,8,14,15-hexahydro-13H-5,8-epoxy-4b,8a,14-triazadibenzo[b,h]cycloocta[1,2,3,4-jkl]cyclopenta[e]-as-indacene-6-carboxylate
 related_synonym: Formula=C29H25N3O5;   InChI=1S/C29H25N3O5/c1-28-29(36-4,27(34)35-3)13-20(37-28)31-18-11-7-5-9-15(18)22-23-17(14-30(2)26(23)33)21-16-10-6-8-12-19(16)32(28)25(21)24(22)31/h5-12,20H,13-14H2,1-4H3/t20-,28+,29+/m1/s1;   InChIKey=QTYMDECKVKSGSM-YMUMJAELSA-N;   KT5823;   SMILES=COC(=O)[C@]1(C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CN(C)C(=O)c4c4c5ccccc5n2c4c13)OC
 xref: CAS:126643-37-6
 xref_mesh: MESH:C073601
 xref: PMID:10922374;   PMID:12851655;   PMID:14614039;   PMID:1666198;   PMID:21209020;   PMID:8529881;   Reaxys:8175390



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KT 5823 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Arhgef17 Rho guanine nucleotide exchange factor 17 multiple interactions ISO KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]] CTD PMID:23195829 Ensembl chr 1:155,233,168...155,290,498 JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP
ISO
KT 5823 inhibits the reaction [BDNF protein results in decreased susceptibility to 3-nitropropionic acid]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of BDNF protein]]
CTD PMID:19428112 PMID:22850435 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Casp3 caspase 3 multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein] CTD PMID:10860942 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO KT 5823 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO KT 5823 inhibits the reaction [Ginkgo biloba extract inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [ginkgolide C inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]]; KT 5823 inhibits the reaction [Quercetin inhibits the reaction [APP protein results in decreased phosphorylation of CREB1 protein]] CTD PMID:18001288 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in decreased expression of CREBBP protein]] CTD PMID:22850435 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP KT 5823 inhibits the reaction [EDN1 protein results in decreased secretion of Norepinephrine]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]; KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:12184995 PMID:16389725 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Edn3 endothelin 3 multiple interactions EXP KT 5823 inhibits the reaction [EDN3 protein results in decreased secretion of Norepinephrine] CTD PMID:12184995 NCBI chr 3:163,562,307...163,586,636
Ensembl chr 3:163,562,520...163,585,093
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]] CTD PMID:23274518 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions EXP KT 5823 inhibits the reaction [manganese chloride results in increased secretion of GNRH1 protein] CTD PMID:17110411 PMID:17290048 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions ISO KT 5823 inhibits the reaction [bisphenol A promotes the reaction [FOS protein binds to GPER1 promoter]]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 mRNA]; KT 5823 inhibits the reaction [bisphenol A results in increased expression of GPER1 protein] CTD PMID:23274518 NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases activity ISO KT 5823 results in decreased activity of GSK3B protein CTD PMID:12534346 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP
ISO
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK1 protein]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK1 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK1 protein]]
CTD PMID:16389725 PMID:17828804 PMID:22850435 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP
ISO
KT 5823 promotes the reaction [EDN1 protein results in increased phosphorylation of MAPK3 protein]
KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MAPK3 protein]
KT 5823 inhibits the reaction [2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [Corticosterone results in increased phosphorylation of MAPK3 protein]]
CTD PMID:16389725 PMID:17828804 PMID:22850435 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapkapk5 MAPK activated protein kinase 5 decreases activity ISO KT 5823 results in decreased activity of MAPKAPK5 protein CTD PMID:12534346 NCBI chr12:34,993,520...35,013,059
Ensembl chr12:34,994,092...35,013,052
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO KT 5823 affects the reaction [heat stable toxin (E coli) results in decreased phosphorylation of MYC protein] CTD PMID:17828804 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 mRNA]; KT 5823 inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein] CTD PMID:27774770 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein] CTD PMID:15733978 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions ISO KT 5823 inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-GMP promotes the reaction [PRKG1 protein binds to and results in increased phosphorylation of ARHGEF17 protein]]; KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr 1:228,409,883...229,638,794
Ensembl chr 1:228,408,947...229,639,080
JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO KT 5823 inhibits the reaction [[8-((4-chlorophenyl)thio)cyclic-3',5'-GMP co-treated with PRKG1 protein] results in increased activity of RHOA protein] CTD PMID:23195829 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP KT 5823 inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] CTD PMID:20453393 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO KT 5823 inhibits the reaction [8-bromocyclic GMP inhibits the reaction [TNF protein results in increased activity of CASP3 protein]] CTD PMID:9388267 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO
EXP
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]; KT 5823 inhibits the reaction [8-bromocyclic GMP results in increased phosphorylation of TRPC6 protein]
KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein]]; KT 5823 inhibits the reaction [4-((3,4-(methylenedioxy)benzyl)amino)-6-methoxyquinazoline analog results in increased phosphorylation of TRPC6 protein]
CTD PMID:20177073 NCBI chr 8:5,759,387...5,864,000
Ensembl chr 8:5,758,935...5,828,092
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] CTD PMID:20453393 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link

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  CHEBI ontology 20059
    role 20009
      application 19747
        fuel 11263
          methanol 3866
            methyl ester 3837
              KT 5823 27
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  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        carboacyl group 17658
                                          univalent carboacyl group 17658
                                            carbamoyl group 17492
                                              carboxamide 17492
                                                lactam 8344
                                                  gamma-lactam 6606
                                                    KT 5823 27
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