Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor
go back to main search page
Accession:CHEBI:85094 term browser browse the term
Definition:An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of cAMP-dependent protein kinase (EC 2.7.11.11).
Synonyms:related_synonym: ATP:protein phosphotransferase (cAMP-dependent) inhibitor;   ATP:protein phosphotransferase (cAMP-dependent) inhibitors;   EC 2.7.11.11 inhibitor;   EC 2.7.11.11 inhibitors;   PKA C inhibitor;   PKA C inhibitors;   PKA inhibitor;   PKA inhibitors;   STK22 inhibitor inhibitor;   STK22 inhibitors inhibitors;   cAMP-dependent protein kinase (EC 2.7.11.11) inhibitors;   cAMP-dependent protein kinase inhibitor;   cAMP-dependent protein kinase inhibitors;   protein kinase A inhibitor;   protein kinase A inhibitors
 xref: Wikipedia:Protein_kinase_A


show annotations for term's descendants           Sort by:
 
KT 5720 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO KT 5720 inhibits the reaction [Capsaicin results in increased expression of ABCA1 protein] CTD PMID:21908651 NCBI chr 5:67,678,267...67,801,162 JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity ISO KT 5720 results in decreased activity of ABCB1 protein CTD PMID:15725475 NCBI chr 4:25,357,467...25,529,941 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO
EXP
KT 5720 inhibits the reaction [Bucladesine affects the localization of ABCC2 protein]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of ABCC2 mRNA]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of ABCC2 protein]
KT 5720 inhibits the reaction [Bucladesine affects the localization of ABCC2 protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]
CTD PMID:26049102 PMID:29052767 PMID:31300867 NCBI chr 1:242,664,657...242,723,239 JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions ISO KT 5720 inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium] CTD PMID:15365637 NCBI chr15:40,830,125...40,935,902 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein] CTD PMID:31300867 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G App amyloid beta precursor protein multiple interactions ISO KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]] CTD PMID:24254769 NCBI chr11:24,019,774...24,236,584 JBrowse link
G Atf2 activating transcription factor 2 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of ATF2 protein modified form] CTD PMID:26049102 NCBI chr 3:58,718,323...58,795,280 JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions EXP KT 5720 inhibits the reaction [NPPA protein results in increased secretion of CALCA protein] CTD PMID:17522345 NCBI chr 1:168,878,212...168,883,176 JBrowse link
G Cartpt CART prepropeptide multiple interactions EXP KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein] CTD PMID:19632277 NCBI chr 2:31,255,098...31,257,452 JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
KT 5720 inhibits the reaction [cilostazol results in increased activity of CASP3 protein]; KT 5720 inhibits the reaction [Colforsin results in increased activity of CASP3 protein]
KT 5720 inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP3 protein]
KT 5720 inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]
CTD PMID:20131233 PMID:21873648 PMID:32115946 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions ISO KT 5720 affects the reaction [muscarinic toxin 7 binds to CHRM1 protein]; KT 5720 promotes the reaction [Acetylcholine binds to CHRM1 protein]; KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]; Staurosporine affects the reaction [KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM1 protein]] CTD PMID:10860942 PMID:16439611 NCBI chr 1:205,567,046...205,583,001 JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO KT 5720 promotes the reaction [N-Methylscopolamine binds to CHRM2 protein] CTD PMID:10860942 NCBI chr 4:65,015,408...65,149,104 JBrowse link
G Chrm3 cholinergic receptor, muscarinic 3 affects binding EXP KT 5720 binds to CHRM3 protein CTD PMID:12435818 NCBI chr17:60,005,137...60,467,250 JBrowse link
G Cidec cell death-inducing DFFA-like effector c multiple interactions ISO KT 5720 inhibits the reaction [Isoproterenol results in increased expression of CIDEC protein] CTD PMID:21097823 NCBI chr 4:146,569,288...146,582,173 JBrowse link
G Csnk2a1 casein kinase 2 alpha 1 multiple interactions ISO KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of CSNK2A1 protein] CTD PMID:24254769 NCBI chr 3:140,709,984...140,756,757 JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO KT 5720 inhibits the reaction [cilostazol affects the expression of EP300 protein] CTD PMID:24254769 NCBI chr 7:113,108,476...113,178,529 JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP KT 5720 inhibits the reaction [Norepinephrine inhibits the reaction [Carbachol results in increased expression of FGF1 protein]] CTD PMID:15264218 NCBI chr18:30,686,555...30,772,667 JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions EXP KT 5720 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein] CTD PMID:22645130 NCBI chr12:15,217,217...15,222,679 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP KT 5720 inhibits the reaction [CARTPT protein results in increased phosphorylation of GRIN1 protein] CTD PMID:19632277 NCBI chr 3:8,103,680...8,130,603 JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA1 mRNA] CTD PMID:26049102 NCBI chr 9:23,703,476...23,720,121 JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA2 mRNA] CTD PMID:26049102 NCBI chr 8:79,184,535...79,196,827 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA4 mRNA] CTD PMID:26049102 NCBI chr 8:79,066,967...79,084,193 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP
ISO
KT 5720 inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]
Dinoprostone inhibits the reaction [KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]]; KT 5720 inhibits the reaction [Dinoprostone inhibits the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]]; KT 5720 promotes the reaction [Lipopolysaccharides results in increased activity of HMOX1 protein]; KT 5720 promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 protein]
CTD PMID:16439612 PMID:24003391 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO KT 5720 inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]] CTD PMID:21457779 NCBI chr 1:182,659,047...182,709,495 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO KT 5720 inhibits the reaction [Bucladesine results in increased expression of JUN protein modified form]; KT 5720 inhibits the reaction [Bucladesine results in increased expression of JUN protein] CTD PMID:26049102 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Lrp1 LDL receptor related protein 1 multiple interactions ISO KT 5720 inhibits the reaction [Capsaicin results in decreased expression of LRP1 protein] CTD PMID:21908651 NCBI chr 7:63,380,325...63,461,029 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]] CTD PMID:11675405 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]] CTD PMID:11675405 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP KT 5720 inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] CTD PMID:17438462 NCBI chr12:38,615,111...38,795,492 JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP KT 5720 inhibits the reaction [NPPA protein results in increased secretion of CALCA protein] CTD PMID:17522345 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Nucb2 nucleobindin 2 multiple interactions EXP KT 5720 inhibits the reaction [NUCB2 protein results in increased import of Calcium] CTD PMID:17627999 NCBI chr 1:170,750,830...170,787,356 JBrowse link
G Pla2g6 phospholipase A2 group VI multiple interactions EXP KT 5720 inhibits the reaction [UCN protein results in decreased expression of PLA2G6 protein] CTD PMID:17885217 NCBI chr 7:110,851,378...110,891,557 JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP KT 5720 inhibits the reaction [Bucladesine results in increased activity of PRKACA protein]; KT 5720 inhibits the reaction [Taurolithocholic Acid results in increased activity of PRKACA protein] CTD PMID:31300867 NCBI chr19:24,155,081...24,178,430 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [KT 5720 co-treated with Dinoprostone] inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; KT 5720 affects the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:24003391 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO KT 5720 inhibits the reaction [cilostazol inhibits the reaction [APP protein results in decreased expression of and results in decreased activity of SIRT1 protein]]; KT 5720 inhibits the reaction [cilostazol results in increased phosphorylation of SIRT1 protein] CTD PMID:24254769 NCBI chr20:25,307,143...25,329,260 JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP KT 5720 inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein] CTD PMID:22645130 NCBI chr 3:89,005,129...89,126,498 JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO KT 5720 inhibits the reaction [isoeugenol results in increased expression of SOCS3 mRNA] CTD PMID:21969073 NCBI chr10:103,193,909...103,197,322 JBrowse link
G Th tyrosine hydroxylase decreases expression
multiple interactions
EXP KT 5720 results in decreased expression of TH mRNA
KT 5720 inhibits the reaction [Colforsin results in increased expression of TH mRNA]; KT 5720 inhibits the reaction [HU 211 results in decreased expression of TH mRNA]
CTD PMID:18992715 NCBI chr 1:198,071,500...198,078,832 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO KT 5720 inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF mRNA]]; KT 5720 inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA] CTD PMID:11675405 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions EXP KT 5720 inhibits the reaction [modafinil results in increased expression of TNFSF11 mRNA] CTD PMID:29649498 NCBI chr15:53,674,990...53,705,171 JBrowse link
G Ucn urocortin multiple interactions EXP KT 5720 inhibits the reaction [UCN protein results in decreased expression of PLA2G6 protein] CTD PMID:17885217 NCBI chr 6:25,238,120...25,238,950 JBrowse link
G Zfp36 zinc finger protein 36 multiple interactions ISO KT 5720 inhibits the reaction [isoeugenol results in increased expression of ZFP36 protein] CTD PMID:21969073 NCBI chr 1:83,669,084...83,671,564 JBrowse link
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [aranidipine results in increased expression of ABCA1 protein] CTD PMID:16306803 NCBI chr 5:67,678,267...67,801,162 JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCB11 mRNA]] CTD PMID:27743861 NCBI chr 3:54,016,854...54,112,797 JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases expression
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of ABCB1 mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of ABCB1 protein
CTD PMID:12926078 PMID:23466342 NCBI chr 4:25,357,467...25,529,941 JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in decreased expression of ABCB4 mRNA] CTD PMID:12926078 NCBI chr 4:25,150,998...25,209,489 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of ABCC2 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Taurolithocholic Acid results in decreased activity of ABCC2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of ABCC2 mRNA]]
CTD PMID:26049102 PMID:27743861 PMID:31300867 NCBI chr 1:242,664,657...242,723,239 JBrowse link
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ADCYAP1 protein results in increased expression of SELENOT mRNA] CTD PMID:18198219 NCBI chr 9:113,102,632...113,122,500 JBrowse link
G Adm adrenomedullin multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ADM protein results in decreased activity of MAPK1 protein] CTD PMID:10374718 NCBI chr 1:164,745,484...164,747,655 JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]] CTD PMID:17823304 NCBI chr 6:52,234,089...52,271,568 JBrowse link
G Akna AT-hook transcription factor multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in decreased expression of AKNA mRNA] CTD PMID:29079362 NCBI chr 5:76,777,415...76,824,380 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases activity
affects phosphorylation
ISO SB 203580 inhibits the reaction [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the phosphorylation of AKT1 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of AKT1 protein
CTD PMID:10998351 PMID:17640974 NCBI chr 6:131,713,716...131,735,319 JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased expression of APOE mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased expression of CETP mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased secretion of APOE protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased secretion of CETP protein] CTD PMID:22056562 NCBI chr 8:46,527,251...46,529,035 JBrowse link
G Apoe apolipoprotein E multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased expression of APOE mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [APOA1 protein results in increased secretion of APOE protein] CTD PMID:22056562 NCBI chr 1:79,353,924...79,357,852 JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of AQP3 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 5:56,239,200...56,244,718 JBrowse link
G Areg amphiregulin multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of AREG protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of AREG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased expression of AREG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased expression of AREG protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased expression of AREG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased expression of AREG protein] CTD PMID:15967414 PMID:16888076 NCBI chr14:16,972,185...16,981,443 JBrowse link
G Atf1 activating transcription factor 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of ATF1 protein] CTD PMID:12164941 PMID:16671086 PMID:22188298 NCBI chr 7:131,361,962...131,404,677 JBrowse link
G Atf3 activating transcription factor 3 multiple interactions EXP
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of ATF3 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of ATF3 protein]
CTD PMID:25136830 PMID:30409902 NCBI chr13:102,751,278...102,800,520 JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions
decreases activity
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the localization of and results in decreased phosphorylation of BAD protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [BAD protein binds to BCL2L1 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of BAD protein
CTD PMID:12629175 NCBI chr 1:204,133,502...204,142,829 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [BAD protein binds to BCL2L1 protein] CTD PMID:12629175 NCBI chr 3:141,253,508...141,304,582 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Quercetin results in decreased expression of BIRC5 protein] CTD PMID:18377872 NCBI chr10:103,072,530...103,081,382 JBrowse link
G Cask calcium/calmodulin dependent serine protein kinase multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CASK protein] CTD PMID:20067577 NCBI chr  X:8,899,500...9,243,014 JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[sodium bisulfite co-treated with sodium sulfite] results in increased cleavage of CASP3 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP3 protein]
CTD PMID:21873648 PMID:32115946 NCBI chr16:45,662,910...45,681,171 JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased expression of CCL2] CTD PMID:11342529 NCBI chr10:67,005,424...67,007,222 JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithium Chloride results in increased expression of CCND1 mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased expression of CCND1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]
CTD PMID:17680988 PMID:22493441 PMID:26964897 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cd68 Cd68 molecule multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [F2 protein results in increased expression of CD68 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [F2 protein results in increased expression of CD68 protein]] CTD PMID:27261088 NCBI chr10:54,381,814...54,383,693 JBrowse link
G Cd86 CD86 molecule multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [F2 protein results in increased expression of CD86 mRNA]] CTD PMID:27261088 NCBI chr11:64,142,193...64,200,816 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of CDKN1A mRNA] CTD PMID:16361081 NCBI chr20:7,149,177...7,159,727 JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of CDKN2B mRNA] CTD PMID:16361081 NCBI chr 5:104,009,839...104,019,082 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPA mRNA] CTD PMID:17407152 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Hydrogen Peroxide results in increased expression of CEBPB mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CEBPB mRNA] CTD PMID:14684744 PMID:21220312 NCBI chr 3:156,398,035...156,399,466 JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
decreases activity
affects localization
ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Octanol results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of CFTR protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CFTR protein affects the transport of Water]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the localization of CFTR protein
CTD PMID:12606488 PMID:14744818 PMID:14967738 PMID:15763242 PMID:15994425 PMID:21724857 NCBI chr 4:46,561,269...46,728,759 JBrowse link
G Cga glycoprotein hormones, alpha polypeptide multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CGA protein results in increased cleavage of SREBF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CGA protein results in increased cleavage of SREBF2 protein] CTD PMID:26125464 NCBI chr 5:49,486,915...49,499,192 JBrowse link
G Chi3l3 chitinase 3-like 3 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with F2 protein] results in increased expression of CHI3L3 mRNA] CTD PMID:27261088 NCBI chr 2:193,808,141...193,825,511 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]] CTD PMID:11576339 NCBI chr10:79,883,622...79,900,625 JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in decreased expression of COL2A1 protein] CTD PMID:21177286 NCBI chr 7:129,098,489...129,127,620 JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] CTD PMID:11576339 NCBI chr 9:47,374,611...47,410,547 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin results in increased expression of CPT1A mRNA] CTD PMID:19053045 NCBI chr 1:200,564,634...200,627,059 JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [bisphenol A results in increased phosphorylation of and results in increased activity of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased phosphorylation of CREB1 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Capsaicin results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [alternariol results in increased expression of CREB1 protein modified form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Asbestos, Crocidolite results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [perfluorooctane sulfonic acid results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]
CTD PMID:10908723 PMID:12164941 PMID:15385614 PMID:15522277 PMID:16159392 PMID:16671086 PMID:17322281 PMID:17680988 PMID:18004999 PMID:18276108 PMID:19282384 PMID:19654912 PMID:21177760 PMID:24726522 PMID:30503586 PMID:30951808 PMID:33359577 NCBI chr 9:65,903,511...65,972,562 JBrowse link
G Crebbp CREB binding protein multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sodium Oxybate results in increased phosphorylation of CREBBP protein] CTD PMID:16675135 NCBI chr10:11,335,551...11,461,888 JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CRTC2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of CRTC2 protein] CTD PMID:33359577 NCBI chr 2:175,709,603...175,719,768 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein modified form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithium Chloride affects the localization of CTNNB1 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Epinephrine results in increased phosphorylation of CTNNB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein]
CTD PMID:22493441 PMID:26964897 NCBI chr 8:120,640,008...120,667,110 JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [3',4'-dimethoxyflavone results in increased expression of CYP11B1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased expression of CYP11B1 mRNA] CTD PMID:22172629 NCBI chr 7:106,838,590...106,845,004 JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP19A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Water Pollutants, Chemical analog results in increased expression of CYP19A1 mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein]
CTD PMID:19147701 PMID:20096755 PMID:20678559 PMID:21932247 PMID:28571770 NCBI chr 8:54,553,165...54,580,758 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions EXP
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TNF protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]
CTD PMID:20093341 PMID:25233930 NCBI chr 6:15,342,312...15,350,886 JBrowse link
G Dio2 iodothyronine deiodinase 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithocholic Acid results in increased activity of DIO2 protein] CTD PMID:19036883 NCBI chr 6:109,665,523...109,679,809 JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein] CTD PMID:14622123 NCBI chr17:10,540,440...10,544,971 JBrowse link
G Edn1 endothelin 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [EDN1 protein results in increased secretion of Norepinephrine] CTD PMID:14759557 PMID:15245872 NCBI chr17:22,454,924...22,460,812 JBrowse link
G Edn3 endothelin 3 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr 3:163,562,307...163,586,636 JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein] CTD PMID:15245872 NCBI chr15:80,640,839...80,672,115 JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithium Chloride results in increased expression of EGFR mRNA] CTD PMID:22493441 NCBI chr14:91,176,931...91,349,722 JBrowse link
G Egr1 early growth response 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of EGR1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Quercetin results in increased expression of EGR1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Quercetin results in increased expression of EGR1 protein] CTD PMID:15621046 PMID:22174042 NCBI chr18:26,463,333...26,465,531 JBrowse link
G Ereg epiregulin multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in increased expression of EREG mRNA] CTD PMID:16888076 NCBI chr14:17,027,287...17,041,062 JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cyclic AMP results in increased activity of ESR1 protein] CTD PMID:20360387 NCBI chr 1:41,106,335...41,499,104 JBrowse link
G F2 coagulation factor II multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [F2 protein results in increased expression of CD68 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [F2 protein results in increased expression of CD68 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [F2 protein results in increased expression of CD86 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with F2 protein] results in increased expression of CHI3L3 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with F2 protein] results in increased expression of MRC1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with F2 protein] results in increased expression of MRC1 protein] CTD PMID:27261088 NCBI chr 3:77,596,196...77,609,486 JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of FAS mRNA] CTD PMID:12414803 NCBI chr 1:231,798,963...231,832,591 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Arachidonic Acid results in increased expression of FOS mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dieldrin results in increased expression of FOS mRNA]
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOS mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]
CTD PMID:10864209 PMID:15179140 PMID:21177286 PMID:31068361 NCBI chr 6:105,121,170...105,124,036 JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOSL1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of FOSL1 mRNA] CTD PMID:21177286 NCBI chr 1:202,754,549...202,763,057 JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of FOSL2 mRNA] CTD PMID:21177286 NCBI chr 6:24,297,898...24,319,157 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[FSHB protein co-treated with Testosterone] results in increased chemical synthesis of Estradiol]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[FSHB protein co-treated with Testosterone] results in increased chemical synthesis of Progesterone]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased expression of AREG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased expression of AREG protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased secretion of Progesterone]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein promotes the reaction [Testosterone results in increased phosphorylation of CREB1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein]
CTD PMID:15967414 PMID:17510244 PMID:18535249 PMID:21177760 NCBI chr 3:93,548,560...93,552,370 JBrowse link
G Gast gastrin decreases secretion EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased secretion of GAST protein CTD PMID:19208342 NCBI chr10:85,264,832...85,269,393 JBrowse link
G Gcg glucagon multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased expression of CCND1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased expression of CCND1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased phosphorylation of CTNNB1 protein] CTD PMID:26964897 NCBI chr 3:47,113,914...47,122,929 JBrowse link
G Gcm1 glial cells missing transcription factor 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased activity of GCM1 protein] CTD PMID:16166624 NCBI chr 8:78,925,687...78,938,924 JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in decreased expression of GH1 mRNA] CTD PMID:29079362 NCBI chr10:91,228,102...91,230,079 JBrowse link
G Gper1 G protein-coupled estrogen receptor 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein] CTD PMID:22645130 NCBI chr12:15,217,217...15,222,679 JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:24910983 NCBI chr 7:108,416,646...108,419,495 JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Acetaminophen results in decreased expression of and results in decreased activity of GPX1 protein] CTD PMID:24910983 NCBI chr 8:109,026,905...109,028,031 JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dopamine results in increased activity of DRD1 protein] which results in increased phosphorylation of GRIN1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of GRIN1 protein] CTD PMID:14622123 NCBI chr 3:8,103,680...8,130,603 JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of GRIN2B protein] CTD PMID:20067577 NCBI chr 4:168,580,824...169,044,110 JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Caffeine results in increased phosphorylation of GSK3B protein] CTD PMID:21229324 NCBI chr11:62,498,997...62,648,665 JBrowse link
G Has2 hyaluronan synthase 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Hydrogen Peroxide results in increased expression of HAS2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA] CTD PMID:21220312 NCBI chr 7:88,113,326...88,139,337 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of HMOX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of HMOX1 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HMOX1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of HMOX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased expression of HMOX1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased expression of HMOX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ferric ammonium citrate results in increased expression of HMOX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [hexacyanoferrate III results in increased expression of HMOX1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nitroprusside results in increased expression of HMOX1 protein]
CTD PMID:15179140 PMID:16439612 PMID:19483313 NCBI chr19:13,466,287...13,474,082 JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of ID1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Iloprost results in increased expression of ID1 mRNA] CTD PMID:20522807 NCBI chr 3:141,210,666...141,212,420 JBrowse link
G Ighe immunoglobulin heavy constant epsilon multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA] CTD PMID:12230500
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IKBKB mRNA] CTD PMID:17407152 NCBI chr16:69,319,487...69,373,251 JBrowse link
G Il18 interleukin 18 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of IL18 protein] CTD PMID:16723495 NCBI chr 8:50,904,630...50,932,887 JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ammonia results in increased secretion of IL1B protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA] CTD PMID:23284918 PMID:29079362 NCBI chr 3:116,577,005...116,583,386 JBrowse link
G Il4 interleukin 4 multiple interactions
decreases secretion
decreases expression
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA alternative form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [IL4 protein results in increased expression of IGHE mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased secretion of IL4 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL4 mRNA
CTD PMID:11886533 PMID:12230500 NCBI chr10:37,771,203...37,776,750 JBrowse link
G Il5 interleukin 5 decreases expression
decreases secretion
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL5 mRNA
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased secretion of IL5 protein
CTD PMID:11886533 NCBI chr10:37,874,342...37,877,213 JBrowse link
G Il6 interleukin 6 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ammonia results in increased secretion of IL6 protein] CTD PMID:23284918 NCBI chr 4:5,214,602...5,219,178 JBrowse link
G Ins2 insulin 2 multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of PLIN2 protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PLIN1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PNPLA2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein] CTD PMID:29288687 NCBI chr 1:197,843,277...197,992,522 JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IRS1 mRNA] CTD PMID:17407152 NCBI chr 9:83,552,964...83,605,797 JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [2-(2-fluorobenzamido)benzoate ethyl ester inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Rolipram inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein] CTD PMID:21457779 NCBI chr 1:182,659,047...182,709,495 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of JUN mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of JUN mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of JUN protein]]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]]
CTD PMID:15179140 PMID:18755854 PMID:21177286 NCBI chr 5:109,894,175...109,897,268 JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with U 0126] inhibits the reaction [Isoproterenol results in increased expression of JUNB mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased expression of JUNB mRNA] CTD PMID:21177286 NCBI chr19:23,176,265...23,178,049 JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dobutamine results in increased activity of [JUN protein binds to JUND protein binds to FOS protein]] CTD PMID:15179140 NCBI chr16:18,734,121...18,735,799 JBrowse link
G Kcne1 potassium voltage-gated channel subfamily E regulatory subunit 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]] CTD PMID:16909339 NCBI chr11:31,580,951...31,594,116 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in decreased expression of KCNH2 protein] CTD PMID:22853924 NCBI chr 4:10,826,834...10,859,009 JBrowse link
G Kcnj2 potassium inwardly-rectifying channel, subfamily J, member 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in decreased expression of KCNJ2 protein] CTD PMID:22853924 NCBI chr10:96,060,849...96,071,401 JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased activity of [KCNQ1 protein binds to KCNE1 protein]] CTD PMID:16909339 NCBI chr 1:198,291,711...198,624,683 JBrowse link
G Kng2 kininogen 2 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [KNG1 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:15750287 NCBI chr11:77,913,876...77,936,247 JBrowse link
G Lep leptin multiple interactions
decreases response to substance
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased chemical synthesis of Reactive Oxygen Species]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased expression of CCL2]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased susceptibility to LEP protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]
CTD PMID:11342529 PMID:19254925 PMID:28571770 NCBI chr 4:57,661,127...57,675,262 JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CGB3 results in increased expression of PRL7D1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased expression of AREG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased expression of AREG protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased secretion of Progesterone]
CTD PMID:15967414 PMID:21220312 PMID:21679748 NCBI chr 1:95,898,269...95,901,973 JBrowse link
G Lipe lipase E, hormone sensitive type multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of LIPE protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein modified form]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of LIPE protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of LIPE mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Thioctic Acid results in increased phosphorylation of LIPE protein] CTD PMID:22941773 PMID:23362264 PMID:29288687 NCBI chr 1:80,965,612...80,984,313 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK1 protein]]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the reaction [Levodopa results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ADM protein results in decreased activity of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK1 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nitroprusside results in increased phosphorylation of MAPK1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Quercetin promotes the reaction [Glucose results in increased expression of MAPK1 protein modified form]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD PMID:10374718 PMID:11675405 PMID:12657697 PMID:16099847 PMID:16439612 PMID:16671086 PMID:17322281 PMID:18004999 PMID:20860660 PMID:21177760 PMID:25044243 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK3 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the reaction [Levodopa results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [1-Methyl-3-isobutylxanthine promotes the reaction [FSHB protein inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein promotes the reaction [1-Methyl-3-isobutylxanthine inhibits the reaction [Testosterone results in increased phosphorylation of MAPK3 protein]]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nitroprusside results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Quercetin promotes the reaction [Glucose results in increased expression of MAPK3 protein modified form]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Ro 31-8425 inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in increased phosphorylation of and results in increased activity of MAPK3 protein; Ro 31-8425 promotes the reaction [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of MAPK3 protein]]
CTD PMID:11675405 PMID:12657697 PMID:15385614 PMID:16099847 PMID:16439612 PMID:16671086 PMID:17322281 PMID:18004999 PMID:20860660 PMID:21177760 PMID:25044243 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Mitf melanocyte inducing transcription factor multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [isosakuranetin results in increased expression of MITF protein] CTD PMID:26524968 NCBI chr 4:130,409,020...130,621,145 JBrowse link
G Mlxipl MLX interacting protein-like multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin inhibits the reaction [Fructose results in increased activity of MLXIPL protein]] CTD PMID:19053045 NCBI chr12:21,542,964...21,577,120 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of MMP9 mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in increased expression of MMP9 mRNA]
CTD PMID:24929186 PMID:29079362 NCBI chr 3:153,684,158...153,692,118 JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with F2 protein] results in increased expression of MRC1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with F2 protein] results in increased expression of MRC1 protein] CTD PMID:27261088 NCBI chr17:77,249,187...77,330,857 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GCG protein results in increased expression of MYC mRNA] CTD PMID:26964897 NCBI chr 7:93,593,705...93,598,633 JBrowse link
G Myh4 myosin heavy chain 4 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Testosterone results in increased expression of MYH4 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Testosterone results in increased expression of MYH4 protein] CTD PMID:21374593 NCBI chr10:51,923,149...51,946,297 JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:18851973 NCBI chr15:28,446,550...28,469,888 JBrowse link
G Myog myogenin multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Testosterone results in increased expression of MYOG mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Testosterone results in increased expression of MYOG protein] CTD PMID:21374593 NCBI chr13:45,745,455...45,748,044 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
multiple interactions
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of NFE2L2 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in increased expression of NFE2L2 protein]
CTD PMID:29870751 NCBI chr 3:60,594,239...60,621,785 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NFKB1 mRNA] CTD PMID:17407152 NCBI chr 2:224,016,214...224,132,135 JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Mevinphos results in increased expression of NOS1 protein] CTD PMID:15245872 PMID:17438462 NCBI chr12:38,615,111...38,795,492 JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:18851973 NCBI chr 5:158,429,042...158,430,351 JBrowse link
G Nr0b1 nuclear receptor subfamily 0, group B, member 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in decreased expression of NR0B1 protein] CTD PMID:18787026 NCBI chr  X:50,756,886...50,761,014 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of NR1H4 mRNA]] CTD PMID:27743861 NCBI chr 7:23,846,122...23,942,085 JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [cadmium acetate results in increased expression of NR4A1 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [bisphenol A results in increased expression of NR4A1 mRNA]
CTD PMID:12021184 PMID:15016657 NCBI chr 7:132,368,399...132,389,300 JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein] CTD PMID:22188298 NCBI chr 3:41,689,847...41,707,036 JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dimaprit results in increased expression of NTF3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Histamine results in increased expression of NTF3 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Neurotransmitter Agents results in increased expression of NTF3 protein] CTD PMID:19854260 PMID:21276809 NCBI chr 4:158,914,984...158,984,453 JBrowse link
G Pgr progesterone receptor multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Hydrogen Peroxide results in increased expression of PGR mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of PGR mRNA] CTD PMID:21220312 NCBI chr 8:6,073,216...6,131,552 JBrowse link
G Pink1 PTEN induced kinase 1 decreases expression
multiple interactions
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of PINK1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in increased expression of PINK1 protein]
CTD PMID:29870751 NCBI chr 5:150,530,523...150,542,635 JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLA2G4A mRNA] CTD PMID:18938131 NCBI chr13:61,877,818...62,022,261 JBrowse link
G Pld1 phospholipase D1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]] CTD PMID:17640750 NCBI chr 2:110,849,205...111,047,692 JBrowse link
G Plin1 perilipin 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PLIN1 protein] CTD PMID:29288687 NCBI chr 1:133,664,294...133,676,854 JBrowse link
G Plin2 perilipin 2 multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in decreased expression of PLIN2 protein CTD PMID:29288687 NCBI chr 5:101,156,643...101,211,738 JBrowse link
G Pln phospholamban decreases phosphorylation EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of PLN protein CTD PMID:27495954 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PNPLA2 protein] CTD PMID:29288687 NCBI chr 1:196,552,723...196,557,805 JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of PNPLA6 mRNA; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of PNPLA6 protein CTD PMID:20380879 NCBI chr12:1,574,387...1,603,735 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of PPARGC1A protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GW9508 inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of PPARGC1A mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [GW9508 inhibits the reaction [malondialdehyde-low density lipoprotein, human results in decreased expression of PPARGC1A protein]]
CTD PMID:16513826 PMID:29288687 PMID:32347098 NCBI chr14:58,860,752...59,516,525 JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Isoproterenol results in increased phosphorylation of PRKAA1 protein] CTD PMID:19167487 NCBI chr 2:54,240,298...54,275,978 JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Atorvastatin results in increased phosphorylation of and results in increased activity of PRKACA protein] CTD PMID:19053045 NCBI chr19:24,155,081...24,178,430 JBrowse link
G Prkar2a protein kinase cAMP-dependent type II regulatory subunit alpha decreases phosphorylation
multiple interactions
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of PRKAR2A protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [resveratrol results in increased phosphorylation of PRKAR2A protein]
CTD PMID:25943029 NCBI chr 8:109,393,189...109,458,832 JBrowse link
G Prkca protein kinase C, alpha decreases activity ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of PRKCA protein CTD PMID:16361081 NCBI chr10:92,889,390...93,288,013 JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased expression of NR4A2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of ATF1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein] CTD PMID:22188298 NCBI chr19:24,470,258...24,473,687 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PLD1 protein promotes the reaction [cobaltous chloride results in increased expression of PTGS2 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Hydrogen Peroxide results in increased expression of PTGS2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]
CTD PMID:17407152 PMID:17640750 PMID:18938131 PMID:19063610 PMID:19147701 PMID:21220312 NCBI chr13:62,164,080...62,169,770 JBrowse link
G Pth parathyroid hormone multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [PTH protein results in decreased uptake of Phosphates] CTD PMID:27432882 NCBI chr 1:167,508,121...167,511,530 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Dinoprostone co-treated with PTGER1 protein] results in increased phosphorylation of RELA protein] CTD PMID:22188298 NCBI chr 1:202,925,001...202,935,484 JBrowse link
G Relb RELB proto-oncogene, NF-kB subunit multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to RELB protein] which binds to CXCL8 promoter]] CTD PMID:17823304 NCBI chr 1:79,257,738...79,285,490 JBrowse link
G Rnf187 ring finger protein 187 decreases stability ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased stability of RNF187 protein CTD PMID:25851810 NCBI chr10:43,709,493...43,715,392 JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 decreases activity EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of ROCK2 protein CTD PMID:10998351 NCBI chr 6:39,679,116...39,774,033 JBrowse link
G Rps6ka3 ribosomal protein S6 kinase A3 decreases activity ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of RPS6KA3 protein CTD PMID:10998351 NCBI chr  X:35,517,306...35,623,296 JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 decreases activity EXP
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of RPS6KA5 protein CTD PMID:10998351 PMID:15522277 PMID:18377872 NCBI chr 6:119,828,823...120,006,190 JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases activity ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of RPS6KB1 protein CTD PMID:10998351 NCBI chr10:71,323,777...71,367,908 JBrowse link
G Ryr2 ryanodine receptor 2 decreases phosphorylation EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased phosphorylation of RYR2 protein CTD PMID:27495954 NCBI chr17:58,389,925...58,975,641 JBrowse link
G S100b S100 calcium binding protein B multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ammonia results in increased secretion of S100B protein] CTD PMID:23284918 NCBI chr20:12,372,866...12,381,619 JBrowse link
G Sct secretin multiple interactions
decreases activity
EXP
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of SCT protein
CTD PMID:10880878 PMID:22194894 NCBI chr 1:196,382,941...196,383,635 JBrowse link
G Selenot selenoprotein T multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ADCYAP1 protein results in increased expression of SELENOT mRNA] CTD PMID:18198219 NCBI chr 2:142,804,387...142,821,438 JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases activity ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of SGK1 protein CTD PMID:10998351 NCBI chr 1:22,980,257...23,098,122 JBrowse link
G Si sucrase-isomaltase multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Berberine results in decreased expression of SI mRNA] CTD PMID:20229011 NCBI chr 2:157,505,893...157,586,228 JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with TNF protein] results in decreased expression of SIRT1 protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dinoprostone results in decreased expression of SIRT1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Resveratrol results in increased expression of SIRT1 protein] CTD PMID:24145604 PMID:25943029 PMID:30409902 NCBI chr20:25,307,143...25,329,260 JBrowse link
G Slc10a1 solute carrier family 10 member 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Chenodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A1 mRNA]] CTD PMID:27743861 NCBI chr 6:100,613,045...100,626,670 JBrowse link
G Slc1a2 solute carrier family 1 member 2 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Raloxifene Hydrochloride results in increased expression of SLC1A2 protein] CTD PMID:22645130 PMID:24782323 NCBI chr 3:89,005,129...89,126,498 JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Oxygen co-treated with Glucose deficiency co-treated with 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxyglucopyranoside] results in increased expression of SLC2A3 protein] CTD PMID:24726522 NCBI chr 4:155,960,944...156,026,000 JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SLC2A4 mRNA] CTD PMID:17407152 NCBI chr10:54,666,015...54,671,581 JBrowse link
G Slc2a5 solute carrier family 2 member 5 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of and results in increased stability of SLC2A5 mRNA] CTD PMID:12820898 NCBI chr 5:160,583,055...160,609,994 JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-((4-chlorophenyl)thio)cyclic-3',5'-AMP affects the splicing of SNAP25 exon]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin affects the splicing of SNAP25 exon] CTD PMID:22684629 NCBI chr 3:124,041,898...124,123,761 JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SOCS3 mRNA] CTD PMID:17407152 NCBI chr10:103,193,909...103,197,322 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide promotes the reaction [Acetaminophen results in decreased expression of and results in decreased activity of SOD1 protein] CTD PMID:24910983 NCBI chr11:29,456,673...29,462,249 JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of SOD2 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Medroxyprogesterone Acetate results in increased expression of SOD2 mRNA] CTD PMID:20685861 NCBI chr 1:47,638,318...47,645,163 JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [8-bromocyclic GMP inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]] CTD PMID:20453393 NCBI chr14:5,308,885...5,315,120 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CGA protein results in increased cleavage of SREBF1 protein] CTD PMID:26125464 NCBI chr10:45,007,637...45,029,650 JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [CGA protein results in increased cleavage of SREBF2 protein] CTD PMID:26125464 NCBI chr 7:113,663,202...113,720,850 JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with SB 203580] inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of STAR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Cyclic AMP co-treated with Verapamil] results in increased expression of STAR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [perfluorooctane sulfonic acid inhibits the reaction [[CRTC2 protein binds to CREB1 protein modified form] which binds to STAR promoter]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [perfluorooctane sulfonic acid results in decreased expression of STAR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [Bucladesine results in increased expression of and results in increased phosphorylation of STAR protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CREB1 protein modified form binds to STAR promoter]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAR protein] CTD PMID:18755854 PMID:18787026 PMID:19282384 PMID:19822634 PMID:23362264 PMID:33359577 NCBI chr16:66,267,094...66,274,368 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Lithium Chloride results in increased phosphorylation of and results in increased activity of STAT3 protein] CTD PMID:22493441 NCBI chr10:85,811,206...85,863,057 JBrowse link
G Stk11 serine/threonine kinase 11 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [5-methyltetrahydrofolate inhibits the reaction [Palmitic Acid results in decreased phosphorylation of STK11 protein]] CTD PMID:26400185 NCBI chr 7:9,574,553...9,591,315 JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [KNG1 promotes the reaction [Capsaicin results in increased secretion of TAC1 protein]] CTD PMID:15750287 NCBI chr 4:35,679,183...35,687,180 JBrowse link
G Tfap2a transcription factor AP-2 alpha multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [butylbenzyl phthalate affects the localization of TFAP2A protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dibutyl Phthalate affects the localization of TFAP2A protein] CTD PMID:22552774 NCBI chr17:24,028,716...24,047,507 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in decreased expression of KCNH2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in decreased expression of KCNJ2 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of CDKN1A mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of CDKN2B mRNA] CTD PMID:11576339 PMID:16361081 PMID:22853924 NCBI chr 1:81,196,532...81,212,848 JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression
EXP [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [imidacloprid results in increased expression of TH mRNA]; [N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with exoenzyme C3, Clostridium botulinum] inhibits the reaction [Nicotine results in increased expression of TH mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of TH mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [HU 211 results in decreased expression of TH mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [imidacloprid results in increased expression of TH mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Nicotine results in increased expression of TH mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of TH mRNA
CTD PMID:18992715 PMID:29246838 NCBI chr 1:198,071,500...198,078,832 JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
[N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide co-treated with TNF protein] results in decreased expression of SIRT1 protein; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dieldrin results in increased expression of TNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline inhibits the reaction [Shiga Toxin results in increased expression of TNF protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Terbutaline results in decreased expression of TNF mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Ammonia results in increased secretion of TNF protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [TNF protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]
CTD PMID:11675405 PMID:17407152 PMID:23284918 PMID:24145604 PMID:25233930 PMID:31068361 NCBI chr20:3,622,011...3,624,629 JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFAIP6 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA] CTD PMID:21220312 NCBI chr 3:36,502,250...36,521,652 JBrowse link
G Tph2 tryptophan hydroxylase 2 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Sertraline results in increased expression of TPH2 mRNA] CTD PMID:11901216 NCBI chr 7:50,685,694...50,789,424 JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium] CTD PMID:21453681 NCBI chr10:57,851,428...57,876,513 JBrowse link
G Tsc2 TSC complex subunit 2 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [FSHB protein results in increased phosphorylation of TSC2 protein] CTD PMID:17510244 NCBI chr10:13,621,135...13,655,773 JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] CTD PMID:20453393 NCBI chr 5:72,712,334...72,724,564 JBrowse link
G Tyr tyrosinase multiple interactions
decreases activity
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [scoparone results in increased expression of TYR protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased activity of TYR protein
CTD PMID:17049123 PMID:30849679 NCBI chr 1:141,115,036...141,210,207 JBrowse link
G Ucp1 uncoupling protein 1 multiple interactions EXP
ISO
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Bucladesine results in increased expression of UCP1 mRNA]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[licarin A affects the susceptibility to [INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone]] which results in increased expression of UCP1 protein]
CTD PMID:12414803 PMID:29288687 NCBI chr19:24,808,782...24,816,853 JBrowse link
G Vasp vasodilator-stimulated phosphoprotein multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of VASP protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [N(6)-benzoyl-cyclic AMP results in increased phosphorylation of VASP protein] CTD PMID:22363678 PMID:32409581 NCBI chr 1:78,910,009...78,925,791 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of VEGFA mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Norepinephrine results in increased expression of VEGFA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA mRNA] CTD PMID:10788502 PMID:19063610 NCBI chr 9:14,955,300...14,970,641 JBrowse link
G Vip vasoactive intestinal peptide multiple interactions ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [VIP protein results in increased expression of AQP3 mRNA] CTD PMID:12542607 NCBI chr 1:42,064,878...42,073,219 JBrowse link
G Xiap X-linked inhibitor of apoptosis increases expression
decreases expression
ISO N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in increased expression of XIAP protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of XIAP mRNA
CTD PMID:21255191 NCBI chr  X:120,890,537...120,938,413 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        inhibitor 18454
          enzyme inhibitor 18247
            EC 2.* (transferase) inhibitor 13894
              EC 2.7.* (P-containing group transferase) inhibitor 13529
                EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8187
                  EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor 194
                    (Rp)-cAMPS 0
                    KT 5720 43
                    N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide 173
                    N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide dihydrochloride 0
                    vanadyl sulfate trihydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    role 19708
      biological role 19708
        inhibitor 18454
          enzyme inhibitor 18247
            EC 2.* (transferase) inhibitor 13894
              EC 2.7.* (P-containing group transferase) inhibitor 13529
                protein kinase inhibitor 13057
                  EC 2.7.11.* (protein-serine/threonine kinase) inhibitor 8187
                    EC 2.7.11.11 (cAMP-dependent protein kinase) inhibitor 194
                      (Rp)-cAMPS 0
                      KT 5720 43
                      N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide 173
                      N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide dihydrochloride 0
                      vanadyl sulfate trihydrate 0
paths to the root