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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:85083 term browser browse the term
Definition:A nucleotide conjugate that is used in combination with ledipasvir (under the trade name Harvoni) for the treatment of chronic hepatitis C genotype 1 infection.
Synonyms:related_synonym: Formula=C22H29FN3O9P;   GI 7977;   GS-7977;   InChI=1S/C22H29FN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)/t14-,16+,18+,20+,22+,36-/m0/s1;   InChIKey=TTZHDVOVKQGIBA-IQWMDFIBSA-N;   PSI-7977;   SMILES=CC(C)OC(=O)[C@H](C)N[P@](=O)(OC[C@H]1O[C@@H](n2ccc(=O)[nH]c2=O)[C@](C)(F)[C@@H]1O)Oc1ccccc1;   Sovaldi;   isopropyl (2S)-2-{[(S)-{[(2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
 xref: CAS:1190307-88-0;   Drug_Central:4811;   KEGG:D10366;   PMID:25123381;   PMID:25159822;   PMID:25261839;   PMID:25304641;   PMID:25322962;   PMID:25583164;   PMID:25601269;   PMID:25614962;   PMID:25619265;   PMID:25621961;   PMID:25622055;   PMID:25641426;   PMID:25645644;   PMID:25659285;   PMID:25674516;   PMID:25676703;   PMID:25708155;   Reaxys:20867484;   Wikipedia:Sofosbuvir

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sofosbuvir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Klrc1 killer cell lectin like receptor C1 decreases expression ISO sofosbuvir co-treated with ledipasvir decreased expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 4:163,453,435...163,463,718
Ensembl chr 4:163,458,528...163,463,718
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G Ncr1 natural cytotoxicity triggering receptor 1 affects expression ISO sofosbuvir co-treated with ledipasvir affects expression of NCR1 protein in natural killer cells RGD PMID:31218578 RGD:40400920 NCBI chr 1:73,178,917...73,226,504
Ensembl chr 1:73,179,013...73,226,777
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19761
    role 19711
      application 19401
        pro-agent 8877
          prodrug 8631
            sofosbuvir 2
              Epclusa 0
              Harvoni 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19761
    subatomic particle 19759
      composite particle 19759
        hadron 19759
          baryon 19759
            nucleon 19759
              atomic nucleus 19759
                atom 19759
                  main group element atom 19653
                    p-block element atom 19653
                      chalcogen 19382
                        oxygen atom 19345
                          oxygen molecular entity 19345
                            hydroxides 19071
                              oxoacid 18269
                                pnictogen oxoacid 10312
                                  phosphorus oxoacid 9233
                                    phosphoric acids 7953
                                      phosphoric acid 7953
                                        phosphoric acid derivative 7632
                                          phosphate 7632
                                            organic phosphate 7631
                                              carbohydrate phosphate 1715
                                                phospho sugar 1640
                                                  aldose phosphate 1638
                                                    aldopentose phosphate 1632
                                                      ribose phosphate 1627
                                                        ribonucleotide 1588
                                                          ribonucleoside 5'-phosphate 603
                                                            ribonucleoside 5'-monophosphate 339
                                                              pyrimidine ribonucleoside 5'-monophosphate 312
                                                                uridine 5'-monophosphate 2
                                                                  sofosbuvir 2
                                                                    Epclusa 0
                                                                    Harvoni 0
paths to the root