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ONTOLOGY REPORT - ANNOTATIONS


Term:2,5-hexanedione
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Accession:CHEBI:85014 term browser browse the term
Definition:A diketone that is hexane substituted by oxo groups at positions 2 and 5. It is a toxic metabolite of hexane and of 2-hexanone
Synonyms:related_synonym: 1,2-Diacetylethane;   2,5-Diketohexane;   2,5-Hexadione;   Acetonyl acetone;   CH3COCH2CH2COCH3;   Formula=C6H10O2;   InChI=1S/C6H10O2/c1-5(7)3-4-6(2)8/h3-4H2,1-2H3;   InChIKey=OJVAMHKKJGICOG-UHFFFAOYSA-N;   NSC 7621;   SMILES=CC(=O)CCC(C)=O;   acetonylacetone;   alpha,beta-diacetylethane;   hexane-2,5-dione
 xref: CAS:110-13-4
 xref_mesh: MESH:C011269
 xref: MetaCyc:CPD-15521;   PMID:1781736;   PMID:24634916;   PMID:25549948;   Reaxys:506525;   Wikipedia:Hexane-2\,5-dione


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2,5-hexanedione term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abi2 abl-interactor 2 JBrowse link 9 67,234,612 67,284,504 RGD:6480464
G Aco2 aconitase 2 JBrowse link 7 123,102,493 123,145,608 RGD:6480464
G Alox15b arachidonate 15-lipoxygenase, type B JBrowse link 10 55,773,748 55,783,489 RGD:6480464
G Angptl4 angiopoietin-like 4 JBrowse link 7 18,627,814 18,634,043 RGD:6480464
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:6480464
G Bcl2l14 BCL2 like 14 JBrowse link 4 168,139,964 168,183,726 RGD:6480464
G Bfar bifunctional apoptosis regulator JBrowse link 10
10
1,464,658
1,464,783
1,471,152
1,497,653
RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccdc171 coiled-coil domain containing 171 JBrowse link 5 101,639,355 102,017,300 RGD:6480464
G Ccdc191 coiled-coil domain containing 191 JBrowse link 11 61,678,138 61,748,773 RGD:6480464
G Cdin1 CDAN1 interacting nuclease 1 JBrowse link 3 107,142,734 107,347,381 RGD:6480464
G Cep112 centrosomal protein 112 JBrowse link 10 96,660,294 97,146,426 RGD:6480464
G Cfap221 cilia and flagella associated protein 221 JBrowse link 13 35,952,808 36,024,371 RGD:6480464
G Ckmt1 creatine kinase, mitochondrial 1 JBrowse link 3 113,318,559 113,324,459 RGD:6480464
G Clca2 chloride channel accessory 2 JBrowse link 2 250,954,423 250,981,544 RGD:6480464
G Clu clusterin JBrowse link 15 42,626,612 42,665,858 RGD:6480464
G Ctxn1 cortexin 1 JBrowse link 12 2,534,212 2,535,823 RGD:6480464
G Dcn decorin JBrowse link 7 38,742,250 38,782,282 RGD:6480464
G Dennd1a DENN domain containing 1A JBrowse link 3 22,061,120 22,501,502 RGD:6480464
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 JBrowse link 2 257,394,692 257,425,344 RGD:6480464
G Dpp7 dipeptidylpeptidase 7 JBrowse link 3 2,569,135 2,573,387 RGD:6480464
G Dpysl2 dihydropyrimidinase-like 2 JBrowse link 15 43,475,640 43,581,725 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Erc1 ELKS/RAB6-interacting/CAST family member 1 JBrowse link 4 152,087,393 152,380,023 RGD:6480464
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:6480464
G Fasn fatty acid synthase JBrowse link 10 109,987,735 110,005,901 RGD:6480464
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:6480464
G Gadd45a growth arrest and DNA-damage-inducible, alpha JBrowse link 4 97,782,512 97,784,814 RGD:6480464
G Gas2 growth arrest-specific 2 JBrowse link 1 107,234,389 107,363,624 RGD:6480464
G Gfap glial fibrillary acidic protein JBrowse link 10 90,990,762 90,999,435 RGD:6480464
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:6480464
G Glud1 glutamate dehydrogenase 1 JBrowse link 16 10,661,486 10,695,557 RGD:6480464
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:6480464
G Gstm3l glutathione S-transferase mu 3-like JBrowse link 2 210,761,729 210,766,501 RGD:6480464
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:6480464
G Hdgfl1 HDGF like 1 JBrowse link 17 40,170,522 40,172,518 RGD:6480464
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:6480464
G Ier3 immediate early response 3 JBrowse link 20 3,438,798 3,440,002 RGD:6480464
G Ift81 intraflagellar transport 81 JBrowse link 12 39,420,161 39,507,412 RGD:6480464
G Igfbp3 insulin-like growth factor binding protein 3 JBrowse link 14 87,457,647 87,465,374 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Ina internexin neuronal intermediate filament protein, alpha JBrowse link 1 266,782,835 266,794,389 RGD:6480464
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:6480464
G Itgb1 integrin subunit beta 1 JBrowse link 19 61,677,512 61,725,537 RGD:6480464
G Kif6 kinesin family member 6 JBrowse link 9 13,016,973 13,311,971 RGD:6480464
G Kit KIT proto-oncogene receptor tyrosine kinase JBrowse link 14 35,072,131 35,149,638 RGD:6480464
G Loxl1 lysyl oxidase-like 1 JBrowse link 8 63,067,757 63,092,124 RGD:6480464
G Lrrc6 leucine rich repeat containing 6 JBrowse link 7 107,130,402 107,231,507 RGD:6480464
G Lrrc69 leucine rich repeat containing 69 JBrowse link 5 28,133,066 28,321,877 RGD:6480464
G Lyz2 lysozyme 2 JBrowse link 7 60,335,968 60,341,264 RGD:6480464
G Macrod1 mono-ADP ribosylhydrolase 1 JBrowse link 1 222,310,916 222,451,485 RGD:6480464
G Map1a microtubule-associated protein 1A JBrowse link 3 113,251,918 113,272,193 RGD:6480464
G Map1b microtubule-associated protein 1B JBrowse link 2 29,675,391 29,768,750 RGD:6480464
G Map2 microtubule-associated protein 2 JBrowse link 9 73,204,753 73,462,965 RGD:6480464
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:6480464
G Mdh1 malate dehydrogenase 1 JBrowse link 14 106,378,349 106,393,642 RGD:6480464
G Mfap3l microfibril associated protein 3 like JBrowse link 16 32,734,059 32,777,091 RGD:6480464
G Mtm1 myotubularin 1 JBrowse link 6 18,821,821 18,840,449 RGD:6480464
G Napa NSF attachment protein alpha JBrowse link 1 77,994,227 78,012,846 RGD:6480464
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 JBrowse link 9 99,617,051 99,651,827 RGD:6480464
G Nefh neurofilament heavy JBrowse link 14 85,181,572 85,191,557 RGD:6480464
G Nefl neurofilament light JBrowse link 15 44,799,378 44,803,251 RGD:6480464
G Nefm neurofilament medium JBrowse link 15 44,855,307 44,860,604 RGD:6480464
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase JBrowse link 10 91,879,608 91,986,242 RGD:6480464
G Nupr2 nuclear protein 2, transcriptional regulator JBrowse link 12 30,300,936 30,304,041 RGD:6480464
G Pdia3 protein disulfide isomerase family A, member 3 JBrowse link 3 113,376,983 113,400,707 RGD:6480464
G Pdlim3 PDZ and LIM domain 3 JBrowse link 16 49,543,140 49,574,362 RGD:6480464
G Pgam1 phosphoglycerate mutase 1 JBrowse link 1 261,158,204 261,165,814 RGD:6480464
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 JBrowse link 10 83,635,557 83,643,862 RGD:6480464
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase JBrowse link 20 8,165,423 8,169,557 RGD:6480464
G Pkm pyruvate kinase M1/2 JBrowse link 8 64,480,963 64,502,957 RGD:6480464
G Pou2f1 POU class 2 homeobox 1 JBrowse link 13 84,075,316 84,217,368 RGD:6480464
G Prkcsh protein kinase C substrate 80K-H JBrowse link 8 23,014,802 23,026,507 RGD:6480464
G Ptgds prostaglandin D2 synthase JBrowse link 3 2,686,125 2,689,059 RGD:6480464
G Pygb glycogen phosphorylase B JBrowse link 3 146,581,063 146,629,504 RGD:6480464
G Pygm glycogen phosphorylase, muscle associated JBrowse link 1 221,756,325 221,771,142 RGD:6480464
G Ralgapa2 Ral GTPase activating protein catalytic subunit alpha 2 JBrowse link 3 140,451,850 140,728,305 RGD:6480464
G Rela RELA proto-oncogene, NF-kB subunit JBrowse link 1 220,992,770 221,003,249 RGD:6480464
G RGD1304694 similar to CG9646-PA JBrowse link 7 125,853,573 125,893,168 RGD:6480464
G RGD1562608 similar to KIAA1328 protein JBrowse link 18 17,394,586 17,678,605 RGD:6480464
G Rtkn2 rhotekin 2 JBrowse link 20 21,919,486 22,004,279 RGD:6480464
G S100z S100 calcium binding protein Z JBrowse link 2 25,188,381 25,203,627 RGD:6480464
G Sclt1 sodium channel and clathrin linker 1 JBrowse link 2 128,523,376 128,675,668 RGD:6480464
G Septin8 septin 8 JBrowse link 10 38,877,422 38,906,480 RGD:6480464
G Sh2d4a SH2 domain containing 4A JBrowse link 16 23,084,247 23,156,825 RGD:6480464
G Shank3 SH3 and multiple ankyrin repeat domains 3 JBrowse link 7 130,474,278 130,534,679 RGD:6480464
G Sil1 SIL1 nucleotide exchange factor JBrowse link 18 28,067,476 28,302,008 RGD:6480464
G Slc10a7 solute carrier family 10, member 7 JBrowse link 19 32,857,984 33,081,359 RGD:6480464
G Sltm SAFB-like, transcription modulator JBrowse link 8 76,977,698 77,022,847 RGD:6480464
G Sod3 superoxide dismutase 3 JBrowse link 14 60,958,583 60,971,143 RGD:6480464
G Sppl3 signal peptide peptidase like 3 JBrowse link 12 47,276,485 47,360,552 RGD:6480464
G Sptan1 spectrin, alpha, non-erythrocytic 1 JBrowse link 3 8,534,437 8,599,259 RGD:6480464
G Stmn1 stathmin 1 JBrowse link 5 152,680,412 152,686,807 RGD:6480464
G Strbp spermatid perinuclear RNA binding protein JBrowse link 3 21,817,680 21,956,988 RGD:6480464
G Styxl1 serine/threonine/tyrosine interacting-like 1 JBrowse link 12 23,954,563 23,987,155 RGD:6480464
G Tax1bp1 Tax1 binding protein 1 JBrowse link 4 82,776,720 82,832,586 RGD:6480464
G Tbc1d5 TBC1 domain family, member 5 JBrowse link 9 1,144,641 1,747,732 RGD:6480464
G Tmem192 transmembrane protein 192 JBrowse link 16 26,620,525 26,642,537 RGD:6480464
G Tpi1 triosephosphate isomerase 1 JBrowse link 4 157,328,375 157,331,905 RGD:6480464
G Uba1 ubiquitin-like modifier activating enzyme 1 JBrowse link X 1,723,135 1,745,147 RGD:6480464
G Ubn2 ubinuclein 2 JBrowse link 4 66,164,639 66,254,297 RGD:6480464
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 JBrowse link 1 190,555,177 190,585,741 RGD:6480464
G Vim vimentin JBrowse link 17 80,882,715 80,891,200 RGD:6480464
G Xiap X-linked inhibitor of apoptosis JBrowse link X 128,409,425 128,455,786 RGD:6480464
G Zfp169 zinc finger protein 169 JBrowse link 17 16,443,324 16,471,329 RGD:6480464
G Zfp407 zinc finger protein 407 JBrowse link 18 81,057,507 81,453,682 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19717
      biological role 19716
        aetiopathogenetic role 18829
          neurotoxin 17390
            2,5-hexanedione 107
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19653
                    p-block element atom 19653
                      carbon group element atom 19548
                        carbon atom 19537
                          organic molecular entity 19537
                            organic group 18465
                              organic divalent group 18458
                                organodiyl group 18458
                                  carbonyl group 18354
                                    carbonyl compound 18354
                                      ketone 15949
                                        diketone 1090
                                          2,5-hexanedione 107
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.