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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2,5-hexanedione
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Accession:CHEBI:85014 term browser browse the term
Definition:A diketone that is hexane substituted by oxo groups at positions 2 and 5. It is a toxic metabolite of hexane and of 2-hexanone
Synonyms:related_synonym: 1,2-Diacetylethane;   2,5-Diketohexane;   2,5-Hexadione;   Acetonyl acetone;   CH3COCH2CH2COCH3;   Formula=C6H10O2;   InChI=1S/C6H10O2/c1-5(7)3-4-6(2)8/h3-4H2,1-2H3;   InChIKey=OJVAMHKKJGICOG-UHFFFAOYSA-N;   NSC 7621;   SMILES=CC(=O)CCC(C)=O;   acetonylacetone;   alpha,beta-diacetylethane;   hexane-2,5-dione
 xref: CAS:110-13-4
 xref_mesh: MESH:C011269
 xref: MetaCyc:CPD-15521;   PMID:1781736;   PMID:24634916;   PMID:25549948;   Reaxys:506525;   Wikipedia:Hexane-2\,5-dione


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2,5-hexanedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 increases expression EXP 2,5-hexanedione results in increased expression of ABI2 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
JBrowse link
G Aco2 aconitase 2 increases expression EXP 2,5-hexanedione results in increased expression of ACO2 protein CTD PMID:19033394 NCBI chr 7:123,102,493...123,145,608
Ensembl chr 7:123,102,468...123,145,635
JBrowse link
G Aif1 allograft inflammatory factor 1 increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of AIF1 protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of AIF1 protein]
CTD PMID:32522579 PMID:32860822 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448
JBrowse link
G Alox15b arachidonate 15-lipoxygenase, type B decreases expression EXP 2,5-hexanedione results in decreased expression of ALOX15B mRNA CTD PMID:22952946 NCBI chr10:55,773,748...55,783,489
Ensembl chr10:55,774,006...55,783,489
JBrowse link
G Angptl4 angiopoietin-like 4 affects expression EXP 2,5-hexanedione affects the expression of ANGPTL4 mRNA CTD PMID:20616210 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Arg1 arginase 1 decreases expression
multiple interactions
EXP 2,5-hexanedione results in decreased expression of ARG1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of ARG1 mRNA]
CTD PMID:32522579 PMID:32860822 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO
EXP
2,5-hexanedione results in increased expression of BAX mRNA; 2,5-hexanedione results in increased expression of BAX protein CTD PMID:17492505 PMID:21901545 PMID:22337490 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression
decreases expression
EXP
ISO
2,5-hexanedione results in increased expression of BCL2 protein
2,5-hexanedione results in decreased expression of BCL2 mRNA
2,5-hexanedione results in decreased expression of BCL2 mRNA; 2,5-hexanedione results in decreased expression of BCL2 protein
CTD PMID:17492505 PMID:21901545 PMID:22337490 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l14 BCL2 like 14 increases expression EXP 2,5-hexanedione results in increased expression of BCL2L14 mRNA CTD PMID:22952946 NCBI chr 4:168,139,964...168,183,726
Ensembl chr 4:168,142,271...168,183,096
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases expression EXP 2,5-hexanedione results in decreased expression of BDNF protein CTD PMID:31760062 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bfar bifunctional apoptosis regulator increases expression EXP 2,5-hexanedione results in increased expression of BFAR mRNA CTD PMID:22952946 NCBI chr10:1,464,783...1,497,653
Ensembl chr10:1,464,765...1,497,653
JBrowse link
G Casp1 caspase 1 increases cleavage
increases expression
multiple interactions
EXP 2,5-hexanedione results in increased cleavage of CASP1 protein
2,5-hexanedione results in increased expression of CASP1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of CASP1 protein]
CTD PMID:32522579 PMID:32860822 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 increases expression ISO
EXP
2,5-hexanedione results in increased expression of CASP3 mRNA; 2,5-hexanedione results in increased expression of CASP3 protein alternative form CTD PMID:17492505 PMID:21901545 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccdc171 coiled-coil domain containing 171 increases expression EXP 2,5-hexanedione results in increased expression of CCDC171 mRNA CTD PMID:22952946 NCBI chr 5:101,639,355...102,017,300 JBrowse link
G Ccdc191 coiled-coil domain containing 191 increases expression EXP 2,5-hexanedione results in increased expression of CCDC191 mRNA CTD PMID:22952946 NCBI chr11:61,678,138...61,748,773
Ensembl chr11:61,678,045...61,748,768
JBrowse link
G Cdin1 CDAN1 interacting nuclease 1 increases expression EXP 2,5-hexanedione results in increased expression of CDIN1 mRNA CTD PMID:22952946 NCBI chr 3:107,142,734...107,347,381
Ensembl chr 3:107,142,762...107,348,650
JBrowse link
G Cep112 centrosomal protein 112 increases expression EXP 2,5-hexanedione results in increased expression of CEP112 mRNA CTD PMID:22952946 NCBI chr10:96,660,294...97,146,426
Ensembl chr10:96,663,740...97,146,424
JBrowse link
G Cfap221 cilia and flagella associated protein 221 increases expression EXP 2,5-hexanedione results in increased expression of CFAP221 mRNA CTD PMID:22952946 NCBI chr13:35,952,808...36,024,371
Ensembl chr13:35,953,088...36,022,197
JBrowse link
G Ckmt1 creatine kinase, mitochondrial 1 increases expression EXP 2,5-hexanedione results in increased expression of CKMT1B protein CTD PMID:19033394 NCBI chr 3:113,318,559...113,324,459
Ensembl chr 3:113,318,563...113,324,461
JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA CTD PMID:22382377 NCBI chr 2:250,954,423...250,981,544
Ensembl chr 2:250,954,397...250,981,623
JBrowse link
G Clu clusterin decreases expression
increases expression
EXP 2,5-hexanedione results in decreased expression of CLU mRNA
2,5-hexanedione results in increased expression of CLU mRNA
CTD PMID:22952946 PMID:27466211 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Ctxn1 cortexin 1 increases expression EXP 2,5-hexanedione results in increased expression of CTXN1 mRNA CTD PMID:22952946 NCBI chr12:2,534,212...2,535,823
Ensembl chr12:2,534,212...2,535,822
JBrowse link
G Dcn decorin increases expression EXP 2,5-hexanedione results in increased expression of DCN mRNA CTD PMID:22952946 NCBI chr 7:38,742,250...38,782,282
Ensembl chr 7:38,742,051...38,782,323
JBrowse link
G Dennd1a DENN domain containing 1A increases expression EXP 2,5-hexanedione results in increased expression of DENND1A mRNA CTD PMID:22952946 NCBI chr 3:22,061,120...22,501,502
Ensembl chr 3:22,058,400...22,500,765
JBrowse link
G Dnaaf11 dynein axonemal assembly factor 11 increases expression EXP 2,5-hexanedione results in increased expression of DNAAF11 mRNA CTD PMID:22952946 NCBI chr 7:107,130,402...107,231,507
Ensembl chr 7:107,130,402...107,223,047
JBrowse link
G Dnajb4 DnaJ heat shock protein family (Hsp40) member B4 increases expression EXP 2,5-hexanedione results in increased expression of DNAJB4 mRNA CTD PMID:22952946 NCBI chr 2:257,394,692...257,425,344
Ensembl chr 2:257,394,818...257,425,242
JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA CTD PMID:22382377 NCBI chr 3:2,569,135...2,573,387
Ensembl chr 3:2,569,135...2,573,387
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 decreases expression EXP 2,5-hexanedione results in decreased expression of DPYSL2 protein CTD PMID:19033394 NCBI chr15:43,475,640...43,581,725
Ensembl chr15:43,477,629...43,542,939
JBrowse link
G Egfr epidermal growth factor receptor increases expression EXP 2,5-hexanedione results in increased expression of EGFR mRNA CTD PMID:16141653 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Erc1 ELKS/RAB6-interacting/CAST family member 1 increases expression EXP 2,5-hexanedione results in increased expression of ERC1 mRNA CTD PMID:22952946 NCBI chr 4:152,087,393...152,380,023
Ensembl chr 4:152,087,379...152,380,184
JBrowse link
G Faslg Fas ligand increases expression EXP 2,5-hexanedione results in increased expression of FASLG mRNA CTD PMID:22337490 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
JBrowse link
G Fasn fatty acid synthase decreases expression EXP 2,5-hexanedione results in decreased expression of FASN protein CTD PMID:19033394 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig increases expression EXP 2,5-hexanedione results in increased expression of FCER1G mRNA CTD PMID:22952946 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP 2,5-hexanedione results in increased expression of GADD45 mRNA CTD PMID:16141653 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gas2 growth arrest-specific 2 increases expression EXP 2,5-hexanedione results in increased expression of GAS2 mRNA CTD PMID:22952946 NCBI chr 1:107,234,389...107,363,624
Ensembl chr 1:107,262,659...107,363,788
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression
increases expression
EXP 2,5-hexanedione results in decreased expression of GFAP protein
2,5-hexanedione results in increased expression of GFAP protein
CTD PMID:19033394 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Ghsr growth hormone secretagogue receptor affects expression EXP 2,5-hexanedione affects the expression of GHSR mRNA CTD PMID:20616210 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
G Glud1 glutamate dehydrogenase 1 increases expression EXP 2,5-hexanedione results in increased expression of GLUD1 protein CTD PMID:19033394 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
JBrowse link
G Gsdmd gasdermin D multiple interactions
increases cleavage
EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased cleavage of GSDMD protein] CTD PMID:32522579 PMID:32860822 NCBI chr 7:116,889,147...116,894,134
Ensembl chr 7:116,889,572...116,894,134
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression EXP 2,5-hexanedione results in decreased expression of GSK3B protein CTD PMID:31760062 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsn gelsolin decreases expression EXP 2,5-hexanedione results in decreased expression of GSN protein CTD PMID:19033394 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gstm3l glutathione S-transferase mu 3-like decreases expression EXP 2,5-hexanedione results in decreased expression of GSTM5 protein CTD PMID:19033394 NCBI chr 2:210,761,729...210,766,501
Ensembl chr 2:210,761,729...210,766,501
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP 2,5-hexanedione results in decreased expression of GSTP1 mRNA CTD PMID:16141653 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hdgfl1 HDGF like 1 decreases expression EXP 2,5-hexanedione results in decreased expression of HDGFL1 mRNA CTD PMID:22952946 NCBI chr17:40,170,522...40,172,518
Ensembl chr17:40,170,541...40,172,426
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B increases expression EXP 2,5-hexanedione results in increased expression of HSPA1B mRNA CTD PMID:16141653 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815
JBrowse link
G Ier3 immediate early response 3 affects expression EXP 2,5-hexanedione affects the expression of IER3 mRNA CTD PMID:20616210 NCBI chr20:3,438,798...3,440,002
Ensembl chr20:3,438,798...3,440,769
JBrowse link
G Ift81 intraflagellar transport 81 increases expression EXP 2,5-hexanedione results in increased expression of IFT81 mRNA CTD PMID:22952946 NCBI chr12:39,420,161...39,507,412
Ensembl chr12:39,423,596...39,506,890
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 decreases expression EXP 2,5-hexanedione results in decreased expression of IGFBP3 mRNA CTD PMID:16141653 NCBI chr14:87,457,647...87,465,374
Ensembl chr14:87,457,647...87,465,374
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of IL1B mRNA; 2,5-hexanedione results in increased expression of IL1B protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of IL1B protein]
CTD PMID:16141653 PMID:32522579 PMID:32860822 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Ina internexin neuronal intermediate filament protein, alpha decreases expression EXP 2,5-hexanedione results in decreased expression of INA protein CTD PMID:19033394 NCBI chr 1:266,782,835...266,794,389
Ensembl chr 1:266,781,617...266,794,431
JBrowse link
G Itgam integrin subunit alpha M increases expression
multiple interactions
ISO
EXP
2,5-hexanedione results in increased expression of ITGAM protein
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of ITGAM protein]
CTD PMID:19464574 PMID:32522579 PMID:32860822 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP 2,5-hexanedione results in decreased expression of ITGB1 mRNA CTD PMID:16141653 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Kif6 kinesin family member 6 increases expression EXP 2,5-hexanedione results in increased expression of KIF6 mRNA CTD PMID:22952946 NCBI chr 9:13,016,973...13,311,971
Ensembl chr 9:13,030,673...13,311,924
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase decreases expression
multiple interactions
EXP 2,5-hexanedione results in decreased expression of KIT protein
resveratrol inhibits the reaction [2,5-hexanedione results in decreased expression of KIT protein]
CTD PMID:17725299 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Loxl1 lysyl oxidase-like 1 increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of LOXL1 protein
2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA
CTD PMID:22382377 NCBI chr 8:63,067,757...63,092,124
Ensembl chr 8:63,067,300...63,092,009
JBrowse link
G Lrrc69 leucine rich repeat containing 69 increases expression EXP 2,5-hexanedione results in increased expression of LRRC69 mRNA CTD PMID:22952946 NCBI chr 5:28,133,066...28,321,877
Ensembl chr 5:28,133,068...28,317,943
JBrowse link
G Lyz2 lysozyme 2 decreases expression
increases expression
EXP 2,5-hexanedione results in decreased expression of LYZ2 mRNA
2,5-hexanedione results in increased expression of LYZ2 mRNA
CTD PMID:22952946 NCBI chr 7:60,335,968...60,341,264
Ensembl chr 7:60,335,969...60,341,264
JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of MACROD1 mRNA
[carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA
CTD PMID:22382377 NCBI chr 1:222,310,916...222,451,485
Ensembl chr 1:222,310,920...222,451,484
JBrowse link
G Map1a microtubule-associated protein 1A decreases expression EXP 2,5-hexanedione results in decreased expression of MAP1A protein CTD PMID:20554699 NCBI chr 3:113,251,918...113,272,193
Ensembl chr 3:113,251,778...113,272,186
JBrowse link
G Map1b microtubule-associated protein 1B decreases expression EXP 2,5-hexanedione results in decreased expression of MAP1B protein; 2,5-hexanedione results in decreased expression of MAP1B protein modified form CTD PMID:20554699 PMID:31760062 NCBI chr 2:29,675,391...29,768,750
Ensembl chr 2:29,675,391...29,768,750
JBrowse link
G Map2 microtubule-associated protein 2 decreases expression EXP 2,5-hexanedione results in decreased expression of MAP2 protein modified form CTD PMID:20554699 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Map3k1 mitogen-activated protein kinase kinase kinase 1 increases expression EXP 2,5-hexanedione results in increased expression of MAP3K1 protein CTD PMID:31760062 NCBI chr 2:43,329,516...43,393,203
Ensembl chr 2:43,329,516...43,393,207
JBrowse link
G Mapt microtubule-associated protein tau decreases expression EXP 2,5-hexanedione results in decreased expression of MAPT protein modified form CTD PMID:20554699 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mbp myelin basic protein multiple interactions
decreases expression
EXP Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MBP protein] CTD PMID:32522579 PMID:32860822 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression EXP 2,5-hexanedione results in increased expression of MDH1 protein CTD PMID:19033394 NCBI chr14:106,378,349...106,393,642
Ensembl chr14:106,378,942...106,393,670
JBrowse link
G Mfap3l microfibril associated protein 3 like increases expression EXP 2,5-hexanedione results in increased expression of MFAP3L mRNA CTD PMID:22952946 NCBI chr16:32,734,059...32,777,091
Ensembl chr16:32,738,265...32,753,278
JBrowse link
G Mir10b microRNA 10b increases expression EXP 2,5-hexanedione results in increased expression of MIR10B mRNA CTD PMID:31760062 NCBI chr 3:61,647,978...61,648,086
Ensembl chr 3:61,647,978...61,648,086
JBrowse link
G Mir1224 microRNA 1224 increases expression EXP 2,5-hexanedione results in increased expression of MIR1224 mRNA CTD PMID:31760062 NCBI chr11:83,992,628...83,992,712
Ensembl chr11:83,992,628...83,992,712
JBrowse link
G Mir125a microRNA 125a increases expression
decreases expression
EXP 2,5-hexanedione results in increased expression of MIR125A mRNA
2,5-hexanedione results in decreased expression of MIR125A mRNA
CTD PMID:31760062 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Mir130b microRNA 130b decreases expression EXP 2,5-hexanedione results in decreased expression of MIR130B mRNA CTD PMID:31760062 NCBI chr11:88,129,773...88,129,854
Ensembl chr11:88,129,773...88,129,854
JBrowse link
G Mir134 microRNA 134 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR134 mRNA CTD PMID:31760062 NCBI chr 6:133,884,547...133,884,619
Ensembl chr 6:133,884,531...133,884,633
JBrowse link
G Mir155 microRNA 155 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR155 mRNA CTD PMID:31760062 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir183 microRNA 183 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR183 mRNA CTD PMID:31760062 NCBI chr 4:57,463,569...57,463,678
Ensembl chr 4:57,463,569...57,463,678
JBrowse link
G Mir193 microRNA 193 increases expression EXP 2,5-hexanedione results in increased expression of MIR193 mRNA CTD PMID:31760062 NCBI chr10:67,065,896...67,065,981 JBrowse link
G Mir193a microRNA 193a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR193A mRNA CTD PMID:31760062 NCBI chr10:67,065,885...67,065,996
Ensembl chr10:67,065,885...67,065,996
JBrowse link
G Mir194-2 microRNA 194-2 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR194-2 mRNA CTD PMID:31760062 NCBI chr 1:221,634,786...221,634,870
Ensembl chr 1:221,634,786...221,634,870
JBrowse link
G Mir196a microRNA 196a increases expression EXP 2,5-hexanedione results in increased expression of MIR196A mRNA CTD PMID:31760062 NCBI chr 7:144,584,235...144,584,344
Ensembl chr 7:144,584,235...144,584,344
JBrowse link
G Mir196c microRNA 196c increases expression EXP 2,5-hexanedione results in increased expression of MIR196C mRNA CTD PMID:31760062 NCBI chr10:84,113,578...84,113,657
Ensembl chr10:84,113,578...84,113,657
JBrowse link
G Mir199a2 microRNA 199a-2 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR199A-2 mRNA; 2,5-hexanedione results in decreased expression of MIR199A2 mRNA CTD PMID:31760062 NCBI chr13:80,125,487...80,125,596
Ensembl chr13:80,125,487...80,125,596
JBrowse link
G Mir200c microRNA 200c decreases expression EXP 2,5-hexanedione results in decreased expression of MIR200C mRNA CTD PMID:31760062 NCBI chr 4:157,236,786...157,236,854 JBrowse link
G Mir202 microRNA 202 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR202 mRNA CTD PMID:31760062 NCBI chr 1:212,295,630...212,295,701
Ensembl chr 1:212,295,630...212,295,701
JBrowse link
G Mir206 microRNA 206 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR206 mRNA CTD PMID:31760062 NCBI chr 9:26,791,764...26,791,847
Ensembl chr 9:26,791,764...26,791,847
JBrowse link
G Mir208a microRNA 208a increases expression EXP 2,5-hexanedione results in increased expression of MIR208A mRNA CTD PMID:31760062 NCBI chr15:33,613,451...33,613,533 JBrowse link
G Mir20a microRNA 20a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR20A mRNA CTD PMID:31760062 NCBI chr15:100,180,334...100,180,418
Ensembl chr15:100,180,334...100,180,418
JBrowse link
G Mir21 microRNA 21 increases expression
decreases expression
EXP 2,5-hexanedione results in increased expression of MIR21 mRNA
2,5-hexanedione results in decreased expression of MIR21 mRNA
CTD PMID:31760062 NCBI chr10:73,902,210...73,902,301
Ensembl chr10:73,902,210...73,902,301
JBrowse link
G Mir212 microRNA 212 increases expression EXP 2,5-hexanedione results in increased expression of MIR212 mRNA CTD PMID:31760062 NCBI chr10:62,014,702...62,014,812
Ensembl chr10:62,014,702...62,014,812
JBrowse link
G Mir22 microRNA 22 increases expression EXP 2,5-hexanedione results in increased expression of MIR22 mRNA CTD PMID:31760062 NCBI chr10:62,299,592...62,299,686
Ensembl chr10:62,299,592...62,299,686
JBrowse link
G Mir223 microRNA 223 increases expression EXP 2,5-hexanedione results in increased expression of MIR223 mRNA CTD PMID:31760062 NCBI chr  X:65,367,812...65,367,921
Ensembl chr  X:65,367,812...65,367,921
JBrowse link
G Mir224 microRNA 224 increases expression EXP 2,5-hexanedione results in increased expression of MIR224 mRNA CTD PMID:31760062 NCBI chr  X:152,223,754...152,223,835
Ensembl chr  X:152,223,754...152,223,835
JBrowse link
G Mir27a microRNA 27a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR27A mRNA CTD PMID:31760062 NCBI chr19:25,318,736...25,318,822
Ensembl chr19:25,318,736...25,318,822
JBrowse link
G Mir27b microRNA 27b increases expression EXP 2,5-hexanedione results in increased expression of MIR27B mRNA CTD PMID:31760062 NCBI chr17:823,461...823,557
Ensembl chr17:823,461...823,557
JBrowse link
G Mir300 microRNA 300 increases expression EXP 2,5-hexanedione results in increased expression of MIR300 mRNA CTD PMID:31760062 NCBI chr 6:133,874,152...133,874,230
Ensembl chr 6:133,874,144...133,874,233
JBrowse link
G Mir30a microRNA 30a increases expression EXP 2,5-hexanedione results in increased expression of MIR30A mRNA CTD PMID:31760062 NCBI chr 9:29,542,635...29,542,705
Ensembl chr 9:29,542,635...29,542,705
JBrowse link
G Mir32 microRNA 32 increases expression EXP 2,5-hexanedione results in increased expression of MIR32 mRNA CTD PMID:31760062 NCBI chr 5:73,934,255...73,934,324
Ensembl chr 5:73,934,255...73,934,324
JBrowse link
G Mir320a microRNA 320a increases expression EXP 2,5-hexanedione results in increased expression of MIR320A mRNA CTD PMID:31760062 NCBI chr15:52,134,276...52,134,357
Ensembl chr15:52,134,276...52,134,357
JBrowse link
G Mir323 microRNA 323 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR323 mRNA CTD PMID:31760062 NCBI chr 6:133,861,199...133,861,284
Ensembl chr 6:133,861,199...133,861,284
JBrowse link
G Mir326 microRNA 326 increases expression EXP 2,5-hexanedione results in increased expression of MIR326 mRNA CTD PMID:31760062 NCBI chr 1:164,518,401...164,518,495
Ensembl chr 1:164,518,401...164,518,495
JBrowse link
G Mir33 microRNA 33 increases expression EXP 2,5-hexanedione results in increased expression of MIR33 mRNA CTD PMID:31760062 NCBI chr 7:123,431,612...123,431,680
Ensembl chr 7:123,431,612...123,431,680
JBrowse link
G Mir330 microRNA 330 increases expression EXP 2,5-hexanedione results in increased expression of MIR330 mRNA CTD PMID:31760062 NCBI chr 1:80,092,681...80,092,777
Ensembl chr 1:80,092,681...80,092,777
JBrowse link
G Mir331 microRNA 331 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR331 mRNA CTD PMID:31760062 NCBI chr 7:34,881,095...34,881,190
Ensembl chr 7:34,881,095...34,881,190
JBrowse link
G Mir339 microRNA 339 increases expression EXP 2,5-hexanedione results in increased expression of MIR339 mRNA CTD PMID:31760062 NCBI chr12:17,369,002...17,369,097
Ensembl chr12:17,369,002...17,369,097
JBrowse link
G Mir344-1 microRNA 344-1 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR344-1 mRNA CTD PMID:31760062
G Mir345 microRNA 345 increases expression EXP 2,5-hexanedione results in increased expression of MIR345 mRNA CTD PMID:31760062 NCBI chr 6:132,748,968...132,749,063
Ensembl chr 6:132,748,968...132,749,063
JBrowse link
G Mir3556a microRNA 3556a decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3556A mRNA CTD PMID:31760062 NCBI chr 4:58,343,919...58,344,036
Ensembl chr 4:58,343,919...58,344,036
JBrowse link
G Mir3558 microRNA 3558 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3558 mRNA CTD PMID:31760062 NCBI chr 6:10,992,691...10,992,804
Ensembl chr 6:10,992,691...10,992,804
JBrowse link
G Mir3560 microRNA 3560 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3560 mRNA CTD PMID:31760062 NCBI chr  X:16,117,863...16,117,974
Ensembl chr  X:16,117,863...16,117,974
JBrowse link
G Mir3573 microRNA 3573 increases expression EXP 2,5-hexanedione results in increased expression of MIR3573 mRNA CTD PMID:31760062 NCBI chr  X:68,892,972...68,893,043
Ensembl chr  X:68,892,972...68,893,043
JBrowse link
G Mir3580 microRNA 3580 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3580 mRNA CTD PMID:31760062 NCBI chr  X:151,295,615...151,295,695
Ensembl chr  X:151,295,615...151,295,695
JBrowse link
G Mir3593 microRNA 3593 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR3593 mRNA CTD PMID:31760062 NCBI chr 6:76,661,799...76,661,889
Ensembl chr 6:76,661,799...76,661,889
JBrowse link
G Mir370 microRNA 370 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR370 mRNA CTD PMID:31760062 NCBI chr 6:133,739,916...133,739,994
Ensembl chr 6:133,739,916...133,739,994
JBrowse link
G Mir375 microRNA 375 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR375 mRNA CTD PMID:31760062 NCBI chr 9:82,161,716...82,161,790
Ensembl chr 9:82,161,716...82,161,790
JBrowse link
G Mir412 microRNA 412 increases expression EXP 2,5-hexanedione results in increased expression of MIR412 mRNA CTD PMID:31760062 NCBI chr 6:133,893,571...133,893,640
Ensembl chr 6:133,893,565...133,893,644
JBrowse link
G Mir423 microRNA 423 increases expression EXP 2,5-hexanedione results in increased expression of MIR423 mRNA CTD PMID:31760062 NCBI chr10:63,098,366...63,098,444
Ensembl chr10:63,098,360...63,098,453
JBrowse link
G Mir433 microRNA 433 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR433 mRNA CTD PMID:31760062 NCBI chr 6:133,712,334...133,712,426
Ensembl chr 6:133,712,334...133,712,426
JBrowse link
G Mir450a1 microRNA 450a-1 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR450A1 mRNA CTD PMID:31760062 NCBI chr  X:158,153,377...158,153,467
Ensembl chr  X:158,153,377...158,153,467
JBrowse link
G Mir487b microRNA 487b increases expression EXP 2,5-hexanedione results in increased expression of MIR487B mRNA CTD PMID:31760062 NCBI chr 6:133,877,124...133,877,205
Ensembl chr 6:133,877,124...133,877,205
JBrowse link
G Mir488 microRNA 488 increases expression EXP 2,5-hexanedione results in increased expression of MIR488 mRNA CTD PMID:31760062 NCBI chr13:76,198,593...76,198,671
Ensembl chr13:76,198,593...76,198,671
JBrowse link
G Mir497 microRNA 497 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR497 mRNA CTD PMID:31760062 NCBI chr10:56,844,977...56,845,045
Ensembl chr10:56,844,977...56,845,045
JBrowse link
G Mir503 microRNA 503 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR503 mRNA CTD PMID:31760062 NCBI chr  X:158,148,476...158,148,546
Ensembl chr  X:158,148,476...158,148,546
JBrowse link
G Mir541 microRNA 541 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR541 mRNA CTD PMID:31760062 NCBI chr 6:133,892,655...133,892,744
Ensembl chr 6:133,892,655...133,892,744
JBrowse link
G Mir542 microRNA 542 increases expression EXP 2,5-hexanedione results in increased expression of MIR542 mRNA CTD PMID:31760062 NCBI chr  X:158,152,146...158,152,224
Ensembl chr  X:158,152,146...158,152,224
JBrowse link
G Mir551b microRNA 551b decreases expression EXP 2,5-hexanedione results in decreased expression of MIR551B mRNA CTD PMID:31760062 NCBI chr 2:116,867,647...116,867,744
Ensembl chr 2:116,867,647...116,867,744
JBrowse link
G Mir582 microRNA 582 increases expression EXP 2,5-hexanedione results in increased expression of MIR582 mRNA CTD PMID:31760062 NCBI chr 2:40,863,750...40,863,830
Ensembl chr 2:40,863,750...40,863,830
JBrowse link
G Mir652 microRNA 652 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR652 mRNA CTD PMID:31760062 NCBI chr  X:114,002,534...114,002,614
Ensembl chr  X:114,002,534...114,002,614
JBrowse link
G Mir653 microRNA 653 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR653 mRNA CTD PMID:31760062 NCBI chr 4:28,658,882...28,658,978
Ensembl chr 4:28,658,882...28,658,978
JBrowse link
G Mir665 microRNA 665 increases expression EXP 2,5-hexanedione results in increased expression of MIR665 mRNA CTD PMID:31760062 NCBI chr 6:133,706,457...133,706,550
Ensembl chr 6:133,706,457...133,706,550
JBrowse link
G Mir675 microRNA 675 increases expression EXP 2,5-hexanedione results in increased expression of MIR675 mRNA CTD PMID:31760062 NCBI chr 1:215,745,981...215,746,064
Ensembl chr 1:215,745,981...215,746,064
JBrowse link
G Mir743a microRNA 743a increases expression EXP 2,5-hexanedione results in increased expression of MIR743A mRNA CTD PMID:31760062 NCBI chr  X:151,252,828...151,252,903
Ensembl chr  X:151,252,828...151,252,903
JBrowse link
G Mir760 microRNA 760 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR760 mRNA CTD PMID:31760062 NCBI chr 2:225,873,354...225,873,433
Ensembl chr 2:225,873,354...225,873,433
JBrowse link
G Mir770 microRNA 770 increases expression EXP 2,5-hexanedione results in increased expression of MIR770 mRNA CTD PMID:31760062 NCBI chr 6:133,682,965...133,683,040
Ensembl chr 6:133,682,957...133,683,050
JBrowse link
G Mir7a2 microRNA 7a-2 increases expression EXP 2,5-hexanedione results in increased expression of MIR7A2 mRNA CTD PMID:31760062 NCBI chr 1:140,576,396...140,576,490
Ensembl chr 1:140,576,396...140,576,490
JBrowse link
G Mir873 microRNA 873 increases expression EXP 2,5-hexanedione results in increased expression of MIR873 mRNA CTD PMID:31760062 NCBI chr 5:52,481,076...52,481,152
Ensembl chr 5:52,481,076...52,481,152
JBrowse link
G Mir877 microRNA 877 increases expression EXP 2,5-hexanedione results in increased expression of MIR877 mRNA CTD PMID:31760062 NCBI chr20:3,318,872...3,318,956
Ensembl chr20:3,318,872...3,318,956
JBrowse link
G Mir883 microRNA 883 decreases expression EXP 2,5-hexanedione results in decreased expression of MIR883 mRNA CTD PMID:31760062 NCBI chr  X:151,260,703...151,260,779
Ensembl chr  X:151,260,703...151,260,779
JBrowse link
G Mirlet7b microRNA let-7b increases expression EXP 2,5-hexanedione results in increased expression of MIRLET7B mRNA CTD PMID:31760062 NCBI chr 7:126,590,627...126,590,711
Ensembl chr 7:126,590,627...126,590,711
JBrowse link
G Mirlet7i microRNA let-7i increases expression EXP 2,5-hexanedione results in increased expression of MIRLET7I mRNA CTD PMID:31760062 NCBI chr 7:66,802,731...66,802,815
Ensembl chr 7:66,802,732...66,802,821
JBrowse link
G Mrc1 mannose receptor, C type 1 decreases expression
multiple interactions
EXP 2,5-hexanedione results in decreased expression of MRC1 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of MRC1 mRNA]
CTD PMID:32522579 PMID:32860822 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Mtm1 myotubularin 1 increases expression EXP 2,5-hexanedione results in increased expression of MTM1 mRNA CTD PMID:22952946 NCBI chr 6:18,821,821...18,840,449
Ensembl chr 6:18,821,815...18,839,409
JBrowse link
G Napa NSF attachment protein alpha decreases expression EXP 2,5-hexanedione results in decreased expression of NAPA protein CTD PMID:19033394 NCBI chr 1:77,994,227...78,012,846
Ensembl chr 1:77,994,203...78,012,845
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 increases expression
decreases expression
EXP 2,5-hexanedione results in increased expression of NDUFA10 protein
2,5-hexanedione results in decreased expression of NDUFA10 protein
CTD PMID:19033394 NCBI chr 9:99,617,051...99,651,827
Ensembl chr 9:99,617,052...99,651,813
JBrowse link
G Nefh neurofilament heavy chain decreases expression EXP 2,5-hexanedione results in decreased expression of NEFH protein CTD PMID:19033394 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nefl neurofilament light chain decreases expression
multiple interactions
EXP 2,5-hexanedione results in decreased expression of NEFL protein
Glyburide inhibits the reaction [2,5-hexanedione results in decreased expression of NEFL protein]
CTD PMID:19033394 PMID:32522579 PMID:32860822 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Nefm neurofilament medium chain decreases expression EXP 2,5-hexanedione results in decreased expression of NEFM protein CTD PMID:19033394 NCBI chr15:44,855,307...44,860,604
Ensembl chr15:44,855,310...44,860,604
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression
EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NLRP3 protein]
2,5-hexanedione results in increased expression of NLRP3 mRNA; 2,5-hexanedione results in increased expression of NLRP3 protein
CTD PMID:32522579 PMID:32860822 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP 2,5-hexanedione results in increased expression of NOS2 mRNA
Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of NOS2 mRNA]
CTD PMID:32522579 PMID:32860822 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nsf N-ethylmaleimide sensitive factor, vesicle fusing ATPase decreases expression EXP 2,5-hexanedione results in decreased expression of NSF protein CTD PMID:19033394 NCBI chr10:91,879,608...91,986,242
Ensembl chr10:91,878,633...92,008,082
JBrowse link
G Nupr2 nuclear protein 2, transcriptional regulator increases expression EXP 2,5-hexanedione results in increased expression of NUPR1L mRNA CTD PMID:22952946 NCBI chr12:30,300,936...30,304,041
Ensembl chr12:30,303,725...30,304,036
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 decreases expression EXP 2,5-hexanedione results in decreased expression of PDIA3 protein CTD PMID:19033394 NCBI chr 3:113,376,983...113,400,707
Ensembl chr 3:113,376,983...113,400,707
JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression EXP 2,5-hexanedione results in decreased expression of PDLIM3 protein CTD PMID:19033394 NCBI chr16:49,543,140...49,574,362
Ensembl chr16:49,543,142...49,574,390
JBrowse link
G Pgam1 phosphoglycerate mutase 1 increases expression EXP 2,5-hexanedione results in increased expression of PGAM1 protein CTD PMID:19033394 NCBI chr 1:261,158,204...261,165,814
Ensembl chr 1:261,158,261...261,165,808
JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 increases expression EXP 2,5-hexanedione results in increased expression of PHOSPHO1 mRNA CTD PMID:22952946 NCBI chr10:83,635,557...83,643,862
Ensembl chr10:83,636,518...83,643,859
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression EXP 2,5-hexanedione results in increased expression of PIM1 mRNA CTD PMID:22952946 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Pkm pyruvate kinase M1/2 increases expression EXP 2,5-hexanedione results in increased expression of PKM protein CTD PMID:19033394 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression EXP 2,5-hexanedione results in increased expression of POU2F1 mRNA CTD PMID:22952946 NCBI chr13:84,075,316...84,217,368
Ensembl chr13:84,083,632...84,217,366
JBrowse link
G Prkcsh protein kinase C substrate 80K-H decreases expression EXP 2,5-hexanedione results in decreased expression of PRKCSH protein CTD PMID:19033394 NCBI chr 8:23,014,802...23,026,507
Ensembl chr 8:23,014,956...23,026,503
JBrowse link
G Ptgds prostaglandin D2 synthase increases expression EXP 2,5-hexanedione results in increased expression of PTGDS mRNA CTD PMID:22952946 PMID:27466211 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Pycard PYD and CARD domain containing increases expression EXP 2,5-hexanedione results in increased expression of PYCARD mRNA; 2,5-hexanedione results in increased expression of PYCARD protein CTD PMID:32860822 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Pygb glycogen phosphorylase B decreases expression EXP 2,5-hexanedione results in decreased expression of PYGB protein CTD PMID:19033394 NCBI chr 3:146,581,063...146,629,504
Ensembl chr 3:146,582,752...146,634,535
JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression EXP 2,5-hexanedione results in decreased expression of PYGM protein CTD PMID:19033394 NCBI chr 1:221,756,325...221,771,142
Ensembl chr 1:221,756,286...221,771,143
JBrowse link
G Ralgapa2 Ral GTPase activating protein catalytic subunit alpha 2 increases expression EXP 2,5-hexanedione results in increased expression of RALGAPA2 mRNA CTD PMID:22952946 NCBI chr 3:140,451,850...140,728,305
Ensembl chr 3:140,468,701...140,728,129
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 2,5-hexanedione results in decreased expression of and affects the localization of RELA protein CTD PMID:22337490 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G RGD1304694 similar to CG9646-PA increases expression EXP 2,5-hexanedione results in increased expression of RGD1304694 mRNA CTD PMID:22952946 NCBI chr 7:125,853,573...125,893,168
Ensembl chr 7:125,857,046...125,893,168
JBrowse link
G RGD1562608 similar to KIAA1328 protein increases expression EXP 2,5-hexanedione results in increased expression of RGD1562608 mRNA CTD PMID:22952946 NCBI chr18:17,394,586...17,678,605
Ensembl chr18:17,403,407...17,676,049
JBrowse link
G Rtkn2 rhotekin 2 increases expression EXP 2,5-hexanedione results in increased expression of RTKN2 mRNA CTD PMID:22952946 NCBI chr20:21,919,486...22,004,279
Ensembl chr20:21,932,878...22,004,279
JBrowse link
G S100z S100 calcium binding protein Z increases expression EXP 2,5-hexanedione results in increased expression of S100Z mRNA CTD PMID:22952946 NCBI chr 2:25,188,381...25,203,627
Ensembl chr 2:25,188,782...25,190,495
JBrowse link
G Sclt1 sodium channel and clathrin linker 1 increases expression EXP 2,5-hexanedione results in increased expression of SCLT1 mRNA CTD PMID:22952946 NCBI chr 2:128,523,376...128,675,668
Ensembl chr 2:128,523,636...128,675,408
JBrowse link
G Septin8 septin 8 decreases expression EXP 2,5-hexanedione results in decreased expression of SEPTIN8 protein CTD PMID:19033394 NCBI chr10:38,877,422...38,906,480
Ensembl chr10:38,877,422...38,906,482
JBrowse link
G Sh2d4a SH2 domain containing 4A decreases expression EXP 2,5-hexanedione results in decreased expression of SH2D4A mRNA CTD PMID:22952946 NCBI chr16:23,084,247...23,156,825
Ensembl chr16:23,083,954...23,156,962
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Sil1 SIL1 nucleotide exchange factor increases expression EXP 2,5-hexanedione results in increased expression of SIL1 mRNA CTD PMID:22952946 NCBI chr18:28,067,476...28,302,008
Ensembl chr18:28,067,484...28,301,863
JBrowse link
G Slc10a7 solute carrier family 10, member 7 increases expression EXP 2,5-hexanedione results in increased expression of SLC10A7 mRNA CTD PMID:22952946 NCBI chr19:32,857,984...33,081,359
Ensembl chr19:32,855,343...33,080,998
JBrowse link
G Sltm SAFB-like, transcription modulator increases expression EXP 2,5-hexanedione results in increased expression of SLTM mRNA CTD PMID:22952946 NCBI chr 8:76,977,698...77,022,847
Ensembl chr 8:76,977,822...77,022,837
JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP 2,5-hexanedione results in increased expression of SOD3 mRNA CTD PMID:22952946 PMID:27466211 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Sppl3 signal peptide peptidase like 3 increases expression EXP 2,5-hexanedione results in increased expression of SPPL3 mRNA CTD PMID:22952946 NCBI chr12:47,276,485...47,360,552
Ensembl chr12:47,276,476...47,360,507
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 decreases expression EXP 2,5-hexanedione results in decreased expression of SPTAN1 protein CTD PMID:19033394 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Stmn1 stathmin 1 decreases expression EXP 2,5-hexanedione results in decreased expression of STMN1 mRNA CTD PMID:22952946 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression EXP 2,5-hexanedione results in increased expression of STRBP mRNA CTD PMID:22952946 NCBI chr 3:21,817,680...21,956,988
Ensembl chr 3:21,828,298...21,904,270
JBrowse link
G Styxl1 serine/threonine/tyrosine interacting-like 1 increases expression EXP 2,5-hexanedione results in increased expression of STYXL1 mRNA CTD PMID:22952946 NCBI chr12:23,954,563...23,987,155
Ensembl chr12:23,954,574...23,987,271
JBrowse link
G Tax1bp1 Tax1 binding protein 1 increases expression EXP 2,5-hexanedione results in increased expression of TAX1BP1 mRNA CTD PMID:22952946 NCBI chr 4:82,776,720...82,832,586
Ensembl chr 4:82,776,746...82,833,773
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 increases expression EXP 2,5-hexanedione results in increased expression of TBC1D5 mRNA CTD PMID:22952946 NCBI chr 9:1,144,641...1,747,732
Ensembl chr 9:1,145,700...1,746,397
JBrowse link
G Tmem192 transmembrane protein 192 increases expression EXP 2,5-hexanedione results in increased expression of TMEM192 mRNA CTD PMID:22952946 NCBI chr16:26,620,525...26,642,537
Ensembl chr16:26,619,598...26,633,796
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
EXP Glyburide inhibits the reaction [2,5-hexanedione results in increased expression of TNF mRNA] CTD PMID:32522579 PMID:32860822 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression EXP 2,5-hexanedione results in increased expression of TPI1 mRNA; 2,5-hexanedione results in increased expression of TPI1 protein CTD PMID:19033394 PMID:22952946 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
Ensembl chr 9:157,328,379...157,331,905
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 increases expression EXP 2,5-hexanedione results in increased expression of UBA1 protein CTD PMID:19033394 NCBI chr  X:1,723,135...1,745,147
Ensembl chr  X:1,723,174...1,741,701
JBrowse link
G Ubn2 ubinuclein 2 increases expression EXP 2,5-hexanedione results in increased expression of UBN2 mRNA CTD PMID:22952946 NCBI chr 4:66,164,639...66,254,297
Ensembl chr 4:66,165,845...66,233,230
JBrowse link
G Uqcrc2 ubiquinol cytochrome c reductase core protein 2 decreases expression EXP 2,5-hexanedione results in decreased expression of UQCRC2 mRNA CTD PMID:22952946 NCBI chr 1:190,555,177...190,585,741
Ensembl chr 1:190,555,177...190,585,734
JBrowse link
G Vim vimentin multiple interactions ISO 2,5-hexanedione promotes the reaction [VIM protein binds to VIM protein] CTD PMID:6361548 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression EXP 2,5-hexanedione results in decreased expression of XIAP mRNA CTD PMID:22337490 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
G Zfp169 zinc finger protein 169 decreases expression EXP 2,5-hexanedione results in decreased expression of ZFP169 protein CTD PMID:19033394 NCBI chr17:16,443,324...16,471,329
Ensembl chr17:16,455,026...16,470,842
JBrowse link
G Zfp407 zinc finger protein 407 increases expression EXP 2,5-hexanedione results in increased expression of ZFP407 mRNA CTD PMID:22952946 NCBI chr18:81,057,507...81,453,682
Ensembl chr18:81,057,519...81,428,971
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    role 19720
      biological role 19720
        aetiopathogenetic role 18973
          neurotoxin 17654
            2,5-hexanedione 190
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      ketone 16825
                                        diketone 1174
                                          2,5-hexanedione 190
paths to the root