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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thrombopoietin receptor agonist
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Accession:CHEBI:85012 term browser browse the term
Definition:An agonist that selectively binds to and activates the thrombopoietin receptor [myeloproliferative leukemia protein or CD110 (Cluster of Differentiation 110)].
Synonyms:related_synonym: TPO receptor agonist;   TPO receptor agonists;   thrombopoietin receptor agonists


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eltrombopag term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpl MPL proto-oncogene, thrombopoietin receptor multiple interactions ISO eltrombopag binds to and results in increased activity of MPL protein CTD PMID:21646437 NCBI chr 5:137,268,412...137,282,032
Ensembl chr 5:137,269,480...137,281,298
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19801
    role 19747
      biological role 19746
        pharmacological role 18825
          agonist 18224
            thrombopoietin receptor agonist 1
              eltrombopag 1
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.