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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:eltrombopag
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Accession:CHEBI:85010 term browser browse the term
Definition:A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).
Synonyms:exact_synonym: 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid
 related_synonym: 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid;   Formula=C25H22N4O4;   InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-;   InChIKey=XDXWLKQMMKQXPV-QYQHSDTDSA-N;   SMILES=CC1=NN(C(=O)\\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1
 xref: CAS:496775-61-2;   Drug_Central:4399
 xref_mesh: MESH:C520809
 xref: PMID:24433306;   PMID:25063763;   PMID:25170628;   PMID:25400215;   PMID:25578417;   PMID:25700916;   Wikipedia:Eltrombopag



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eltrombopag term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpl MPL proto-oncogene, thrombopoietin receptor multiple interactions ISO eltrombopag binds to and results in increased activity of MPL protein CTD PMID:21646437 NCBI chr 5:131,973,895...131,987,472
Ensembl chr 5:131,973,895...131,986,797
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  CHEBI ontology 19904
    role 19880
      biological role 19878
        xenobiotic 18765
          eltrombopag 1
Path 2
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  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19852
                    p-block element atom 19852
                      carbon group element atom 19797
                        carbon atom 19792
                          organic molecular entity 19792
                            organic group 18983
                              organic divalent group 18958
                                organodiyl group 18958
                                  carbonyl group 18911
                                    carbonyl compound 18911
                                      carboxylic acid 18634
                                        aromatic carboxylic acid 12256
                                          benzoic acids 12231
                                            eltrombopag 1
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