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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:eltrombopag
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Accession:CHEBI:85010 term browser browse the term
Definition:A hydrazine in which each nitrogen atom is substituted, one by a 3'-carboxy-2-hydroxy[1,1'-biphenyl]-3-yl group and the other by a 1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene group. A small molecule agonist of the c-mpl (TpoR) receptor (the physiological target of the hormone thrombopoietin), it has been developed as a medication for conditions that lead to thrombocytopenia (abnormally low platelet counts).
Synonyms:exact_synonym: 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazinyl}-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid
 related_synonym: 3'-{(2Z)-2-[1-(3,4-dimethylphenyl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene]hydrazino}-2'-hydroxybiphenyl-3-carboxylic acid;   Formula=C25H22N4O4;   InChI=1S/C25H22N4O4/c1-14-10-11-19(12-15(14)2)29-24(31)22(16(3)28-29)27-26-21-9-5-8-20(23(21)30)17-6-4-7-18(13-17)25(32)33/h4-13,26,30H,1-3H3,(H,32,33)/b27-22-;   InChIKey=XDXWLKQMMKQXPV-QYQHSDTDSA-N;   SMILES=CC1=NN(C(=O)\\C1=N/Nc1cccc(-c2cccc(c2)C(O)=O)c1O)c1ccc(C)c(C)c1
 xref: CAS:496775-61-2;   Drug_Central:4399
 xref_mesh: MESH:C520809
 xref: PMID:24433306;   PMID:25063763;   PMID:25170628;   PMID:25400215;   PMID:25578417;   PMID:25700916;   Wikipedia:Eltrombopag



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eltrombopag term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpl MPL proto-oncogene, thrombopoietin receptor multiple interactions ISO eltrombopag binds to and results in increased activity of MPL protein CTD PMID:21646437 NCBI chr 5:131,973,897...131,987,472
Ensembl chr 5:131,973,895...131,986,797
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Term Annotations click to browse term
  CHEBI ontology 20069
    role 20021
      biological role 20020
        xenobiotic 18665
          eltrombopag 1
Path 2
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  CHEBI ontology 20069
    subatomic particle 20068
      composite particle 20068
        hadron 20068
          baryon 20068
            nucleon 20068
              atomic nucleus 20068
                atom 20068
                  main group element atom 19969
                    p-block element atom 19969
                      carbon group element atom 19892
                        carbon atom 19885
                          organic molecular entity 19885
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18898
                                    carbonyl compound 18898
                                      carboxylic acid 18596
                                        aromatic carboxylic acid 11814
                                          benzoic acids 11789
                                            eltrombopag 1
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