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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:8464 term browser browse the term
Definition:A diphenyldiazene compound having two amino substituents at the 2- and 4-positions and an aminosulphonyl substituent at the 4'-position. It was the first antibacterial drug, (introduced 1935) and the first of the sulfonamide antibiotics.
Synonyms:exact_synonym: 4-[(2,4-diaminophenyl)diazenyl]benzenesulfonamide
 related_synonym: Formula=C12H13N5O2S;   InChI=1S/C12H13N5O2S/c13-8-1-6-12(11(14)7-8)17-16-9-2-4-10(5-3-9)20(15,18)19/h1-7H,13-14H2,(H2,15,18,19)/b17-16+;   InChIKey=ABBQGOCHXSPKHJ-WUKNDPDISA-N;   Prontosil rubrum;   Rubiazol;   SMILES=Nc1ccc(c(N)c1)\\N=N\\c1ccc(cc1)S(N)(=O)=O;   Sulfamidochrysoidine;   p-((2,4-Diaminophenyl)azo)benzenesulphonamide
 xref: Beilstein:757127;   CAS:103-12-8;   Drug_Central:3561;   KEGG:C07573;   KEGG:D08542
 xref_mesh: MESH:C003359
 xref: PMID:19283418;   PMID:20781405;   PMID:2080660;   Patent:DE607537;   Patent:US2085037;   Reaxys:757127;   Wikipedia:Prontosil

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Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO sulfamidochrysoidine binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:88,126,519...88,136,063
Ensembl chr 2:88,126,667...88,135,410
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO sulfamidochrysoidine binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        antimicrobial agent 17329
          prontosil 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        aromatic amine 13633
                                          anilines 12339
                                            substituted aniline 11835
                                              sulfanilamide 246
                                                prontosil 2
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