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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at The data is made available under the Creative Commons License (CC BY 3.0, For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

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Accession:CHEBI:8464 term browser browse the term
Definition:A diphenyldiazene compound having two amino substituents at the 2- and 4-positions and an aminosulphonyl substituent at the 4'-position. It was the first antibacterial drug, (introduced 1935) and the first of the sulfonamide antibiotics.
Synonyms:exact_synonym: 4-[(2,4-diaminophenyl)diazenyl]benzenesulfonamide
 related_synonym: Formula=C12H13N5O2S;   InChI=1S/C12H13N5O2S/c13-8-1-6-12(11(14)7-8)17-16-9-2-4-10(5-3-9)20(15,18)19/h1-7H,13-14H2,(H2,15,18,19)/b17-16+;   InChIKey=ABBQGOCHXSPKHJ-WUKNDPDISA-N;   Prontosil rubrum;   Rubiazol;   SMILES=Nc1ccc(c(N)c1)\\N=N\\c1ccc(cc1)S(N)(=O)=O;   Sulfamidochrysoidine;   p-((2,4-Diaminophenyl)azo)benzenesulphonamide
 xref: Beilstein:757127;   CAS:103-12-8;   Drug_Central:3561;   KEGG:C07573;   KEGG:D08542
 xref_mesh: MESH:C003359
 xref: PMID:19283418;   PMID:20781405;   PMID:2080660;   Patent:DE607537;   Patent:US2085037;   Reaxys:757127;   Wikipedia:Prontosil

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prontosil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ca3 carbonic anhydrase 3 multiple interactions ISO sulfamidochrysoidine binds to and results in decreased activity of CA3 protein CTD PMID:17826101 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO sulfamidochrysoidine binds to and results in decreased activity of CA2 protein CTD PMID:17826101 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      biological role 19746
        antimicrobial agent 17469
          prontosil 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    main group molecular entity 19693
                      s-block molecular entity 19474
                        hydrogen molecular entity 19466
                          hydrides 18830
                            inorganic hydride 17688
                              pnictogen hydride 17668
                                nitrogen hydride 17540
                                  azane 17273
                                    ammonia 17272
                                      organic amino compound 17272
                                        aromatic amine 13708
                                          anilines 12381
                                            substituted aniline 11854
                                              sulfanilamide 249
                                                prontosil 2
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