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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:proguanil
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Accession:CHEBI:8455 term browser browse the term
Definition:A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.
Synonyms:exact_synonym: N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide
 related_synonym: 1-(p-chlorophenyl)-5-isopropylbiguanide;   Chlorguanide;   Chloroguanide;   Formula=C11H16ClN5;   InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17);   InChIKey=SSOLNOMRVKKSON-UHFFFAOYSA-N;   N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide;   SMILES=CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1;   proguanilum
 xref: Beilstein:2811599;   CAS:500-92-5;   DrugBank:DB01131;   Drug_Central:2282;   HMDB:HMDB0015263;   KEGG:C07631;   KEGG:D08428;   LINCS:LSM-2618
 xref_mesh: MESH:D002727
 xref: PMID:10348748;   PMID:10848923;   PMID:15504827;   PMID:8866915;   Reaxys:2811599;   Wikipedia:Proguanil


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proguanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing
decreases activity		 ISO CYP2C19 protein results in increased metabolism of Proguanil
Proguanil results in decreased activity of CYP2C19 protein		 CTD PMID:11124226 PMID:12464242 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Proguanil results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Proguanil results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Proguanil inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Proguanil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      biological role 19785
        antimicrobial agent 18104
          antimicrobial drug 9668
            antiprotozoal drug 7398
              proguanil 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            organic molecule 19658
                              organic cyclic compound 19471
                                carbocyclic compound 18563
                                  benzenoid aromatic compound 17970
                                    benzenes 17830
                                      chlorobenzenes 14814
                                        monochlorobenzenes 11620
                                          proguanil 5
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