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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:proguanil
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Accession:CHEBI:8455 term browser browse the term
Definition:A biguanide compound which has isopropyl and p-chlorophenyl substituents on the terminal N atoms. A prophylactic antimalarial drug, it works by inhibiting the enzyme dihydrofolate reductase, which is involved in the reproduction of the malaria parasites Plasmodium falciparum and P. vivax within the red blood cells.
Synonyms:exact_synonym: N-(4-chlorophenyl)-N'-(propan-2-yl)imidodicarbonimidic diamide
 related_synonym: 1-(p-chlorophenyl)-5-isopropylbiguanide;   Chlorguanide;   Chloroguanide;   Formula=C11H16ClN5;   InChI=1S/C11H16ClN5/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9/h3-7H,1-2H3,(H5,13,14,15,16,17);   InChIKey=SSOLNOMRVKKSON-UHFFFAOYSA-N;   N-(4-Chlorophenyl)-N'-(isopropyl)-imidodicarbonimidic diamide;   SMILES=CC(C)NC(=N)NC(=N)Nc1ccc(Cl)cc1;   proguanilum
 xref: Beilstein:2811599;   CAS:500-92-5;   DrugBank:DB01131;   Drug_Central:2282;   HMDB:HMDB0015263;   KEGG:C07631;   KEGG:D08428;   LINCS:LSM-2618
 xref_mesh: MESH:D002727
 xref: PMID:10348748;   PMID:10848923;   PMID:15504827;   PMID:8866915;   Reaxys:2811599;   Wikipedia:Proguanil


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proguanil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases metabolic processing
decreases activity
ISO CYP2C19 protein results in increased metabolism of Proguanil
Proguanil results in decreased activity of CYP2C19 protein
CTD PMID:11124226 PMID:12464242 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO Proguanil results in decreased activity of CYP2D6 protein CTD PMID:11124226 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO Proguanil results in decreased activity of CYP3A4 protein CTD PMID:11124226 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Proguanil inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Proguanil inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19792
      biological role 19792
        antimicrobial agent 17383
          antimicrobial drug 6218
            antiprotozoal drug 3827
              proguanil 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19732
                    p-block element atom 19732
                      carbon group element atom 19636
                        carbon atom 19625
                          organic molecular entity 19625
                            organic molecule 19556
                              organic cyclic compound 19365
                                carbocyclic compound 18273
                                  benzenoid aromatic compound 17320
                                    benzenes 17063
                                      chlorobenzenes 13531
                                        monochlorobenzenes 9534
                                          proguanil 5
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