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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:poly(cytidylic acid)
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Accession:CHEBI:84498 term browser browse the term
Definition:A polynucleotide comprised of cytidine units connected via 3'->5' phosphodiester linkages.
Synonyms:related_synonym: Formula=(C9H12N3O7P)nC18H26N6O15P2;   Poly C;   Poly(rC);   Polyribocytidylic acid;   polycytidylic acid
 xref: CAS:30811-80-4
 xref_mesh: MESH:D011066


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poly(cytidylic acid) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 multiple interactions
increases expression		 ISO Minocycline inhibits the reaction [Poly C results in increased expression of GRIA1 mRNA] CTD PMID:19660546 NCBI chr 5:153,489,615...153,813,869
Ensembl chr 5:153,489,615...153,813,869 		JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A increases expression
multiple interactions		 ISO Poly C results in increased expression of GRIN2A mRNA
Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2A mRNA]		 CTD PMID:19660546 NCBI chr16:9,753,404...10,182,908
Ensembl chr16:9,753,404...10,182,928 		JBrowse link
G GRIN2C glutamate ionotropic receptor NMDA type subunit 2C multiple interactions
increases expression		 ISO Minocycline inhibits the reaction [Poly C results in increased expression of GRIN2C mRNA] CTD PMID:19660546 NCBI chr17:74,842,023...74,861,532
Ensembl chr17:74,842,023...74,861,504 		JBrowse link
G IL1B interleukin 1 beta increases expression ISO Poly C results in increased expression of IL1B protein CTD PMID:19660546 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
poly(I:C) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABHD2 abhydrolase domain containing 2, acylglycerol lipase multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ABHD2 mRNA CTD PMID:26923065 NCBI chr15:89,040,998...89,202,355
Ensembl chr15:89,087,459...89,202,355 		JBrowse link
G ABLIM1 actin binding LIM protein 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ABLIM1 mRNA CTD PMID:26923065 NCBI chr10:114,431,110...114,801,373
Ensembl chr10:114,431,112...114,768,061 		JBrowse link
G ACADS acyl-CoA dehydrogenase short chain multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of ACADS mRNA CTD PMID:26923065 NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008 		JBrowse link
G ADAM10 ADAM metallopeptidase domain 10 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ADAM10 mRNA CTD PMID:26923065 NCBI chr15:58,588,809...58,749,707
Ensembl chr15:58,588,809...58,749,791 		JBrowse link
G ADAR adenosine deaminase RNA specific affects localization EXP Poly I-C affects the localization of ADAR protein CTD PMID:22240577 NCBI chr 1:154,582,057...154,627,997
Ensembl chr 1:154,581,695...154,628,013 		JBrowse link
G AHCYL1 adenosylhomocysteinase like 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of AHCYL1 mRNA CTD PMID:26923065 NCBI chr 1:109,984,765...110,023,742
Ensembl chr 1:109,984,765...110,023,742 		JBrowse link
G AHR aryl hydrocarbon receptor increases expression EXP Poly I-C results in increased expression of AHR mRNA; Poly I-C results in increased expression of AHR protein CTD PMID:27783115 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152 		JBrowse link
G AKAP5 A-kinase anchoring protein 5 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of AKAP5 mRNA CTD PMID:26923065 NCBI chr14:64,465,499...64,474,503
Ensembl chr14:64,465,499...64,474,503 		JBrowse link
G APP amyloid beta precursor protein multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of APP mRNA CTD PMID:26923065 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions
increases degradation		 ISO APPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; APPL1 protein inhibits the reaction [Poly I-C results in increased expression of TNF protein]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IKBKE protein]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased degradation of APPL1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; trametinib inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]; U 0126 inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr 3:57,227,729...57,273,471
Ensembl chr 3:57,227,726...57,278,105 		JBrowse link
G ARC activity regulated cytoskeleton associated protein affects methylation ISO Poly I-C affects the methylation of ARC promoter CTD PMID:32843831 NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479 		JBrowse link
G ARFGEF3 ARFGEF family member 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ARFGEF3 mRNA CTD PMID:26923065 NCBI chr 6:138,161,939...138,344,663
Ensembl chr 6:138,161,939...138,344,663 		JBrowse link
G ARG2 arginase 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of ARG2 mRNA CTD PMID:26923065 NCBI chr14:67,619,920...67,651,708
Ensembl chr14:67,619,920...67,651,708 		JBrowse link
G ARHGAP11A Rho GTPase activating protein 11A multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of ARHGAP11A mRNA CTD PMID:26923065 NCBI chr15:32,615,144...32,639,941
Ensembl chr15:32,615,144...32,639,941 		JBrowse link
G ARHGAP44 Rho GTPase activating protein 44 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ARHGAP44 mRNA CTD PMID:26923065 NCBI chr17:12,789,498...12,991,643
Ensembl chr17:12,789,498...12,991,643 		JBrowse link
G ARHGAP9 Rho GTPase activating protein 9 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of ARHGAP9 mRNA CTD PMID:26923065 NCBI chr12:57,472,269...57,488,824
Ensembl chr12:57,472,264...57,488,814 		JBrowse link
G ARHGEF12 Rho guanine nucleotide exchange factor 12 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ARHGEF12 mRNA CTD PMID:26923065 NCBI chr11:120,336,413...120,489,937
Ensembl chr11:120,336,413...120,489,937 		JBrowse link
G ARHGEF7 Rho guanine nucleotide exchange factor 7 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ARHGEF7 mRNA CTD PMID:26923065 NCBI chr13:111,114,619...111,305,734
Ensembl chr13:111,114,559...111,305,737 		JBrowse link
G ARSB arylsulfatase B multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ARSB mRNA CTD PMID:26923065 NCBI chr 5:78,777,209...78,985,958
Ensembl chr 5:78,777,209...78,986,087 		JBrowse link
G ART3 ADP-ribosyltransferase 3 (inactive) multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of ART3 mRNA CTD PMID:26923065 NCBI chr 4:76,011,190...76,112,786
Ensembl chr 4:76,011,184...76,114,048 		JBrowse link
G ATF3 activating transcription factor 3 increases expression EXP Poly I-C results in increased expression of ATF3 mRNA CTD PMID:27783115 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777 		JBrowse link
G ATP2B2 ATPase plasma membrane Ca2+ transporting 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ATP2B2 mRNA CTD PMID:26923065 NCBI chr 3:10,324,023...10,708,007
Ensembl chr 3:10,324,023...10,708,007 		JBrowse link
G ATXN3 ataxin 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ATXN3 mRNA CTD PMID:26923065 NCBI chr14:92,044,775...92,106,582
Ensembl chr14:92,044,496...92,106,621 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Poly I-C results in increased expression of BAX protein CTD PMID:21418039 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression EXP Poly I-C results in decreased expression of BCL2 protein CTD PMID:21418039 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of BCL2A1 mRNA CTD PMID:26923065 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196 		JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
affects methylation		 ISO [Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of BDNF mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of BDNF mRNA]
Poly I-C affects the methylation of BDNF promoter		 CTD PMID:24889602 PMID:32843831 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058 		JBrowse link
G BID BH3 interacting domain death agonist decreases expression EXP Poly I-C results in decreased expression of BID protein CTD PMID:21418039 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 multiple interactions EXP Poly I-C promotes the reaction [arsenic trioxide results in decreased expression of BIRC5 protein] CTD PMID:21418039 NCBI chr17:78,214,253...78,225,635
Ensembl chr17:78,214,186...78,225,636 		JBrowse link
G BIRC6 baculoviral IAP repeat containing 6 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of BIRC6 mRNA CTD PMID:26923065 NCBI chr 2:32,357,023...32,618,878
Ensembl chr 2:32,357,023...32,619,571 		JBrowse link
G BLMH bleomycin hydrolase multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of BLMH mRNA CTD PMID:26923065 NCBI chr17:30,248,203...30,291,944
Ensembl chr17:30,248,203...30,292,056 		JBrowse link
G BLTP1 bridge-like lipid transfer protein family member 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of BLTP1 mRNA CTD PMID:26923065 NCBI chr 4:122,152,331...122,362,752
Ensembl chr 4:122,152,331...122,364,167 		JBrowse link
G BRMS1L BRMS1 like transcriptional repressor multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of BRMS1L mRNA CTD PMID:26923065 NCBI chr14:35,826,338...35,871,963
Ensembl chr14:35,826,338...35,932,325 		JBrowse link
G BROX BRO1 domain and CAAX motif containing multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of BROX mRNA CTD PMID:26923065 NCBI chr 1:222,712,564...222,735,187
Ensembl chr 1:222,712,553...222,735,196 		JBrowse link
G C16orf90 chromosome 16 open reading frame 90 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of C10H16ORF90 mRNA CTD PMID:26923065 NCBI chr16:3,493,484...3,496,652
Ensembl chr16:3,493,484...3,495,489 		JBrowse link
G C1QTNF7 C1q and TNF related 7 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of C1QTNF7 mRNA CTD PMID:26923065 NCBI chr 4:15,339,786...15,446,167
Ensembl chr 4:15,339,818...15,446,167 		JBrowse link
G CA3 carbonic anhydrase 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CA3 mRNA CTD PMID:26923065 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040 		JBrowse link
G CAGE1 cancer antigen 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CAGE1 mRNA CTD PMID:26923065 NCBI chr 6:7,326,659...7,389,742
Ensembl chr 6:7,326,656...7,389,742 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein]]; arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP3 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP3 protein] CTD PMID:21418039 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP8 caspase 8 multiple interactions
increases activity		 EXP arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP8 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP8 protein] CTD PMID:21418039 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity		 EXP Acetylcysteine inhibits the reaction [arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]]; Acetylcysteine inhibits the reaction [Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein]]; arsenic trioxide promotes the reaction [Poly I-C results in increased activity of CASP9 protein]; Poly I-C promotes the reaction [arsenic trioxide results in increased activity of CASP9 protein] CTD PMID:21418039 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CAT catalase decreases expression ISO Poly I-C results in decreased expression of CAT mRNA CTD PMID:23939143 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CAV1 caveolin 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CAV1 mRNA CTD PMID:26923065 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179 		JBrowse link
G CBX1 chromobox 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CBX1 mRNA CTD PMID:26923065 NCBI chr17:48,070,059...48,101,478
Ensembl chr17:48,070,052...48,101,478 		JBrowse link
G CBX6 chromobox 6 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CBX6 mRNA CTD PMID:26923065 NCBI chr22:38,861,422...38,872,216
Ensembl chr22:38,861,422...38,872,249 		JBrowse link
G CCL1 C-C motif chemokine ligand 1 increases expression EXP Poly I-C results in increased expression of CCL1 mRNA CTD PMID:27783115 NCBI chr17:34,360,328...34,363,233
Ensembl chr17:34,360,328...34,363,233 		JBrowse link
G CCL11 C-C motif chemokine ligand 11 multiple interactions
increases secretion		 ISO methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL11 protein] CTD PMID:24056979 NCBI chr17:34,285,742...34,288,334
Ensembl chr17:34,285,742...34,288,334 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions
increases secretion
increases expression		 ISO
EXP		 methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL2 protein]
Poly I-C results in increased expression of CCL2 mRNA		 CTD PMID:23939143 PMID:24056979 PMID:34740670 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,274...34,257,208 		JBrowse link
G CCL3 C-C motif chemokine ligand 3 multiple interactions
increases expression		 ISO Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL3 protein] CTD PMID:19500611 NCBI chr17:36,088,256...36,090,143
Ensembl chr17:36,088,256...36,090,169 		JBrowse link
G CCL4 C-C motif chemokine ligand 4 multiple interactions
increases expression
increases secretion		 ISO
EXP		 Ethanol inhibits the reaction [Poly I-C results in increased expression of CCL4 protein]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL4 protein]
6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of CCL4 mRNA]		 CTD PMID:19500611 PMID:24056979 PMID:27783115 NCBI chr17:36,103,827...36,105,614
Ensembl chr17:36,103,827...36,105,621 		JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions
increases expression
increases secretion		 ISO
EXP		 APPL1 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CCL5 protein]; trametinib promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]
Poly I-C results in increased expression of CCL5; Poly I-C results in increased expression of CCL5 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; [Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of CCL5]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of CCL5]		 CTD PMID:23688403 PMID:24056979 PMID:24709138 PMID:25780039 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793 		JBrowse link
G CD40 CD40 molecule increases expression
multiple interactions		 EXP Poly I-C results in increased expression of CD40 protein
[Poly I-C co-treated with IFNG protein] results in increased secretion of CD40 protein		 CTD PMID:15246609 PMID:16224278 NCBI chr20:46,118,314...46,129,858
Ensembl chr20:46,118,271...46,129,863 		JBrowse link
G CD80 CD80 molecule increases expression EXP Poly I-C results in increased expression of CD80 protein CTD PMID:15246609 NCBI chr 3:119,524,293...119,559,614
Ensembl chr 3:119,524,293...119,559,614 		JBrowse link
G CD83 CD83 molecule increases expression
multiple interactions		 EXP Poly I-C results in increased expression of CD83 protein
CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD83 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD83 protein]		 CTD PMID:17698565 NCBI chr 6:14,117,256...14,136,918
Ensembl chr 6:14,117,256...14,136,918 		JBrowse link
G CD86 CD86 molecule multiple interactions
increases expression		 EXP [Poly I-C co-treated with IFNG protein] results in increased secretion of CD86 protein; CEP-11004 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased expression of CD86 protein]; Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of CD86 protein] CTD PMID:15246609 PMID:16224278 PMID:16890772 PMID:17698565 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139 		JBrowse link
G CDC42 cell division cycle 42 multiple interactions EXP [Poly I-C co-treated with Atorvastatin] results in decreased expression of CDC42 mRNA CTD PMID:34696514 NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,052,627...22,101,360 		JBrowse link
G CDX2 caudal type homeobox 2 multiple interactions EXP [Poly I-C co-treated with 6-formylindolo(3,2-b)carbazole] results in increased expression of CDX2 mRNA; [Poly I-C co-treated with Tetrachlorodibenzodioxin] results in increased expression of CDX2 mRNA CTD PMID:27783115 NCBI chr13:27,960,918...27,969,315
Ensembl chr13:27,960,918...27,969,315 		JBrowse link
G CELF1 CUGBP Elav-like family member 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CELF1 mRNA CTD PMID:26923065 NCBI chr11:47,465,937...47,565,539
Ensembl chr11:47,465,933...47,565,569 		JBrowse link
G CFAP263 cilia and flagella associated protein 263 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CCDC113 mRNA CTD PMID:26923065 NCBI chr16:58,249,936...58,283,836
Ensembl chr16:58,231,157...58,283,836 		JBrowse link
G CFP complement factor properdin multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CFP mRNA CTD PMID:26923065 NCBI chr  X:47,623,282...47,630,305
Ensembl chr  X:47,623,172...47,630,305 		JBrowse link
G CHSY1 chondroitin sulfate synthase 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CHSY1 mRNA CTD PMID:26923065 NCBI chr15:101,175,727...101,252,048
Ensembl chr15:101,175,727...101,252,048 		JBrowse link
G CIBAR2 CBY1 interacting BAR domain containing 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CIBAR2 mRNA CTD PMID:26923065 NCBI chr16:85,098,358...85,112,472
Ensembl chr16:85,098,358...85,112,472 		JBrowse link
G CLCC1 chloride channel CLIC like 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CLCC1 mRNA CTD PMID:26923065 NCBI chr 1:108,929,505...108,963,484
Ensembl chr 1:108,881,885...108,963,527 		JBrowse link
G CLEC14A C-type lectin domain containing 14A multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CLEC14A mRNA CTD PMID:26923065 NCBI chr14:38,254,000...38,256,093
Ensembl chr14:38,254,000...38,256,093 		JBrowse link
G CLIP3 CAP-Gly domain containing linker protein 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CLIP3 mRNA CTD PMID:26923065 NCBI chr19:36,014,660...36,032,873
Ensembl chr19:36,014,660...36,033,343 		JBrowse link
G CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CNNM1 mRNA CTD PMID:26923065 NCBI chr10:99,329,356...99,394,330
Ensembl chr10:99,329,356...99,394,330 		JBrowse link
G CNR1 cannabinoid receptor 1 multiple interactions ISO Cannabidiol inhibits the reaction [Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein]]; Poly I-C inhibits the reaction [Rimonabant binds to CNR1 protein] CTD PMID:31202911 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347 		JBrowse link
G CNR2 cannabinoid receptor 2 increases expression ISO Poly I-C results in increased expression of CNR2 mRNA CTD PMID:27317300 NCBI chr 1:23,870,515...23,913,362
Ensembl chr 1:23,870,515...23,913,362 		JBrowse link
G CNTN1 contactin 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CNTN1 mRNA CTD PMID:26923065 NCBI chr12:40,692,439...41,072,415
Ensembl chr12:40,692,439...41,072,415 		JBrowse link
G CRABP1 cellular retinoic acid binding protein 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CRABP1 mRNA CTD PMID:26923065 NCBI chr15:78,340,353...78,348,225
Ensembl chr15:78,340,353...78,348,225 		JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions
increases secretion
increases expression		 ISO
EXP		 Ethanol inhibits the reaction [Poly I-C results in increased expression of CSF2 protein]
Smoke inhibits the reaction [Poly I-C results in increased secretion of CSF2 protein]		 CTD PMID:19500611 PMID:35817128 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CTTNBP2 cortactin binding protein 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CTTNBP2 mRNA CTD PMID:26923065 NCBI chr 7:117,710,651...117,873,441
Ensembl chr 7:117,710,651...117,874,139 		JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 increases expression
multiple interactions		 ISO Poly I-C results in increased expression of CXCL1 mRNA
Poly I-C results in increased expression of CXCL1 protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of CXCL1 protein]		 CTD PMID:19500611 PMID:23939143 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308 		JBrowse link
G CXCL10 C-X-C motif chemokine ligand 10 multiple interactions
increases secretion
increases expression		 ISO
EXP		 APPL1 protein promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; chrysin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Quercetin inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of CXCL10 mRNA]
Poly I-C results in increased secretion of CXCL10 protein
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; [Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein; bafilomycin A1 inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Cannabidiol inhibits the reaction [Poly I-C results in increased secretion of CXCL10 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of CXCL10 mRNA]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Particulate Matter inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]; Phosphorothioate Oligonucleotides inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Smoke inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]; Smoke inhibits the reaction [Poly I-C results in increased secretion of CXCL10 protein]; Vehicle Emissions inhibits the reaction [[Pam(3)CSK(4) peptide co-treated with Antigens, Bacterial co-treated with Poly I-C co-treated with Lipopolysaccharides co-treated with FSL-1 lipoprotein, synthetic co-treated with Imiquimod co-treated with Polyribonucleotides co-treated with ProMune] results in increased expression of CXCL10 protein]
Poly I-C results in increased expression of CXCL10 mRNA; Poly I-C results in increased expression of CXCL10 protein		 CTD PMID:19426678 PMID:25780039 PMID:26682054 PMID:28003376 PMID:28572013 More... NCBI chr 4:76,021,118...76,023,497
Ensembl chr 4:76,021,118...76,023,497 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression ISO Poly I-C results in increased expression of CXCL2 mRNA CTD PMID:23939143 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression
increases secretion		 EXP 1,3-bis(4-hydroxyphenyl)-4-methyl-5-(4-(2-piperidinylethoxy)phenol)-1H-pyrazole inhibits the reaction [Estradiol promotes the reaction [Poly I-C results in increased expression of CXCL8 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of CXCL8 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of CXCL8 protein]; [Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; CpG ODN 2006 inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of CXCL8 protein]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; Particulate Matter promotes the reaction [Poly I-C results in increased expression of CXCL8]; Poly I-C affects the reaction [Gold Sodium Thiosulfate results in increased secretion of CXCL8 protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; RTKI cpd inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; Smoke inhibits the reaction [Poly I-C results in increased secretion of CXCL8 protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; Vehicle Emissions promotes the reaction [Poly I-C results in increased expression of CXCL8]; Vehicle Emissions promotes the reaction [Poly I-C results in increased secretion of CXCL8 protein]
Poly I-C results in increased expression of CXCL8; Poly I-C results in increased expression of CXCL8 mRNA; Poly I-C results in increased expression of CXCL8 protein		 CTD PMID:17669408 PMID:18779317 PMID:20932985 PMID:23618096 PMID:23688403 More... NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,519...73,743,716 		JBrowse link
G CXCL9 C-X-C motif chemokine ligand 9 multiple interactions
increases secretion
increases expression		 ISO Luteolin inhibits the reaction [Poly I-C results in increased expression of CXCL9 mRNA]; methyldithiocarbamate inhibits the reaction [Poly I-C results in increased secretion of CXCL9 protein] CTD PMID:19426678 PMID:24056979 NCBI chr 4:76,001,275...76,007,509
Ensembl chr 4:76,001,275...76,007,509 		JBrowse link
G CYFIP2 cytoplasmic FMR1 interacting protein 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CYFIP2 mRNA CTD PMID:26923065 NCBI chr 5:157,266,123...157,395,594
Ensembl chr 5:157,266,079...157,395,595 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP Poly I-C promotes the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1A1 mRNA] CTD PMID:27783115 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536 		JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 decreases expression ISO Poly I-C results in decreased expression of CYP2C11 mRNA CTD PMID:23939143 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases expression ISO Poly I-C results in decreased expression of CYP2C6V1 mRNA CTD PMID:23939143 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G CYRIA CYFIP related Rac1 interactor A multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of CYRIA mRNA CTD PMID:26923065 NCBI chr 2:16,549,459...16,665,834
Ensembl chr 2:16,549,459...16,666,331 		JBrowse link
G CYSRT1 cysteine rich tail 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of CYSRT1 mRNA CTD PMID:26923065 NCBI chr 9:137,225,174...137,226,315
Ensembl chr 9:137,225,174...137,226,315 		JBrowse link
G DAB1 DAB adaptor protein 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of DAB1 mRNA CTD PMID:26923065 NCBI chr 1:56,994,778...58,546,726
Ensembl chr 1:56,994,778...58,546,734 		JBrowse link
G DCK deoxycytidine kinase multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of DCK mRNA CTD PMID:26923065 NCBI chr 4:70,993,649...71,030,914
Ensembl chr 4:70,992,538...71,030,914 		JBrowse link
G DCUN1D3 defective in cullin neddylation 1 domain containing 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of DCUN1D3 mRNA CTD PMID:26923065 NCBI chr16:20,854,925...20,900,358
Ensembl chr16:20,854,925...20,900,358 		JBrowse link
G DCUN1D4 defective in cullin neddylation 1 domain containing 4 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of DCUN1D4 mRNA CTD PMID:26923065 NCBI chr 4:51,833,884...51,916,837
Ensembl chr 4:51,843,000...51,916,837 		JBrowse link
G DDX3X DEAD-box helicase 3 X-linked multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of DDX3X mRNA CTD PMID:26923065 NCBI chr  X:41,333,308...41,364,472
Ensembl chr  X:41,333,348...41,364,472 		JBrowse link
G DEFB4A defensin beta 4A increases secretion EXP Poly I-C results in increased secretion of DEFB4 protein CTD PMID:17669408 NCBI chr 8:7,894,677...7,896,716
Ensembl chr 8:7,894,677...7,896,716
Ensembl chr 8:7,894,677...7,896,716 		JBrowse link
G DLG1 discs large MAGUK scaffold protein 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of DLG1 mRNA CTD PMID:26923065 NCBI chr 3:197,042,560...197,299,321
Ensembl chr 3:197,042,560...197,299,330 		JBrowse link
G DNM2 dynamin 2 multiple interactions ISO DNM2 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein] CTD PMID:25780039 NCBI chr19:10,718,079...10,831,903
Ensembl chr19:10,718,055...10,833,488 		JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in increased expression of DNMT1 mRNA; [Arsenicals co-treated with Poly I-C] results in increased expression of DNMT1 mRNA CTD PMID:34303791 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in increased expression of DNMT3A mRNA; [Arsenicals co-treated with Poly I-C] results in increased expression of DNMT3A mRNA CTD PMID:34303791 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590 		JBrowse link
G EEA1 early endosome antigen 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of EEA1 mRNA CTD PMID:26923065 NCBI chr12:92,770,637...92,929,295
Ensembl chr12:92,770,637...92,929,331 		JBrowse link
G EGR1 early growth response 1 multiple interactions
affects methylation		 ISO [Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of EGR1 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of EGR1 mRNA]
Poly I-C affects the methylation of EGR1 promoter		 CTD PMID:24889602 PMID:32843831 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303 		JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 increases expression
increases phosphorylation
increases response to substance		 EXP
ISO		 Poly I-C results in increased expression of EIF2AK2 mRNA
Poly I-C results in increased phosphorylation of EIF2AK2 protein
EIF2AK2 results in increased susceptibility to Poly I-C		 CTD PMID:10944112 PMID:17669408 PMID:22240577 PMID:22558189 NCBI chr 2:37,099,210...37,156,980
Ensembl chr 2:37,099,210...37,157,522 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation EXP Poly I-C results in increased phosphorylation of EIF2S1 protein CTD PMID:22240577 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516 		JBrowse link
G F11R F11 receptor multiple interactions
decreases expression		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; CpG ODN 2006 inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; RTKI cpd inhibits the reaction [Poly I-C results in decreased expression of F11R protein]; SB 203580 inhibits the reaction [Poly I-C results in decreased expression of F11R protein] CTD PMID:20932985 NCBI chr 1:160,995,211...161,021,152
Ensembl chr 1:160,995,211...161,021,175 		JBrowse link
G FABP4 fatty acid binding protein 4 increases expression ISO Poly I-C results in increased expression of FABP4 mRNA CTD PMID:15705927 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G FAM107A family with sequence similarity 107 member A multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of FAM107A mRNA CTD PMID:26923065 NCBI chr 3:58,564,117...58,627,610
Ensembl chr 3:58,564,117...58,627,610 		JBrowse link
G FMR1 fragile X messenger ribonucleoprotein 1 multiple interactions
decreases expression		 ISO Suramin inhibits the reaction [Poly I-C results in decreased expression of FMR1 protein] CTD PMID:23516405 NCBI chr  X:147,911,919...147,951,125
Ensembl chr  X:147,911,919...147,951,125 		JBrowse link
G FXYD3 FXYD domain containing ion transport regulator 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of FXYD3 mRNA CTD PMID:26923065 NCBI chr19:35,115,823...35,124,324
Ensembl chr19:35,115,823...35,124,324 		JBrowse link
G FYTTD1 forty-two-three domain containing 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of FYTTD1 mRNA CTD PMID:26923065 NCBI chr 3:197,749,533...197,787,596
Ensembl chr 3:197,737,179...197,787,596 		JBrowse link
G G3BP1 G3BP stress granule assembly factor 1 affects localization EXP Poly I-C affects the localization of G3BP1 protein CTD PMID:22240577 NCBI chr 5:151,771,954...151,812,785
Ensembl chr 5:151,771,045...151,812,911 		JBrowse link
G G3BP2 G3BP stress granule assembly factor 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of G3BP2 mRNA CTD PMID:26923065 NCBI chr 4:75,642,786...75,724,437
Ensembl chr 4:75,641,849...75,724,589 		JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GABRA1 mRNA CTD PMID:26923065 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981 		JBrowse link
G GABRB2 gamma-aminobutyric acid type A receptor subunit beta2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GABRB2 mRNA CTD PMID:26923065 NCBI chr 5:161,288,436...161,548,404
Ensembl chr 5:161,288,429...161,549,044 		JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GABRG2 mRNA CTD PMID:26923065 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977 		JBrowse link
G GAD1 glutamate decarboxylase 1 decreases expression
multiple interactions		 ISO Poly I-C results in decreased expression of GAD1 protein
Cannabidiol inhibits the reaction [Poly I-C results in decreased expression of GAD1 protein]		 CTD PMID:31202911 NCBI chr 2:170,813,210...170,861,151
Ensembl chr 2:170,813,213...170,861,151 		JBrowse link
G GDAP1 ganglioside induced differentiation associated protein 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GDAP1 mRNA CTD PMID:26923065 NCBI chr 8:74,350,403...74,488,872
Ensembl chr 8:74,320,613...74,518,007 		JBrowse link
G GDI1 GDP dissociation inhibitor 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GDI1 mRNA CTD PMID:26923065 NCBI chr  X:154,437,154...154,443,467
Ensembl chr  X:154,436,913...154,443,467 		JBrowse link
G GET3 guided entry of tail-anchored proteins factor 3, ATPase multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of GET3 mRNA CTD PMID:26923065 NCBI chr19:12,737,106...12,748,323
Ensembl chr19:12,737,139...12,748,323 		JBrowse link
G GFAP glial fibrillary acidic protein increases expression ISO Poly I-C results in increased expression of GFAP mRNA CTD PMID:27317300 NCBI chr17:44,903,159...44,915,500
Ensembl chr17:44,903,159...44,916,937 		JBrowse link
G GH1 growth hormone 1 decreases expression ISO Poly I-C results in decreased expression of GH protein CTD PMID:21195166 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839 		JBrowse link
G GLCE glucuronic acid epimerase multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GLCE mRNA CTD PMID:26923065 NCBI chr15:69,160,635...69,272,207
Ensembl chr15:69,160,584...69,272,217 		JBrowse link
G GLRB glycine receptor beta multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GLRB mRNA CTD PMID:26923065 NCBI chr 4:157,076,150...157,172,090
Ensembl chr 4:157,076,125...157,172,090 		JBrowse link
G GLYR1 glyoxylate reductase 1 homolog multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GLYR1 mRNA CTD PMID:26923065 NCBI chr16:4,803,203...4,847,288
Ensembl chr16:4,803,203...4,847,288 		JBrowse link
G GMFB glia maturation factor beta multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GMFB mRNA CTD PMID:26923065 NCBI chr14:54,474,485...54,488,980
Ensembl chr14:54,474,484...54,489,025 		JBrowse link
G GMPPB GDP-mannose pyrophosphorylase B multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of GMPPB mRNA CTD PMID:26923065 NCBI chr 3:49,719,916...49,723,951
Ensembl chr 3:49,716,844...49,723,973 		JBrowse link
G GPATCH2L G-patch domain containing 2 like multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GPATCH2L mRNA CTD PMID:26923065 NCBI chr14:76,151,922...76,235,555
Ensembl chr14:76,151,916...76,254,342 		JBrowse link
G GPBP1 GC-rich promoter binding protein 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of GPBP1 mRNA CTD PMID:26923065 NCBI chr 5:57,174,059...57,264,679
Ensembl chr 5:57,173,948...57,264,679 		JBrowse link
G GSR glutathione-disulfide reductase decreases expression ISO Poly I-C results in decreased expression of GSR mRNA CTD PMID:23939143 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846 		JBrowse link
G GZMB granzyme B increases expression
multiple interactions		 EXP Poly I-C results in increased expression of GZMB mRNA; Poly I-C results in increased expression of GZMB protein
Particulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Particulate Matter inhibits the reaction [Poly I-C results in increased expression of GZMB protein]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB mRNA]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of GZMB protein]		 CTD PMID:23618096 NCBI chr14:24,630,954...24,634,190
Ensembl chr14:24,630,954...24,634,267 		JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of HEY2 mRNA CTD PMID:26923065 NCBI chr 6:125,749,632...125,761,269
Ensembl chr 6:125,747,664...125,761,269 		JBrowse link
G HMGB1 high mobility group box 1 multiple interactions EXP Indoprofen inhibits the reaction [Poly I-C results in increased secretion of and affects the localization of HMGB1 protein]; Poly I-C results in increased secretion of and affects the localization of HMGB1 protein CTD PMID:34755645 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597 		JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression		 ISO Diclofenac promotes the reaction [Poly I-C results in increased expression of HMOX1 mRNA] CTD PMID:23939143 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 increases expression ISO Poly I-C results in increased expression of HSP90AA1 mRNA CTD PMID:23939143 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699 		JBrowse link
G HSPA1A heat shock protein family A (Hsp70) member 1A increases expression ISO Poly I-C results in increased expression of HSPA1A mRNA CTD PMID:23939143 NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946 		JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 increases expression ISO Poly I-C results in increased expression of HSPA8 mRNA CTD PMID:23939143 NCBI chr11:123,057,489...123,062,462
Ensembl chr11:123,057,489...123,063,230 		JBrowse link
G HTR2A 5-hydroxytryptamine receptor 2A increases expression ISO Poly I-C results in increased expression of HTR2A mRNA CTD PMID:24889602 NCBI chr13:46,831,546...46,898,082
Ensembl chr13:46,831,546...46,897,076 		JBrowse link
G IBTK inhibitor of Bruton tyrosine kinase multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of IBTK mRNA CTD PMID:26923065 NCBI chr 6:82,169,987...82,247,744
Ensembl chr 6:82,169,986...82,247,754 		JBrowse link
G IDO1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of IDO1 mRNA
poly(I:C) co-treated with tryptophan or alone increases activity and expression of IDO1 protein in Langerhans cell-like dendritic cells		 CTD
RGD		 PMID:27783115 PMID:26198597 RGD:11528429 NCBI chr 8:39,913,891...39,928,790
Ensembl chr 8:39,902,275...39,928,790 		JBrowse link
G IDO2 indoleamine 2,3-dioxygenase 2 increases expression EXP Poly I-C results in increased expression of IDO2 mRNA CTD PMID:27783115 NCBI chr 8:39,934,651...40,016,392
Ensembl chr 8:39,934,614...40,016,392 		JBrowse link
G IFIH1 interferon induced with helicase C domain 1 multiple interactions
increases expression		 EXP IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA] CTD PMID:30341573 PMID:31154625 NCBI chr 2:162,267,074...162,318,684
Ensembl chr 2:162,267,074...162,318,684 		JBrowse link
G IFIT1 interferon induced protein with tetratricopeptide repeats 1 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of IFIT1 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIT1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFIT1 mRNA]		 CTD PMID:31154625 NCBI chr10:89,392,623...89,406,487
Ensembl chr10:89,392,546...89,406,487 		JBrowse link
G IFIT2 interferon induced protein with tetratricopeptide repeats 2 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of IFIT2 mRNA
Acetylcysteine inhibits the reaction [Dieldrin inhibits the reaction [Poly I-C results in increased expression of IFIT2 mRNA]]; Dieldrin inhibits the reaction [Poly I-C results in increased expression of IFIT2 mRNA]		 CTD PMID:34051100 NCBI chr10:89,302,046...89,309,271
Ensembl chr10:89,283,694...89,309,271 		JBrowse link
G IFITM1 interferon induced transmembrane protein 1 increases expression EXP Poly I-C results in increased expression of IFITM1 mRNA CTD PMID:22240577 NCBI chr11:314,040...315,272
Ensembl chr11:310,041...315,272 		JBrowse link
G IFNA1 interferon alpha 1 increases expression ISO Poly I-C results in increased expression of IFNA1 mRNA CTD PMID:28726298 NCBI chr 9:21,440,439...21,441,316
Ensembl chr 9:21,440,439...21,441,316 		JBrowse link
G IFNB1 interferon beta 1 increases expression
increases secretion
multiple interactions		 EXP
ISO		 Poly I-C results in increased expression of IFNB1 mRNA; Poly I-C results in increased expression of IFNB1 protein
Poly I-C results in increased secretion of IFNB1 protein
MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
apilimod inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; APPL1 protein promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; BX795 inhibits the reaction [Poly I-C results in increased expression of IFNB1 protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Progesterone inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Resveratrol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; trametinib promotes the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA; Cannabidiol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Dronabinol inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Smoke inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; Wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA]		 CTD PMID:16116226 PMID:16399790 PMID:17669408 PMID:18279804 PMID:18323514 More... NCBI chr 9:21,077,104...21,077,942
Ensembl chr 9:21,077,104...21,077,942 		JBrowse link
G IFNG interferon gamma multiple interactions
increases secretion
increases expression		 EXP
ISO		 [Poly I-C co-treated with IFNG protein] results in increased secretion of CD40 protein; [Poly I-C co-treated with IFNG protein] results in increased secretion of CD86 protein; Smoke inhibits the reaction [Poly I-C results in increased expression of IFNG mRNA]
Poly I-C results in increased secretion of IFNG protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IFNG protein]
Poly I-C results in increased expression of IFNG mRNA; Poly I-C results in increased expression of IFNG protein		 CTD PMID:9328138 PMID:16224278 PMID:17321468 PMID:19500611 PMID:23618096 More... NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IFNL1 interferon lambda 1 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of IFNL1 mRNA
Smoke inhibits the reaction [Poly I-C results in increased expression of IFNL1 mRNA]		 CTD PMID:35817128 NCBI chr19:39,296,407...39,298,673
Ensembl chr19:39,296,407...39,298,673 		JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions
decreases expression		 ISO IL6 protein affects the reaction [Poly I-C results in decreased expression of IGF1 protein]
Poly I-C results in decreased expression of IGF1 mRNA; Poly I-C results in decreased expression of IGF1 protein		 CTD PMID:1705203 PMID:21195166 NCBI chr12:102,395,874...102,481,839
Ensembl chr12:102,395,874...102,481,744 		JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 multiple interactions
decreases expression		 ISO IL6 protein affects the reaction [Poly I-C results in decreased expression of IGFBP3 protein] CTD PMID:21195166 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874 		JBrowse link
G IGSF6 immunoglobulin superfamily member 6 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of IGSF6 mRNA CTD PMID:26923065 NCBI chr16:21,639,550...21,652,608
Ensembl chr16:21,639,550...21,652,608 		JBrowse link
G IKBKE inhibitor of nuclear factor kappa B kinase subunit epsilon multiple interactions
increases phosphorylation		 ISO APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IKBKE protein] CTD PMID:25780039 NCBI chr 1:206,470,476...206,496,889
Ensembl chr 1:206,470,476...206,496,889 		JBrowse link
G IL10 interleukin 10 multiple interactions
increases expression
increases secretion		 EXP
ISO		 CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of IL10 protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of IL10 protein]
Poly I-C results in increased expression of IL10 mRNA
Poly I-C results in increased expression of IL10 mRNA; Poly I-C results in increased expression of IL10 protein
Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL10 protein]		 CTD PMID:16224278 PMID:17698565 PMID:22771370 PMID:23618096 PMID:23939143 More... NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL12A interleukin 12A multiple interactions
increases expression		 EXP 6-formylindolo(3,2-b)carbazole inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]; indole-3-carbinol inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [Poly I-C results in increased expression of IL12A mRNA] CTD PMID:27783115 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B multiple interactions
increases expression		 EXP
ISO		 [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; Particulate Matter analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Vehicle Emissions analog inhibits the reaction [Poly I-C results in increased expression of IL12B protein]
Poly I-C results in increased expression of IL12B mRNA; Poly I-C results in increased expression of IL12B protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IL12B protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL12B mRNA]		 CTD PMID:16890772 PMID:19426678 PMID:19500611 PMID:23266719 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL17A interleukin 17A increases expression ISO Poly I-C results in increased expression of IL17A protein CTD PMID:30836164 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases secretion
increases expression		 ISO
EXP		 APPL1 protein inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of IL1B mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of IL1B protein]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of IL1B mRNA]
Poly I-C results in increased secretion of IL1B protein
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; 6-formylindolo(3,2-b)carbazole promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL1B protein]; Tetrachlorodibenzodioxin promotes the reaction [Poly I-C results in increased expression of IL1B mRNA]
Poly I-C results in increased expression of IL1B mRNA; Poly I-C results in increased expression of IL1B protein		 CTD PMID:16687389 PMID:17321468 PMID:19500611 PMID:22771370 PMID:23618096 More... NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2 interleukin 2 increases expression
increases secretion		 ISO
EXP		 Poly I-C results in increased expression of IL2 mRNA
Poly I-C results in increased secretion of IL2 protein		 CTD PMID:9328138 PMID:23618096 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725 		JBrowse link
G IL27 interleukin 27 increases expression
multiple interactions		 ISO Poly I-C results in increased expression of IL27 mRNA
Luteolin inhibits the reaction [Poly I-C results in increased expression of IL27 mRNA]		 CTD PMID:19426678 NCBI chr16:28,499,362...28,506,834
Ensembl chr16:28,499,362...28,512,051 		JBrowse link
G IL33 interleukin 33 multiple interactions
increases expression		 EXP
ISO		 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of IL33 protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL33 protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL33 protein]
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Poly I-C results in increased expression of IL33 protein]		 CTD PMID:25747661 PMID:30017638 NCBI chr 9:6,215,149...6,257,983
Ensembl chr 9:6,215,786...6,257,983 		JBrowse link
G IL4 interleukin 4 multiple interactions
increases expression
increases secretion
increases response to substance		 EXP
ISO		 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of IL4 protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2; [Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2; [Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein; [Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprost; [Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone; [Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; amorolfine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Estradiol promotes the reaction [Poly I-C results in increased expression of IL4 protein]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CCL5 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Itraconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Ketoconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; luliconazole promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Particulate Matter inhibits the reaction [Poly I-C results in increased secretion of IL4 protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; Terbinafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased secretion of IL4 protein]
IL4 protein results in increased susceptibility to Poly I-C		 CTD PMID:23618096 PMID:23688403 PMID:30017638 PMID:30836164 PMID:34740670 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases secretion
increases expression		 EXP
ISO		 [Vehicle Emissions analog co-treated with Poly I-C] results in increased secretion of IL6 protein; CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of IL6 protein]; Particulate Matter promotes the reaction [Poly I-C results in increased expression of IL6]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of IL6 protein]; Smoke inhibits the reaction [Poly I-C results in increased secretion of IL6 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; TRAF6 mutant form inhibits the reaction [Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]]; Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; Vehicle Emissions promotes the reaction [Poly I-C results in increased expression of IL6]
Poly I-C results in increased expression of IL6 mRNA; Poly I-C results in increased expression of IL6 protein
Ethanol inhibits the reaction [Poly I-C results in increased expression of IL6 protein]; IL6 protein affects the reaction [Poly I-C results in decreased expression of IGF1 protein]; IL6 protein affects the reaction [Poly I-C results in decreased expression of IGFBP3 protein]; IL6 protein affects the reaction [Poly I-C results in increased expression of PRL2B1 mRNA]; IL6 protein affects the reaction [Poly I-C results in increased phosphorylation of and results in increased activity of STAT3 protein]; Luteolin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; pitavastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of IL6 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of IL6 mRNA]
Poly I-C results in increased expression of IL6; Poly I-C results in increased expression of IL6 mRNA		 CTD PMID:9328138 PMID:16399790 PMID:16687389 PMID:17698565 PMID:18323514 More... NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IRF3 interferon regulatory factor 3 increases phosphorylation
affects localization
multiple interactions		 EXP
ISO		 Poly I-C results in increased phosphorylation of IRF3 protein
Poly I-C affects the localization of IRF3 protein
APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; BX795 inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; chrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; DNM2 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; Quercetin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; Sodium Selenite inhibits the reaction [Poly I-C results in increased activity of IRF3 protein]
[Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C affects the localization of IRF3 protein]; [Vehicle Emissions analog co-treated with Poly I-C] affects the localization of IRF3 protein; Cannabidiol inhibits the reaction [Poly I-C affects the localization of IRF3 protein]; Dronabinol inhibits the reaction [Poly I-C results in increased localization of IRF3 protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]		 CTD PMID:16399790 PMID:18279804 PMID:18779317 PMID:19426678 PMID:25780039 More... NCBI chr19:49,659,572...49,665,857
Ensembl chr19:49,659,569...49,665,875 		JBrowse link
G IRF7 interferon regulatory factor 7 increases expression
multiple interactions		 EXP
ISO		 Poly I-C results in increased expression of IRF7 mRNA
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA]
IRF7 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; IRF7 protein mutant form affects the reaction [Nicotine inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]]; IRF7 protein mutant form inhibits the reaction [Nicotine inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIH1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IFIT1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IRF9 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT2 mRNA]; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased secretion of IFNB1 protein]; Nicotine inhibits the reaction [Poly I-C results in increased expression of IRF7 mRNA]		 CTD PMID:22240577 PMID:28726298 PMID:31154625 NCBI chr11:612,555...615,950
Ensembl chr11:612,553...615,983 		JBrowse link
G IRF9 interferon regulatory factor 9 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of IRF9 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of IRF9 mRNA]		 CTD PMID:22240577 PMID:31154625 NCBI chr14:24,161,265...24,166,565
Ensembl chr14:24,161,234...24,168,043 		JBrowse link
G ISG15 ISG15 ubiquitin like modifier increases expression
multiple interactions		 EXP
ISO		 Poly I-C results in increased expression of ISG15 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of ISG15 mRNA]		 CTD PMID:31154625 PMID:36958387 NCBI chr 1:1,013,497...1,014,540
Ensembl chr 1:1,001,138...1,014,540 		JBrowse link
G ITGAM integrin subunit alpha M increases expression ISO Poly I-C results in increased expression of ITGAM mRNA; Poly I-C results in increased expression of ITGAM protein CTD PMID:27317300 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892 		JBrowse link
G JCAD junctional cadherin 5 associated multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of JCAD mRNA CTD PMID:26923065 NCBI chr10:30,012,803...30,115,494
Ensembl chr10:30,012,803...30,115,494 		JBrowse link
G KCNA2 potassium voltage-gated channel subfamily A member 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of KCNA2 mRNA CTD PMID:26923065 NCBI chr 1:110,593,580...110,631,440
Ensembl chr 1:110,519,837...110,631,474 		JBrowse link
G KCNIP4 potassium voltage-gated channel interacting protein 4 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of KCNIP4 mRNA CTD PMID:26923065 NCBI chr 4:20,728,606...21,948,772
Ensembl chr 4:20,728,606...21,948,772 		JBrowse link
G KCNQ5 potassium voltage-gated channel subfamily Q member 5 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of KCNQ5 mRNA CTD PMID:26923065 NCBI chr 6:72,622,064...73,198,853
Ensembl chr 6:72,621,792...73,198,853 		JBrowse link
G KIF5B kinesin family member 5B multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of KIF5B mRNA CTD PMID:26923065 NCBI chr10:32,009,015...32,056,425
Ensembl chr10:32,009,015...32,056,425 		JBrowse link
G KIF5C kinesin family member 5C multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of KIF5C mRNA CTD PMID:26923065 NCBI chr 2:148,875,227...149,026,759
Ensembl chr 2:148,875,227...149,026,759 		JBrowse link
G KLF4 KLF transcription factor 4 multiple interactions
increases expression		 EXP Poly I-C promotes the reaction [MSI1 protein results in increased expression of KLF4 protein]
Poly I-C results in increased expression of KLF4 protein		 CTD PMID:29486283 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482 		JBrowse link
G KLRK1 killer cell lectin like receptor K1 increases expression ISO Poly I-C results in increased expression of KLRK1 mRNA; Poly I-C results in increased expression of KLRK1 protein CTD PMID:16472598 NCBI chr12:10,372,353...10,390,041
Ensembl chr12:10,372,353...10,391,874 		JBrowse link
G KPNA3 karyopherin subunit alpha 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of KPNA3 mRNA CTD PMID:26923065 NCBI chr13:49,699,320...49,792,682
Ensembl chr13:49,699,320...49,792,682 		JBrowse link
G KPNA7 karyopherin subunit alpha 7 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of KPNA7 mRNA
Atorvastatin inhibits the reaction [Poly I-C results in increased expression of KPNA7 mRNA]; Ivermectin inhibits the reaction [Poly I-C results in increased expression of KPNA7 mRNA]		 CTD PMID:34696514 NCBI chr 7:99,145,804...99,219,419
Ensembl chr 7:99,173,572...99,250,075 		JBrowse link
G LSM14B LSM family member 14B multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of LSM14B mRNA CTD PMID:26923065 NCBI chr20:62,122,475...62,135,374
Ensembl chr20:62,122,461...62,135,374 		JBrowse link
G MAL2 mal, T cell differentiation protein 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MAL2 mRNA CTD PMID:26923065 NCBI chr 8:119,208,363...119,245,673
Ensembl chr 8:119,165,034...119,245,673 		JBrowse link
G MAP3K11 mitogen-activated protein kinase kinase kinase 11 increases phosphorylation EXP Poly I-C results in increased phosphorylation of MAP3K11 protein CTD PMID:17698565 NCBI chr11:65,597,757...65,614,221
Ensembl chr11:65,597,756...65,615,382 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases phosphorylation
increases phosphorylation
multiple interactions		 ISO Poly I-C results in decreased phosphorylation of MAPK1 protein
Poly I-C results in increased phosphorylation of MAPK1 protein
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK1 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK1 protein]		 CTD PMID:23516405 PMID:25780039 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases phosphorylation
increases phosphorylation
multiple interactions		 ISO Poly I-C results in decreased phosphorylation of MAPK3 protein
Poly I-C results in increased phosphorylation of MAPK3 protein
Suramin inhibits the reaction [Poly I-C results in decreased phosphorylation of MAPK3 protein]; trametinib inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Poly I-C results in increased phosphorylation of MAPK3 protein]		 CTD PMID:23516405 PMID:25780039 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK4 mitogen-activated protein kinase 4 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MAPK4 mRNA CTD PMID:26923065 NCBI chr18:50,559,612...50,731,826
Ensembl chr18:50,560,087...50,731,826 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MAPK9 mRNA CTD PMID:26923065 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MAPRE1 microtubule associated protein RP/EB family member 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MAPRE1 mRNA CTD PMID:26923065 NCBI chr20:32,819,777...32,850,405
Ensembl chr20:32,819,954...32,850,405 		JBrowse link
G MARCHF7 membrane associated ring-CH-type finger 7 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MARCHF7 mRNA CTD PMID:26923065 NCBI chr 2:159,712,506...159,771,027
Ensembl chr 2:159,712,457...159,771,027 		JBrowse link
G MBLAC2 metallo-beta-lactamase domain containing 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MBLAC2 mRNA CTD PMID:26923065 NCBI chr 5:90,458,209...90,474,771
Ensembl chr 5:90,458,209...90,474,771 		JBrowse link
G MBP myelin basic protein multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MBP mRNA CTD PMID:26923065 NCBI chr18:76,978,833...77,133,708
Ensembl chr18:76,978,827...77,133,683 		JBrowse link
G MEF2C myocyte enhancer factor 2C multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MEF2C mRNA CTD PMID:26923065 NCBI chr 5:88,717,117...88,904,105
Ensembl chr 5:88,717,117...88,904,257 		JBrowse link
G MICOS13 mitochondrial contact site and cristae organizing system subunit 13 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of MICOS13 mRNA CTD PMID:26923065 NCBI chr19:5,678,422...5,680,516
Ensembl chr19:5,678,421...5,680,516 		JBrowse link
G MICU3 mitochondrial calcium uptake family member 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MICU3 mRNA CTD PMID:26923065 NCBI chr 8:17,027,238...17,138,640
Ensembl chr 8:17,027,238...17,122,642 		JBrowse link
G MIR148B microRNA 148b multiple interactions EXP [Arsenicals co-treated with Poly I-C] results in decreased expression of MIR148B mRNA CTD PMID:34303791 NCBI chr12:54,337,216...54,337,314
Ensembl chr12:54,337,216...54,337,314 		JBrowse link
G MIR152 microRNA 152 multiple interactions EXP [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in decreased expression of MIR152 mRNA; [Arsenicals co-treated with Poly I-C] results in decreased expression of MIR152 mRNA CTD PMID:34303791 NCBI chr17:48,037,161...48,037,247
Ensembl chr17:48,037,161...48,037,247 		JBrowse link
G MIR155 microRNA 155 multiple interactions
increases expression		 ISO MIR155 mRNA inhibits the reaction [Progesterone inhibits the reaction [Poly I-C results in increased expression of MIR155 mRNA]]; Progesterone inhibits the reaction [Poly I-C results in increased expression of MIR155 mRNA] CTD PMID:22546503 NCBI chr21:25,573,980...25,574,044
Ensembl chr21:25,573,980...25,574,044 		JBrowse link
G MIR26A1 microRNA 26a-1 multiple interactions ISO MIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF protein] CTD PMID:24423102 NCBI chr 3:37,969,404...37,969,480
Ensembl chr 3:37,969,404...37,969,480 		JBrowse link
G MIR29C microRNA 29c multiple interactions EXP [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in decreased expression of MIR29C mRNA; [Arsenicals co-treated with Poly I-C] results in decreased expression of MIR29C mRNA CTD PMID:34303791 NCBI chr 1:207,801,852...207,801,939
Ensembl chr 1:207,801,852...207,801,939 		JBrowse link
G MRPS15 mitochondrial ribosomal protein S15 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of MRPS15 mRNA CTD PMID:26923065 NCBI chr 1:36,455,718...36,464,384
Ensembl chr 1:36,455,718...36,464,384 		JBrowse link
G MSI1 musashi RNA binding protein 1 multiple interactions EXP Poly I-C promotes the reaction [MSI1 protein results in increased expression of KLF4 protein]; Poly I-C promotes the reaction [MSI1 protein results in increased expression of MYC protein]; Poly I-C promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]; Poly I-C promotes the reaction [MSI1 protein results in increased expression of SOX2 protein] CTD PMID:29486283 NCBI chr12:120,339,662...120,369,164
Ensembl chr12:120,341,330...120,369,164 		JBrowse link
G MTPN myotrophin multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MTPN mRNA CTD PMID:26923065 NCBI chr 7:135,926,760...135,977,359
Ensembl chr 7:135,926,760...135,977,359 		JBrowse link
G MTREX Mtr4 exosome RNA helicase multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of MTREX mRNA CTD PMID:26923065 NCBI chr 5:55,307,989...55,425,579
Ensembl chr 5:55,307,989...55,425,579 		JBrowse link
G MX1 MX dynamin like GTPase 1 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of MX1 mRNA
Acetylcysteine inhibits the reaction [Dieldrin inhibits the reaction [Poly I-C results in increased expression of MX1 mRNA]]; Dieldrin inhibits the reaction [Poly I-C results in increased expression of MX1 mRNA]		 CTD PMID:17669408 PMID:22558189 PMID:34051100 NCBI chr21:41,420,558...41,459,214
Ensembl chr21:41,420,020...41,470,071 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions		 EXP Poly I-C results in increased expression of MYC protein
Poly I-C promotes the reaction [MSI1 protein results in increased expression of MYC protein]		 CTD PMID:29486283 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor increases expression
multiple interactions		 ISO Poly I-C results in increased expression of MYD88 mRNA
cinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of MYD88 mRNA]		 CTD PMID:18306459 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024 		JBrowse link
G NAA60 N-alpha-acetyltransferase 60, NatF catalytic subunit multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of NAA60 mRNA CTD PMID:26923065 NCBI chr16:3,443,611...3,486,963
Ensembl chr16:3,443,649...3,486,953 		JBrowse link
G NAPB NSF attachment protein beta multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of NAPB mRNA CTD PMID:26923065 NCBI chr20:23,374,522...23,421,488
Ensembl chr20:23,374,519...23,421,519 		JBrowse link
G NAPEPLD N-acyl phosphatidylethanolamine phospholipase D multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of NAPEPLD mRNA CTD PMID:26923065 NCBI chr 7:103,099,776...103,150,001
Ensembl chr 7:103,099,776...103,149,560 		JBrowse link
G NBEA neurobeachin multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of NBEA mRNA CTD PMID:26923065 NCBI chr13:34,942,270...35,672,736
Ensembl chr13:34,942,270...35,673,022 		JBrowse link
G NDST3 N-deacetylase and N-sulfotransferase 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of NDST3 mRNA CTD PMID:26923065 NCBI chr 4:118,033,322...118,258,634
Ensembl chr 4:118,033,618...118,258,634 		JBrowse link
G NECAB1 N-terminal EF-hand calcium binding protein 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of NECAB1 mRNA CTD PMID:26923065 NCBI chr 8:90,791,775...90,959,393
Ensembl chr 8:90,791,741...90,959,393 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of NFKB1 mRNA
[Ivermectin co-treated with Atorvastatin] inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]; Atorvastatin inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]; Ivermectin inhibits the reaction [Poly I-C results in increased expression of NFKB1 mRNA]		 CTD PMID:34696514 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha increases phosphorylation
multiple interactions		 EXP Poly I-C results in increased phosphorylation of NFKBIA protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; [Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]		 CTD PMID:18779317 PMID:20932985 PMID:23688403 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NLGN3 neuroligin 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of NLGN3 mRNA CTD PMID:26923065 NCBI chr  X:71,144,841...71,175,307
Ensembl chr  X:71,144,821...71,175,255 		JBrowse link
G NMU neuromedin U multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of NMU mRNA CTD PMID:26923065 NCBI chr 4:55,595,231...55,636,793
Ensembl chr 4:55,595,229...55,636,698 		JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO pitavastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; Pravastatin inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of NOS2 mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of NOS2 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of NOS2 protein]
Diclofenac promotes the reaction [Poly I-C results in increased expression of NOS2 mRNA]
Poly I-C results in increased expression of NOS2 mRNA; Poly I-C results in increased expression of NOS2 protein		 CTD PMID:17321468 PMID:18279804 PMID:18323514 PMID:21195166 PMID:23939143 More... NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NRSN1 neurensin 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of NRSN1 mRNA CTD PMID:26923065 NCBI chr 6:24,126,215...24,147,530
Ensembl chr 6:24,126,186...24,154,900 		JBrowse link
G NUF2 NUF2 component of NDC80 kinetochore complex multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of NUF2 mRNA CTD PMID:26923065 NCBI chr 1:163,321,954...163,355,759
Ensembl chr 1:163,266,576...163,355,764 		JBrowse link
G OAS1 2'-5'-oligoadenylate synthetase 1 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of OAS1 mRNA
[[Poly I-C co-treated with Interferon-alpha] results in increased activity of OAS1 protein] which results in increased abundance of 2',5'-oligoadenylate; [Poly I-C co-treated with Interferon-alpha] results in increased activity of OAS1 protein; IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of OAS1 mRNA]		 CTD PMID:17669408 PMID:22240577 PMID:26055709 PMID:31154625 NCBI chr12:112,906,962...112,933,219
Ensembl chr12:112,905,856...112,933,219 		JBrowse link
G OAS2 2'-5'-oligoadenylate synthetase 2 increases expression EXP Poly I-C results in increased expression of OAS2 mRNA CTD PMID:22240577 PMID:22558189 NCBI chr12:112,978,519...113,011,723
Ensembl chr12:112,978,395...113,011,723 		JBrowse link
G OR4E1 olfactory receptor family 4 subfamily E member 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of OR4E1 mRNA CTD PMID:26923065 NCBI chr14:21,667,886...21,673,818
Ensembl chr14:21,667,886...21,673,818 		JBrowse link
G P2RX7 purinergic receptor P2X 7 decreases expression
multiple interactions		 ISO Poly I-C results in decreased expression of P2RX7 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RX7 protein]		 CTD PMID:23516405 NCBI chr12:121,132,876...121,188,032
Ensembl chr12:121,132,819...121,188,032 		JBrowse link
G P2RY2 purinergic receptor P2Y2 decreases expression
multiple interactions		 ISO Poly I-C results in decreased expression of P2RY2 protein
Suramin inhibits the reaction [Poly I-C results in decreased expression of P2RY2 protein]		 CTD PMID:23516405 NCBI chr11:73,218,281...73,242,427
Ensembl chr11:73,218,281...73,242,427 		JBrowse link
G PAK2 p21 (RAC1) activated kinase 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of PAK2 mRNA CTD PMID:26923065 NCBI chr 3:196,739,857...196,832,647
Ensembl chr 3:196,739,857...196,832,647 		JBrowse link
G PARD6G par-6 family cell polarity regulator gamma multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of PARD6G mRNA CTD PMID:26923065 NCBI chr18:80,157,232...80,247,514
Ensembl chr18:80,157,232...80,247,514 		JBrowse link
G PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of PCMTD1 mRNA CTD PMID:26923065 NCBI chr 8:51,817,575...51,899,186
Ensembl chr 8:51,817,575...51,899,186 		JBrowse link
G PDAP1 PDGFA associated protein 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of PDAP1 mRNA CTD PMID:26923065 NCBI chr 7:99,394,673...99,408,597
Ensembl chr 7:99,392,048...99,408,597 		JBrowse link
G PDCD6IP programmed cell death 6 interacting protein multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of PDCD6IP mRNA CTD PMID:26923065 NCBI chr 3:33,798,630...33,869,703
Ensembl chr 3:33,798,571...33,869,707 		JBrowse link
G PHACTR1 phosphatase and actin regulator 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of PHACTR1 mRNA CTD PMID:26923065 NCBI chr 6:12,716,767...13,287,837
Ensembl chr 6:12,716,312...13,290,446 		JBrowse link
G PHF7 PHD finger protein 7 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of PHF7 mRNA CTD PMID:26923065 NCBI chr 3:52,410,660...52,423,641
Ensembl chr 3:52,410,660...52,423,641 		JBrowse link
G PKIB cAMP-dependent protein kinase inhibitor beta decreases expression
multiple interactions		 ISO Poly I-C results in decreased expression of PKIB mRNA
[Poly I-C co-treated with HU 211] results in decreased expression of PKIB mRNA		 CTD PMID:26923065 NCBI chr 6:122,471,921...122,726,373
Ensembl chr 6:122,471,917...122,726,373 		JBrowse link
G PLCB1 phospholipase C beta 1 increases expression ISO Poly I-C results in increased expression of PLCB1 mRNA CTD PMID:24889602 NCBI chr20:8,132,266...8,884,900
Ensembl chr20:8,077,251...8,968,360 		JBrowse link
G PLCXD2 phosphatidylinositol specific phospholipase C X domain containing 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of PLCXD2 mRNA CTD PMID:26923065 NCBI chr 3:111,674,676...111,727,007
Ensembl chr 3:111,674,676...111,846,447 		JBrowse link
G PLEKHA8 pleckstrin homology domain containing A8 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of PLEKHA8 mRNA CTD PMID:26923065 NCBI chr 7:30,028,412...30,130,483
Ensembl chr 7:30,027,404...30,130,483 		JBrowse link
G PLPPR4 phospholipid phosphatase related 4 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of PLPPR4 mRNA CTD PMID:26923065 NCBI chr 1:99,262,924...99,309,584
Ensembl chr 1:99,264,292...99,309,590 		JBrowse link
G PMVK phosphomevalonate kinase multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of PMVK mRNA CTD PMID:26923065 NCBI chr 1:154,924,740...154,942,658
Ensembl chr 1:154,924,740...154,936,719 		JBrowse link
G POU5F1 POU class 5 homeobox 1 multiple interactions
increases expression		 EXP Poly I-C promotes the reaction [MSI1 protein results in increased expression of POU5F1 protein]
Poly I-C results in increased expression of POU5F1 protein		 CTD PMID:29486283 NCBI chr 6:31,164,337...31,170,682
Ensembl chr 6:31,164,337...31,180,731 		JBrowse link
G PRF1 perforin 1 multiple interactions
increases expression		 EXP Particulate Matter inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]; Vehicle Emissions inhibits the reaction [Poly I-C results in increased expression of PRF1 protein]
Poly I-C results in increased expression of PRF1 mRNA; Poly I-C results in increased expression of PRF1 protein		 CTD PMID:23618096 NCBI chr10:70,597,348...70,602,741
Ensembl chr10:70,597,348...70,602,759 		JBrowse link
G PRKCI protein kinase C iota multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of PRKCI mRNA CTD PMID:26923065 NCBI chr 3:170,222,424...170,305,977
Ensembl chr 3:170,222,424...170,305,977 		JBrowse link
G PRODH2 proline dehydrogenase 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of PRODH2 mRNA CTD PMID:26923065 NCBI chr19:35,799,988...35,812,845
Ensembl chr19:35,799,988...35,813,299 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 ISO Poly I-C results in increased expression of PTGS2 protein
[Poly I-C results in increased susceptibility to 4-iodo-2,5-dimethoxyphenylisopropylamine] which results in increased expression of PTGS2 mRNA; Poly I-C promotes the reaction [4-iodo-2,5-dimethoxyphenylisopropylamine results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Poly I-C results in increased expression of PTGS2 protein]; Sodium Selenite inhibits the reaction [Poly I-C results in increased expression of PTGS2 protein]		 CTD PMID:16116226 PMID:18279804 PMID:24889602 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PVALB parvalbumin multiple interactions ISO [Poly I-C co-treated with Cannabidiol] results in increased expression of PVALB protein CTD PMID:31326506 NCBI chr22:36,800,703...36,819,499
Ensembl chr22:36,800,684...36,819,479 		JBrowse link
G RAC1 Rac family small GTPase 1 multiple interactions ISO
EXP		 [Poly I-C co-treated with HU 211] results in decreased expression of RAC1 mRNA
[Poly I-C co-treated with Atorvastatin] results in decreased expression of RAC1 mRNA; [Poly I-C co-treated with Ivermectin] results in decreased expression of RAC1 mRNA		 CTD PMID:26923065 PMID:34696514 NCBI chr 7:6,374,527...6,403,967
Ensembl chr 7:6,374,527...6,403,967 		JBrowse link
G RARB retinoic acid receptor beta multiple interactions EXP [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in decreased expression of RARB mRNA; [Arsenicals co-treated with Poly I-C co-treated with Alitretinoin] results in decreased expression of RARB protein; [Arsenicals co-treated with Poly I-C] affects the expression of RARB mRNA; [Arsenicals co-treated with Poly I-C] results in decreased expression of RARB protein CTD PMID:34303791 NCBI chr 3:24,829,321...25,597,932
Ensembl chr 3:24,687,887...25,597,932 		JBrowse link
G RDM1 RAD52 motif containing 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of RDM1 mRNA CTD PMID:26923065 NCBI chr17:35,918,080...35,930,773
Ensembl chr17:35,918,066...35,930,773 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit affects localization
increases phosphorylation
multiple interactions		 EXP Poly I-C affects the localization of RELA protein
Poly I-C results in increased phosphorylation of RELA protein
TP53 protein affects the reaction [Poly I-C affects the localization of RELA protein]		 CTD PMID:18779317 PMID:24709138 PMID:27836898 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RGS4 regulator of G protein signaling 4 increases expression ISO Poly I-C results in increased expression of RGS4 mRNA CTD PMID:24889602 NCBI chr 1:163,068,871...163,076,802
Ensembl chr 1:163,068,775...163,076,802 		JBrowse link
G RHOA ras homolog family member A multiple interactions EXP [Poly I-C co-treated with Atorvastatin co-treated with Ivermectin] results in increased expression of RHOA mRNA; [Poly I-C co-treated with Atorvastatin] results in increased expression of RHOA mRNA CTD PMID:34696514 NCBI chr 3:49,359,145...49,411,976
Ensembl chr 3:49,359,139...49,412,998 		JBrowse link
G RIGI RNA sensor RIG-I increases expression
multiple interactions		 EXP Poly I-C results in increased expression of RIGI mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of RIGI mRNA]		 CTD PMID:27183587 PMID:30341573 PMID:31154625 NCBI chr 9:32,455,302...32,526,196
Ensembl chr 9:32,455,302...32,526,208 		JBrowse link
G RIMBP2 RIMS binding protein 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of RIMBP2 mRNA CTD PMID:26923065 NCBI chr12:130,396,133...130,716,299
Ensembl chr12:130,396,133...130,768,228 		JBrowse link
G RIMOC1 RAB7A interacting MON1-CCZ1 complex subunit 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of RIMOC1 mRNA CTD PMID:26923065 NCBI chr 5:41,904,344...41,921,636
Ensembl chr 5:41,904,188...41,921,636 		JBrowse link
G RNF141 ring finger protein 141 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of RNF141 mRNA CTD PMID:26923065 NCBI chr11:10,511,673...10,541,187
Ensembl chr11:10,511,673...10,541,230 		JBrowse link
G RPL31 ribosomal protein L31 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of RPL31 mRNA CTD PMID:26923065 NCBI chr 2:101,002,289...101,019,724
Ensembl chr 2:101,002,229...101,024,032 		JBrowse link
G RPS6KB2 ribosomal protein S6 kinase B2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of RPS6KB2 mRNA CTD PMID:26923065 NCBI chr11:67,428,494...67,435,401
Ensembl chr11:67,428,460...67,435,401 		JBrowse link
G RTN4RL1 reticulon 4 receptor like 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of RTN4RL1 mRNA CTD PMID:26923065 NCBI chr17:1,934,677...2,025,334
Ensembl chr17:1,934,677...2,025,334 		JBrowse link
G S100A3 S100 calcium binding protein A3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of S100A3 mRNA CTD PMID:26923065 NCBI chr 1:153,547,329...153,549,258
Ensembl chr 1:153,547,329...153,549,258 		JBrowse link
G SEMA6D semaphorin 6D multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SEMA6D mRNA CTD PMID:26923065 NCBI chr15:47,184,089...47,774,228
Ensembl chr15:47,184,101...47,774,228 		JBrowse link
G SEPTIN6 septin 6 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SEPTIN6 mRNA CTD PMID:26923065 NCBI chr  X:119,615,724...119,693,168
Ensembl chr  X:119,615,724...119,693,370 		JBrowse link
G SERPINE1 serpin family E member 1 increases expression
multiple interactions		 EXP Poly I-C results in increased expression of SERPINE1 mRNA; Poly I-C results in increased expression of SERPINE1 protein
Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]		 CTD PMID:30341573 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247 		JBrowse link
G SESN2 sestrin 2 increases expression ISO Poly I-C results in increased expression of SESN2 mRNA CTD PMID:25637945 NCBI chr 1:28,259,518...28,282,491
Ensembl chr 1:28,259,518...28,282,491 		JBrowse link
G SGTB small glutamine rich tetratricopeptide repeat co-chaperone beta multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SGTB mRNA CTD PMID:26923065 NCBI chr 5:65,665,928...65,723,013
Ensembl chr 5:65,665,928...65,723,035 		JBrowse link
G SH3RF1 SH3 domain containing ring finger 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SH3RF1 mRNA CTD PMID:26923065 NCBI chr 4:169,094,259...169,270,956
Ensembl chr 4:169,094,259...169,270,956 		JBrowse link
G SHROOM2 shroom family member 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SHROOM2 mRNA CTD PMID:26923065 NCBI chr  X:9,786,429...9,949,443
Ensembl chr  X:9,786,429...9,949,443 		JBrowse link
G SIDT1 SID1 transmembrane family member 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SIDT1 mRNA CTD PMID:26923065 NCBI chr 3:113,532,555...113,637,111
Ensembl chr 3:113,532,555...113,629,575 		JBrowse link
G SLC14A1 solute carrier family 14 member 1 (Kidd blood group) multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SLC14A1 mRNA CTD PMID:26923065 NCBI chr18:45,724,181...45,752,520
Ensembl chr18:45,687,025...45,752,520 		JBrowse link
G SLC17A7 solute carrier family 17 member 7 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SLC17A7 mRNA CTD PMID:26923065 NCBI chr19:49,429,401...49,441,527
Ensembl chr19:49,429,401...49,442,360 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SLC25A12 mRNA CTD PMID:26923065 NCBI chr 2:171,783,405...171,894,244
Ensembl chr 2:171,783,405...171,999,859 		JBrowse link
G SLC25A14 solute carrier family 25 member 14 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SLC25A14 mRNA CTD PMID:26923065 NCBI chr  X:130,339,919...130,373,357
Ensembl chr  X:130,339,888...130,373,361 		JBrowse link
G SLC2A13 solute carrier family 2 member 13 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SLC2A13 mRNA CTD PMID:26923065 NCBI chr12:39,755,025...40,106,081
Ensembl chr12:39,755,025...40,106,089 		JBrowse link
G SLC3A1 solute carrier family 3 member 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SLC3A1 mRNA CTD PMID:26923065 NCBI chr 2:44,275,480...44,322,437
Ensembl chr 2:44,275,458...44,321,494 		JBrowse link
G SLC4A10 solute carrier family 4 member 10 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SLC4A10 mRNA CTD PMID:26923065 NCBI chr 2:161,624,416...161,985,270
Ensembl chr 2:161,424,332...161,985,282 		JBrowse link
G SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SMARCD1 mRNA CTD PMID:26923065 NCBI chr12:50,085,342...50,100,707
Ensembl chr12:50,085,200...50,100,707 		JBrowse link
G SND1 staphylococcal nuclease and tudor domain containing 1 affects localization EXP Poly I-C affects the localization of SND1 protein CTD PMID:22240577 NCBI chr 7:127,652,194...128,092,593
Ensembl chr 7:127,652,194...128,092,609 		JBrowse link
G SNRK SNF related kinase multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SNRK mRNA CTD PMID:26923065 NCBI chr 3:43,286,540...43,351,143
Ensembl chr 3:43,286,512...43,424,764 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 increases expression
multiple interactions		 ISO Poly I-C results in increased expression of SOCS1 mRNA
Progesterone promotes the reaction [Poly I-C results in increased expression of SOCS1 mRNA]		 CTD PMID:22546503 NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression ISO Poly I-C results in increased expression of SOCS3 mRNA CTD PMID:21195166 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression ISO Poly I-C results in increased expression of SOD2 mRNA CTD PMID:23939143 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529 		JBrowse link
G SOX2 SRY-box transcription factor 2 multiple interactions
increases expression		 EXP Poly I-C promotes the reaction [MSI1 protein results in increased expression of SOX2 protein]
Poly I-C results in increased expression of SOX2 protein		 CTD PMID:29486283 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436 		JBrowse link
G SPAG6 sperm associated antigen 6 decreases expression ISO Poly I-C results in decreased expression of SPAG6 mRNA CTD PMID:26923065 NCBI chr10:22,345,496...22,417,610
Ensembl chr10:22,345,445...22,454,224 		JBrowse link
G SRSF12 serine and arginine rich splicing factor 12 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SRSF12 mRNA CTD PMID:26923065 NCBI chr 6:89,095,959...89,118,071
Ensembl chr 6:89,095,959...89,118,071 		JBrowse link
G SRSF7 serine and arginine rich splicing factor 7 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SRSF7 mRNA CTD PMID:26923065 NCBI chr 2:38,743,599...38,751,494
Ensembl chr 2:38,743,599...38,751,494 		JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions
increases expression
increases phosphorylation		 ISO
EXP		 sodium arsenite inhibits the reaction [Poly I-C results in increased phosphorylation of STAT1 protein]
Poly I-C results in increased expression of STAT1 mRNA
IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]; Nicotine inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]		 CTD PMID:30726814 PMID:31154625 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960 		JBrowse link
G STAT2 signal transducer and activator of transcription 2 multiple interactions
increases expression		 EXP IRF7 protein mutant form inhibits the reaction [Poly I-C results in increased expression of STAT2 mRNA] CTD PMID:31154625 NCBI chr12:56,341,597...56,360,107
Ensembl chr12:56,341,597...56,360,203 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO IL6 protein affects the reaction [Poly I-C results in increased phosphorylation of and results in increased activity of STAT3 protein]; Poly I-C results in increased phosphorylation of and results in increased activity of STAT3 protein CTD PMID:21195166 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G STXBP6 syntaxin binding protein 6 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of STXBP6 mRNA CTD PMID:26923065 NCBI chr14:24,809,454...25,050,147
Ensembl chr14:24,809,454...25,050,147 		JBrowse link
G SVIP small VCP interacting protein multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SVIP mRNA CTD PMID:26923065 NCBI chr11:22,818,927...22,829,801
Ensembl chr11:22,813,799...22,830,299 		JBrowse link
G SYT11 synaptotagmin 11 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of SYT11 mRNA CTD PMID:26923065 NCBI chr 1:155,859,567...155,885,199
Ensembl chr 1:155,859,567...155,885,199 		JBrowse link
G TBC1D9 TBC1 domain family member 9 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of TBC1D9 mRNA CTD PMID:26923065 NCBI chr 4:140,620,782...140,756,385
Ensembl chr 4:140,620,782...140,756,385 		JBrowse link
G TBK1 TANK binding kinase 1 increases phosphorylation
multiple interactions		 ISO Poly I-C results in increased phosphorylation of TBK1 protein
APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein]		 CTD PMID:25780039 NCBI chr12:64,452,120...64,502,114
Ensembl chr12:64,452,090...64,502,114 		JBrowse link
G TFB1M transcription factor B1, mitochondrial multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of TFB1M mRNA CTD PMID:26923065 NCBI chr 6:155,229,871...155,314,484
Ensembl chr 6:155,256,134...155,314,493 		JBrowse link
G TGFB1 transforming growth factor beta 1 increases secretion EXP Poly I-C results in increased secretion of TGFB1 protein CTD PMID:34740670 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THY1 Thy-1 cell surface antigen multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of THY1 mRNA CTD PMID:26923065 NCBI chr11:119,415,476...119,424,985
Ensembl chr11:119,415,476...119,424,985 		JBrowse link
G TIAL1 TIA1 cytotoxic granule associated RNA binding protein like 1 affects localization EXP Poly I-C affects the localization of TIAL1 protein CTD PMID:22240577 NCBI chr10:119,573,465...119,596,964
Ensembl chr10:119,571,802...119,597,029 		JBrowse link
G TICAM1 TIR domain containing adaptor molecule 1 increases expression EXP Poly I-C results in increased expression of TICAM1 mRNA CTD PMID:21418039 NCBI chr19:4,815,932...4,831,712
Ensembl chr19:4,815,932...4,831,712 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression ISO Poly I-C results in increased expression of TIMP1 mRNA CTD PMID:21195166 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TLR2 toll like receptor 2 increases expression EXP Poly I-C results in increased expression of TLR2 mRNA CTD PMID:17669408 NCBI chr 4:153,684,280...153,710,637
Ensembl chr 4:153,684,070...153,706,260 		JBrowse link
G TLR3 toll like receptor 3 multiple interactions
increases activity
increases expression		 EXP
ISO		 [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of IL12B protein; [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-aminopyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to 1-nitropyrene; [Poly I-C binds to TLR3 protein] which affects the susceptibility to pyrene; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 mRNA; [Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of TLR3 protein; Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; Poly I-C binds to and results in increased activity of TLR3 protein; Quinacrine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]; TLR3 mRNA promotes the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TLR3 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]
MIR26A mRNA inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]
Poly I-C results in increased expression of TLR3 mRNA
cinnamaldehyde inhibits the reaction [Poly I-C results in increased expression of TLR3 mRNA]		 CTD PMID:16399790 PMID:17669408 PMID:18306459 PMID:18779317 PMID:21398612 More... NCBI chr 4:186,069,156...186,088,073
Ensembl chr 4:186,068,911...186,088,073 		JBrowse link
G TLR7 toll like receptor 7 increases expression EXP Poly I-C results in increased expression of TLR7 mRNA CTD PMID:17669408 NCBI chr  X:12,867,072...12,890,361
Ensembl chr  X:12,867,072...12,890,361 		JBrowse link
G TMEM266 transmembrane protein 266 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of TMEM266 mRNA CTD PMID:26923065 NCBI chr15:76,059,985...76,204,963
Ensembl chr15:76,059,958...76,229,121 		JBrowse link
G TMEM273 transmembrane protein 273 multiple interactions ISO [Poly I-C co-treated with HU 211] results in increased expression of TMEM273 mRNA CTD PMID:26923065 NCBI chr10:49,154,736...49,188,391
Ensembl chr10:49,154,725...49,188,585 		JBrowse link
G TMPRSS2 transmembrane serine protease 2 decreases response to substance ISO TMPRSS2 gene mutant form results in decreased susceptibility to Poly I-C CTD PMID:30626688 NCBI chr21:41,529,791...41,531,118
Ensembl chr21:41,464,300...41,531,116 		JBrowse link
G TMX1 thioredoxin related transmembrane protein 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of TMX1 mRNA CTD PMID:26923065 NCBI chr14:51,240,247...51,257,655
Ensembl chr14:51,240,162...51,257,655 		JBrowse link
G TNF tumor necrosis factor increases secretion
increases expression
multiple interactions		 EXP
ISO		 Poly I-C results in increased secretion of TNF protein
Poly I-C results in increased expression of TNF mRNA; Poly I-C results in increased expression of TNF protein
cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; MIR26A mRNA inhibits the reaction [Poly I-C results in increased expression of TNF protein]
APPL1 protein inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Citrinin inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Cycloheximide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Ethanol inhibits the reaction [Poly I-C results in increased expression of TNF protein]; Ethanol inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Ethanol promotes the reaction [Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]]; Hydroxamic Acids analog inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Hydroxamic Acids analog promotes the reaction [Dimethyl Sulfoxide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]]; Luteolin inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]; Poly I-C promotes the reaction [deoxynivalenol results in increased expression of TNF mRNA]; sodium arsenite inhibits the reaction [Poly I-C results in increased expression of TNF mRNA]
2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane promotes the reaction [Poly I-C results in increased expression of TNF protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of TNF protein]; [[Poly I-C binds to and results in increased activity of TLR3 protein] which co-treated with Nanotubes, Carbon] results in increased secretion of TNF protein; CEP-11004 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; CpG ODN 2006 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of TNF protein]; N-(3,5-bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; pyrazolanthrone inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; RTKI cpd inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; SB 203580 inhibits the reaction [Poly I-C results in increased secretion of TNF protein]		 CTD PMID:16687389 PMID:17238832 PMID:17321468 PMID:17669408 PMID:17698565 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFSF10 TNF superfamily member 10 increases expression ISO Poly I-C results in increased expression of TNFSF10 mRNA; Poly I-C results in increased expression of TNFSF10 protein CTD PMID:16472598 NCBI chr 3:172,505,508...172,523,430
Ensembl chr 3:172,505,508...172,523,475 		JBrowse link
G TNKS2 tankyrase 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of TNKS2 mRNA CTD PMID:26923065 NCBI chr10:91,798,426...91,865,475
Ensembl chr10:91,798,426...91,865,475 		JBrowse link
G TP53 tumor protein p53 multiple interactions EXP TP53 protein affects the reaction [Poly I-C affects the localization of RELA protein]; TP53 protein affects the reaction [Poly I-C results in increased expression of CXCL8 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased expression of IFNB1 mRNA]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of NFKBIA protein]; TP53 results in increased susceptibility to [Poly I-C co-treated with Fluorouracil] CTD PMID:18779317 PMID:20367642 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538 		JBrowse link
G TPD52 tumor protein D52 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of TPD52 mRNA CTD PMID:26923065 NCBI chr 8:80,031,082...80,171,564
Ensembl chr 8:80,034,745...80,231,232 		JBrowse link
G TPK1 thiamin pyrophosphokinase 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of TERF2IP mRNA CTD PMID:26923065 NCBI chr 7:144,451,941...144,836,437
Ensembl chr 7:144,451,941...144,836,395 		JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions EXP TRAF6 mutant form inhibits the reaction [Vehicle Emissions analog promotes the reaction [Poly I-C results in increased expression of IL6 mRNA]] CTD PMID:16399790 NCBI chr11:36,483,769...36,510,272
Ensembl chr11:36,483,769...36,510,272 		JBrowse link
G TRIM2 tripartite motif containing 2 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of TRIM2 mRNA CTD PMID:26923065 NCBI chr 4:153,152,163...153,339,317
Ensembl chr 4:153,152,163...153,339,319 		JBrowse link
G TSLP thymic stromal lymphopoietin multiple interactions
increases expression		 EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol promotes the reaction [Poly I-C results in increased expression of TSLP protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA; [Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Estradiol promotes the reaction [Poly I-C results in increased expression of TSLP protein]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; helenalin inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP mRNA]; IL4 protein promotes the reaction [Poly I-C results in increased expression of TSLP protein]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]
Poly I-C results in increased expression of TSLP mRNA; Poly I-C results in increased expression of TSLP protein		 CTD PMID:23688403 PMID:30017638 NCBI chr 5:111,070,062...111,078,026
Ensembl chr 5:111,070,062...111,078,026 		JBrowse link
G TSPYL5 TSPY like 5 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of TSPYL5 mRNA CTD PMID:26923065 NCBI chr 8:97,273,488...97,277,928
Ensembl chr 8:97,273,488...97,277,928 		JBrowse link
G TTC3 tetratricopeptide repeat domain 3 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of TTC3 mRNA CTD PMID:26923065 NCBI chr21:37,073,254...37,203,118
Ensembl chr21:37,073,226...37,203,112 		JBrowse link
G TWIST1 twist family bHLH transcription factor 1 decreases expression ISO Poly I-C results in decreased expression of TWIST1 mRNA CTD PMID:26923065 NCBI chr 7:19,113,047...19,117,636
Ensembl chr 7:19,020,991...19,117,636 		JBrowse link
G TWSG1 twisted gastrulation BMP signaling modulator 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of TWSG1 mRNA CTD PMID:26923065 NCBI chr18:9,334,773...9,402,420
Ensembl chr18:9,334,767...9,402,420 		JBrowse link
G TXN thioredoxin multiple interactions
increases expression		 ISO Diclofenac inhibits the reaction [Poly I-C results in increased expression of TXN1 mRNA] CTD PMID:23939143 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507 		JBrowse link
G UBL4A ubiquitin like 4A multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of UBL4A mRNA CTD PMID:26923065 NCBI chr  X:154,483,717...154,486,615
Ensembl chr  X:154,483,717...154,486,615 		JBrowse link
G UBR1 ubiquitin protein ligase E3 component n-recognin 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of UBR1 mRNA CTD PMID:26923065 NCBI chr15:42,942,897...43,106,038
Ensembl chr15:42,942,897...43,106,113 		JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 decreases expression ISO Poly I-C results in decreased expression of UGT2B1 mRNA CTD PMID:23939143 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,173...68,576,413 		JBrowse link
G USP32 ubiquitin specific peptidase 32 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of USP32 mRNA CTD PMID:26923065 NCBI chr17:60,177,327...60,422,416
Ensembl chr17:60,177,327...60,422,470 		JBrowse link
G VSNL1 visinin like 1 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of VSNL1 mRNA CTD PMID:26923065 NCBI chr 2:17,539,972...17,657,018
Ensembl chr 2:17,539,126...17,657,018 		JBrowse link
G WAC WW domain containing adaptor with coiled-coil multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of WAC mRNA CTD PMID:26923065 NCBI chr10:28,532,779...28,623,112
Ensembl chr10:28,532,493...28,623,112 		JBrowse link
G WDR47 WD repeat domain 47 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of WDR47 mRNA CTD PMID:26923065 NCBI chr 1:108,970,214...109,042,102
Ensembl chr 1:108,970,214...109,042,113 		JBrowse link
G ZBTB6 zinc finger and BTB domain containing 6 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ZBTB6 mRNA CTD PMID:26923065 NCBI chr 9:122,908,056...122,913,323
Ensembl chr 9:122,908,056...122,913,323 		JBrowse link
G ZDHHC21 zinc finger DHHC-type palmitoyltransferase 21 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ZDHHC21 mRNA CTD PMID:26923065 NCBI chr 9:14,588,797...14,693,432
Ensembl chr 9:14,611,071...14,693,432 		JBrowse link
G ZNF354C zinc finger protein 354C multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ZFP354C mRNA CTD PMID:26923065 NCBI chr 5:179,060,373...179,083,977
Ensembl chr 5:179,060,373...179,083,977 		JBrowse link
G ZNF487 zinc finger protein 487 multiple interactions ISO [Poly I-C co-treated with HU 211] results in decreased expression of ZFP763 mRNA CTD PMID:26923065 NCBI chr10:43,436,848...43,523,894
Ensembl chr10:43,436,841...43,483,181 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    chemical entity 26024
      group 25876
        organic group 23606
          nucleotide residue 330
            polynucleotide 330
              poly(cytidylic acid) 319
                poly(I:C) 318
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      chalcogen 24917
                        oxygen atom 24817
                          oxygen molecular entity 24806
                            hydroxides 24049
                              oxoacid 22975
                                pnictogen oxoacid 13799
                                  phosphorus oxoacid 12848
                                    phosphoric acids 11880
                                      phosphoric acid 11872
                                        phosphoric acid derivative 11674
                                          phosphate 11673
                                            organic phosphate 11673
                                              carbohydrate phosphate 1897
                                                phospho sugar 1742
                                                  aldose phosphate 1739
                                                    aldopentose phosphate 1731
                                                      ribose phosphate 1724
                                                        ribonucleotide 1683
                                                          ribonucleoside 5'-phosphate 645
                                                            ribonucleoside 5'-monophosphate 352
                                                              pyrimidine ribonucleoside 5'-monophosphate 324
                                                                cytidine 5'-monophosphate 323
                                                                  cytidine 5'-monophosphate residue 319
                                                                    poly(cytidylic acid) 319
                                                                      poly(I:C) 318
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