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ONTOLOGY REPORT - ANNOTATIONS


Term:prochloraz
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Accession:CHEBI:8434 term browser browse the term
Definition:A member of the class of ureas that is 1H-imidazole-1-carboxamide substituted by a propyl and a 2-(2,4,6-trichlorophenoxy)ethyl group at the amino nitrogen atom. A fungicide active against a wide range of diseases affecting field crops, fruit, turf and vegetables.
Synonyms:exact_synonym: N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]-1H-imidazole-1-carboxamide
 related_synonym: Formula=C15H16Cl3N3O2;   InChI=1S/C15H16Cl3N3O2/c1-2-4-20(15(22)21-5-3-19-10-21)6-7-23-14-12(17)8-11(16)9-13(14)18/h3,5,8-10H,2,4,6-7H2,1H3;   InChIKey=TVLSRXXIMLFWEO-UHFFFAOYSA-N;   SMILES=CCCN(CCOc1c(Cl)cc(Cl)cc1Cl)C(=O)n1ccnc1
 xref: CAS:67747-09-5 "ChemIDplus";   CAS:67747-09-5 "KEGG COMPOUND";   KEGG:C11182
 xref_mesh: MESH:C045362
 xref: PMID:24401010 "Europe PMC";   PMID:24964350 "Europe PMC";   PMID:25163568 "Europe PMC";   PPDB:536;   Pesticides:prochloraz "Alan Wood's Pesticides";   Reaxys:8155344 "Reaxys"


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prochloraz term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb11 ATP binding cassette subfamily B member 11 JBrowse link 3 55,480,024 55,587,946 RGD:6480464
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B JBrowse link 4 22,225,123 22,307,577 RGD:6480464
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:6480464
G Abcc3 ATP binding cassette subfamily C member 3 JBrowse link 10 82,047,308 82,116,928 RGD:6480464
G Abcg2 ATP binding cassette subfamily G member 2 JBrowse link 4 88,765,441 88,890,268 RGD:6480464
G Aco1 aconitase 1 JBrowse link 5 56,425,076 56,481,218 RGD:6480464
G Acot3 acyl-CoA thioesterase 3 JBrowse link 6 107,531,508 107,537,446 RGD:6480464
G Acot9 acyl-CoA thioesterase 9 JBrowse link X 43,543,069 43,592,200 RGD:6480464
G Actn1 actinin, alpha 1 JBrowse link 6 103,376,557 103,470,497 RGD:6480464
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide JBrowse link 2 243,702,035 243,720,063 RGD:6480464
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:6480464
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 JBrowse link 1 238,222,689 238,264,381 RGD:6480464
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 JBrowse link 15 27,849,943 27,852,083 RGD:6480464
G Ar androgen receptor JBrowse link X 67,656,253 67,828,998 RGD:6480464
G Arnt aryl hydrocarbon receptor nuclear translocator JBrowse link 2 196,594,178 196,651,486 RGD:6480464
G Asns asparagine synthetase (glutamine-hydrolyzing) JBrowse link 4 33,742,876 33,761,106 RGD:6480464
G Atm ATM serine/threonine kinase JBrowse link 8 58,015,938 58,119,973 RGD:6480464
G Atp8b1 ATPase phospholipid transporting 8B1 JBrowse link 18 60,013,388 60,152,920 RGD:6480464
G Bace1 beta-secretase 1 JBrowse link 8 50,140,092 50,162,388 RGD:6480464
G Bace2 beta-secretase 2 JBrowse link 11 37,798,397 37,880,624 RGD:6480464
G Bcl2l1 Bcl2-like 1 JBrowse link 3 148,259,594 148,314,191 RGD:6480464
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:6480464
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:6480464
G Bsn bassoon (presynaptic cytomatrix protein) JBrowse link 8 116,873,721 116,965,396 RGD:6480464
G Cacna1a calcium voltage-gated channel subunit alpha1 A JBrowse link 19 25,453,236 25,749,550 RGD:6480464
G Cacna1b calcium voltage-gated channel subunit alpha1 B JBrowse link 3 1,740,026 1,924,959 RGD:6480464
G Cacna1c calcium voltage-gated channel subunit alpha1 C JBrowse link 4 150,635,808 151,270,790 RGD:6480464
G Cacna1d calcium voltage-gated channel subunit alpha1 D JBrowse link 16 6,110,294 6,405,022 RGD:6480464
G Cacna1g calcium voltage-gated channel subunit alpha1 G JBrowse link 10 82,129,071 82,197,828 RGD:6480464
G Cacna1i calcium voltage-gated channel subunit alpha1 I JBrowse link 7 121,521,787 121,619,300 RGD:6480464
G Cacna2d3 calcium voltage-gated channel auxiliary subunit alpha2delta 3 JBrowse link 16 4,871,348 5,795,825 RGD:6480464
G Cacnb1 calcium voltage-gated channel auxiliary subunit beta 1 JBrowse link 10 85,954,138 85,974,764 RGD:6480464
G Cacnb3 calcium voltage-gated channel auxiliary subunit beta 3 JBrowse link 7 140,311,120 140,324,902 RGD:6480464
G Cacng2 calcium voltage-gated channel auxiliary subunit gamma 2 JBrowse link 7 119,228,112 119,353,332 RGD:6480464
G Cacng6 calcium voltage-gated channel auxiliary subunit gamma 6 JBrowse link 1 64,307,684 64,322,124 RGD:6480464
G Cacng7 calcium voltage-gated channel auxiliary subunit gamma 7 JBrowse link 1 64,374,547 64,405,380 RGD:6480464
G Cadm1 cell adhesion molecule 1 JBrowse link 8 51,858,906 52,200,591 RGD:6480464
G Camk2b calcium/calmodulin-dependent protein kinase II beta JBrowse link 14 86,208,876 86,297,727 RGD:6480464
G Camk2g calcium/calmodulin-dependent protein kinase II gamma JBrowse link 15 3,936,721 3,995,740 RGD:6480464
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:6480464
G Cd44 CD44 molecule (Indian blood group) JBrowse link 3 92,695,083 92,783,820 RGD:6480464
G Cd81 Cd81 molecule JBrowse link 1 216,237,663 216,253,460 RGD:6480464
G Cdkn1a cyclin-dependent kinase inhibitor 1A JBrowse link 20 6,348,422 6,358,864 RGD:6480464
G Ces2c carboxylesterase 2C JBrowse link 1 282,640,752 282,648,319 RGD:6480464
G Chga chromogranin A JBrowse link 6 126,434,226 126,445,569 RGD:6480464
G Cpt2 carnitine palmitoyltransferase 2 JBrowse link 5 127,505,646 127,523,016 RGD:6480464
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:6480464
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:6480464
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:6480464
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:6480464
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:6480464
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:6480464
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 JBrowse link 1 251,325,923 251,338,404 RGD:6480464
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 JBrowse link 1 83,103,925 83,119,578 RGD:6480464
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:6480464
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 JBrowse link 2 236,414,131 236,431,650 RGD:6480464
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6480464
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6480464
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:6480464
G Dcc DCC netrin 1 receptor JBrowse link 18 66,518,213 67,629,801 RGD:6480464
G Dlg1 discs large MAGUK scaffold protein 1 JBrowse link 11 72,164,566 72,378,895 RGD:6480464
G Dlg4 discs large MAGUK scaffold protein 4 JBrowse link 10 56,625,845 56,655,543 RGD:6480464
G Dlgap3 DLG associated protein 3 JBrowse link 5 145,234,757 145,304,536 RGD:6480464
G Dlgap4 DLG associated protein 4 JBrowse link 3 152,752,091 152,846,118 RGD:6480464
G Doc2a double C2 domain alpha JBrowse link 1 198,282,828 198,288,611 RGD:6480464
G Dpp10 dipeptidyl peptidase like 10 JBrowse link 13 39,430,590 41,173,706 RGD:6480464
G Dpp6 dipeptidyl peptidase like 6 JBrowse link 4 4,021,021 4,943,675 RGD:6480464
G Dpyd dihydropyrimidine dehydrogenase JBrowse link 2 221,823,692 222,694,627 RGD:6480464
G Egf epidermal growth factor JBrowse link 2 68,820,616 68,895,537 RGD:6480464
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:6480464
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase JBrowse link 11 82,945,104 82,978,364 RGD:6480464
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:6480464
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:6480464
G Erbb2 erb-b2 receptor tyrosine kinase 2 JBrowse link 10 86,367,596 86,391,728 RGD:6480464
G Erbb3 erb-b2 receptor tyrosine kinase 3 JBrowse link 7 2,989,202 3,010,610 RGD:6480464
G Erbb4 erb-b2 receptor tyrosine kinase 4 JBrowse link 9 75,021,790 76,178,936 RGD:6480464
G Ercc1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 1 80,256,973 80,268,198 RGD:6480464
G Ercc2 ERCC excision repair 2, TFIIH core complex helicase subunit JBrowse link 1 80,293,574 80,307,334 RGD:6480464
G Esr1 estrogen receptor 1 JBrowse link 1 41,192,029 41,594,799 RGD:6480464
G Esr2 estrogen receptor 2 JBrowse link 6 99,163,953 99,214,711 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Fmr1 fragile X mental retardation 1 JBrowse link X 154,684,924 154,722,369 RGD:6480464
G Fyn FYN proto-oncogene, Src family tyrosine kinase JBrowse link 20 44,436,354 44,630,316 RGD:6480464
G Gabra4 gamma-aminobutyric acid type A receptor alpha4 subunit JBrowse link 14 39,154,072 39,230,994 RGD:6480464
G Gabrb1 gamma-aminobutyric acid type A receptor beta 1 subunit JBrowse link 14 38,631,192 39,112,598 RGD:6480464
G Gdnf glial cell derived neurotrophic factor JBrowse link 2 56,884,181 56,912,964 RGD:6480464
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:6480464
G Gls glutaminase JBrowse link 9 54,212,622 54,284,879 RGD:6480464
G Gria2 glutamate ionotropic receptor AMPA type subunit 2 JBrowse link 2 179,584,302 179,704,629 RGD:6480464
G Gria4 glutamate ionotropic receptor AMPA type subunit 4 JBrowse link 8 1,548,145 2,045,874 RGD:6480464
G Grik1 glutamate ionotropic receptor kainate type subunit 1 JBrowse link 11 27,811,954 28,213,940 RGD:6480464
G Grik2 glutamate ionotropic receptor kainate type subunit 2 JBrowse link 20 53,791,428 54,517,691 RGD:6480464
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:6480464
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B JBrowse link 4 169,541,620 170,000,216 RGD:6480464
G Grip1 glutamate receptor interacting protein 1 JBrowse link 7 64,672,723 64,854,939 RGD:6480464
G Gsr glutathione-disulfide reductase JBrowse link 16 62,197,617 62,239,987 RGD:6480464
G Gsta5 glutathione S-transferase alpha 5 JBrowse link 8 85,553,659 85,564,914 RGD:6480464
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 19 11,046,905 11,057,440 RGD:6480464
G Hes6 hes family bHLH transcription factor 6 JBrowse link 9 98,549,698 98,551,438 RGD:6480464
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 JBrowse link X 21,696,796 21,699,241 RGD:6480464
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 JBrowse link 19 50,246,404 50,317,892 RGD:6480464
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 JBrowse link 2 200,712,895 200,722,429 RGD:6480464
G Hspb8 heat shock protein family B (small) member 8 JBrowse link 12 45,905,371 45,920,014 RGD:6480464
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:6480464
G Igf2r insulin-like growth factor 2 receptor JBrowse link 1 48,176,095 48,264,482 RGD:6480464
G Il1rapl1 interleukin 1 receptor accessory protein-like 1 JBrowse link X 55,439,388 57,004,865 RGD:6480464
G Lhb luteinizing hormone subunit beta JBrowse link 1 101,409,992 101,413,725 RGD:6480464
G Lrrc7 leucine rich repeat containing 7 JBrowse link 2 264,910,594 265,300,860 RGD:6480464
G Ly6d lymphocyte antigen 6 family member D JBrowse link 7 115,993,304 115,994,812 RGD:6480464
G Magi2 membrane associated guanylate kinase, WW and PDZ domain containing 2 JBrowse link 4 10,995,241 12,472,423 RGD:6480464
G Manba mannosidase beta JBrowse link 2 240,668,213 240,760,264 RGD:6480464
G Mdga2 MAM domain containing glycosylphosphatidylinositol anchor 2 JBrowse link 6 88,442,620 89,292,454 RGD:6480464
G Mdm2 MDM2 proto-oncogene JBrowse link 7 60,719,060 60,743,618 RGD:6480464
G Mgst2 microsomal glutathione S-transferase 2 JBrowse link 2 140,708,396 140,727,381 RGD:6480464
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:6480464
G Mlx MAX dimerization protein MLX JBrowse link 10 88,997,011 89,002,154 RGD:6480464
G Mrps18b mitochondrial ribosomal protein S18B JBrowse link 20 3,344,870 3,350,929 RGD:6480464
G Msmo1 methylsterol monooxygenase 1 JBrowse link 16 26,859,441 26,875,880 RGD:6480464
G Nf1 neurofibromin 1 JBrowse link 10 66,732,460 66,928,706 RGD:6480464
G Nlgn1 neuroligin 1 JBrowse link 2 111,057,291 111,973,681 RGD:6480464
G Notch2 notch receptor 2 JBrowse link 2 200,187,184 200,320,403 RGD:6480464
G Notch3 notch receptor 3 JBrowse link 7 14,138,495 14,189,688 RGD:6480464
G Notch4 notch receptor 4 JBrowse link 20 4,329,794 4,353,868 RGD:6480464
G Nploc4 NPL4 homolog, ubiquitin recognition factor JBrowse link 10 109,553,518 109,610,087 RGD:6480464
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:6480464
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:6480464
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 JBrowse link 13 89,585,072 89,591,278 RGD:6480464
G Nrcam neuronal cell adhesion molecule JBrowse link 6 64,297,843 64,867,408 RGD:6480464
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:6480464
G Nrxn1 neurexin 1 JBrowse link 6 13,886,757 15,191,660 RGD:6480464
G Nrxn2 neurexin 2 JBrowse link 1 221,792,191 221,908,047 RGD:6480464
G Ntrk2 neurotrophic receptor tyrosine kinase 2 JBrowse link 17 5,934,651 6,245,778 RGD:6480464
G Odc1 ornithine decarboxylase 1 JBrowse link 6 42,852,529 42,859,142 RGD:6480464
G Pdyn prodynorphin JBrowse link 3 122,194,327 122,206,671 RGD:6480464
G Pgr progesterone receptor JBrowse link 8 7,128,656 7,187,796 RGD:6480464
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:6480464
G Ppargc1a PPARG coactivator 1 alpha JBrowse link 14 63,095,291 63,190,688 RGD:6480464
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:6480464
G Rara retinoic acid receptor, alpha JBrowse link 10 86,838,819 86,884,224 RGD:6480464
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:6480464
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:6480464
G Rxra retinoid X receptor alpha JBrowse link 3 6,272,560 6,295,354 RGD:6480464
G Scgb2a2 secretoglobin, family 2A, member 2 JBrowse link 1 225,825,419 225,830,374 RGD:6480464
G Shank2 SH3 and multiple ankyrin repeat domains 2 JBrowse link 1 217,149,156 217,593,950 RGD:6480464
G Slc1a2 solute carrier family 1 member 2 JBrowse link 3 92,518,679 92,665,731 RGD:6480464
G Slc1a6 solute carrier family 1 member 6 JBrowse link 7 13,730,101 13,758,170 RGD:6480464
G Slc22a1 solute carrier family 22 member 1 JBrowse link 1 48,273,639 48,300,645 RGD:6480464
G Slit1 slit guidance ligand 1 JBrowse link 1 260,843,481 260,992,366 RGD:6480464
G Sptbn2 spectrin, beta, non-erythrocytic 2 JBrowse link 1 219,964,429 220,006,811 RGD:6480464
G Srd5a2 steroid 5 alpha-reductase 2 JBrowse link 6 25,279,635 25,315,501 RGD:6480464
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:6480464
G Stbd1 starch binding domain 1 JBrowse link 14 16,976,355 16,979,760 RGD:6480464
G Stmn2 stathmin 2 JBrowse link 2 95,424,251 95,471,900 RGD:6480464
G Sts steroid sulfatase JBrowse link X 45,420,418 45,428,748 RGD:6480464
G Stxbp1 syntaxin binding protein 1 JBrowse link 3 11,823,779 11,885,479 RGD:6480464
G Syngap1 synaptic Ras GTPase activating protein 1 JBrowse link 20 5,535,434 5,564,657 RGD:6480464
G Syp synaptophysin JBrowse link X 15,694,699 15,709,244 RGD:6480464
G Tff3 trefoil factor 3 JBrowse link 20 9,850,800 9,855,481 RGD:6480464
G Tgfb1 transforming growth factor, beta 1 JBrowse link 1 82,480,875 82,497,196 RGD:6480464
G Timm10b translocase of inner mitochondrial membrane 10B JBrowse link 1 170,471,265 170,474,111 RGD:6480464
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:6480464
G Tsc2 TSC complex subunit 2 JBrowse link 10 13,962,006 13,996,684 RGD:6480464
G Tshb thyroid stimulating hormone subunit beta JBrowse link 2 205,207,799 205,215,199 RGD:6480464
G Ubqln2 ubiquilin 2 JBrowse link X 18,723,313 18,726,732 RGD:6480464
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:6480464
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:6480464
G Unc5b unc-5 netrin receptor B JBrowse link 20 30,339,680 30,406,593 RGD:6480464
G Xrcc5 X-ray repair cross complementing 5 JBrowse link 9 79,659,275 79,748,050 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19614
    role 19557
      biological role 19550
        xenobiotic 18180
          prochloraz 174
Path 2
Term Annotations click to browse term
  CHEBI ontology 19614
    subatomic particle 19610
      composite particle 19610
        hadron 19610
          baryon 19610
            nucleon 19610
              atomic nucleus 19610
                atom 19610
                  main group element atom 19489
                    p-block element atom 19489
                      carbon group element atom 19362
                        carbon atom 19354
                          organic molecular entity 19354
                            organic group 18313
                              organic divalent group 18303
                                organodiyl group 18303
                                  carbonyl group 18188
                                    carbonyl compound 18188
                                      carboxylic acid 17853
                                        carboacyl group 16940
                                          univalent carboacyl group 16940
                                            carbamoyl group 16620
                                              carboxamide 16620
                                                monocarboxylic acid amide 13184
                                                  urea 4931
                                                    ureas 4928
                                                      prochloraz 174
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.