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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:procaine
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Accession:CHEBI:8430 term browser browse the term
Definition:A benzoate ester, formally the result of esterification of 4-aminobenzoic acid with 2-diethylaminoethanol but formed experimentally by reaction of ethyl 4-aminobenzoate with 2-diethylaminoethanol.
Synonyms:exact_synonym: 2-(diethylamino)ethyl 4-aminobenzoate
 related_synonym: 2-Diethylaminoethyl p-aminobenzoate;   4-aminobenzoic acid 2-diethylaminoethyl ester;   Formula=C13H20N2O2;   InChI=1S/C13H20N2O2/c1-3-15(4-2)9-10-17-13(16)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3;   InChIKey=MFDFERRIHVXMIY-UHFFFAOYSA-N;   SMILES=CCN(CC)CCOC(=O)c1ccc(N)cc1;   Vitamin H3;   beta-(diethylamino)ethyl 4-aminobenzoate;   beta-(diethylamino)ethyl p-aminobenzoate;   novocaine;   p-Aminobenzoic acid 2-diethylaminoethyl ester;   procaina;   procainum
 xref: Beilstein:913480;   CAS:59-46-1;   DrugBank:DB00721;   Drug_Central:2271;   HMDB:HMDB0014859;   KEGG:C07375;   KEGG:D08422;   LINCS:LSM-5396
 xref_mesh: MESH:D011343
 xref: PMID:12941824;   PMID:15687733;   PMID:19669330;   PMID:19885602;   PMID:23254173;   PMID:23600203;   PMID:23718080;   PMID:23962059;   PMID:24005047;   PMID:6784593;   Reaxys:913480;   Wikipedia:Procaine
 cyclic_relationship: is_conjugate_base_of CHEBI:52160



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procaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of AKT1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]
CTD PMID:32061592 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated increases expression ISO Procaine results in increased expression of ALPL mRNA CTD PMID:22083529 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Calca calcitonin-related polypeptide alpha increases secretion ISO Procaine results in increased secretion of CALCA protein CTD PMID:18172555 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Procaine inhibits the reaction [Paraoxon results in increased expression of CASP12 protein] CTD PMID:20079824 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Cdh5 cadherin 5 decreases expression
multiple interactions
ISO Procaine results in decreased expression of CDH5 protein
HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]
CTD PMID:32061592 NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
JBrowse link
G Ces2h carboxylesterase 2H increases hydrolysis ISO CES2 protein results in increased hydrolysis of Procaine CTD PMID:9300133 PMID:15475733 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Procaine results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
affects binding
ISO [HRH1 protein binds to Procaine] which results in increased import of Calcium; HRH1 protein affects the reaction [Procaine results in decreased expression of CDH5 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of AKT1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]; HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]; HRH1 protein affects the reaction [Procaine results in increased transport of fluorescein isothiocyanate bovine serum albumin] CTD PMID:32061592 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of ITPR1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of ITPR1 protein]
CTD PMID:32061592 NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of MAPK1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK1 protein]
CTD PMID:32061592 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of MAPK3 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of MAPK3 protein]
CTD PMID:32061592 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Procaine results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation
multiple interactions
ISO Procaine results in increased phosphorylation of PLCG1 protein
HRH1 protein affects the reaction [Procaine results in increased phosphorylation of PLCG1 protein]
CTD PMID:32061592 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 increases activity EXP Procaine results in increased activity of TRPV1 protein CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      biological role 19751
        aetiopathogenetic role 19027
          allergen 17254
            4-aminobenzoic acid 26
              procaine 14
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic group 18718
                              organic divalent group 18702
                                organodiyl group 18702
                                  carbonyl group 18651
                                    carbonyl compound 18651
                                      carboxylic acid 18346
                                        aromatic carboxylic acid 11735
                                          benzoic acids 11709
                                            aminobenzoic acid 1633
                                              4-aminobenzoic acid 26
                                                procaine 14
paths to the root