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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:procainamide
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Accession:CHEBI:8428 term browser browse the term
Definition:A benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias.
Synonyms:exact_synonym: 4-amino-N-[2-(diethylamino)ethyl]benzamide
 related_synonym: Biocoryl;   Formula=C13H21N3O;   InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);   InChIKey=REQCZEXYDRLIBE-UHFFFAOYSA-N;   SMILES=CCN(CC)CCNC(=O)c1ccc(N)cc1;   p-Amino-N-(2-diethylaminoethyl)benzamide;   p-Aminobenzoic diethylaminoethylamide;   procainamida;   procainamidum
 xref: Beilstein:2214285;   CAS:51-06-9;   DrugBank:DB01035;   Drug_Central:2270;   KEGG:C07401;   KEGG:D08421;   LINCS:LSM-3681
 xref_mesh: MESH:D011342
 xref: PMID:16230360;   PMID:2494958;   PMID:29276243;   PMID:29494946;   Reaxys:2214285;   Wikipedia:Procainamide


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procainamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Procainamide results in increased expression of CDKN2A protein CTD PMID:17938735 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Foxp3 forkhead box P3 increases expression ISO Procainamide results in increased expression of FOXP3 protein CTD PMID:19109157 NCBI chr  X:15,753,175...15,768,648
Ensembl chr  X:15,753,175...15,768,522
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO
EXP
Procainamide results in increased expression of HSD11B2 mRNA CTD PMID:15489962 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Procainamide binds to and results in decreased activity of KCNH2 protein CTD PMID:15272206 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide CTD PMID:20199096 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Nat1 N-acetyltransferase 1 increases acetylation ISO NAT1 protein results in increased acetylation of Procainamide CTD PMID:16003948 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573
JBrowse link
G Nat2 N-acetyltransferase 2 affects acetylation ISO NAT2 protein affects the acetylation of Procainamide CTD PMID:15930747 NCBI chr16:23,960,709...23,991,570
Ensembl chr16:23,961,067...23,991,570
JBrowse link
G Rassf1 Ras association domain family member 1 increases expression ISO Procainamide results in increased expression of RASSF1 protein CTD PMID:17938735 NCBI chr 8:116,307,149...116,318,289
Ensembl chr 8:116,307,141...116,318,289
JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Procainamide inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr20:45,658,398...45,669,192 JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Procainamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:10966924 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Procainamide analog inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Procainamide inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,631,425...47,685,379
Ensembl chr10:47,632,192...47,666,921
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Procainamide analog inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Procainamide inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Procainamide results in increased expression of WIPI1 mRNA CTD PMID:15342952 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19773
    role 19723
      application 19413
        pharmaceutical 19301
          drug 19301
            cardiovascular drug 7666
              anti-arrhythmia drug 933
                procainamide 13
                  procainamide hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19771
      composite particle 19771
        hadron 19771
          baryon 19771
            nucleon 19771
              atomic nucleus 19771
                atom 19771
                  main group element atom 19665
                    p-block element atom 19665
                      carbon group element atom 19583
                        carbon atom 19573
                          organic molecular entity 19573
                            organic group 18603
                              organic divalent group 18594
                                organodiyl group 18594
                                  carbonyl group 18507
                                    carbonyl compound 18507
                                      carboxylic acid 18159
                                        carboacyl group 17415
                                          univalent carboacyl group 17415
                                            carbamoyl group 17211
                                              carboxamide 17211
                                                monocarboxylic acid amide 14599
                                                  arenecarboxamide 6539
                                                    benzamides 6539
                                                      procainamide 13
                                                        procainamide hydrochloride 0
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