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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:procainamide
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Accession:CHEBI:8428 term browser browse the term
Definition:A benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias.
Synonyms:exact_synonym: 4-amino-N-[2-(diethylamino)ethyl]benzamide
 related_synonym: Biocoryl;   Formula=C13H21N3O;   InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);   InChIKey=REQCZEXYDRLIBE-UHFFFAOYSA-N;   SMILES=CCN(CC)CCNC(=O)c1ccc(N)cc1;   p-Amino-N-(2-diethylaminoethyl)benzamide;   p-Aminobenzoic diethylaminoethylamide;   procainamida;   procainamidum
 xref: CAS:51-06-9;   DrugBank:DB01035;   Drug_Central:2270;   KEGG:C07401;   KEGG:D08421;   LINCS:LSM-3681
 xref_mesh: MESH:D011342
 xref: PMID:16230360;   PMID:2494958;   PMID:29276243;   PMID:29494946;   Reaxys:2214285;   Wikipedia:Procainamide


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procainamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Procainamide results in increased expression of CDKN2A protein CTD PMID:17938735 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248 		JBrowse link
G Foxp3 forkhead box P3 increases expression ISO Procainamide results in increased expression of FOXP3 protein CTD PMID:19109157 NCBI chr  X:17,580,380...17,601,181
Ensembl chr  X:17,580,380...17,595,894 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO
EXP 		Procainamide results in increased expression of HSD11B2 mRNA CTD PMID:15489962 NCBI chr19:50,307,569...50,312,812
Ensembl chr19:50,307,569...50,312,812 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Procainamide binds to and results in decreased activity of KCNH2 protein CTD PMID:15272206 NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:11,692,980...11,751,421 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide CTD PMID:20199096 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Nat1 N-acetyltransferase 1 increases acetylation ISO NAT1 protein results in increased acetylation of Procainamide CTD PMID:16003948 NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527 		JBrowse link
G Nat2 N-acetyltransferase 2 affects acetylation ISO NAT2 protein affects the acetylation of Procainamide CTD PMID:15930747 NCBI chr16:26,974,874...27,005,191
Ensembl chr16:26,974,601...26,976,304 		JBrowse link
G Rassf1 Ras association domain family member 1 increases expression ISO Procainamide results in increased expression of RASSF1 protein CTD PMID:17938735 NCBI chr 8:117,103,665...117,114,805
Ensembl chr 8:117,103,362...117,114,805 		JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Procainamide inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr20:45,527,275...45,647,675
Ensembl chr20:45,527,315...45,648,475 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Procainamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:10966924 NCBI chr 1:50,783,218...50,872,358
Ensembl chr 1:50,783,218...50,872,353 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Procainamide analog inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Procainamide inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,533,583...46,587,096 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Procainamide analog inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Procainamide inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,490,262...46,532,954
Ensembl chr10:46,489,831...46,533,425 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Procainamide results in increased expression of WIPI1 mRNA CTD PMID:15342952 NCBI chr10:95,042,451...95,079,679
Ensembl chr10:95,042,441...95,079,293 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            cardiovascular drug 8994
              anti-arrhythmia drug 1569
                procainamide 13
                  procainamide hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              monocarboxylic acid amide 15953
                                                arenecarboxamide 8285
                                                  benzamides 8285
                                                    procainamide 13
                                                      procainamide hydrochloride 0
paths to the root