The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Probenecid results in decreased activity of ABCC1 protein [Probenecid results in decreased activity of ABCC1 protein] which results in decreased export of 10-nitro-oleic acid metabolite; Probenecid affects the reaction [ABCC1 protein results in increased transport of Valproic Acid]; Probenecid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein] Probenecid affects the activity of ABCC1 protein [Probenecid results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
ABCC2 protein results in increased export of Probenecid Probenecid results in increased activity of ABCC2 protein [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of resveratrol metabolite; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Probenecid promotes the reaction [ABCC2 protein affects the transport of docetaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Etoposide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Paclitaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Vinblastine]; Probenecid promotes the reaction [ABCC2 protein results in decreased susceptibility to Paclitaxel]
Probenecid inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP] Probenecid affects the reaction [ABCC4 protein affects the uptake of Cyclic AMP analog] [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid] results in decreased expression of ABCC4 protein
[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]
[Probenecid co-treated with adefovir] results in increased expression of AGT protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of AGT protein; Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein]
[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX mRNA; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX protein]
[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 mRNA; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 protein]
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CASP1 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CASP1 mRNA
[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 protein]
[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased activity of CAT protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased activity of CAT protein]
Probenecid inhibits the reaction [Uric Acid results in increased expression of CCL2 protein] 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CCL2 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CCL2 mRNA Probenecid analog results in increased expression of CCL2 mRNA
[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA]
[adefovir co-treated with Probenecid] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan] inhibits the reaction [adefovir results in increased expression of CST3 protein]; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein]
[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYC1 protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYC1 protein]
Probenecid promotes the reaction [CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide]; Probenecid promotes the reaction [CYP2C8 protein affects the metabolism of Carbamazepine]
Probenecid results in decreased expression of CYP3A4 mRNA Probenecid promotes the reaction [CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide]; Probenecid promotes the reaction [CYP3A4 protein affects the metabolism of Carbamazepine]
[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of GFAP protein; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GFAP protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GFAP protein]
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein
[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of OCLN protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of OCLN protein]
Probenecid results in decreased activity of PANX1 protein Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]
Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein]
Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid] Probenecid affects the activity of SLC22A12 protein Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]; Probenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]
Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 protein]
Probenecid inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] Probenecid results in decreased activity of SLC22A9 protein Probenecid inhibits the reaction [SLC22A19 protein results in increased uptake of ochratoxin A] Probenecid inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]
Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein]
Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein]
Probenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]; Probenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]; Probenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to adefovir]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein] Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein] Probenecid results in decreased activity of SLC22A6 protein Probenecid results in decreased expression of SLC22A6 mRNA
Probenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]; Probenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamide)-3,3-dimethylbutanoate metabolite] [adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine] Probenecid results in decreased expression of SLC22A8 mRNA; Probenecid results in decreased expression of SLC22A8 protein Probenecid results in decreased activity of SLC22A8 protein
[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC2A1 protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC2A1 protein]
Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein]
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]; 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein]
Probenecid binds to and results in decreased activity of TAS2R16 protein; Probenecid inhibits the reaction [salicin results in increased activity of TAS2R16 protein]
Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Propylthiouracil results in increased activity of TAS2R38 protein] Probenecid results in decreased activity of TAS2R38 protein
Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of and results in increased secretion of TGFB1 protein] [adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]; 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein
[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein]
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TLR4 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TLR4 mRNA