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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:probenecid
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Accession:CHEBI:8426 term browser browse the term
Definition:A sulfonamide in which the nitrogen of 4-sulfamoylbenzoic acid is substituted with two propyl groups.
Synonyms:exact_synonym: 4-(dipropylsulfamoyl)benzoic acid
 related_synonym: 4-((Dipropylamino)sulfonyl)benzoic acid;   4-(Di-n-propylsulfamoyl)benzoesaeure;   4-(N,N-Dipropylsulfamoyl)benzoesaeure;   Formula=C13H19NO4S;   InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16);   InChIKey=DBABZHXKTCFAPX-UHFFFAOYSA-N;   Probenecid Acid;   SMILES=CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O;   p-(Dipropylsulfamoyl)benzoic acid;   probenecida;   probenecide;   probenecidum
 xref: Beilstein:2815775;   CAS:57-66-9;   DrugBank:DB01032;   Drug_Central:2268;   KEGG:C07372;   KEGG:D00475;   LINCS:LSM-4140
 xref_mesh: MESH:D011339
 xref: PMID:21861129;   PMID:21938493;   PMID:22321288;   PMID:22561103;   PMID:22582566;   PMID:22681402;   PMID:22854641;   PMID:23129053;   PMID:509935;   Patent:US2608507;   Reaxys:2815775;   Wikipedia:Probenecid



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probenecid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca8 ATP binding cassette subfamily A member 8 multiple interactions ISO Probenecid inhibits the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] CTD PMID:12379217 NCBI chr10:94,917,520...94,991,199
Ensembl chr10:94,917,520...94,990,988
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions
affects activity
EXP
ISO
Probenecid results in decreased activity of ABCC1 protein
[Probenecid results in decreased activity of ABCC1 protein] which results in decreased export of 10-nitro-oleic acid metabolite; Probenecid affects the reaction [ABCC1 protein results in increased transport of Valproic Acid]; Probenecid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]
Probenecid affects the activity of ABCC1 protein
[Probenecid results in decreased activity of ABCC1 protein] which results in increased uptake of Vincristine
CTD PMID:9096673 PMID:9334814 PMID:12893836 PMID:15066675 PMID:15585369 More... NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases export
increases activity
multiple interactions
EXP
ISO
ABCC2 protein results in increased export of Probenecid
Probenecid results in increased activity of ABCC2 protein
[Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of resveratrol metabolite; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium
Probenecid inhibits the reaction [ABCC2 protein affects the export of 6-carboxyfluorescein]; Probenecid inhibits the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein analog]; Probenecid promotes the reaction [ABCC2 protein affects the transport of docetaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Etoposide]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Paclitaxel]; Probenecid promotes the reaction [ABCC2 protein affects the transport of Vinblastine]; Probenecid promotes the reaction [ABCC2 protein results in decreased susceptibility to Paclitaxel]
CTD PMID:11477083 PMID:12608533 PMID:12704183 PMID:15849751 PMID:15904671 More... NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions ISO Probenecid inhibits the reaction [ABCC3 protein affects the transport of estradiol-17 beta-glucuronide] CTD PMID:12704183 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO
EXP
Probenecid inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP]
Probenecid affects the reaction [ABCC4 protein affects the uptake of Cyclic AMP analog]
[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of ABCC4 protein; [adefovir co-treated with Probenecid] results in decreased expression of ABCC4 protein
CTD PMID:11856762 PMID:28587784 PMID:35114312 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO Probenecid inhibits the reaction [ABCC5 protein results in decreased susceptibility to Thioguanine] CTD PMID:15897250 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 multiple interactions ISO Probenecid inhibits the reaction [ABCC6 protein affects the transport of N-ethylmaleimide-S-glutathione] CTD PMID:11880368 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein] CTD PMID:22865646 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP [adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of ACTA2 protein] CTD PMID:35114312 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Agt angiotensinogen multiple interactions EXP [Probenecid co-treated with adefovir] results in increased expression of AGT protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of AGT protein; Cromolyn Sodium inhibits the reaction [[Probenecid co-treated with adefovir] results in increased expression of AGT protein] CTD PMID:35114312 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX mRNA; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of BAX protein] CTD PMID:24768735 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 mRNA; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of BCL2 protein] CTD PMID:24768735 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Card10 caspase recruitment domain family, member 10 multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CARD10 mRNA CTD PMID:25406165 NCBI chr 7:110,330,460...110,371,551
Ensembl chr 7:110,330,408...110,359,224
JBrowse link
G Casp1 caspase 1 multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CASP1 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CASP1 mRNA CTD PMID:25406165 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 mRNA]; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CASP9 protein] CTD PMID:24768735 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased activity of CAT protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased activity of CAT protein] CTD PMID:24768735 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases expression
EXP
ISO
Probenecid inhibits the reaction [Uric Acid results in increased expression of CCL2 protein]
1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CCL2 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of CCL2 mRNA
Probenecid analog results in increased expression of CCL2 mRNA
CTD PMID:16113518 PMID:24104198 PMID:25406165 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO Probenecid promotes the reaction [10-nitro-oleic acid results in decreased expression of CCND1 protein] CTD PMID:29158255 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO Probenecid promotes the reaction [10-nitro-oleic acid results in increased expression of CDKN1A protein] CTD PMID:29158255 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cox7c cytochrome c oxidase subunit 7C multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of COX7C mRNA] CTD PMID:24768735 NCBI chr 2:16,841,771...16,843,796
Ensembl chr 2:16,840,837...16,843,760
JBrowse link
G Cst3 cystatin C multiple interactions EXP [adefovir co-treated with Probenecid] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan co-treated with adefovir] results in increased expression of CST3 protein; [Probenecid co-treated with Valsartan] inhibits the reaction [adefovir results in increased expression of CST3 protein]; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of CST3 protein] CTD PMID:35114312 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions ISO Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of CYBA mRNA] CTD PMID:23325087 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYC1 protein; geraniol inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of CYC1 protein] CTD PMID:24768735 NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO Probenecid promotes the reaction [CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide]; Probenecid promotes the reaction [CYP2C8 protein affects the metabolism of Carbamazepine] CTD PMID:15915352
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
multiple interactions
ISO Probenecid results in decreased expression of CYP3A4 mRNA
Probenecid promotes the reaction [CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide]; Probenecid promotes the reaction [CYP3A4 protein affects the metabolism of Carbamazepine]
CTD PMID:15915352 PMID:16837568 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of FADD mRNA CTD PMID:25406165 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Faslg Fas ligand multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of FASL mRNA CTD PMID:25406165 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of GFAP protein; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GFAP protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of GFAP protein] CTD PMID:25064079 PMID:28807673 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpr55 G protein-coupled receptor 55 multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of GPR55 protein CTD PMID:28807673 NCBI chr 9:86,584,906...86,640,601
Ensembl chr 9:86,590,885...86,640,613
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions ISO Probenecid inhibits the reaction [cidofovir results in increased secretion of HAVCR1 protein] CTD PMID:29738843 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of IL1A mRNA CTD PMID:25406165 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Ins1 insulin 1 multiple interactions EXP Probenecid promotes the reaction [Colforsin results in increased secretion of INS1 protein] CTD PMID:12153439 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [Probenecid binds to Dextrans] inhibits the reaction [Dextran Sulfate results in increased secretion of MPO protein] CTD PMID:30102254 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of NOX4 mRNA] CTD PMID:23325087 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] affects the localization of and results in decreased expression of NR4A2 protein CTD PMID:25406165 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Ocln occludin multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of OCLN protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of OCLN protein] CTD PMID:25064079 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Panx1 Pannexin 1 decreases activity
multiple interactions
ISO Probenecid results in decreased activity of PANX1 protein
Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate]
CTD PMID:19023039 PMID:19213873 NCBI chr 8:11,851,176...11,889,774
Ensembl chr 8:11,850,730...11,889,774
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Probenecid promotes the reaction [10-nitro-oleic acid results in increased cleavage of PARP1 protein] CTD PMID:29158255 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ren renin multiple interactions ISO Probenecid inhibits the reaction [Bumetanide results in increased secretion of REN protein] CTD PMID:7040495 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC18A2 protein CTD PMID:19653878 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A1 protein] CTD PMID:22865646 PMID:22967667 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a12 solute carrier family 22 member 12 multiple interactions
affects activity
ISO Probenecid inhibits the reaction [SLC22A12 protein results in increased uptake of Uric Acid]
Probenecid affects the activity of SLC22A12 protein
Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC22A12 protein]; Probenecid inhibits the reaction [SLC22A12 protein affects the transport of Uric Acid]
CTD PMID:14694169 PMID:14747372 PMID:21272127 PMID:22865646 PMID:22967667 NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A2 protein] CTD PMID:22865646 PMID:22967667 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a20 solute carrier family 22 member 20 multiple interactions ISO Probenecid inhibits the reaction [SLC22A20 protein results in increased uptake of estrone sulfate] CTD PMID:16478971 NCBI chr 1:203,257,374...203,273,854
Ensembl chr 1:203,257,374...203,273,822
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions
decreases activity
ISO
EXP
Probenecid inhibits the reaction [SLC22A9 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate]
Probenecid results in decreased activity of SLC22A9 protein
Probenecid inhibits the reaction [SLC22A19 protein results in increased uptake of ochratoxin A]
Probenecid inhibits the reaction [SLC22A19 protein affects the transport of estrone sulfate]
CTD PMID:15068970 PMID:16079298 PMID:17132213 PMID:28629854 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc22a4 solute carrier family 22 member 4 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A4 protein] CTD PMID:22865646 PMID:22967667 NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A5 protein] CTD PMID:22865646 PMID:22967667 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
decreases activity
decreases expression
ISO
EXP
Probenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]; Probenecid inhibits the reaction [[SLC22A6 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]; Probenecid inhibits the reaction [SLC22A6 protein affects the transport of Uric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-((2-phosphonylmethoxy)ethyl)guanine]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to 9-(S)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Acetylcysteine]]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to adefovir]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to N(6)-cyclopropyl-9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine]; Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of [mercuric oxide co-treated with Acetylcysteine]]; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] affects the expression of SLC22A6 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein; Probenecid inhibits the reaction [SLC22A6 protein results in increased uptake of ochratoxin A]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A6 protein]
Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in decreased expression of SLC22A6 protein]
Probenecid results in decreased activity of SLC22A6 protein
Probenecid results in decreased expression of SLC22A6 mRNA
CTD PMID:10336520 PMID:11602689 PMID:12472777 PMID:12606766 PMID:19643159 More... NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases expression
decreases activity
ISO
EXP
Probenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyadenosin-N(6)-yl)aristolactam I]; Probenecid inhibits the reaction [[SLC22A8 results in increased uptake of Aristolochic Acids] which results in increased chemical synthesis of 7-(deoxyguanosin-N(2)-yl)aristolactam I]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of 6-carboxyfluorescein]; Probenecid inhibits the reaction [SLC22A8 protein results in increased import of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamide)-3,3-dimethylbutanoate metabolite]
[adefovir co-treated with Probenecid co-treated with Cromolyn Sodium] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid co-treated with Valsartan] results in increased expression of SLC22A8 protein; [adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in decreased expression of SLC22A8 protein]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Methotrexate]; Probenecid inhibits the reaction [SLC22A8 protein results in increased uptake of Penicillin G]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine]
Probenecid results in decreased expression of SLC22A8 mRNA; Probenecid results in decreased expression of SLC22A8 protein
Probenecid results in decreased activity of SLC22A8 protein
CTD PMID:10224140 PMID:11306713 PMID:15319347 PMID:16006492 PMID:19643159 More... NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC2A1 protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC2A1 protein] CTD PMID:25064079 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a9 solute carrier family 2 member 9 multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 mRNA]; Probenecid inhibits the reaction [potassium oxonate results in increased expression of SLC2A9 protein] CTD PMID:22967667 NCBI chr14:72,328,334...72,461,981
Ensembl chr14:72,328,320...72,461,981
JBrowse link
G Slc5a6 solute carrier family 5 member 6 multiple interactions ISO Probenecid inhibits the reaction [SLC5A6 protein results in increased transport of Biotin] CTD PMID:15561972 NCBI chr 6:25,319,187...25,331,713
Ensembl chr 6:25,320,442...25,331,712
JBrowse link
G Slc5a8 solute carrier family 5 member 8 decreases activity ISO Probenecid results in decreased activity of SLC5A8 protein CTD PMID:15090606 NCBI chr 7:23,272,891...23,313,811
Ensembl chr 7:23,272,427...23,314,642
JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]; 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of SLC6A3 protein; [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of SLC6A3 protein] CTD PMID:19653878 PMID:25064079 PMID:25406165 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Probenecid inhibits the reaction [SLCO1B3 protein results in increased uptake of Fluorescein] CTD PMID:27989701 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Tas2r118 taste receptor, type 2, member 118 multiple interactions ISO Probenecid binds to and results in decreased activity of TAS2R16 protein; Probenecid inhibits the reaction [salicin results in increased activity of TAS2R16 protein] CTD PMID:21629661 NCBI chr 4:52,449,208...52,450,107
Ensembl chr 4:52,449,208...52,450,107
JBrowse link
G Tas2r138 taste receptor, type 2, member 138 multiple interactions
decreases activity
ISO Probenecid inhibits the reaction [Phenylthiourea results in increased activity of TAS2R38 protein]; Probenecid inhibits the reaction [Propylthiouracil results in increased activity of TAS2R38 protein]
Probenecid results in decreased activity of TAS2R38 protein
CTD PMID:21629661 NCBI chr 4:69,428,344...69,429,339
Ensembl chr 4:69,428,344...69,429,339
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO
EXP
Probenecid inhibits the reaction [4-cresol sulfate results in increased expression of and results in increased secretion of TGFB1 protein]
[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein; Cromolyn Sodium inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]; Valsartan inhibits the reaction [[adefovir co-treated with Probenecid] results in increased expression of TGFB1 protein]
CTD PMID:23325087 PMID:35114312 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]; 1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]; 1,1-bis(3'-indolyl)-1-(p-anisyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in decreased expression of TH protein CTD PMID:19653878 PMID:25406165 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions ISO [Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein; Trehalose inhibits the reaction [[Probenecid co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in decreased expression of TJP1 protein] CTD PMID:25064079 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO 1,1-bis(3'-indolyl)-1-(4-chlorophenyl)methane inhibits the reaction [[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TLR4 mRNA]; [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TLR4 mRNA CTD PMID:25406165 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Probenecid] results in increased expression of TNF mRNA CTD PMID:25406165 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects response to substance ISO UGT1A3 affects the susceptibility to Probenecid CTD PMID:17880178 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects response to substance ISO UGT1A9 affects the susceptibility to Probenecid CTD PMID:17880178 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 affects response to substance ISO UGT2B7 affects the susceptibility to Probenecid CTD PMID:17880178 NCBI chr14:20,896,682...20,919,604
Ensembl chr14:20,896,682...20,919,604
JBrowse link
G Umod uromodulin multiple interactions ISO Probenecid inhibits the reaction [potassium oxonate results in increased expression of and results in decreased secretion of UMOD protein] CTD PMID:22865646 NCBI chr 1:173,816,341...173,829,681
Ensembl chr 1:173,816,339...173,830,302
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19834
    role 19810
      application 19653
        pharmaceutical 19492
          drug 19492
            renal agent 415
              uricosuric drug 400
                probenecid 66
Path 2
Term Annotations click to browse term
  CHEBI ontology 19834
    subatomic particle 19832
      composite particle 19832
        hadron 19832
          baryon 19832
            nucleon 19832
              atomic nucleus 19832
                atom 19832
                  main group element atom 19782
                    p-block element atom 19782
                      carbon group element atom 19730
                        carbon atom 19727
                          organic molecular entity 19727
                            organic group 18947
                              organic divalent group 18922
                                organodiyl group 18922
                                  carbonyl group 18879
                                    carbonyl compound 18879
                                      carboxylic acid 18605
                                        aromatic carboxylic acid 12266
                                          benzoic acids 12241
                                            probenecid 66
paths to the root