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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:primidone
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Accession:CHEBI:8412 term browser browse the term
Definition:A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Synonyms:exact_synonym: 5-ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione
 related_synonym: 2-deoxyphenobarbital;   5-Phenyl-5-ethyl-Hexahydropyrimidine-4,6-dione;   Formula=C12H14N2O2;   InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16);   InChIKey=DQMZLTXERSFNPB-UHFFFAOYSA-N;   SMILES=CCC1(C(=O)NCNC1=O)c1ccccc1;   primidona;   primidonum
 xref: CAS:125-33-7;   DrugBank:DB00794;   Drug_Central:2267;   HMDB:HMDB0014932;   KEGG:C07371;   KEGG:D00474;   LINCS:LSM-2700
 xref_mesh: MESH:D011324
 xref: PMID:10716065;   PMID:17253477;   PMID:24712318;   PMID:24812533;   Reaxys:218034;   Wikipedia:Primidone



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primidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Primidone results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Primidone results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Primidone results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il24 interleukin 24 increases expression ISO Primidone results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Primidone results in decreased activity of PON1 protein CTD PMID:28032682 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Primidone results in increased expression of S100A8 mRNA CTD PMID:28138970 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Primidone results in increased expression of S100A9 mRNA CTD PMID:28138970 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Primidone results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 20057
    role 20023
      biological role 20010
        xenobiotic 18687
          primidone 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 20057
    subatomic particle 20056
      composite particle 20068
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19971
                    p-block element atom 19971
                      carbon group element atom 19889
                        carbon atom 19894
                          organic molecular entity 19882
                            organic molecule 19830
                              organic cyclic compound 19603
                                organic heterocyclic compound 18888
                                  organic heteromonocyclic compound 17537
                                    diazines 12364
                                      pyrimidines 12193
                                        pyrimidone 8869
                                          primidone 8
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