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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:primidone
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Accession:CHEBI:8412 term browser browse the term
Definition:A pyrimidone that is dihydropyrimidine-4,6(1H,5H)-dione substituted by an ethyl and a phenyl group at position 5. It is used as an anticonvulsant for treatment of various types of seizures.
Synonyms:exact_synonym: 5-ethyl-5-phenyldihydropyrimidine-4,6(1H,5H)-dione
 related_synonym: 2-deoxyphenobarbital;   5-Phenyl-5-ethyl-Hexahydropyrimidine-4,6-dione;   Formula=C12H14N2O2;   InChI=1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16);   InChIKey=DQMZLTXERSFNPB-UHFFFAOYSA-N;   SMILES=CCC1(C(=O)NCNC1=O)c1ccccc1;   primidona;   primidonum
 xref: CAS:125-33-7;   DrugBank:DB00794;   Drug_Central:2267;   HMDB:HMDB0014932;   KEGG:C07371;   KEGG:D00474;   LINCS:LSM-2700
 xref_mesh: MESH:D011324
 xref: PMID:10716065;   PMID:17253477;   PMID:24712318;   PMID:24812533;   Reaxys:218034;   Wikipedia:Primidone


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primidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Primidone results in decreased activity of ABCB11 protein CTD PMID:28437613 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Primidone results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Primidone results in increased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il24 interleukin 24 increases expression ISO Primidone results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Primidone results in decreased activity of PON1 protein CTD PMID:28032682 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO Primidone results in increased expression of S100A8 mRNA CTD PMID:28138970 NCBI chr 2:190,073,239...190,074,333
Ensembl chr 2:190,073,815...190,074,354
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO Primidone results in increased expression of S100A9 mRNA CTD PMID:28138970 NCBI chr 2:190,097,436...190,100,209
Ensembl chr 2:190,097,554...190,100,276
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Primidone results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:160,799,979...160,802,228
Ensembl chr 3:160,799,981...160,802,433
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19773
    role 19719
      biological role 19719
        xenobiotic 18391
          primidone 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19773
    subatomic particle 19772
      composite particle 19772
        hadron 19772
          baryon 19772
            nucleon 19772
              atomic nucleus 19772
                atom 19772
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19579
                        carbon atom 19569
                          organic molecular entity 19569
                            organic molecule 19502
                              organic cyclic compound 19329
                                organic heterocyclic compound 18544
                                  organic heteromonocyclic compound 16992
                                    diazines 12211
                                      pyrimidines 12033
                                        pyrimidone 8853
                                          primidone 8
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