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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triprolidine
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Accession:CHEBI:84116 term browser browse the term
Definition:An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.
Synonyms:exact_synonym: 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine
 related_synonym: (E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridine;   Formula=C19H22N2;   InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+;   InChIKey=CBEQULMOCCWAQT-WOJGMQOQSA-N;   SMILES=Cc1ccc(cc1)C(=C/CN1CCCC1)\\c1ccccn1;   trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene;   trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene;   trans-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine;   tripolidina;   triprolidinum
 xref: CAS:486-12-4;   DrugBank:DB00427;   Drug_Central:2763;   HMDB:HMDB0014571;   KEGG:D08648
 xref_mesh: MESH:D014311
 xref: PMID:1362947;   PMID:1362948;   PMID:3944383;   PMID:6509877;   PMID:7258744;   PMID:8529817;   Patent:US2712020;   Patent:US2712023;   Reaxys:87215;   Wikipedia:Triprolidine
 cyclic_relationship: is_conjugate_base_of CHEBI:84117


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triprolidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule decreases expression ISO Triprolidine results in decreased expression of CD14 protein CTD PMID:11556524 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein CTD PMID:11306145 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases activity
ISO
EXP
[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein; HRH1 protein promotes the reaction [Triprolidine results in decreased susceptibility to CXCL8 protein]; Triprolidine binds to and results in decreased activity of HRH1 protein; Triprolidine binds to and results in increased activity of HRH1 protein; Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]]; Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein]
Triprolidine results in decreased activity of HRH1 protein
Triprolidine binds to and results in decreased activity of HRH1 protein; Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]
CTD PMID:1912125, PMID:2419744, PMID:7522859, PMID:10661506, PMID:11306145, PMID:11527950, PMID:15167971, PMID:16143415, PMID:21276809 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Itga4 integrin subunit alpha 4 decreases expression ISO Triprolidine results in decreased expression of ITGA4 protein CTD PMID:11556524 NCBI chr 3:66,178,745...66,265,547
Ensembl chr 3:66,193,059...66,263,960
JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Triprolidine results in decreased expression of ITGAX protein CTD PMID:11556524 NCBI chr 1:199,555,560...199,576,948
Ensembl chr 1:199,555,722...199,576,932
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Triprolidine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Triprolidine results in decreased expression of LRP1 protein CTD PMID:11556524 NCBI chr 7:70,846,313...70,927,028
Ensembl chr 7:70,846,344...70,926,903
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] CTD PMID:15167971 NCBI chr 2:204,886,158...204,939,523
Ensembl chr 2:204,886,202...204,940,453
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Triprolidine inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,636,883...158,705,886
Ensembl chr 4:158,636,884...158,705,886
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C multiple interactions ISO [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein CTD PMID:11306145 NCBI chr13:55,061,561...55,174,150
Ensembl chr13:55,061,562...55,173,692
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]] CTD PMID:10661506 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        pharmacological role 18821
          antagonist 16219
            histamine antagonist 4606
              H1-receptor antagonist 4102
                triprolidine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    main group molecular entity 19696
                      s-block molecular entity 19456
                        hydrogen molecular entity 19447
                          hydrides 18703
                            inorganic hydride 17433
                              pnictogen hydride 17405
                                nitrogen hydride 17247
                                  azane 16964
                                    ammonia 16963
                                      organic amino compound 16962
                                        tertiary amino compound 8638
                                          N-alkylpyrrolidine 1141
                                            triprolidine 11
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