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Accession:CHEBI:84116 term browser browse the term
Definition:An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.
Synonyms:exact_synonym: 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine
 related_synonym: (E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridine;   Formula=C19H22N2;   InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+;   InChIKey=CBEQULMOCCWAQT-WOJGMQOQSA-N;   SMILES=Cc1ccc(cc1)C(=C/CN1CCCC1)\\c1ccccn1;   trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene;   trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene;   trans-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine;   tripolidina;   triprolidinum
 xref: CAS:486-12-4 "ChemIDplus";   CAS:486-12-4 "NIST Chemistry WebBook";   DrugBank:DB00427;   Drug_Central:2763 "DrugCentral";   HMDB:HMDB0014571;   KEGG:D08648
 xref_mesh: MESH:D014311
 xref: PMID:1362947 "Europe PMC";   PMID:1362948 "Europe PMC";   PMID:3944383 "Europe PMC";   PMID:6509877 "Europe PMC";   PMID:7258744 "Europe PMC";   PMID:8529817 "Europe PMC";   Patent:US2712020;   Patent:US2712023;   Reaxys:87215 "Reaxys";   Wikipedia:Triprolidine
 cyclic_relationship: is_conjugate_base_of CHEBI:84117

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triprolidine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cd40 CD40 molecule JBrowse link 3 161,519,789 161,534,943 RGD:6480464
G Hrh1 histamine receptor H 1 JBrowse link 4 146,374,596 146,458,148 RGD:6480464
G Itga4 integrin subunit alpha 4 JBrowse link 3 66,178,745 66,265,547 RGD:6480464
G Itgax integrin subunit alpha X JBrowse link 1 199,555,560 199,576,948 RGD:6480464
G Kcnh2 potassium voltage-gated channel subfamily H member 2 JBrowse link 4 7,355,066 7,387,282 RGD:6480464
G Lrp1 LDL receptor related protein 1 JBrowse link 7 70,846,313 70,927,028 RGD:6480464
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:6480464
G Ntf3 neurotrophin 3 JBrowse link 4 158,636,883 158,705,886 RGD:6480464
G Ptprc protein tyrosine phosphatase, receptor type, C JBrowse link 13 55,061,561 55,174,150 RGD:6480464
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      biological role 19611
        pharmacological role 18684
          antagonist 15784
            histamine antagonist 4485
              H1-receptor antagonist 4009
                triprolidine 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    main group molecular entity 19545
                      s-block molecular entity 19329
                        hydrogen molecular entity 19319
                          hydrides 18242
                            inorganic hydride 17104
                              pnictogen hydride 17062
                                nitrogen hydride 16885
                                  azane 16564
                                    ammonia 16561
                                      organic amino compound 16560
                                        tertiary amino compound 8521
                                          N-alkylpyrrolidine 1092
                                            triprolidine 11
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.