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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:triprolidine
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Accession:CHEBI:84116 term browser browse the term
Definition:An N-alkylpyrrolidine that is acrivastine in which the pyridine ring is lacking the propenoic acid substituent. It is a sedating antihistamine that is used (generally as the monohydrochloride monohydrate) for the relief of the symptoms of uticaria, rhinitis, and various pruritic skin disorders.
Synonyms:exact_synonym: 2-[(1E)-1-(4-methylphenyl)-3-(pyrrolidin-1-yl)prop-1-en-1-yl]pyridine
 related_synonym: (E)-2-[3-(1-pyrrolidinyl)-1-p-toluenepropenyl]pyridine;   Formula=C19H22N2;   InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3/b18-11+;   InChIKey=CBEQULMOCCWAQT-WOJGMQOQSA-N;   SMILES=Cc1ccc(cc1)C(=C/CN1CCCC1)\\c1ccccn1;   trans-1-(2-pyridyl)-3-pyrrolidino-1-p-tolylprop-1-ene;   trans-1-(4-methylphenyl)-1-(2-pyridyl)-3-pyrrolidinoprop-1-ene;   trans-2-(3-(1-pyrrolidinyl)-1-p-tolylpropenyl)pyridine;   tripolidina;   triprolidinum
 xref: CAS:486-12-4;   DrugBank:DB00427;   Drug_Central:2763;   HMDB:HMDB0014571;   KEGG:D08648
 xref_mesh: MESH:D014311
 xref: PMID:1362947;   PMID:1362948;   PMID:3944383;   PMID:6509877;   PMID:7258744;   PMID:8529817;   Patent:US2712020;   Patent:US2712023;   Reaxys:87215;   Wikipedia:Triprolidine
 cyclic_relationship: is_conjugate_base_of CHEBI:84117



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triprolidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmp6 bone morphogenetic protein 6 increases expression ISO Triprolidine results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Cd14 CD14 molecule decreases expression ISO Triprolidine results in decreased expression of CD14 protein CTD PMID:11556524 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein CTD PMID:11306145 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Ereg epiregulin increases expression ISO Triprolidine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions
decreases activity
ISO
EXP
[Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of CD40 protein; [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein; HRH1 protein promotes the reaction [Triprolidine results in decreased susceptibility to CXCL8 protein]; Triprolidine binds to and results in decreased activity of HRH1 protein; Triprolidine binds to and results in increased activity of HRH1 protein; Triprolidine inhibits the reaction [[Histamine results in increased activity of HRH1 protein] which results in increased abundance of Calcium]; Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in decreased abundance of Cyclic AMP]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased export of Calcium]]; Triprolidine inhibits the reaction [HRH1 protein promotes the reaction [Histamine results in increased metabolism of Phosphatidylinositols]]; Triprolidine inhibits the reaction [Pyrilamine binds to HRH1 protein]
Triprolidine results in decreased activity of HRH1 protein
Triprolidine binds to and results in decreased activity of HRH1 protein; Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein]
CTD PMID:1912125 PMID:2419744 PMID:7522859 PMID:10661506 PMID:11306145 More... NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Il24 interleukin 24 increases expression ISO Triprolidine results in increased expression of IL24 mRNA CTD PMID:32816093 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Itga4 integrin subunit alpha 4 decreases expression ISO Triprolidine results in decreased expression of ITGA4 protein CTD PMID:11556524 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Triprolidine results in decreased expression of ITGAX protein CTD PMID:11556524 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Triprolidine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Triprolidine results in decreased expression of LRP1 protein CTD PMID:11556524 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Triprolidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH1 protein] which results in increased expression of NGF protein] CTD PMID:15167971 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Triprolidine inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C multiple interactions ISO [Triprolidine inhibits the reaction [Histamine binds to and results in increased activity of HRH1 protein]] which results in decreased expression of PTPRC protein CTD PMID:11306145 NCBI chr13:49,596,193...49,708,283
Ensembl chr13:49,596,193...49,708,692
JBrowse link
G Slpi secretory leukocyte peptidase inhibitor decreases expression ISO Triprolidine results in decreased expression of SLPI mRNA CTD PMID:32816093 NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Triprolidine inhibits the reaction [1-phenyl-3-dimethylamino-1,2,3,4-tetrahydronaphthalene analog promotes the reaction [TH protein results in increased chemical synthesis of Dopamine]] CTD PMID:10661506 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      biological role 20007
        pharmacological role 19087
          antagonist 16715
            histamine antagonist 4857
              H1-receptor antagonist 4123
                triprolidine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    main group molecular entity 19956
                      s-block molecular entity 19752
                        hydrogen molecular entity 19745
                          hydrides 19114
                            inorganic hydride 17882
                              pnictogen hydride 17865
                                nitrogen hydride 17754
                                  azane 17503
                                    ammonia 17502
                                      organic amino compound 17502
                                        tertiary amino compound 8848
                                          N-alkylpyrrolidine 1185
                                            triprolidine 15
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