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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antazoline
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Accession:CHEBI:84115 term browser browse the term
Definition:A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug.
Synonyms:exact_synonym: N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
 related_synonym: 2-(N-Benzylanilinomethyl)-2-imidazoline;   2-(N-Phenyl-N-benzylaminomethyl)imidazoline;   4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine;   Formula=C17H19N3;   InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19);   InChIKey=REYFJDPCWQRWAA-UHFFFAOYSA-N;   SMILES=C(N(Cc1ccccc1)c1ccccc1)C1=NCCN1;   antazolina;   antazolinum
 xref: CAS:91-75-8;   DrugBank:DB08799;   Drug_Central:224;   HMDB:HMDB0015689;   KEGG:D07458;   LINCS:LSM-6023
 xref_mesh: MESH:D000865
 xref: PMID:1180129;   PMID:16394564;   PMID:22967497;   PMID:23669609;   PMID:23847054;   PMID:23990192;   PMID:3793827;   PMID:5792228;   PMID:712601;   PMID:7199833;   PMID:9145778;   Reaxys:233924;   Wikipedia:Antazoline


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antazoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Antazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
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G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Antazoline results in increased activity of TAAR1 protein
[Antazoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      biological role 19734
        xenobiotic 18381
          antazoline 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    main group molecular entity 19672
                      s-block molecular entity 19430
                        hydrogen molecular entity 19420
                          hydrides 18686
                            inorganic hydride 17411
                              pnictogen hydride 17383
                                nitrogen hydride 17224
                                  azane 16941
                                    ammonia 16940
                                      organic amino compound 16939
                                        tertiary amino compound 8630
                                          antazoline 2
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