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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:antazoline
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Accession:CHEBI:84115 term browser browse the term
Definition:A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug.
Synonyms:exact_synonym: N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
 related_synonym: 2-(N-Benzylanilinomethyl)-2-imidazoline;   2-(N-Phenyl-N-benzylaminomethyl)imidazoline;   4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine;   Formula=C17H19N3;   InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19);   InChIKey=REYFJDPCWQRWAA-UHFFFAOYSA-N;   SMILES=C(N(Cc1ccccc1)c1ccccc1)C1=NCCN1;   antazolina;   antazolinum
 xref: CAS:91-75-8;   DrugBank:DB08799;   Drug_Central:224;   HMDB:HMDB0015689;   KEGG:D07458;   LINCS:LSM-6023
 xref_mesh: MESH:D000865
 xref: PMID:1180129;   PMID:16394564;   PMID:22967497;   PMID:23669609;   PMID:23847054;   PMID:23990192;   PMID:3793827;   PMID:5792228;   PMID:712601;   PMID:7199833;   PMID:9145778;   Reaxys:233924;   Wikipedia:Antazoline


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antazoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Antazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions		 ISO Antazoline results in increased activity of TAAR1 protein
[Antazoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP		 CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        xenobiotic 18774
          antazoline 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    main group molecular entity 19865
                      s-block molecular entity 19697
                        hydrogen molecular entity 19678
                          hydrides 19184
                            inorganic hydride 18194
                              pnictogen hydride 18184
                                nitrogen hydride 18096
                                  azane 17900
                                    ammonia 17899
                                      organic amino compound 17899
                                        tertiary amino compound 10158
                                          antazoline 2
paths to the root