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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:antazoline
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Accession:CHEBI:84115 term browser browse the term
Definition:A member of the class of imidazolines that is 2-aminomethyl-2-imidazoline in which the exocyclic amino hydrogens are replaced by benzyl and phenyl groups. Antazoline is only found in individuals that have taken the drug.
Synonyms:exact_synonym: N-benzyl-N-(4,5-dihydro-1H-imidazol-2-ylmethyl)aniline
 related_synonym: 2-(N-Benzylanilinomethyl)-2-imidazoline;   2-(N-Phenyl-N-benzylaminomethyl)imidazoline;   4,5-Dihydro-N-phenyl-N-phenylmethyl-1H-imidazole-2-methanamine;   Formula=C17H19N3;   InChI=1S/C17H19N3/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16/h1-10H,11-14H2,(H,18,19);   InChIKey=REYFJDPCWQRWAA-UHFFFAOYSA-N;   SMILES=C(N(Cc1ccccc1)c1ccccc1)C1=NCCN1;   antazolina;   antazolinum
 xref: CAS:91-75-8;   DrugBank:DB08799;   Drug_Central:224;   HMDB:HMDB0015689;   KEGG:D07458;   LINCS:LSM-6023
 xref_mesh: MESH:D000865
 xref: PMID:1180129;   PMID:16394564;   PMID:22967497;   PMID:23669609;   PMID:23847054;   PMID:23990192;   PMID:3793827;   PMID:5792228;   PMID:712601;   PMID:7199833;   PMID:9145778;   Reaxys:233924;   Wikipedia:Antazoline


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antazoline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Antazoline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G Taar1 trace-amine-associated receptor 1 increases activity
multiple interactions
ISO Antazoline results in increased activity of TAAR1 protein
[Antazoline results in increased activity of TAAR1 protein] which results in increased abundance of Cyclic AMP
CTD PMID:19725810 NCBI chr 1:21,517,742...21,518,740
Ensembl chr 1:21,517,258...21,532,084
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        xenobiotic 18442
          antazoline 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    main group molecular entity 19708
                      s-block molecular entity 19493
                        hydrogen molecular entity 19488
                          hydrides 18845
                            inorganic hydride 17691
                              pnictogen hydride 17672
                                nitrogen hydride 17545
                                  azane 17279
                                    ammonia 17278
                                      organic amino compound 17278
                                        tertiary amino compound 8677
                                          antazoline 2
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