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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-histidine derivative
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Accession:CHEBI:84076 term browser browse the term
Definition:A proteinogenic amino acid derivative resulting from the formal reaction of L-histidine at the amino group, carboxy group, or the imidazolyl moiety, or from the replacement of any hydrogen of L-histidine by a heteroatom.
Synonyms:related_synonym: L-histidine derivatives



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ergothioneine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Ergothioneine inhibits the reaction [Cisplatin results in decreased activity of ACHE protein] CTD PMID:20932872 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased phosphorylation of AKT1 protein] CTD PMID:33580994 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of CASP3 protein] CTD PMID:33580994 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased activity of CAT protein] CTD PMID:33580994 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of FOS protein] CTD PMID:33580994 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased activity of GPT protein] CTD PMID:33580994 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein] CTD PMID:33580994 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of PIK3CA protein] CTD PMID:33580994 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein] CTD PMID:33580994 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Ergothioneine inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein] CTD PMID:33580994 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20059
    role 20009
      biological role 20008
        biochemical role 19630
          metabolite 19611
            histidine 10
              L-histidine 10
                L-histidine derivative 10
                  (3S)-3-hydroxy-L-enduracididine 0
                  (8alpha-FAD)-L-histidine + 0
                  2'-(S-L-cysteinyl)-L-histidine 0
                  2,5-diiodo-L-histidine 0
                  2-(3-amino-3-carboxypropyl)-L-histidine + 0
                  2-L-bromohistidine 0
                  2-[3-carboxy-3-(dimethylamino)propyl]-L-histidine 0
                  2-[3-carboxylato-3-(trimethylammonio)propyl]-L-histidine + 0
                  2-sulfenohercynine 0
                  3'-L-histidyl-AMP 0
                  3-(N(tele)-L-histidino)-L-tyrosine residue 0
                  5-iodo-L-histidine 0
                  L-enduracididine 0
                  L-histidine 2-naphthylamide 0
                  L-histidine amide 0
                  L-homocarnosine 0
                  MLN-4760 0
                  N(alpha)-acetyl-N(tele)-(1,4-dihydroxynonan-3-yl)-L-histidine 0
                  N(pros)-methyl-L-histidine + 0
                  N(pros)-methyl-L-histidine zwitterion 0
                  N(pros)-phospho-L-histidine + 0
                  N(tele)-methyl-L-histidine + 0
                  N-Aminoacyl-L-histidine 0
                  N-acetyl-1-[(2R)-5-hydroxy-2-pentyltetrahydrofuran-3-yl]-L-histidine 0
                  N-acetyl-1-[(2R,3S,5R)-5-hydroxy-2-pentyltetrahydrofuran-3-yl]-L-histidine 0
                  N-acetyl-1-methyl-L-histidine 0
                  N-acetyl-3-methyl-L-histidine 0
                  N-acetyl-L-histidine 0
                  S-(5-histidyl)cysteine sulfoxide 0
                  bunodosine 391 0
                  ergothioneine + 10
                  ergothioneine thione form 0
                  heme-L-histidine 0
                  hercynylcysteine sulfoxide 0
                  hercynylselenocysteine 0
                  ovothiol A 0
                  ovothiol B 0
                  ovothiol C 0
                  phospho-L-histidine + 0
                  remikiren 0
                  selenoneine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20059
    subatomic particle 20056
      composite particle 20056
        hadron 20056
          baryon 20056
            nucleon 20056
              atomic nucleus 20056
                atom 20056
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19873
                          organic molecular entity 19873
                            organic group 18943
                              organic divalent group 18928
                                organodiyl group 18928
                                  carbonyl group 18877
                                    carbonyl compound 18877
                                      carboxylic acid 18565
                                        amino acid 14936
                                          alpha-amino acid 12944
                                            L-alpha-amino acid 11603
                                              L-histidine 10
                                                L-histidine derivative 10
                                                  (3S)-3-hydroxy-L-enduracididine 0
                                                  (8alpha-FAD)-L-histidine + 0
                                                  2'-(S-L-cysteinyl)-L-histidine 0
                                                  2,5-diiodo-L-histidine 0
                                                  2-(3-amino-3-carboxypropyl)-L-histidine + 0
                                                  2-L-bromohistidine 0
                                                  2-[3-carboxy-3-(dimethylamino)propyl]-L-histidine 0
                                                  2-[3-carboxylato-3-(trimethylammonio)propyl]-L-histidine + 0
                                                  2-sulfenohercynine 0
                                                  3'-L-histidyl-AMP 0
                                                  3-(N(tele)-L-histidino)-L-tyrosine residue 0
                                                  5-iodo-L-histidine 0
                                                  L-enduracididine 0
                                                  L-histidine 2-naphthylamide 0
                                                  L-histidine amide 0
                                                  L-homocarnosine 0
                                                  MLN-4760 0
                                                  N(alpha)-acetyl-N(tele)-(1,4-dihydroxynonan-3-yl)-L-histidine 0
                                                  N(pros)-methyl-L-histidine + 0
                                                  N(pros)-methyl-L-histidine zwitterion 0
                                                  N(pros)-phospho-L-histidine + 0
                                                  N(tele)-methyl-L-histidine + 0
                                                  N-Aminoacyl-L-histidine 0
                                                  N-acetyl-1-[(2R)-5-hydroxy-2-pentyltetrahydrofuran-3-yl]-L-histidine 0
                                                  N-acetyl-1-[(2R,3S,5R)-5-hydroxy-2-pentyltetrahydrofuran-3-yl]-L-histidine 0
                                                  N-acetyl-1-methyl-L-histidine 0
                                                  N-acetyl-3-methyl-L-histidine 0
                                                  N-acetyl-L-histidine 0
                                                  S-(5-histidyl)cysteine sulfoxide 0
                                                  bunodosine 391 0
                                                  ergothioneine + 10
                                                  ergothioneine thione form 0
                                                  heme-L-histidine 0
                                                  hercynylcysteine sulfoxide 0
                                                  hercynylselenocysteine 0
                                                  ovothiol A 0
                                                  ovothiol B 0
                                                  ovothiol C 0
                                                  phospho-L-histidine + 0
                                                  remikiren 0
                                                  selenoneine 0
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