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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trabectedin
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Accession:CHEBI:84050 term browser browse the term
Definition:A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.
Synonyms:exact_synonym: (6R,6aR,7R,13S,14S,16R,20R)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydro-2'H,6aH-spiro[7,13-epimino-6,16-(epithiopropanooxymethano)[1,3]dioxolo[7,8]isoquinolino[3,2-b][3]benzazocine-20,1'-isoquinolin]-5-yl acetate
 related_synonym: ET-743;   ET743;   Ect 743;   Ecteinascidin;   Ecteinascidin 743;   Formula=C39H43N3O11S;   InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1;   InChIKey=PKVRCIRHQMSYJX-AIFWHQITSA-N;   SMILES=COc1cc2c(CCN[C@]22CS[C@H]3[C@H]4[C@@H]5N(C)[C@@H](Cc6cc(C)c(OC)c(O)c56)[C@H](O)N4[C@@H](COC2=O)c2c4OCOc4c(C)c(OC(C)=O)c32)cc1O;   Yondelis
 xref: CAS:114899-77-3;   DrugBank:DB05109;   Drug_Central:4633;   HMDB:HMDB0015609;   KEGG:C16875;   KEGG:D06199
 xref_mesh: MESH:C099150
 xref: PMID:18728699;   PMID:21403840;   PMID:21499557;   PMID:23149213;   PMID:24001124;   PMID:24277455;   PMID:24662672;   PMID:24692579;   PMID:24696229;   PMID:24707261;   PMID:24755886;   PMID:24756367;   PMID:24803896;   PMID:24844217;   PMID:24917554;   PMID:24941346;   PMID:24982387;   PMID:25048043;   PMID:25048044;   PMID:25050069;   PMID:25076252;   PMID:25100135;   PMID:25209722;   PMID:25263179;   PMID:25273374;   PMID:25479910;   Reaxys:7617615;   Wikipedia:Trabectedin


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trabectedin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP-binding cassette, sub-family B member 1A multiple interactions
increases expression		 EXP
ISO		 [ABCB1A protein mutant form co-treated with ABCB1B protein mutant form] results in increased susceptibility to trabectedin
trabectedin results in increased expression of ABCB1A mRNA		 CTD PMID:12154027 PMID:19238326 NCBI chr 5:8,617,091...8,798,575
Ensembl chr 5:8,710,077...8,798,575 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions
increases expression		 EXP
ISO		 [ABCB1A protein mutant form co-treated with ABCB1B protein mutant form] results in increased susceptibility to trabectedin
trabectedin results in increased expression of ABCB1B mRNA		 CTD PMID:12154027 PMID:19238326 NCBI chr 5:8,848,147...8,916,314
Ensembl chr 5:8,848,147...8,916,315 		JBrowse link
G Aco1 aconitase 1 increases expression ISO Trabectedin results in increased expression of ACO1 mRNA; Trabectedin results in increased expression of ACO1 protein CTD PMID:36396105 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Car3 carbonic anhydrase 3 decreases expression ISO trabectedin results in decreased expression of CAR3 mRNA CTD PMID:12154027 NCBI chr 3:14,928,598...14,937,441
Ensembl chr 3:14,928,572...14,937,583 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO trabectedin results in decreased expression of CCNA2 mRNA CTD PMID:15961672 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO trabectedin results in decreased expression of CCNB1 mRNA CTD PMID:15961672 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO
EXP		 trabectedin results in decreased expression of CCNB2 mRNA CTD PMID:15961672 NCBI chr 9:70,314,971...70,328,836
Ensembl chr 9:70,314,974...70,328,829 		JBrowse link
G Ccnd1 cyclin D1 increases expression ISO trabectedin results in increased expression of CCND1 mRNA CTD PMID:12154027 NCBI chr 7:144,483,668...144,493,568
Ensembl chr 7:144,483,668...144,493,662 		JBrowse link
G Ccne1 cyclin E1 increases expression EXP trabectedin results in increased expression of CCNE1 mRNA CTD PMID:15961672 NCBI chr 7:37,797,409...37,806,915
Ensembl chr 7:37,797,409...37,806,959 		JBrowse link
G Cdk1 cyclin dependent kinase 1 increases expression ISO trabectedin results in increased expression of CDK1 mRNA CTD PMID:12154027 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression ISO trabectedin results in decreased expression of CYP1A2 mRNA CTD PMID:12154027 NCBI chr 9:57,584,220...57,590,938
Ensembl chr 9:57,584,220...57,590,986 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO trabectedin results in decreased activity of CYP2E1 protein CTD PMID:12154027 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp3a13 cytochrome P450, family 3, subfamily a, polypeptide 13 decreases expression ISO trabectedin results in decreased expression of CYP3A13 mRNA CTD PMID:12154027 NCBI chr 5:137,891,195...137,923,872
Ensembl chr 5:137,891,194...137,919,881 		JBrowse link
G Dhfr dihydrofolate reductase decreases expression EXP trabectedin results in decreased expression of DHFR mRNA CTD PMID:15961672 NCBI chr13:92,491,291...92,525,561
Ensembl chr13:92,491,234...92,525,561 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression EXP
ISO		 trabectedin results in increased expression of E2F1 mRNA CTD PMID:15961672 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO Trabectedin results in decreased expression of GPX4 mRNA; Trabectedin results in decreased expression of GPX4 protein CTD PMID:36396105 NCBI chr10:79,883,000...79,892,273
Ensembl chr10:79,883,000...79,892,273 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases expression ISO Trabectedin results in increased expression of HIF1A mRNA; Trabectedin results in increased expression of HIF1A protein CTD PMID:36396105 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 increases expression ISO Trabectedin results in increased expression of KEAP1 protein CTD PMID:36396105 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 increases expression ISO trabectedin results in increased expression of MKI67 protein CTD PMID:12154027 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases response to substance		 ISO everolimus inhibits the reaction [MTOR results in decreased susceptibility to trabectedin] CTD PMID:21622721 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 decreases expression ISO Trabectedin results in decreased expression of NFE2L2 protein CTD PMID:36396105 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfya nuclear transcription factor-Y alpha multiple interactions EXP trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr17:48,693,917...48,716,782
Ensembl chr17:48,693,913...48,716,934 		JBrowse link
G Nfyb nuclear transcription factor-Y beta multiple interactions EXP trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr10:82,584,534...82,599,985
Ensembl chr10:82,584,535...82,599,978 		JBrowse link
G Nfyc nuclear transcription factor-Y gamma multiple interactions EXP trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 4:120,614,632...120,688,776
Ensembl chr 4:120,614,635...120,688,769 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Trabectedin results in increased expression of TFRC mRNA; Trabectedin results in increased expression of TFRC protein CTD PMID:36396105 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression EXP trabectedin results in decreased expression of TK1 mRNA CTD PMID:15961672 NCBI chr11:117,706,345...117,716,913
Ensembl chr11:117,706,352...117,716,918 		JBrowse link
G Zfp457 zinc finger protein 457 decreases response to substance ISO ZNF93 protein results in decreased susceptibility to trabectedin CTD PMID:19742314 NCBI chr13:67,440,514...67,454,476
Ensembl chr13:67,436,202...67,454,549 		JBrowse link
Term paths to the root
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  CHEBI ontology 22178
    role 22194
      application 21744
        anti-inflammatory agent 17331
          trabectedin 27
Path 2
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  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      monocarboxylic acid 18952
                                        acetic acid 11454
                                          acetate ester 4125
                                            trabectedin 27
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