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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trabectedin
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Accession:CHEBI:84050 term browser browse the term
Definition:A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.
Synonyms:exact_synonym: (6R,6aR,7R,13S,14S,16R,20R)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydro-2'H,6aH-spiro[7,13-epimino-6,16-(epithiopropanooxymethano)[1,3]dioxolo[7,8]isoquinolino[3,2-b][3]benzazocine-20,1'-isoquinolin]-5-yl acetate
 related_synonym: ET-743;   ET743;   Ect 743;   Ecteinascidin;   Ecteinascidin 743;   Formula=C39H43N3O11S;   InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1;   InChIKey=PKVRCIRHQMSYJX-AIFWHQITSA-N;   SMILES=COc1cc2c(CCN[C@]22CS[C@H]3[C@H]4[C@@H]5N(C)[C@@H](Cc6cc(C)c(OC)c(O)c56)[C@H](O)N4[C@@H](COC2=O)c2c4OCOc4c(C)c(OC(C)=O)c32)cc1O;   Yondelis
 xref: CAS:114899-77-3;   DrugBank:DB05109;   Drug_Central:4633;   HMDB:HMDB0015609;   KEGG:C16875;   KEGG:D06199
 xref_mesh: MESH:C099150
 xref: PMID:18728699;   PMID:21403840;   PMID:21499557;   PMID:23149213;   PMID:24001124;   PMID:24277455;   PMID:24662672;   PMID:24692579;   PMID:24696229;   PMID:24707261;   PMID:24755886;   PMID:24756367;   PMID:24803896;   PMID:24844217;   PMID:24917554;   PMID:24941346;   PMID:24982387;   PMID:25048043;   PMID:25048044;   PMID:25050069;   PMID:25076252;   PMID:25100135;   PMID:25209722;   PMID:25263179;   PMID:25273374;   PMID:25479910;   Reaxys:7617615;   Wikipedia:Trabectedin


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trabectedin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases expression		 ISO [ABCB1A protein mutant form co-treated with ABCB1B protein mutant form] results in increased susceptibility to trabectedin
trabectedin results in increased expression of ABCB1A mRNA		 CTD PMID:12154027 PMID:19238326 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ACO1 aconitase 1 increases expression EXP Trabectedin results in increased expression of ACO1 mRNA; Trabectedin results in increased expression of ACO1 protein CTD PMID:36396105 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769 		JBrowse link
G CA3 carbonic anhydrase 3 decreases expression ISO trabectedin results in decreased expression of CAR3 mRNA CTD PMID:12154027 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040 		JBrowse link
G CCNA2 cyclin A2 decreases expression EXP trabectedin results in decreased expression of CCNA2 mRNA CTD PMID:15961672 NCBI chr 4:121,816,444...121,823,883
Ensembl chr 4:121,816,444...121,823,883 		JBrowse link
G CCNB1 cyclin B1 decreases expression EXP trabectedin results in decreased expression of CCNB1 mRNA CTD PMID:15961672 NCBI chr 5:69,167,150...69,178,245
Ensembl chr 5:69,167,135...69,178,245 		JBrowse link
G CCNB2 cyclin B2 decreases expression EXP
ISO		 trabectedin results in decreased expression of CCNB2 mRNA CTD PMID:15961672 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045 		JBrowse link
G CCND1 cyclin D1 increases expression ISO trabectedin results in increased expression of CCND1 mRNA CTD PMID:12154027 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCNE1 cyclin E1 increases expression ISO trabectedin results in increased expression of CCNE1 mRNA CTD PMID:15961672 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CDK1 cyclin dependent kinase 1 increases expression ISO trabectedin results in increased expression of CDK1 mRNA CTD PMID:12154027 NCBI chr10:60,778,331...60,794,852
Ensembl chr10:60,778,331...60,794,852 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression ISO trabectedin results in decreased expression of CYP1A2 mRNA CTD PMID:12154027 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity ISO trabectedin results in decreased activity of CYP2E1 protein CTD PMID:12154027 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220 		JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity ISO Trabectedin results in decreased activity of CYP3A2 protein CTD PMID:12154027 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248 		JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 decreases expression ISO trabectedin results in decreased expression of CYP3A13 mRNA CTD PMID:12154027 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,996 		JBrowse link
G DHFR dihydrofolate reductase decreases expression ISO trabectedin results in decreased expression of DHFR mRNA CTD PMID:15961672 NCBI chr 5:80,626,226...80,654,983
Ensembl chr 5:80,626,226...80,654,983 		JBrowse link
G E2F1 E2F transcription factor 1 increases expression ISO
EXP		 trabectedin results in increased expression of E2F1 mRNA CTD PMID:15961672 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385 		JBrowse link
G GPX4 glutathione peroxidase 4 decreases expression EXP Trabectedin results in decreased expression of GPX4 mRNA; Trabectedin results in decreased expression of GPX4 protein CTD PMID:36396105 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression EXP Trabectedin results in increased expression of HIF1A mRNA; Trabectedin results in increased expression of HIF1A protein CTD PMID:36396105 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 increases expression EXP Trabectedin results in increased expression of KEAP1 protein CTD PMID:36396105 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G MKI67 marker of proliferation Ki-67 increases expression ISO trabectedin results in increased expression of MKI67 protein CTD PMID:12154027 NCBI chr10:128,096,659...128,126,423
Ensembl chr10:128,096,659...128,126,423 		JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions
decreases response to substance		 EXP everolimus inhibits the reaction [MTOR results in decreased susceptibility to trabectedin] CTD PMID:21622721 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 decreases expression EXP Trabectedin results in decreased expression of NFE2L2 protein CTD PMID:36396105 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFYA nuclear transcription factor Y subunit alpha multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 6:41,072,974...41,102,403
Ensembl chr 6:41,072,974...41,102,403 		JBrowse link
G NFYB nuclear transcription factor Y subunit beta multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr12:104,117,086...104,138,210
Ensembl chr12:104,117,086...104,138,241 		JBrowse link
G NFYC nuclear transcription factor Y subunit gamma multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 1:40,691,704...40,771,603
Ensembl chr 1:40,691,648...40,771,603 		JBrowse link
G TFRC transferrin receptor increases expression EXP Trabectedin results in increased expression of TFRC mRNA; Trabectedin results in increased expression of TFRC protein CTD PMID:36396105 NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153 		JBrowse link
G TK1 thymidine kinase 1 decreases expression ISO trabectedin results in decreased expression of TK1 mRNA CTD PMID:15961672 NCBI chr17:78,174,079...78,187,204
Ensembl chr17:78,174,091...78,187,233 		JBrowse link
G ZNF93 zinc finger protein 93 decreases response to substance EXP ZNF93 protein results in decreased susceptibility to trabectedin CTD PMID:19742314 NCBI chr19:19,900,946...19,935,575
Ensembl chr19:19,900,913...19,963,464 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26041
    role 25957
      application 25179
        anti-inflammatory agent 17811
          trabectedin 27
Path 2
Term Annotations click to browse term
  CHEBI ontology 26041
    subatomic particle 26016
      composite particle 26016
        hadron 26016
          baryon 26016
            nucleon 26016
              atomic nucleus 26016
                atom 26016
                  main group element atom 25841
                    p-block element atom 25841
                      carbon group element atom 25441
                        carbon atom 25399
                          organic molecular entity 25399
                            heteroorganic entity 24773
                              organochalcogen compound 24384
                                organooxygen compound 24061
                                  carbon oxoacid 22757
                                    carboxylic acid 22737
                                      monocarboxylic acid 21735
                                        acetic acid 11430
                                          acetate ester 4181
                                            trabectedin 27
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