|
G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases activity |
ISO |
Primaquine results in decreased activity of ABCB11 protein |
CTD |
PMID:20829430 |
|
NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
|
|
G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
decreases activity |
ISO |
Primaquine results in decreased activity of ABCB4 protein |
CTD |
PMID:28437613 |
|
NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions increases activity |
ISO EXP |
Primaquine binds to and results in increased activity of AHR protein Primaquine results in increased activity of AHR protein [Primaquine results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Primaquine results in increased expression of CYP1A1 protein]; Primaquine binds to and results in increased activity of AHR protein; Primaquine inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein] |
CTD |
PMID:11259546 PMID:14742684 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
|
|
G |
Cftr |
CF transmembrane conductance regulator |
multiple interactions |
EXP |
Primaquine inhibits the reaction [Cyclic AMP affects the localization of and results in increased activity of CFTR protein] |
CTD |
PMID:12529251 |
|
NCBI chr 4:42,693,263...42,860,679
Ensembl chr 4:42,692,836...42,860,676
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases activity increases response to substance increases expression decreases degradation multiple interactions |
ISO EXP |
Primaquine results in increased activity of CYP1A1 promoter; Primaquine results in increased activity of CYP1A1 protein CYP1A1 protein results in increased susceptibility to Primaquine Primaquine results in increased expression of CYP1A1 mRNA; Primaquine results in increased expression of CYP1A1 protein Primaquine results in decreased degradation of CYP1A1 protein [Primaquine results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Primaquine results in increased expression of CYP1A1 protein]; Primaquine binds to and results in decreased activity of CYP1A1 protein |
CTD |
PMID:9860486 PMID:11259546 PMID:12451431 PMID:12623754 PMID:14742684 PMID:17954527 PMID:18502397 PMID:26477383 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases activity increases metabolic processing multiple interactions increases expression affects metabolic processing |
ISO |
Primaquine results in increased activity of CYP1A2 promoter CYP1A2 protein results in increased metabolism of Primaquine [CYP1A2 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine Primaquine results in increased expression of CYP1A2 mRNA CYP1A2 protein affects the metabolism of Primaquine |
CTD |
PMID:12451431 PMID:12623754 PMID:12920490 PMID:17954527 PMID:18502397 PMID:19616568 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
ISO |
Primaquine results in increased expression of CYP1B1 mRNA |
CTD |
PMID:12623754 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
|
|
G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
multiple interactions increases metabolic processing |
ISO |
[CYP2B6 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine CYP2B6 protein results in increased metabolism of Primaquine |
CTD |
PMID:19616568 |
|
NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
|
|
G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions increases response to substance affects metabolic processing increases metabolic processing |
ISO |
[CYP2D6 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine CYP2D6 protein results in increased susceptibility to Primaquine CYP2D6 protein affects the metabolism of Primaquine CYP2D6 protein results in increased metabolism of Primaquine |
CTD |
PMID:12920490 PMID:19616568 PMID:26477383 |
|
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases metabolic processing multiple interactions |
ISO |
CYP2E1 protein results in increased metabolism of Primaquine [CYP2E1 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine |
CTD |
PMID:19616568 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
|
|
G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases metabolic processing multiple interactions |
ISO |
CYP3A4 protein results in increased metabolism of Primaquine [CYP3A4 protein results in increased expression of HBG2 protein] which affects the susceptibility to Primaquine |
CTD |
PMID:19616568 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
|
|
G |
Egf |
epidermal growth factor |
multiple interactions |
ISO |
Primaquine inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein] |
CTD |
PMID:23125191 |
|
NCBI chr 2:68,820,616...68,895,537
|
|
G |
Egfr |
epidermal growth factor receptor |
multiple interactions |
ISO |
Primaquine inhibits the reaction [EGF protein results in increased uptake of and results in increased degradation of EGFR protein] |
CTD |
PMID:23125191 |
|
NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
|
|
G |
F3 |
coagulation factor III, tissue factor |
increases expression |
ISO |
Primaquine results in increased expression of F3 protein |
CTD |
PMID:25569083 |
|
NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
|
|
G |
G6pd |
glucose-6-phosphate dehydrogenase |
affects response to substance decreases response to substance |
ISO |
G6PD protein affects the susceptibility to Primaquine G6PD protein results in decreased susceptibility to Primaquine |
CTD |
PMID:19616568 PMID:22330256 |
|
NCBI chr X:156,274,800...156,293,935
Ensembl chr X:156,274,800...156,293,926
|
|
G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone reductase 2 |
multiple interactions |
ISO |
Primaquine binds to and results in decreased activity of NQO2 protein |
CTD |
PMID:15078100 |
|
NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
|
|
G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions |
ISO |
Primaquine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] |
CTD |
PMID:21599003 |
|
NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
|
|