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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prilocaine
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Accession:CHEBI:8404 term browser browse the term
Definition:An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
Synonyms:exact_synonym: N-(2-methylphenyl)-N(2)-propylalaninamide
 related_synonym: 2-(Propylamino)-o-propionotoluidide;   2-Methyl-alpha-propylaminopropionanilide;   Formula=C13H20N2O;   InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);   InChIKey=MVFGUOIZUNYYSO-UHFFFAOYSA-N;   N-(2-Methylphenyl)-2-(propylamino)propanamide;   Propitocaine;   SMILES=CCCNC(C)C(=O)Nc1ccccc1C;   alpha-n-Propylamino-2-methylpropionanilide;   o-Methyl-2-propylaminopropionanilide;   o-Methyl-alpha-propylaminopropionanilide;   prilocaina;   prilocaine base;   prilocainum
 alt_id: CHEBI:308749
 xref: Beilstein:2108498;   CAS:721-50-6;   DrugBank:DB00750;   Drug_Central:2265;   KEGG:C07531;   KEGG:D00553;   LINCS:LSM-5078
 xref_mesh: MESH:D011318
 xref: PMID:26049614;   PMID:26199764;   PMID:26356490;   PMID:9989796;   Patent:GB839943;   Patent:US3160662;   Wikipedia:Prilocaine


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prilocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Prilocaine results in increased phosphorylation of AKT1 protein CTD PMID:37561044 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Il6 interleukin 6 increases expression ISO Prilocaine results in increased expression of IL6 protein CTD PMID:37561044 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Prilocaine results in increased expression of NOS2 protein CTD PMID:37561044 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Prilocaine results in increased expression of and results in increased phosphorylation of RELA protein CTD PMID:37561044 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      application 19741
        pharmaceutical 19579
          drug 19579
            anaesthetic 11849
              local anaesthetic 7702
                prilocaine 4
                  prilocaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbon oxoacid 18687
                                    carboxylic acid 18684
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17579
                                            carboxamide 17579
                                              amino acid amide 1466
                                                prilocaine 4
                                                  prilocaine hydrochloride 0
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