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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prilocaine
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Accession:CHEBI:8404 term browser browse the term
Definition:An amino acid amide in which N-propyl-DL-alanine and 2-methylaniline have combined to form the amide bond; used as a local anaesthetic.
Synonyms:exact_synonym: N-(2-methylphenyl)-N(2)-propylalaninamide
 related_synonym: 2-(Propylamino)-o-propionotoluidide;   2-Methyl-alpha-propylaminopropionanilide;   Formula=C13H20N2O;   InChI=1S/C13H20N2O/c1-4-9-14-11(3)13(16)15-12-8-6-5-7-10(12)2/h5-8,11,14H,4,9H2,1-3H3,(H,15,16);   InChIKey=MVFGUOIZUNYYSO-UHFFFAOYSA-N;   N-(2-Methylphenyl)-2-(propylamino)propanamide;   Propitocaine;   SMILES=CCCNC(C)C(=O)Nc1ccccc1C;   alpha-n-Propylamino-2-methylpropionanilide;   o-Methyl-2-propylaminopropionanilide;   o-Methyl-alpha-propylaminopropionanilide;   prilocaina;   prilocaine base;   prilocainum
 alt_id: CHEBI:308749
 xref: Beilstein:2108498;   CAS:721-50-6;   DrugBank:DB00750;   Drug_Central:2265;   KEGG:C07531;   KEGG:D00553;   LINCS:LSM-5078
 xref_mesh: MESH:D011318
 xref: PMID:26049614;   PMID:26199764;   PMID:26356490;   PMID:9989796;   Patent:GB839943;   Patent:US3160662;   Wikipedia:Prilocaine


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prilocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Prilocaine results in increased phosphorylation of AKT1 protein CTD PMID:37561044 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610 		JBrowse link
G Il6 interleukin 6 increases expression ISO Prilocaine results in increased expression of IL6 protein CTD PMID:37561044 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Prilocaine results in increased expression of NOS2 protein CTD PMID:37561044 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Prilocaine results in increased expression of and results in increased phosphorylation of RELA protein CTD PMID:37561044 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    role 20820
      application 20621
        pharmaceutical 20416
          drug 20416
            anaesthetic 12021
              local anaesthetic 7765
                prilocaine 4
                  prilocaine hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      carbon group element atom 20715
                        carbon atom 20710
                          organic molecular entity 20710
                            heteroorganic entity 20219
                              organochalcogen compound 19904
                                organooxygen compound 19806
                                  carbon oxoacid 19155
                                    carboxylic acid 19152
                                      carboacyl group 18085
                                        univalent carboacyl group 18085
                                          carbamoyl group 17921
                                            carboxamide 17921
                                              amino acid amide 1483
                                                prilocaine 4
                                                  prilocaine hydrochloride 0
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