CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: (5E)-5-(4-chlorobenzylidene)-2,2-dimethyl-1-(1,2,4-triazol-1-ylmethyl)cyclopentanol
Accession: CHEBI:84005
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Definition: A member of the class of cyclopentanols carrying 1,2,4-triazol-1-ylmethyl and 4-chlorobenzylidene and geminal dimethyl substituents at positions 1, 2 and 5 respectively.
Synonyms: exact_synonym: (5E)-5-(4-chlorobenzylidene)-2,2-dimethyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol
related_synonym: Formula=C17H20ClN3O; InChI=1S/C17H20ClN3O/c1-16(2)8-7-14(9-13-3-5-15(18)6-4-13)17(16,22)10-21-12-19-11-20-21/h3-6,9,11-12,22H,7-8,10H2,1-2H3/b14-9+; InChIKey=PPDBOQMNKNNODG-NTEUORMPSA-N; SMILES=CC1(C)CC\\C(=C/c2ccc(Cl)cc2)C1(O)Cn1cncn1
xref: PPDB:673
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Ar
androgen receptor
multiple interactions
ISO
triticonazole inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]
CTD
PMID:33049310
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Ass1
argininosuccinate synthase 1
increases expression
EXP
triticonazole results in increased expression of ASS1 mRNA
CTD
PMID:33032228
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
increases expression
EXP
triticonazole results in increased expression of CYP11B1 mRNA
CTD
PMID:33032228
NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004
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Esr1
estrogen receptor 1
multiple interactions
ISO
triticonazole binds to and results in increased activity of ESR1 protein
CTD
PMID:33049310
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions
ISO
triticonazole binds to and results in increased activity of ESR2 protein
CTD
PMID:33049310
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Fabp12
fatty acid binding protein 12
increases expression
EXP
triticonazole results in increased expression of FABP12 mRNA
CTD
PMID:33032228
NCBI chr 2:91,539,568...91,554,999
Ensembl chr 2:91,500,539...91,554,996
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Mmp14
matrix metallopeptidase 14
decreases expression
EXP
triticonazole results in decreased expression of MMP14 mRNA
CTD
PMID:33032228
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
triticonazole binds to and results in increased activity of NR1I2 protein
CTD
PMID:33049310
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
triticonazole binds to and results in increased activity of PPARG protein
CTD
PMID:33049310
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Serpinb13
serpin family B member 13
increases expression
EXP
triticonazole results in increased expression of SERPINB13 mRNA
CTD
PMID:33032228
NCBI chr13:23,118,584...23,150,760
Ensembl chr13:23,118,584...23,150,760
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Tmem255b
transmembrane protein 255B
increases expression
EXP
triticonazole results in increased expression of TMEM255B mRNA
CTD
PMID:33032228
NCBI chr16:76,079,840...76,108,179
Ensembl chr16:76,079,845...76,106,795
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