Term: | zaragozic acid C |
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Accession: | CHEBI:83934
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Definition: | A polyketide isolated from fungi that is a potent inhibitor of fungal and mammalian squalene synthase. |
Synonyms: | exact_synonym: | (1S,3S,4S,5R,6R,7R)-1-[(4R,5R)-4-acetoxy-5-methyl-6-phenylhexyl]-4,7-dihydroxy-6-{[(4E,6R)-6-methyl-9-phenylnon-4-enoyl]oxy}-2,8-dioxabicyclo[3.2.1]octane-3,4,5-tricarboxylic acid |
| related_synonym: | (+)-Zaragozic acid; Formula=C40H50O14; InChI=1S/C40H50O14/c1-25(15-12-20-28-16-6-4-7-17-28)14-10-11-22-31(42)52-33-32(43)38(53-34(35(44)45)39(50,36(46)47)40(33,54-38)37(48)49)23-13-21-30(51-27(3)41)26(2)24-29-18-8-5-9-19-29/h4-10,14,16-19,25-26,30,32-34,43,50H,11-13,15,20-24H2,1-3H3,(H,44,45)(H,46,47)(H,48,49)/b14-10+/t25-,26+,30+,32+,33+,34+,38-,39+,40-/m0/s1; InChIKey=KQMNJFMTGHRJHM-ZFSXNWTMSA-N; L-697350; SMILES=C[C@H](CCCc1ccccc1)\\C=C\\CCC(=O)O[C@@H]1[C@@H](O)[C@]2(CCC[C@@H](OC(C)=O)[C@H](C)Cc3ccccc3)O[C@@]1(C(O)=O)[C@@](O)([C@H](O2)C(O)=O)C(O)=O |
| xref: | CAS:146389-62-0; MetaCyc:CPD-4585; PMID:11031024; PMID:14613174; PMID:15635219; PMID:16941713; PMID:19053214; Reaxys:6839401 |
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