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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile
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Accession:CHEBI:83920 term browser browse the term
Definition:A member of the class of triazoles that is 1-chloro-4-(3-phenylpropyl)benzene substituted at position 3 of the propyl moiety by cyano and 1,2,4-triazol-1-ylmethyl groups.
Synonyms:exact_synonym: 4-(4-chlorophenyl)-2-phenyl-2-(1H-1,2,4-triazol-1-ylmethyl)butanenitrile
 related_synonym: Formula=C19H17ClN4;   InChI=1S/C19H17ClN4/c20-18-8-6-16(7-9-18)10-11-19(12-21,13-24-15-22-14-23-24)17-4-2-1-3-5-17/h1-9,14-15H,10-11,13H2;   InChIKey=RQDJADAKIFFEKQ-UHFFFAOYSA-N;   SMILES=Clc1ccc(CCC(Cn2cncn2)(C#N)c2ccccc2)cc1
 xref: PPDB:293


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fenbuconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actb actin, beta increases expression ISO fenbuconazole results in increased expression of ACTB mRNA CTD PMID:15942997 NCBI chr12:13,715,843...13,718,813
Ensembl chr12:13,715,843...13,718,841
JBrowse link
G C5ar1 complement C5a receptor 1 decreases expression ISO fenbuconazole results in decreased expression of C5AR1 mRNA CTD PMID:15942997 NCBI chr 1:78,186,777...78,195,132
Ensembl chr 1:78,186,776...78,195,328
JBrowse link
G Calr calreticulin increases expression ISO fenbuconazole results in increased expression of CALR mRNA CTD PMID:15942997 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Cd63 Cd63 molecule increases expression ISO fenbuconazole results in increased expression of CD63 mRNA CTD PMID:15942997 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582
JBrowse link
G Comt catechol-O-methyltransferase increases expression ISO fenbuconazole results in increased expression of COMT mRNA CTD PMID:15942997 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity ISO fenbuconazole results in decreased activity of CYP19A1 protein CTD PMID:16996190 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression
multiple interactions
ISO fenbuconazole results in increased expression of CYP2B10 protein
fenbuconazole binds to and results in increased activity of CYP2B10 protein
CTD PMID:16542693 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO fenbuconazole results in decreased expression of CYP7A1 mRNA CTD PMID:15942997 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Eef1a1 eukaryotic translation elongation factor 1 alpha 1 increases expression ISO fenbuconazole results in increased expression of EEF1A1 mRNA CTD PMID:15942997 NCBI chr 8:85,838,594...85,841,816
Ensembl chr 8:85,838,869...85,840,818
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO fenbuconazole binds to and results in increased activity of ESR1 protein CTD PMID:16626760 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO fenbuconazole binds to and results in increased activity of ESR2 protein CTD PMID:16626760 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig increases expression ISO fenbuconazole results in increased expression of FCER1G mRNA CTD PMID:15942997 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase increases expression ISO fenbuconazole results in increased expression of GAPDH mRNA CTD PMID:15942997 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO fenbuconazole results in increased expression of HSPA1A mRNA CTD PMID:15942997 NCBI chr20:4,875,834...4,881,751
Ensembl chr20:4,877,324...4,879,779
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression ISO fenbuconazole results in increased expression of HSPD1 mRNA CTD PMID:15942997 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO fenbuconazole results in decreased expression of ICAM1 mRNA CTD PMID:15942997 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression ISO fenbuconazole results in increased expression of MAPK3 mRNA CTD PMID:15942997 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO fenbuconazole results in increased expression of MMP12 mRNA CTD PMID:15942997 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mpg N-methylpurine-DNA glycosylase increases expression ISO fenbuconazole results in increased expression of MPG mRNA CTD PMID:15942997 NCBI chr10:15,661,768...15,667,995
Ensembl chr10:15,661,608...15,668,022
JBrowse link
G Msh3 mutS homolog 3 decreases expression ISO fenbuconazole results in decreased expression of MSH3 mRNA CTD PMID:15942997 NCBI chr 2:21,790,048...21,931,791
Ensembl chr 2:21,790,044...21,931,720
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO fenbuconazole results in increased activity of NR1I2 protein CTD PMID:16565514 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Oat ornithine aminotransferase increases expression ISO fenbuconazole results in increased expression of OAT mRNA CTD PMID:15942997 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO fenbuconazole results in increased expression of PLAT mRNA CTD PMID:15942997 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Pou2f1 POU class 2 homeobox 1 increases expression ISO fenbuconazole results in increased expression of POU2F1 mRNA CTD PMID:15942997 NCBI chr13:84,075,316...84,217,368
Ensembl chr13:84,083,632...84,217,366
JBrowse link
G Rpl27 ribosomal protein L27 increases expression ISO fenbuconazole results in increased expression of RPL27 mRNA CTD PMID:15942997 NCBI chr10:89,352,864...89,356,563
Ensembl chr10:89,352,835...89,356,547
JBrowse link
G Rps19 ribosomal protein S19 increases expression ISO fenbuconazole results in increased expression of RPS19 mRNA CTD PMID:15942997 NCBI chr 1:81,750,873...81,756,629
Ensembl chr 1:81,750,928...81,756,627
JBrowse link
G Rps3a ribosomal protein S3a increases expression ISO fenbuconazole results in increased expression of RPS3A mRNA CTD PMID:15942997 NCBI chr 2:185,440,477...185,444,846
Ensembl chr 2:185,440,291...185,444,897
JBrowse link
G Rps7 ribosomal protein S7 increases expression ISO fenbuconazole results in increased expression of RPS7 mRNA CTD PMID:15942997 NCBI chr 6:47,899,525...47,904,389
Ensembl chr 6:47,899,525...47,904,437
JBrowse link
G Sord sorbitol dehydrogenase increases expression ISO fenbuconazole results in increased expression of SORD mRNA CTD PMID:15942997 NCBI chr 3:114,176,127...114,207,368
Ensembl chr 3:114,176,309...114,207,366
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases expression ISO fenbuconazole results in decreased expression of SULT1A1 mRNA CTD PMID:15942997 NCBI chr 1:198,100,586...198,104,106
Ensembl chr 1:198,100,586...198,104,109
JBrowse link
G Tgfb3 transforming growth factor, beta 3 increases expression ISO fenbuconazole results in increased expression of TGFB3 mRNA CTD PMID:15942997 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Tuba1b tubulin, alpha 1B increases expression ISO fenbuconazole results in increased expression of TUBA1B mRNA CTD PMID:15942997 NCBI chr 7:140,614,746...140,617,721
Ensembl chr 7:140,614,752...140,617,721
JBrowse link
G Vmp1 vacuole membrane protein 1 increases expression ISO fenbuconazole results in increased expression of VMP1 mRNA CTD PMID:15942997 NCBI chr10:73,901,988...74,001,900
Ensembl chr10:73,902,837...74,001,895
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        pseudohalo group 2882
          cyano group 2882
            nitrile 2882
              4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile 33
                (R)-fenbuconazole + 33
                (S)-fenbuconazole + 33
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  heteroarene 16447
                                    monocyclic heteroarene 13303
                                      azole 12471
                                        triazoles 3636
                                          4-(4-chlorophenyl)-2-phenyl-2-(1,2,4-triazol-1-ylmethyl)butanenitrile 33
                                            (R)-fenbuconazole + 33
                                            (S)-fenbuconazole + 33
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.