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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:L-cysteine derivative
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Accession:CHEBI:83824 term browser browse the term
Definition:A proteinogenic amino acid derivative resulting from the formal reaction of L-cysteine at the amino group, carboxy group, or thiol group, or from the replacement of any hydrogen of L-cysteine by a heteroatom.
Synonyms:related_synonym: L-cysteine derivatives


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8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTA3 glutathione S-transferase alpha 3 affects binding ISO 8,9-dihydro-8-(S-glutathionyl)-9-hydroxyaflatoxin B1 binds to GSTA3 protein CTD PMID:8910329 NCBI chr 6:52,896,646...52,909,799
Ensembl chr 6:52,896,639...52,909,698
JBrowse link
alliin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CTSD cathepsin D multiple interactions ISO alliin affects the reaction [Isoproterenol affects the activity of CTSD protein] CTD PMID:17623887 NCBI chr11:1,752,755...1,763,927
Ensembl chr11:1,752,755...1,764,573
Ensembl chr11:1,752,755...1,764,573
JBrowse link
G FASN fatty acid synthase multiple interactions EXP alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of FASN protein] CTD PMID:29305303 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FGF2 fibroblast growth factor 2 decreases secretion
multiple interactions
EXP alliin results in decreased secretion of FGF2 protein
alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein]
CTD PMID:16351512 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO
EXP
alliin inhibits the reaction [Isoproterenol results in increased activity of HMGCR protein]
alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of HMGCR protein]
CTD PMID:16640830 PMID:29305303 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G LCAT lecithin-cholesterol acyltransferase multiple interactions ISO alliin inhibits the reaction [Isoproterenol results in decreased activity of LCAT protein] CTD PMID:16640830 NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF1 protein] CTD PMID:29305303 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 mRNA]; alliin inhibits the reaction [1,3-dichloro-2-propanol results in increased expression of SREBF2 protein] CTD PMID:29305303 NCBI chr22:41,833,105...41,907,308
Ensembl chr22:41,833,079...41,907,307
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP alliin promotes the reaction [FGF2 protein results in increased expression of TP53 protein] CTD PMID:16351512 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G VEGFA vascular endothelial growth factor A decreases secretion EXP alliin results in decreased secretion of VEGFA protein CTD PMID:16351512 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP Cilastatin inhibits the reaction [Vancomycin results in decreased expression of and affects the localization of ABCB1 protein]; Cilastatin results in increased expression of and affects the localization of ABCB1 protein CTD PMID:28549670 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G DPEP1 dipeptidase 1 decreases activity EXP Cilastatin results in decreased activity of DPEP1 protein CTD PMID:30664745 NCBI chr16:89,613,308...89,641,540
Ensembl chr16:89,613,308...89,638,456
JBrowse link
gamma-glutamyl-glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSTA4 glutathione S-transferase alpha 4 multiple interactions ISO GSTA4 protein binds to and affects the metabolism of gamma-glutamyl-glutathione CTD PMID:2619714 NCBI chr 6:52,977,952...52,995,332
Ensembl chr 6:52,977,948...52,995,304
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions ISO GSTP1 protein binds to and affects the metabolism of gamma-glutamyl-glutathione CTD PMID:2619714 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions
increases expression
ISO Glutathione promotes the reaction [Quercetin results in increased expression of ABCA1 mRNA]; Quercetin promotes the reaction [Glutathione results in increased expression of ABCA1 mRNA] CTD PMID:25204422 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 affects export ISO ABCB4 protein affects the export of Glutathione CTD PMID:11302927 NCBI chr 7:87,398,988...87,476,722
Ensembl chr 7:87,401,697...87,480,435
Ensembl chr 7:87,401,697...87,480,435
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 affects export
increases uptake
multiple interactions
increases export
affects transport
EXP
ISO
ABCC1 protein affects the export of Glutathione
ABCC1 protein results in increased uptake of Glutathione
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to arsenite]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [ABCC1 results in decreased susceptibility to monomethylarsonous acid analog]; [Glutathione binds to 10-nitro-oleic acid] promotes the reaction [ABCC1 protein results in increased export of 10-nitro-oleic acid metabolite]; [Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; [Glutathione co-treated with naringenin] inhibits the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; ABCC1 protein affects the reaction [chrysin results in increased transport of Glutathione]; ABCC1 protein affects the transport of [arsenite co-treated with Glutathione]; Apigenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]; estradiol-17 beta-glucuronide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]; Genistein promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of Antimony Potassium Tartrate]; Glutathione affects the reaction [ABCC1 protein results in increased secretion of arsenic trioxide]; Glutathione binds to and affects the folding of and affects the activity of ABCC1 protein; Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione promotes the reaction [ABCC1 protein affects the export of 4-Nitroquinoline-1-oxide analog]; Glutathione promotes the reaction [ABCC1 protein affects the transport of Bilirubin]; Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [Genistein affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin affects the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]; Glutathione promotes the reaction [naringenin results in increased activity of ABCC1 protein]; Glutathione results in increased stability of and results in decreased degradation of and affects the localization of ABCC1 protein mutant form; naringenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; PAK 104P promotes the reaction [ABCC1 protein affects the export of Glutathione]; Quercetin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the export of Glutathione]; Verapamil promotes the reaction [ABCC1 protein affects the transport of Glutathione]; Verapamil promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Vincristine inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]
[verlukast results in decreased activity of ABCC1 protein] inhibits the reaction [Arsenates results in increased export of Glutathione]
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; ABCC1 protein promotes the reaction [Nitric Oxide results in increased secretion of Glutathione]; buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]
ABCC1 protein affects the transport of Glutathione; ABCC1 protein affects the transport of Glutathione analog
CTD PMID:11278867 PMID:11306701 PMID:12018890 PMID:12485947 PMID:12504668 PMID:15161912 PMID:15245331 PMID:15498506 PMID:15561710 PMID:15579473 PMID:15581632 PMID:15766272 PMID:16679408 PMID:17272743 PMID:20584751 PMID:21856323 PMID:21918036 PMID:23542460 PMID:29158255 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions
affects abundance
affects transport
EXP
ISO
ABCC2 protein affects the transport of [5-chloromethylfluorescein co-treated with Glutathione]; Glutathione promotes the reaction [ABCC2 protein affects the export of phenethyl isothiocyanate]
ABCC2 protein affects the abundance of Glutathione
ABCC2 protein affects the transport of Glutathione
ABCC2 protein affects the transport of Glutathione analog
CTD PMID:16002050 PMID:16049127 PMID:16611851 PMID:20584751 PMID:25450747 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions EXP ABCC3 protein affects the reaction [chrysin results in increased transport of Glutathione]; Glutathione promotes the reaction [ABCC3 protein affects the transport of calcein AM] CTD PMID:15210835 PMID:21856323 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCC4 ATP binding cassette subfamily C member 4 multiple interactions
affects transport
EXP ABCC4 protein results in increased export of [2,6-dibromobenzoquinone binds to Glutathione]; ABCC4 protein results in increased export of [2,6-dichloro-(1,4)benzoquinone binds to Glutathione]; Glutathione promotes the reaction [ABCC4 protein affects the transport of calcein AM]
ABCC4 protein affects the transport of Glutathione analog
CTD PMID:15210835 PMID:20584751 PMID:28885828 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G ABCC5 ATP binding cassette subfamily C member 5 multiple interactions
affects transport
EXP ABCC5 protein affects the reaction [chrysin results in increased transport of Glutathione]
ABCC5 protein affects the transport of Glutathione analog
CTD PMID:20584751 PMID:21856323 NCBI chr 3:183,919,934...184,018,010
Ensembl chr 3:183,919,934...184,017,939
JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 multiple interactions EXP Glutathione promotes the reaction [ABCC6 protein affects the transport of calcein AM] CTD PMID:15210835 NCBI chr16:16,149,565...16,223,617
Ensembl chr16:16,148,928...16,223,522
Ensembl chr16:16,148,928...16,223,522
JBrowse link
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) multiple interactions
increases export
EXP 2',5'-dihydroxychalcone promotes the reaction [ABCG2 protein results in increased export of Glutathione]; Methotrexate inhibits the reaction [ABCG2 protein results in increased export of Glutathione] CTD PMID:20332504 NCBI chr 4:88,090,264...88,231,626
Ensembl chr 4:88,090,150...88,231,628
JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression ISO Glutathione deficiency results in increased expression of ACOX1 mRNA CTD PMID:15345336 NCBI chr17:75,941,507...75,979,199
Ensembl chr17:75,941,507...75,979,177
JBrowse link
G ACSL4 acyl-CoA synthetase long chain family member 4 increases expression ISO Glutathione deficiency results in increased expression of ACSL4 mRNA CTD PMID:15345336 NCBI chr  X:109,641,335...109,733,325
Ensembl chr  X:109,624,244...109,733,403
JBrowse link
G ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions EXP Glutathione inhibits the reaction [ADH5 protein results in increased reduction of S-Nitrosoglutathione] CTD PMID:19428350 NCBI chr 4:99,070,978...99,088,788
Ensembl chr 4:99,070,978...99,088,801
JBrowse link
G AGT angiotensinogen multiple interactions
decreases abundance
ISO
EXP
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione]
AGT protein modified form results in increased chemical synthesis of [4-oxo-2-nonenal binds to Glutathione]
AGT protein modified form results in decreased abundance of Glutathione; AGT protein results in decreased abundance of Glutathione
CTD PMID:17272743 PMID:30703374 PMID:31144504 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions ISO AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in increased abundance of Glutathione] CTD PMID:12398935 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP AIFM1 protein inhibits the reaction [arsenic acid results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Nitroprusside results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [Paraquat results in decreased reduction of Glutathione]; AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione] CTD PMID:15316071 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKAP1 A-kinase anchoring protein 1 increases expression ISO Glutathione deficiency results in increased expression of AKAP1 mRNA CTD PMID:15345336 NCBI chr17:57,085,246...57,121,344
Ensembl chr17:57,085,092...57,121,346
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B increases glutathionylation
increases reduction
affects binding
EXP Glutathione results in increased glutathionylation of AKR1B1 protein modified form
Glutathione results in increased reduction of AKR1B1 protein modified form
AKR1B1 protein binds to Glutathione
CTD PMID:11306073 PMID:19061876 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKR1D1 aldo-keto reductase family 1 member D1 increases expression ISO Glutathione deficiency results in increased expression of AKR1D1 mRNA CTD PMID:15345336 NCBI chr 7:138,076,459...138,118,305
Ensembl chr 7:138,002,324...138,118,305
JBrowse link
G AKR7A2 aldo-keto reductase family 7 member A2 increases expression
multiple interactions
ISO
EXP
Glutathione deficiency results in increased expression of AKR7A2 mRNA
AKR7A2 protein inhibits the reaction [Vitamin K 3 results in decreased abundance of Glutathione]
CTD PMID:15345336 PMID:22001351 NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,146
Ensembl chr 1:19,303,965...19,312,146
JBrowse link
G AKR7A3 aldo-keto reductase family 7 member A3 increases expression ISO Glutathione deficiency results in increased expression of AKR7A3 mRNA CTD PMID:15345336 PMID:20621112 NCBI chr 1:19,274,229...19,289,362
Ensembl chr 1:19,282,573...19,288,770
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of AKT1 protein] CTD PMID:17640567 PMID:24015256 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions ISO Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of ALAD protein] CTD PMID:21620807 NCBI chr 9:113,386,312...113,401,301
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALB albumin multiple interactions EXP [4,4'-diphenylmethane diisocyanate co-treated with Glutathione] binds to and results in increased metabolism of ALB protein CTD PMID:23791970 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALDH1A1 aldehyde dehydrogenase 1 family member A1 increases expression ISO Glutathione deficiency results in increased expression of ALDH1A1 mRNA CTD PMID:20621112 NCBI chr 9:72,900,671...72,953,053
Ensembl chr 9:72,900,671...73,080,442
JBrowse link
G AP2M1 adaptor related protein complex 2 subunit mu 1 increases expression ISO Glutathione deficiency results in increased expression of AP2M1 mRNA CTD PMID:15345336 NCBI chr 3:184,174,855...184,184,091
Ensembl chr 3:184,174,689...184,184,091
JBrowse link
G APLP2 amyloid beta precursor like protein 2 increases expression ISO Glutathione deficiency results in increased expression of APLP2 mRNA CTD PMID:15345336 NCBI chr11:130,069,894...130,144,805
Ensembl chr11:130,068,147...130,144,811
JBrowse link
G APOA1 apolipoprotein A1 multiple interactions ISO [Glutathione co-treated with Quercetin] promotes the reaction [APOA1 protein results in increased export of Cholesterol] CTD PMID:25204422 NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622
Ensembl chr11:116,835,751...116,837,622
JBrowse link
G APOE apolipoprotein E decreases abundance
multiple interactions
ISO APOE gene mutant form results in decreased abundance of Glutathione
notoginsenoside R1 inhibits the reaction [APOE gene mutant form results in decreased abundance of Glutathione]
CTD PMID:24933211 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393
JBrowse link
G APP amyloid beta precursor protein decreases abundance
multiple interactions
ISO APP protein modified form results in decreased abundance of Glutathione
vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]
resveratrol inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]
CTD PMID:25654502 PMID:29545167 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AS3MT arsenite methyltransferase multiple interactions
affects folding
ISO
EXP
Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenic acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of arsenous acid]; Glutathione affects the reaction [AS3MT protein affects the metabolism of dimethylarsine]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine oxide]; Glutathione affects the reaction [AS3MT protein results in increased chemical synthesis of trimethylarsine]
Glutathione affects the folding of AS3MT protein
Glutathione promotes the reaction [[AS3MT protein polymorphism results in increased metabolism of arsenite] which results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein binds to and results in increased methylation of arsenite]; Glutathione promotes the reaction [AS3MT protein binds to S-Adenosylmethionine]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of dimethylarsinous acid]; Glutathione promotes the reaction [AS3MT protein results in increased chemical synthesis of methylarsonite]; Glutathione promotes the reaction [AS3MT protein results in increased methylation of arsenite]; Glutathione results in increased reduction of and affects the folding of AS3MT protein
CTD PMID:15606138 PMID:22868225 PMID:22955273 PMID:25349987 NCBI chr10:102,869,470...102,901,899
Ensembl chr10:102,869,470...102,901,899
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions EXP Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [Camptothecin results in increased expression of ATF4 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein] CTD PMID:24515801 PMID:30266318 NCBI chr22:39,514,494...39,522,686
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions ISO SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form] CTD PMID:27349771 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070
JBrowse link
G ATG5 autophagy related 5 multiple interactions
affects abundance
ISO [ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]; [ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione; ATG5 protein affects the reaction [Acetaminophen affects the abundance of Glutathione]
ATG5 protein affects the abundance of Glutathione
CTD PMID:22491424 NCBI chr 6:106,184,476...106,325,789
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G ATG7 autophagy related 7 multiple interactions EXP Glutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein] CTD PMID:29247770 NCBI chr 3:11,272,348...11,564,652
Ensembl chr 3:11,272,309...11,557,665
JBrowse link
G ATP1B1 ATPase Na+/K+ transporting subunit beta 1 increases expression ISO Glutathione deficiency results in increased expression of ATP1B1 mRNA CTD PMID:20621112 NCBI chr 1:169,106,690...169,132,719
Ensembl chr 1:169,105,697...169,132,722
JBrowse link
G ATP7B ATPase copper transporting beta decreases abundance
multiple interactions
EXP ATP7B gene mutant form results in decreased abundance of Glutathione
Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Zinc Sulfate inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]
CTD PMID:24368744 NCBI chr13:51,932,669...52,012,130
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP
ISO
Glutathione results in increased expression of BAX protein
Glutathione inhibits the reaction [Acrolein results in increased expression of BAX protein]
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased expression of BAX protein]
CTD PMID:10897038 PMID:21621595 PMID:24036456 PMID:24376112 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases export
EXP
ISO
Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in decreased expression of BCL2 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]
[diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of BCL2 mRNA; Glutathione inhibits the reaction [Acrolein results in decreased expression of BCL2 protein]
BCL2 protein results in decreased export of Glutathione
CTD PMID:15561710 PMID:17640567 PMID:22564015 PMID:24036456 PMID:24376112 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions EXP Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]] CTD PMID:17640567 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL3 BCL3 transcription coactivator decreases expression ISO Glutathione deficiency results in decreased expression of BCL3 mRNA CTD PMID:20621112 NCBI chr19:44,742,620...44,760,044
Ensembl chr19:44,747,705...44,760,044
JBrowse link
G BDH2 3-hydroxybutyrate dehydrogenase 2 increases expression ISO Glutathione deficiency results in increased expression of BDH2 mRNA CTD PMID:20621112 NCBI chr 4:103,077,592...103,099,862
Ensembl chr 4:103,077,592...103,099,870
JBrowse link
G BIRC2 baculoviral IAP repeat containing 2 multiple interactions EXP Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]] CTD PMID:17640567 NCBI chr11:102,347,214...102,378,670
Ensembl chr11:102,347,211...102,378,670
JBrowse link
G BIRC3 baculoviral IAP repeat containing 3 multiple interactions EXP Glutathione inhibits the reaction [Thimerosal results in decreased expression of BIRC3 protein] CTD PMID:12140745 NCBI chr11:102,317,373...102,339,403
Ensembl chr11:102,317,450...102,339,403
JBrowse link
G BMI1 BMI1 proto-oncogene, polycomb ring finger increases abundance EXP BMI1 protein results in increased abundance of Glutathione CTD PMID:21445297 NCBI chr10:22,321,099...22,331,484
Ensembl chr10:22,321,099...22,331,484
JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions ISO Glutathione inhibits the reaction [manganese chloride results in increased expression of BNIP3 protein] CTD PMID:19442826 NCBI chr10:131,967,683...131,982,013
Ensembl chr10:131,966,455...131,982,013
JBrowse link
G BST2 bone marrow stromal cell antigen 2 decreases expression ISO Glutathione deficiency results in decreased expression of BST2 mRNA CTD PMID:20621112 NCBI chr19:17,402,939...17,405,630
Ensembl chr19:17,402,939...17,405,630
JBrowse link
G C5 complement C5 decreases expression ISO Glutathione deficiency results in decreased expression of C5 mRNA CTD PMID:20621112 NCBI chr 9:120,952,335...121,074,865
Ensembl chr 9:120,952,335...121,050,275
Ensembl chr 9:120,952,335...121,050,275
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
EXP
ISO
[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of CASP3 protein]; Glutathione inhibits the reaction [aristolochic acid I results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Curcumin results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP3 protein]
Glutathione results in increased activity of CASP3 protein
Glutathione inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Glutathione inhibits the reaction [JP8 aviation fuel results in increased activity of CASP3 protein]
Glutathione inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein]
CTD PMID:10385654 PMID:11969376 PMID:12140745 PMID:14660655 PMID:15683462 PMID:17640567 PMID:21300145 PMID:21621595 PMID:24036456 PMID:24376112 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP6 caspase 6 increases expression ISO Glutathione deficiency results in increased expression of CASP6 mRNA CTD PMID:15345336 NCBI chr 4:109,688,628...109,703,445
Ensembl chr 4:109,688,622...109,703,583
JBrowse link
G CASP7 caspase 7 multiple interactions EXP Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP7 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein] CTD PMID:24515801 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 multiple interactions ISO
EXP
Glutathione inhibits the reaction [Acrolein results in increased expression of CASP8 protein]
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of CASP8 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein]
CTD PMID:24376112 PMID:24515801 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione inhibits the reaction [Thimerosal results in increased activity of CASP9 protein] CTD PMID:12140745 PMID:18594523 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases response to substance
ISO [INS1 protein co-treated with Glutathione] affects the activity of CAT protein; [Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of CAT mRNA; CAT inhibits the reaction [Buthionine Sulfoximine results in decreased abundance of Glutathione]; CAT protein inhibits the reaction [casiopeina II results in decreased abundance of Glutathione]
CAT protein results in decreased susceptibility to Glutathione
Glutathione inhibits the reaction [diphenyldiselenide results in decreased activity of CAT protein]; Glutathione inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]; Glutathione inhibits the reaction [tetrabromobisphenol A results in decreased activity of CAT protein]
CTD PMID:19419996 PMID:20580664 PMID:21354300 PMID:21620807 PMID:25362599 PMID:26187465 PMID:27718046 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAV2 caveolin 2 increases expression ISO Glutathione deficiency results in increased expression of CAV2 mRNA CTD PMID:20621112 NCBI chr 7:116,499,738...116,508,541
Ensembl chr 7:116,287,380...116,508,541
JBrowse link
G CBR3 carbonyl reductase 3 multiple interactions ISO [GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein CTD PMID:25446851 NCBI chr21:36,134,901...36,146,562
Ensembl chr21:36,135,079...36,146,562
JBrowse link
G CBS cystathionine beta-synthase decreases abundance ISO CBS gene mutant form results in decreased abundance of Glutathione CTD PMID:15016621 NCBI chr21:43,053,190...43,076,873
Ensembl chr21:43,053,191...43,076,943
JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL2 protein] CTD PMID:10919993 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL20 C-C motif chemokine ligand 20 decreases expression EXP Glutathione results in decreased expression of CCL20 mRNA CTD PMID:22385246 NCBI chr 2:227,813,842...227,817,556
Ensembl chr 2:227,805,739...227,817,564
JBrowse link
G CCL5 C-C motif chemokine ligand 5 multiple interactions EXP Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Dermatophagoides pteronyssinus antigen p 1 results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Particulate Matter analog results in increased secretion of CCL5 protein]; Glutathione inhibits the reaction [Vehicle Emissions analog results in increased secretion of CCL5 protein] CTD PMID:10919993 NCBI chr17:35,871,491...35,880,360
Ensembl chr17:35,871,491...35,880,793
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]] CTD PMID:17640567 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CD14 CD14 molecule increases expression ISO Glutathione deficiency results in increased expression of CD14 mRNA CTD PMID:15345336 NCBI chr 5:140,631,732...140,633,701
Ensembl chr 5:140,631,728...140,633,701
JBrowse link
G CD36 CD36 molecule multiple interactions
decreases expression
ISO [GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein
Glutathione results in decreased expression of CD36 protein
CTD PMID:26187465 NCBI chr 7:80,602,207...80,679,277
Ensembl chr 7:80,369,575...80,679,277
JBrowse link
G CD40LG CD40 ligand multiple interactions EXP Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein] CTD PMID:27634759 NCBI chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
Ensembl chr  X:136,648,158...136,660,390
JBrowse link
G CD86 CD86 molecule multiple interactions EXP Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein]; Glutathione inhibits the reaction [Thimerosal results in increased expression of CD86 protein] CTD PMID:20457211 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139
JBrowse link
G CDC25B cell division cycle 25B multiple interactions EXP [CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate CTD PMID:20025242 NCBI chr20:3,786,951...3,806,118
Ensembl chr20:3,786,772...3,806,121
JBrowse link
G CDC25C cell division cycle 25C multiple interactions EXP [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate CTD PMID:20025242 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,265...138,338,355
JBrowse link
G CDK4 cyclin dependent kinase 4 increases expression ISO Glutathione deficiency results in increased expression of CDK4 mRNA CTD PMID:15345336 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions EXP Glutathione inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein] CTD PMID:22927544 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CDO1 cysteine dioxygenase type 1 increases abundance ISO CDO1 protein results in increased abundance of Glutathione CTD PMID:23665415 NCBI chr 5:115,804,733...115,816,659
Ensembl chr 5:115,804,733...115,816,659
JBrowse link
G CEBPB CCAAT enhancer binding protein beta multiple interactions ISO Glutathione inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA] CTD PMID:21220312 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CFTR CF transmembrane conductance regulator multiple interactions
affects export
decreases activity
EXP
ISO
[Bicarbonates co-treated with Glutathione co-treated with Ascorbic Acid] results in increased activity of CFTR protein; [Glutathione co-treated with Diamide] results in decreased activity of CFTR protein; Dithiothreitol inhibits the reaction [Glutathione results in decreased activity of CFTR protein]; Ethylmaleimide inhibits the reaction [Glutathione results in decreased activity of CFTR protein]
CFTR protein affects the export of Glutathione
Glutathione analog results in decreased activity of CFTR protein
CTD PMID:15561710 PMID:15657297 PMID:15857825 PMID:32374624 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of CHUK protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of CHUK protein]] CTD PMID:17067557 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CLDN4 claudin 4 multiple interactions ISO Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 mRNA]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 7:73,830,996...73,832,690
Ensembl chr 7:73,799,542...73,832,693
Ensembl chr 7:73,799,542...73,832,693
JBrowse link
G CLU clusterin increases expression ISO Glutathione deficiency results in increased expression of CLU mRNA CTD PMID:15345336 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G CNTF ciliary neurotrophic factor multiple interactions EXP Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]] CTD PMID:16896058 NCBI chr11:58,622,665...58,625,733
Ensembl chr11:58,622,665...58,625,733
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression ISO Glutathione deficiency results in increased expression of CPT1A mRNA CTD PMID:15345336 NCBI chr11:68,754,620...68,844,410
Ensembl chr11:68,754,620...68,844,410
JBrowse link
G CREG1 cellular repressor of E1A stimulated genes 1 increases expression ISO Glutathione deficiency results in increased expression of CREG1 mRNA CTD PMID:20621112 NCBI chr 1:167,541,013...167,553,762
Ensembl chr 1:167,529,117...167,553,805
JBrowse link
G CRYAB crystallin alpha B multiple interactions ISO Glutathione inhibits the reaction [arsenite results in increased expression of CRYAB protein] CTD PMID:15175009 NCBI chr11:111,908,564...111,923,740
Ensembl chr11:111,908,564...111,923,722
JBrowse link
G CTPS1 CTP synthase 1 increases expression ISO Glutathione deficiency results in increased expression of CTPS mRNA CTD PMID:20621112 NCBI chr 1:40,979,696...41,012,565
Ensembl chr 1:40,979,688...41,012,565
JBrowse link
G CXCL1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
ISO Glutathione deficiency results in decreased expression of CXCL1 mRNA
Glutathione deficiency promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of CXCL1 protein]
CTD PMID:20621112 PMID:26149495 NCBI chr 4:73,869,393...73,871,308
Ensembl chr 4:73,869,393...73,871,308
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
decreases abundance
decreases expression
EXP Benzo(a)pyrene promotes the reaction [CXCL8 protein results in decreased abundance of Glutathione]; Glutathione analog inhibits the reaction [Ozone results in increased expression of CXCL8 protein]; Glutathione inhibits the reaction [[Particulate Matter analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CXCL8 protein]; Glutathione inhibits the reaction [[Vehicle Emissions analog co-treated with Dermatophagoides pteronyssinus antigen p 1] results in increased secretion of CXCL8 protein]; Glutathione inhibits the reaction [acetylleucyl-leucyl-norleucinal results in increased expression of CXCL8 mRNA]; Glutathione inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of CXCL8 mRNA]; Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased secretion of CXCL8 protein]; Glutathione inhibits the reaction [Ethylmercuric Chloride results in increased secretion of CXCL8 protein]; Glutathione inhibits the reaction [lactacystin results in increased expression of CXCL8 mRNA]; Glutathione inhibits the reaction [MG 262 results in increased expression of CXCL8 mRNA]; Glutathione inhibits the reaction [Particulate Matter analog results in increased secretion of CXCL8 protein]; Glutathione inhibits the reaction [Thimerosal results in increased secretion of CXCL8 protein]; Glutathione inhibits the reaction [Vehicle Emissions analog results in increased secretion of CXCL8 protein]
Glutathione results in decreased expression of CXCL8 mRNA
CTD PMID:10919993 PMID:12208513 PMID:15379216 PMID:20457211 PMID:22385246 PMID:28238931 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP [[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein CTD PMID:21621595 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO
EXP
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of CYP1A1 mRNA; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
[CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac
CTD PMID:18078826 PMID:21094198 PMID:24246759 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP [CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP1A2 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP1A2 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [myristicin results in decreased activity of CYP1A2 protein] CTD PMID:20825217 PMID:24246759 PMID:26091900 PMID:31102647 PMID:32198085 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 multiple interactions EXP [CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; CYP1B1 protein affects the metabolism of [2-hydroxyestradiol co-treated with Glutathione]; CYP1B1 protein affects the metabolism of [4-hydroxyestradiol co-treated with Glutathione] CTD PMID:14679015 PMID:24246759 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 multiple interactions EXP [CYP2A6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac CTD PMID:24246759 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions EXP [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2B6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] CTD PMID:24246759 PMID:32198085 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2C18 cytochrome P450 family 2 subfamily C member 18 multiple interactions EXP [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac CTD PMID:24246759 NCBI chr10:94,683,729...94,736,190
Ensembl chr10:94,683,729...94,736,190
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 multiple interactions EXP [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2C19 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol] CTD PMID:24246759 PMID:31102647 PMID:32198085 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C8 cytochrome P450 family 2 subfamily C member 8 multiple interactions EXP [CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac CTD PMID:24246759 NCBI chr10:95,036,772...95,069,497
Ensembl chr10:95,036,772...95,069,497
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 multiple interactions EXP [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2C9 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione affects the reaction [CYP2C9 protein results in increased hydroxylation of bromfenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac] CTD PMID:24246759 PMID:31815452 PMID:32198085 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions EXP [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2D6 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP2D6 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP2D6 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [notopterol results in decreased activity of CYP2D6 protein] CTD PMID:20825217 PMID:24246759 PMID:31102647 PMID:32198085 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,881
Ensembl chr22:42,126,499...42,130,881
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP
ISO
[CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2E1 protein results in increased metabolism of Ethanol] which results in decreased abundance of Glutathione; [CYP2E1 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Glutathione inhibits the reaction [CYP2E1 protein results in increased susceptibility to Styrene]
Glutathione inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein]
1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; [[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde; [Glutathione co-treated with [CYP2E1 protein results in increased metabolism of Phenol]] results in increased chemical synthesis of [Glutathione binds to hydroquinone metabolite]
CTD PMID:8211999 PMID:10573527 PMID:16872732 PMID:21842885 PMID:24246759 PMID:28803762 PMID:32198085 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 multiple interactions EXP [CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac CTD PMID:24246759 NCBI chr 1:59,893,308...59,926,773
Ensembl chr 1:59,893,308...59,926,773
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions
affects binding
EXP [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A4 protein co-treated with NADP co-treated with Glutathione] results in increased glutathionylation of and results in increased activity of 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-(1,2,4)triazolo(4,3-b)pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine; [CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione; [CYP3A4 protein results in increased metabolism of chelidonine] which results in increased abundance of Glutathione analog; [CYP3A4 protein results in increased metabolism of notopterol] promotes the reaction [Glutathione binds to notopterol]; Acetylcysteine inhibits the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; Buthionine Sulfoximine promotes the reaction [[CYP3A4 protein co-treated with neferine] results in decreased abundance of Glutathione]; CYP3A4 protein promotes the reaction [Acetaminophen results in decreased abundance of Glutathione]; Glutathione affects the reaction [CYP3A4 protein binds to 1-pyrenebutanol]; Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Glutathione affects the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxyquinoline]; Glutathione inhibits the reaction [Saquinavir results in decreased activity of CYP3A4 protein]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; neferine promotes the reaction [[CYP3A4 protein co-treated with Buthionine Sulfoximine] results in decreased abundance of Glutathione]
Glutathione binds to CYP3A4 protein
CTD PMID:15523003 PMID:18206979 PMID:20825217 PMID:24246759 PMID:25451576 PMID:27485346 PMID:31102647 PMID:32198085 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G CYP3A5 cytochrome P450 family 3 subfamily A member 5 multiple interactions EXP [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; CYP3A5 protein promotes the reaction [tetrandrine results in decreased abundance of Glutathione] CTD PMID:24246759 PMID:26302866 NCBI chr 7:99,648,194...99,679,996
Ensembl chr 7:99,648,194...99,679,998
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP
ISO
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Dinitrochlorobenzene results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of DDIT3 mRNA]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein]
Glutathione inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein]
CTD PMID:17171638 PMID:20493918 PMID:24515801 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DECR1 2,4-dienoyl-CoA reductase 1 increases expression ISO Glutathione deficiency results in increased expression of DECR1 mRNA CTD PMID:15345336 NCBI chr 8:90,001,437...90,053,633
Ensembl chr 8:90,001,405...90,053,633
JBrowse link
G DECR2 2,4-dienoyl-CoA reductase 2 increases expression ISO Glutathione deficiency results in increased expression of DECR2 mRNA CTD PMID:15345336 NCBI chr16:401,885...412,482
Ensembl chr16:401,858...412,487
JBrowse link
G DEFB4A defensin beta 4A decreases expression EXP Glutathione results in decreased expression of DEFB4A mRNA CTD PMID:22385246 NCBI chr 8:7,894,677...7,896,716
Ensembl chr 8:7,894,677...7,896,716
Ensembl chr 8:7,894,677...7,896,716
Ensembl chr 8:7,894,677...7,896,716
JBrowse link
G DEK DEK proto-oncogene decreases chemical synthesis EXP DEK protein results in decreased chemical synthesis of Glutathione CTD PMID:28558019 NCBI chr 6:18,223,860...18,264,541
Ensembl chr 6:18,223,860...18,264,548
JBrowse link
G DGAT1 diacylglycerol O-acyltransferase 1 multiple interactions ISO Glutathione inhibits the reaction [Alcohols results in increased expression of DGAT1 protein] CTD PMID:28803762 NCBI chr 8:144,314,584...144,326,852
Ensembl chr 8:144,314,584...144,326,910
JBrowse link
G DIO1 iodothyronine deiodinase 1 increases expression ISO Glutathione deficiency results in increased expression of DIO1 mRNA CTD PMID:15345336 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
JBrowse link
G DLG4 discs large MAGUK scaffold protein 4 multiple interactions EXP Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of DLG4 protein] CTD PMID:27624276 PMID:28153600 NCBI chr17:7,187,187...7,220,050
Ensembl chr17:7,189,890...7,219,841
Ensembl chr17:7,189,890...7,219,841
Ensembl chr17:7,189,890...7,219,841
JBrowse link
G DUSP1 dual specificity phosphatase 1 multiple interactions ISO Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 mRNA]; Glutathione inhibits the reaction [Cadmium results in increased expression of DUSP1 protein] CTD PMID:18573614 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G EGF epidermal growth factor affects abundance ISO EGF protein affects the abundance of Glutathione CTD PMID:10544272 NCBI chr 4:109,912,883...110,013,766
Ensembl chr 4:109,912,883...110,013,766
JBrowse link
G EGFR epidermal growth factor receptor multiple interactions EXP
ISO
Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased phosphorylation of EGFR protein]
[Acetaminophen results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein; [phorone results in decreased abundance of Glutathione] which results in increased phosphorylation of and results in increased activity of EGFR protein
CTD PMID:14660655 PMID:28123000 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628
JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 decreases expression ISO Glutathione deficiency results in decreased expression of EIF2AK2 mRNA CTD PMID:20621112 NCBI chr 2:37,099,210...37,157,065
Ensembl chr 2:37,099,210...37,157,065
Ensembl chr 2:37,099,210...37,157,065
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions EXP Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2AK3 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] CTD PMID:24515801 PMID:30266318 NCBI chr 2:88,556,741...88,627,464
Ensembl chr 2:88,556,741...88,627,464
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions EXP Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of EIF2S1 protein] CTD PMID:30266318 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,151...67,386,516
Ensembl chr14:67,360,151...67,386,516
JBrowse link
G EPAS1 endothelial PAS domain protein 1 multiple interactions EXP Glutathione inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein] CTD PMID:23958427 NCBI chr 2:46,297,407...46,386,697
Ensembl chr 2:46,293,667...46,386,697
JBrowse link
G EPHX1 epoxide hydrolase 1 increases expression ISO Glutathione deficiency results in increased expression of EPHX1 mRNA CTD PMID:15345336 NCBI chr 1:225,810,124...225,845,563
Ensembl chr 1:225,810,092...225,845,563
Ensembl chr 1:225,810,092...225,845,563
JBrowse link
G EPO erythropoietin multiple interactions ISO
EXP
EPO protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]
EPO protein inhibits the reaction [Cisplatin results in decreased abundance of Glutathione]
CTD PMID:16405037 PMID:22013135 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G EXTL1 exostosin like glycosyltransferase 1 decreases expression ISO Glutathione deficiency results in decreased expression of EXTL1 mRNA CTD PMID:20621112 NCBI chr 1:26,021,775...26,036,464
Ensembl chr 1:26,019,884...26,036,464
JBrowse link
G F3 coagulation factor III, tissue factor increases activity EXP Glutathione results in increased activity of F3 protein CTD PMID:17726162 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FAHD1 fumarylacetoacetate hydrolase domain containing 1 decreases expression ISO Glutathione deficiency results in decreased expression of FAHD1 mRNA CTD PMID:20621112 NCBI chr16:1,827,224...1,840,207
Ensembl chr16:1,826,941...1,840,207
JBrowse link
G FAS Fas cell surface death receptor multiple interactions
affects chemical synthesis
ISO [FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; FAS protein affects the reaction [Acetaminophen affects the chemical synthesis of Glutathione]; Glutathione promotes the reaction [FAS protein results in increased activity of CASP3 protein]
FAS protein affects the chemical synthesis of Glutathione
CTD PMID:10385654 PMID:23628456 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FASLG Fas ligand decreases abundance
multiple interactions
EXP
ISO
FASL protein results in decreased abundance of Glutathione
Glutathione inhibits the reaction [Acrolein results in increased expression of FASL protein]
verlukast promotes the reaction [FASL protein results in decreased abundance of Glutathione]
CTD PMID:17724027 PMID:24376112 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FASN fatty acid synthase decreases expression
multiple interactions
ISO Glutathione deficiency results in decreased expression of FASN mRNA
Glutathione inhibits the reaction [Alcohols results in increased expression of FASN protein]
CTD PMID:20621112 PMID:28803762 NCBI chr17:82,078,338...82,098,303
Ensembl chr17:82,078,338...82,098,294
JBrowse link
G FGF1 fibroblast growth factor 1 multiple interactions ISO 2-tert-butylhydroquinone promotes the reaction [FGF1 protein results in increased abundance of and results in increased secretion of Glutathione]; FGF1 protein results in increased abundance of and results in increased secretion of Glutathione CTD PMID:16524372 NCBI chr 5:142,592,178...142,698,070
Ensembl chr 5:142,592,178...142,698,070
JBrowse link
G FN1 fibronectin 1 multiple interactions ISO [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of and results in increased secretion of FN1 protein]; [S-ethyl glutathione results in increased abundance of Glutathione] inhibits the reaction [manganese chloride results in increased expression of FN1 mRNA] CTD PMID:19524604 NCBI chr 2:215,360,862...215,436,167
Ensembl chr 2:215,360,440...215,436,073
JBrowse link
G FNDC5 fibronectin type III domain containing 5 multiple interactions
increases abundance
ISO FNDC5 protein inhibits the reaction [AGT protein modified form results in decreased abundance of Glutathione]
FNDC5 protein results in increased abundance of Glutathione
CTD PMID:30703374 PMID:32165127 NCBI chr 1:32,862,268...32,872,484
Ensembl chr 1:32,862,268...32,872,482
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Glutathione affects the reaction [Sodium Selenite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOS mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of FOS mRNA] CTD PMID:15105052 PMID:15520183 PMID:18449455 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSL1 FOS like 1, AP-1 transcription factor subunit multiple interactions ISO Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA] CTD PMID:15520183 NCBI chr11:65,892,049...65,900,545
Ensembl chr11:65,892,049...65,900,573
JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions ISO Glutathione inhibits the reaction [sodium arsenite results in decreased expression of FSHB protein] CTD PMID:20580664 NCBI chr11:30,231,014...30,235,194
Ensembl chr11:30,231,016...30,235,261
Ensembl chr11:30,231,016...30,235,261
JBrowse link
G FTH1 ferritin heavy chain 1 multiple interactions EXP Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of FTH1 mRNA] CTD PMID:16631525 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G FTL ferritin light chain multiple interactions ISO Glutathione inhibits the reaction [arsenite results in increased expression of FTL1 protein] CTD PMID:15175009 NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879
JBrowse link
G FYN FYN proto-oncogene, Src family tyrosine kinase multiple interactions EXP Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of FYN protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of FYN protein] CTD PMID:14572611 NCBI chr 6:111,660,332...111,873,452
Ensembl chr 6:111,660,332...111,873,452
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase multiple interactions ISO
EXP
Glutathione inhibits the reaction [Quartz results in decreased activity of G6PDX protein]
Glutathione inhibits the reaction [Asbestos, Amosite results in decreased activity of G6PD protein]
Glutathione inhibits the reaction [Oxygen deficiency results in increased expression of G6PD mRNA]
CTD PMID:14613721 PMID:15225644 PMID:18370412 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP
ISO
[Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone binds to GAPDH protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] promotes the reaction [1,2-naphthoquinone results in decreased activity of GAPDH protein]; [GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog; Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; Glutathione results in increased metabolism of and results in increased activity of GAPDH protein modified form; NAD analog inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]; NADP inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog]
Glutathione inhibits the reaction [arsenite results in decreased expression of GAPDH protein]
CTD PMID:15175009 PMID:15788719 PMID:21827172 NCBI chr12:6,534,517...6,538,371
Ensembl chr12:6,534,512...6,538,374
JBrowse link
G GCH1 GTP cyclohydrolase 1 increases expression ISO Glutathione deficiency results in increased expression of GCH1 mRNA CTD PMID:15345336 NCBI chr14:54,842,016...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions
increases abundance
increases expression
affects chemical synthesis
EXP
ISO
[[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Chenodeoxycholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [GCLC results in increased abundance of Glutathione] which results in decreased susceptibility to Cadmium Chloride; [Ginkgo biloba extract results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLC protein] which results in increased abundance of Glutathione]; GCLC protein inhibits the reaction [buthionine sulfoximine ethyl ester promotes the reaction [ABCC1 protein results in increased export of Glutathione]]
GCLC mRNA results in increased abundance of Glutathione; GCLC protein results in increased abundance of Glutathione
[2-tert-butylhydroquinone results in increased activity of GCLC protein] which results in increased abundance of Glutathione; [Buthionine Sulfoximine results in decreased activity of GCLC protein] inhibits the reaction [indenoindole results in increased abundance of Glutathione]; [Buthionine Sulfoximine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [Cysteamine results in decreased activity of GCLC protein] which results in decreased abundance of Glutathione; [FAS protein results in increased expression of GCLC mRNA] which results in increased chemical synthesis of Glutathione; [FAS protein results in increased expression of GCLC protein] which results in increased chemical synthesis of Glutathione; [GCLC mRNA results in increased abundance of Glutathione] which results in decreased expression of CD36 protein; [KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione]; GCLC protein inhibits the reaction [Hydrogen Peroxide results in decreased abundance of Glutathione]; GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]
Glutathione deficiency results in increased expression of GCLC mRNA
GCLC polymorphism affects the chemical synthesis of Glutathione
[HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione
CTD PMID:7955076 PMID:10544272 PMID:11673643 PMID:12504668 PMID:14978233 PMID:15282320 PMID:15345336 PMID:15707499 PMID:16599007 PMID:17724089 PMID:18556457 PMID:19914271 PMID:20159942 PMID:20621112 PMID:21728338 PMID:21833590 PMID:22762311 PMID:23628456 PMID:26187465 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit multiple interactions
increases abundance
increases chemical synthesis
affects response to substance
affects metabolic processing
decreases abundance
increases expression
EXP
ISO
[Chenodeoxycholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; [Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[Lithocholic Acid results in increased expression of GCLM protein] which results in increased abundance of Glutathione]; GCLM gene SNP results in decreased chemical synthesis of and results in decreased abundance of Glutathione
GCLM gene SNP results in increased abundance of Glutathione
GCLM protein results in increased chemical synthesis of Glutathione
GCLM protein affects the susceptibility to Glutathione
GCLM protein affects the metabolism of Glutathione
GCLM gene mutant form results in decreased abundance of Glutathione; GCLM protein mutant form results in decreased abundance of Glutathione
Glutathione deficiency results in increased expression of GCLM mRNA
[GCLM gene mutant form results in decreased abundance of Glutathione] which results in decreased susceptibility to Benzo(a)pyrene; [GCLM gene mutant form results in decreased abundance of Glutathione] which results in increased expression of CBR3 protein; GCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]
CTD PMID:12975258 PMID:15345336 PMID:17584759 PMID:17724089 PMID:20159942 PMID:20417186 PMID:20621112 PMID:22253057 PMID:23135907 PMID:23704229 PMID:24107266 PMID:25446851 PMID:32715377 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GGT1 gamma-glutamyltransferase 1 multiple interactions ISO [acivicin results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; [hexylglutathione results in decreased activity of GGT1 protein] which results in decreased susceptibility to Glutathione; GGT1 protein affects the reaction [acetaminophen cysteine results in decreased abundance of Glutathione] CTD PMID:15629191 PMID:19419996 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
JBrowse link
G GLRX glutaredoxin multiple interactions EXP
ISO
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]]
[GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]
CTD PMID:12680778 PMID:20025242 PMID:24451382 NCBI chr 5:95,813,849...95,822,726
Ensembl chr 5:95,751,319...95,822,726
JBrowse link
G GLRX3 glutaredoxin 3 multiple interactions EXP [frenolicin B results in decreased activity of GLRX3 protein] which results in decreased abundance of Glutathione CTD PMID:30661989 NCBI chr10:130,136,391...130,182,877
Ensembl chr10:130,136,391...130,184,521
JBrowse link
G GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase decreases expression ISO Glutathione deficiency results in decreased expression of GNE mRNA CTD PMID:20621112 NCBI chr 9:36,214,441...36,277,056
Ensembl chr 9:36,214,441...36,277,056
Ensembl chr 9:36,214,441...36,277,056
JBrowse link
G GNL3 G protein nucleolar 3 increases expression ISO Glutathione deficiency results in increased expression of GNL3 mRNA CTD PMID:20621112 NCBI chr 3:52,685,920...52,694,497
Ensembl chr 3:52,681,156...52,694,497
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO [GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; GPX1 protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] CTD PMID:16636302 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GSK3B glycogen synthase kinase 3 beta increases abundance EXP GSK3B protein mutant form results in increased abundance of Glutathione CTD PMID:25246272 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
Ensembl chr 3:119,821,323...120,094,417
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
decreases activity
affects activity
increases expression
EXP
ISO
[CDC25B protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate; [CDC25C protein co-treated with GLRX protein co-treated with GSR protein co-treated with Glutathione] results in increased reduction of sodium arsenate
Glutathione results in decreased activity of GSR protein
Glutathione inhibits the reaction [Chlorpyrifos results in decreased activity of GSR protein]
Glutathione deficiency affects the activity of GSR protein
Glutathione deficiency results in increased expression of GSR mRNA
1'-acetoxychavicol acetate analog inhibits the reaction [GSR protein results in increased reduction of Glutathione]; AGT protein promotes the reaction [GSR protein affects the chemical synthesis of Glutathione]; Glutathione inhibits the reaction [Alcohols results in decreased expression of GSR protein]
CTD PMID:15345336 PMID:15707499 PMID:17272743 PMID:20025242 PMID:20230805 PMID:23172834 PMID:24038001 PMID:28803762 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSS glutathione synthetase multiple interactions EXP [Arsenic results in increased expression of GSS protein] which results in increased chemical synthesis of Glutathione CTD PMID:18487201 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 affects metabolic processing
affects binding
multiple interactions
EXP
ISO
GSTA1 protein affects the metabolism of Glutathione
Glutathione binds to GSTA1 protein
[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]; GSTA1 protein affects the metabolism of [2-hydroxymenthofuran co-treated with Glutathione]
GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTA1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]; GSTA1 protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]
CTD PMID:3783048 PMID:7712478 PMID:8886613 PMID:9084911 PMID:9877184 PMID:10437668 PMID:10496977 PMID:10751412 PMID:11115505 PMID:11368548 PMID:11849043 PMID:12147362 PMID:12516103 PMID:14690442 PMID:16890185 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTA2 glutathione S-transferase alpha 2 affects metabolic processing
increases expression
multiple interactions
EXP
ISO
GSTA2 protein affects the metabolism of Glutathione
Glutathione deficiency results in increased expression of GSTA3 mRNA
[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione; Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]; GSTA2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]
GSTA2 protein affects the metabolism of Glutathione; GSTA3 protein affects the metabolism of Glutathione
[GSTA2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine
CTD PMID:3783048 PMID:6095330 PMID:8973562 PMID:9084911 PMID:9877184 PMID:15345336 PMID:28478157 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
JBrowse link
G GSTA3 glutathione S-transferase alpha 3 affects binding
multiple interactions
ISO
EXP
Glutathione binds to GSTA3 protein
GSTA3 protein binds to and affects the metabolism of Glutathione
CTD PMID:8910329 PMID:15454730 PMID:15595823 NCBI chr 6:52,896,646...52,909,799
Ensembl chr 6:52,896,639...52,909,698
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 affects metabolic processing
multiple interactions
EXP
ISO
GSTA4 protein affects the metabolism of Glutathione
[GSTA4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTA4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine
CTD PMID:14727915 PMID:28478157 NCBI chr 6:52,977,952...52,995,332
Ensembl chr 6:52,977,948...52,995,304
JBrowse link
G GSTA5 glutathione S-transferase alpha 5 increases expression ISO Glutathione deficiency results in increased expression of GSTA5 mRNA CTD PMID:15345336 NCBI chr 6:52,831,742...52,846,095
Ensembl chr 6:52,831,655...52,846,095
Ensembl chr 6:52,831,655...52,846,095
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in decreased expression of GSTK1 mRNA CTD PMID:22564015 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854
JBrowse link
G GSTM1 glutathione S-transferase mu 1 multiple interactions
decreases abundance
affects metabolic processing
increases expression
affects binding
EXP
ISO
4-O-decyl-gabosine D inhibits the reaction [Glutathione binds to GSTM1 protein]; [GSTM1 protein co-treated with 4-hydroxy-2-nonenal] results in decreased abundance of Glutathione; GSTM1 protein affects the metabolism of [1,2,5,6-dibenzanthracene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione]; GSTM1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Benzo(a)pyrene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [chrysene co-treated with Glutathione]; GSTM1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTM1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]
GSTM1 gene mutant form results in decreased abundance of Glutathione
GSTM1 protein affects the metabolism of Glutathione
Glutathione analog binds to and results in decreased activity of GSTM1 protein; GSTM1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione analog]; GSTM1 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
Glutathione deficiency results in increased expression of GSTM1 mRNA
CTD PMID:1883342 PMID:2604743 PMID:2904809 PMID:6095330 PMID:7826396 PMID:8886613 PMID:8973562 PMID:9084911 PMID:9403173 PMID:9545290 PMID:11368548 PMID:11849043 PMID:14979731 PMID:15345336 PMID:21925487 PMID:22085405 PMID:25420021 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTM2 glutathione S-transferase mu 2 affects metabolic processing
multiple interactions
EXP
ISO
GSTM2 protein affects the metabolism of Glutathione
[GSTM2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine
Dinitrochlorobenzene promotes the reaction [GSTM2 protein affects the metabolism of Glutathione]; GSTM2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]; GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione]
CTD PMID:2604743 PMID:8924604 PMID:8973562 PMID:9794801 PMID:10858281 PMID:28478157 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTM3 glutathione S-transferase mu 3 affects metabolic processing EXP GSTM3 protein affects the metabolism of Glutathione CTD PMID:9545290 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G GSTM4 glutathione S-transferase mu 4 multiple interactions EXP [GSTM4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTM4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTM4 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione] CTD PMID:8203914 PMID:28478157 NCBI chr 1:109,656,076...109,665,497
Ensembl chr 1:109,656,099...109,674,836
JBrowse link
G GSTM5 glutathione S-transferase mu 5 affects metabolic processing ISO GSTM5 protein affects the metabolism of Glutathione CTD PMID:9545290 NCBI chr 1:109,711,751...109,718,268
Ensembl chr 1:109,711,780...109,775,428
JBrowse link
G GSTP1 glutathione S-transferase pi 1 decreases activity
multiple interactions
increases expression
affects metabolic processing
EXP
ISO
Glutathione analog results in decreased activity of GSTP1 protein
GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione]
Glutathione deficiency results in increased expression of GSTP1 mRNA
GSTP1 protein affects the metabolism of Glutathione
Glutathione inhibits the reaction [4-hydroxy-2-nonenal results in decreased expression of GSTP1 protein]; GSTP1 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]
[[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 4'-hydroxydiclofenac; [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac] which results in increased abundance of 5-hydroxydiclofenac; [CYP1A1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1A2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP1B1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2A6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2B6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C18 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C19 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2C8 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased metabolism of Diclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP2D6 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP2E1 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP2J2 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of Diclofenac; [CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased hydroxylation of Diclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac; [CYP3A5 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct]; [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine; [GSTP1 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine; GSTP1 gene affects the reaction [Glutathione affects the metabolism of Thiotepa]; GSTP1 protein affects the metabolism of [4-oxo-2-nonenal co-treated with Glutathione]; GSTP1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of [acrylodan co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Atrazine co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(c)phenanthrene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [benzo(g)chrysene co-treated with Glutathione]; GSTP1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]; GSTP1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]; GSTP1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]; GSTP1 protein promotes the reaction [Glutathione binds to Atrazine]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 2'-(glutathion-S-yl)-deschlorodiclofenac]; Ketoconazole inhibits the reaction [[CYP3A4 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 5-hydroxydiclofenac]; Sulfaphenazole inhibits the reaction [[CYP2C9 protein co-treated with GSTP1 protein co-treated with Glutathione] results in increased abundance of 4'-hydroxydiclofenac]
CTD PMID:7712478 PMID:7826396 PMID:8886613 PMID:8973562 PMID:9403173 PMID:9877184 PMID:10334868 PMID:11196146 PMID:11368548 PMID:11849043 PMID:12470677 PMID:13679171 PMID:15115887 PMID:15528046 PMID:18607078 PMID:20570720 PMID:20621112 PMID:24246759 PMID:28478157 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GSTT1 glutathione S-transferase theta 1 affects metabolic processing
multiple interactions
EXP
ISO
GSTT1 protein affects the metabolism of Glutathione
GSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione]
GSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]
CTD PMID:14727918 PMID:14998683 PMID:15533900
G GSTZ1 glutathione S-transferase zeta 1 affects metabolic processing
affects binding
multiple interactions
EXP GSTZ1 protein affects the metabolism of Glutathione
Glutathione binds to GSTZ1 protein
GSTZ1 protein binds to and affects the metabolism of Glutathione
CTD PMID:1846734 PMID:9396740 PMID:11327815 PMID:12852784 PMID:15173170 NCBI chr14:77,321,002...77,331,597
Ensembl chr14:77,320,996...77,331,597
JBrowse link
G H2AX H2A.X variant histone multiple interactions ISO Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AX protein] CTD PMID:21722719 NCBI chr11:119,093,874...119,095,465
Ensembl chr11:119,093,854...119,095,467
JBrowse link
G HADHA hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression ISO Glutathione deficiency results in increased expression of HADHA mRNA CTD PMID:15345336 NCBI chr 2:26,190,635...26,244,632
Ensembl chr 2:26,190,635...26,244,672
JBrowse link
G HAS2 hyaluronan synthase 2 multiple interactions ISO Glutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA] CTD PMID:21220312 NCBI chr 8:121,612,116...121,641,440
Ensembl chr 8:121,612,116...121,641,440
JBrowse link
G HFE homeostatic iron regulator increases expression ISO Glutathione deficiency results in increased expression of HFE mRNA CTD PMID:15345336 NCBI chr 6:26,087,347...26,098,343
Ensembl chr 6:26,087,281...26,098,343
JBrowse link
G HGF hepatocyte growth factor increases abundance
multiple interactions
ISO HGF protein results in increased abundance of Glutathione
[HGF protein results in increased activity of GCLC protein] which results in increased chemical synthesis of Glutathione
CTD PMID:10544272 NCBI chr 7:81,699,006...81,770,438
Ensembl chr 7:81,699,010...81,770,438
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [Vanadates results in increased expression of HIF1A protein] CTD PMID:11641398 PMID:16678800 PMID:17658243 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Glutathione deficiency results in increased expression of HMGCR mRNA CTD PMID:15345336 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,362,101
Ensembl chr 5:75,336,329...75,362,101
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
affects expression
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; [Acetylcysteine results in increased abundance of Glutathione] inhibits the reaction [sodium arsenite results in increased expression of HMOX1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA; [cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]; [Dimethyl Fumarate results in decreased abundance of Glutathione] which results in increased expression of HMOX1 protein; Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Air Pollutants results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Cadmium Chloride results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Dimethyl Fumarate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Ethacrynic Acid results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [phenethyl isothiocyanate results in increased expression of HMOX1 protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased expression of HMOX1 mRNA]; Glutathione inhibits the reaction [Raloxifene Hydrochloride results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] inhibits the reaction [Ethanol results in decreased abundance of Glutathione]]
[zinc protoporphyrin results in decreased activity of HMOX1 protein] inhibits the reaction [resveratrol results in increased abundance of Glutathione]; Glutathione inhibits the reaction [arsenite results in increased expression of HMOX1 protein]
Glutathione deficiency results in increased expression of HMOX1 mRNA; Glutathione results in increased expression of HMOX1 mRNA
Glutathione affects the expression of HMOX1 mRNA
CTD PMID:8743975 PMID:12420312 PMID:15175009 PMID:15602829 PMID:16631525 PMID:18078826 PMID:18332044 PMID:20020861 PMID:20621112 PMID:20888885 PMID:20934533 PMID:20961405 PMID:21971136 PMID:23649983 PMID:23691207 PMID:26945724 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HNF4A hepatocyte nuclear factor 4 alpha increases expression ISO Glutathione deficiency results in increased expression of HNF4A mRNA CTD PMID:15345336 NCBI chr20:44,355,699...44,434,596
Ensembl chr20:44,355,700...44,434,596
JBrowse link
G HRAS HRas proto-oncogene, GTPase multiple interactions EXP [Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene; Dactinomycin promotes the reaction [[Zinostatin co-treated with Glutathione] results in increased cleavage of HRAS gene] CTD PMID:9345283 NCBI chr11:532,242...535,576
Ensembl chr11:532,242...537,287
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 multiple interactions ISO Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD17B1 protein] CTD PMID:20580664 NCBI chr17:42,552,923...42,555,214
Ensembl chr17:42,552,922...42,555,214
Ensembl chr17:42,552,922...42,555,214
JBrowse link
G HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 multiple interactions ISO Glutathione inhibits the reaction [sodium arsenite results in decreased activity of HSD3B1 protein] CTD PMID:20580664 NCBI chr 1:119,507,203...119,515,058
Ensembl chr 1:119,507,198...119,515,054
JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B multiple interactions ISO Glutathione inhibits the reaction [arsenite results in increased expression of HSPA1B protein] CTD PMID:15175009 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Glutathione inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Glutathione inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein] CTD PMID:20493918 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G HSPB1 heat shock protein family B (small) member 1 multiple interactions ISO Glutathione inhibits the reaction [arsenite results in increased expression of HSPB1 protein] CTD PMID:15175009 NCBI chr 7:76,302,673...76,304,292
Ensembl chr 7:76,302,673...76,304,295
JBrowse link
G IAPP islet amyloid polypeptide multiple interactions EXP IAPP protein inhibits the reaction [[Copper co-treated with Glutathione] results in increased abundance of Hydrogen Peroxide] CTD PMID:23793354 NCBI chr12:21,354,959...21,379,980
Ensembl chr12:21,354,959...21,379,980
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions EXP [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:20351055 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
increases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Glutathione] CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,504
Ensembl chr15:90,083,045...90,102,504
JBrowse link
G IFNG interferon gamma multiple interactions ISO
EXP
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IFNG protein; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IFNG protein]]
CTD PMID:12847270 PMID:16896058 PMID:17079650 PMID:18214930 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions
increases expression
ISO deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGF1 mRNA] CTD PMID:19805407 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IGFALS insulin like growth factor binding protein acid labile subunit multiple interactions
increases expression
ISO deoxynivalenol inhibits the reaction [Glutathione results in increased expression of IGFALS mRNA] CTD PMID:19805407 NCBI chr16:1,790,413...1,794,908
Ensembl chr16:1,790,413...1,794,971
JBrowse link
G IGFBP3 insulin like growth factor binding protein 3 multiple interactions
increases expression
ISO deoxynivalenol promotes the reaction [Glutathione results in increased expression of IGFBP3 mRNA] CTD PMID:19805407 NCBI chr 7:45,912,245...45,921,272
Ensembl chr 7:45,912,245...45,921,874
JBrowse link
G IKBKB inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions
affects abundance
ISO GCLC protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]; GCLM protein inhibits the reaction [IKBKB protein mutant form results in decreased abundance of Glutathione]; Glutathione inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein]; Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]
IKBKB protein affects the abundance of Glutathione
CTD PMID:17067557 PMID:20159942 NCBI chr 8:42,270,727...42,332,460
Ensembl chr 8:42,271,302...42,332,653
Ensembl chr 8:42,271,302...42,332,653
JBrowse link
G IL10 interleukin 10 multiple interactions EXP [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL10 protein CTD PMID:18214930 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541
JBrowse link
G IL13 interleukin 13 multiple interactions EXP [Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL13 protein; Glutathione inhibits the reaction [[Thimerosal co-treated with Lipopolysaccharides] results in increased secretion of IL13 protein] CTD PMID:17079650 PMID:18214930 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL1B interleukin 1 beta increases abundance
decreases expression
multiple interactions
EXP
ISO
IL1B protein results in increased abundance of Glutathione
Glutathione results in decreased expression of IL1B mRNA
Glutathione deficiency promotes the reaction [Phenol results in increased secretion of IL1B protein]; Glutathione deficiency promotes the reaction [Tobacco Smoke Pollution results in increased secretion of and results in increased expression of IL1B protein]
CTD PMID:10802230 PMID:17922553 PMID:22385246 PMID:26149495 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL33 interleukin 33 increases expression ISO Glutathione deficiency results in increased expression of IL33 mRNA CTD PMID:20621112 NCBI chr 9:6,214,591...6,257,983
Ensembl chr 9:6,215,786...6,257,983
JBrowse link
G IL4 interleukin 4 multiple interactions ISO
EXP
[IL4 gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased abundance of Glutathione
[Patulin results in decreased abundance of Glutathione] which results in decreased secretion of IL4 protein; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]
CTD PMID:18214930 PMID:22107450 PMID:27634759 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Glutathione analog promotes the reaction [Ozone results in increased expression of IL6 protein]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]] CTD PMID:15379216 PMID:17079650 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INS insulin multiple interactions EXP INS protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] CTD PMID:26739624 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G ISG20 interferon stimulated exonuclease gene 20 increases expression ISO Glutathione deficiency results in increased expression of ISG20 mRNA CTD PMID:20621112 NCBI chr15:88,635,614...88,656,483
Ensembl chr15:88,636,153...88,656,483
Ensembl chr15:88,636,153...88,656,483
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions EXP Glutathione inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ITGAM mRNA] CTD PMID:16357311 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G JAK2 Janus kinase 2 multiple interactions ISO Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein] CTD PMID:12847270 NCBI chr 9:4,984,390...5,129,948
Ensembl chr 9:4,984,390...5,128,183
Ensembl chr 9:4,984,390...5,128,183
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
ISO
EXP
Glutathione affects the reaction [Sodium Selenite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUN mRNA]; Glutathione inhibits the reaction [tert-Butylhydroperoxide results in increased expression of JUN mRNA]
Glutathione inhibits the reaction [Camptothecin results in increased phosphorylation of JUN protein]
Glutathione deficiency results in increased phosphorylation of JUN protein
CTD PMID:12774022 PMID:15105052 PMID:15520183 PMID:18449455 PMID:30266318 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
Ensembl chr 1:58,780,791...58,784,047
JBrowse link
G JUNB JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of JUNB mRNA] CTD PMID:15520183 NCBI chr19:12,791,486...12,793,315
Ensembl chr19:12,791,486...12,793,315
JBrowse link
G KEAP1 kelch like ECH associated protein 1 multiple interactions
increases abundance
EXP
ISO
[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione; [Plant Extracts results in decreased expression of KEAP1 protein] which results in increased chemical synthesis of Glutathione; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]
KEAP1 gene mutant form results in increased abundance of Glutathione
Glutathione inhibits the reaction [falcarindiol binds to and results in increased alkylation of KEAP1 protein]
[KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]] which results in increased expression of GCLC mRNA; Glutathione inhibits the reaction [1,2-dihydroxynaphthalene analog results in increased metabolism of KEAP1 protein]; Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased glutathionylation of KEAP1 protein]; KEAP1 gene mutant form inhibits the reaction [Diquat results in decreased abundance of Glutathione]
CTD PMID:19608619 PMID:20026152 PMID:20800667 PMID:21972102 PMID:22762311 PMID:25807370 PMID:26827822 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558
JBrowse link
G KLF4 Kruppel like factor 4 increases abundance
multiple interactions
EXP KLF4 results in increased abundance of Glutathione
[KLF4 results in increased expression of GCLC mRNA] which results in increased abundance of Glutathione
CTD PMID:21833590 NCBI chr 9:107,484,852...107,489,769
Ensembl chr 9:107,484,852...107,490,482
JBrowse link
G KLKB1 kallikrein B1 increases expression ISO Glutathione deficiency results in increased expression of KLKB1 mRNA CTD PMID:15345336 NCBI chr 4:186,215,714...186,258,477
Ensembl chr 4:186,208,979...186,258,471
JBrowse link
G KRT18 keratin 18 increases expression ISO Glutathione deficiency results in increased expression of KRT18 mRNA CTD PMID:15345336 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906
JBrowse link
G LCK LCK proto-oncogene, Src family tyrosine kinase multiple interactions EXP Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LCK protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LCK protein] CTD PMID:14572611 NCBI chr 1:32,251,265...32,286,165
Ensembl chr 1:32,251,239...32,286,165
JBrowse link
G LEPR leptin receptor multiple interactions ISO LEPR gene mutant form results in increased oxidation of and results in decreased abundance of Glutathione CTD PMID:29743445 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions ISO Glutathione inhibits the reaction [sodium arsenite results in decreased expression of LHB protein]
Glutathione inhibits the reaction [LHB protein results in increased abundance of CEBPB mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]; Glutathione inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA]
CTD PMID:20580664 PMID:21220312 NCBI chr19:49,015,980...49,017,091
Ensembl chr19:49,015,980...49,017,090
Ensembl chr19:49,015,980...49,017,090
JBrowse link
G LRP1 LDL receptor related protein 1 decreases expression ISO Glutathione deficiency results in decreased expression of LRP1 mRNA CTD PMID:20621112 NCBI chr12:57,128,401...57,213,377
Ensembl chr12:57,128,483...57,213,361
JBrowse link
G LYN LYN proto-oncogene, Src family tyrosine kinase multiple interactions EXP Glutathione inhibits the reaction [bis(2-hydroxy-2-ethylbutanoato)oxochromate(V) results in increased phosphorylation of LYN protein]; Glutathione inhibits the reaction [Potassium Dichromate results in increased phosphorylation of LYN protein] CTD PMID:14572611 NCBI chr 8:55,876,041...56,014,169
Ensembl chr 8:55,879,835...56,014,169
JBrowse link
G MAOB monoamine oxidase B multiple interactions EXP Glutathione inhibits the reaction [MAOB protein results in increased chemical synthesis of 6-formylindolo(3,2-b)carbazole] CTD PMID:26686552 NCBI chr  X:43,766,610...43,882,450
Ensembl chr  X:43,766,610...43,882,450
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta increases expression
multiple interactions
ISO
EXP
Glutathione deficiency results in increased expression of MAP1LC3B mRNA
Glutathione inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form]
CTD PMID:15345336 PMID:29247770 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G MAP2 microtubule associated protein 2 multiple interactions EXP Glutathione inhibits the reaction [Particulate Matter results in decreased expression of MAP2 mRNA] CTD PMID:28153600 NCBI chr 2:209,424,047...209,734,118
Ensembl chr 2:209,424,058...209,734,118
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO
EXP
Glutathione inhibits the reaction [Cadmium Chloride results in increased activity of MAPK1 protein]; Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [pyrrolidine dithiocarbamic acid results in decreased activity of MAPK1 protein]
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [ciglitazone results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK1 protein; Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased activity of MAPK1 protein]; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK1 protein]
CTD PMID:10658192 PMID:12083801 PMID:15252869 PMID:21971136 PMID:22767315 PMID:23370007 PMID:24015256 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO
EXP
Glutathione inhibits the reaction [Cadmium Chloride results in increased activity of MAPK3 protein]; Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK3 protein]
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [ciglitazone results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [GW 1929 results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]
[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased phosphorylation of MAPK3 protein; Glutathione inhibits the reaction [Pyocyanine results in increased phosphorylation of MAPK3 protein]
CTD PMID:12083801 PMID:15252869 PMID:21971136 PMID:22767315 PMID:24015256 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP
ISO
Glutathione deficiency promotes the reaction [antimony trioxide results in increased activity of MAPK8 protein]
Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK8 protein]
Glutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Dopamine results in increased phosphorylation of MAPK8 protein]
CTD PMID:16112521 PMID:17481858 PMID:20423716 PMID:22767315 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions ISO Glutathione inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK9 protein]
Glutathione inhibits the reaction [cadmium sulfate results in increased phosphorylation of MAPK9 protein]
CTD PMID:20423716 PMID:22767315 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099
JBrowse link
G ME1 malic enzyme 1 increases expression ISO Glutathione deficiency results in increased expression of ME1 mRNA CTD PMID:15345336 NCBI chr 6:83,210,402...83,431,078
Ensembl chr 6:83,210,402...83,431,051
JBrowse link
G MET MET proto-oncogene, receptor tyrosine kinase multiple interactions ISO MET gene mutant form promotes the reaction [[Cholesterol, Dietary co-treated with Sodium Cholate] results in increased oxidation of Glutathione] CTD PMID:27394961 NCBI chr 7:116,672,196...116,798,386
Ensembl chr 7:116,672,196...116,798,386
Ensembl chr 7:116,672,196...116,798,386
JBrowse link
G MGMT O-6-methylguanine-DNA methyltransferase multiple interactions EXP Glutathione affects the reaction [MGMT protein results in increased susceptibility to Mitomycin] CTD PMID:16039682 NCBI chr10:129,467,241...129,770,983
Ensembl chr10:129,467,190...129,770,983
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 multiple interactions ISO [Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein; Dithiothreitol inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein]; Glutathione binds to and results in increased activity of MGST1 protein; Leukotriene C4 inhibits the reaction [Glutathione binds to and results in increased activity of MGST1 protein]; MGST1 protein affects the metabolism of [6-bromoacetyl-2-dimethylaminonaphthalene co-treated with Glutathione]; MGST1 protein affects the metabolism of [acrylodan co-treated with Glutathione]; sodium arsenite inhibits the reaction [[Peroxynitrous Acid co-treated with Glutathione] results in increased activity of MGST1 protein] CTD PMID:9890956 PMID:12470677 PMID:16386761 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MMP2 matrix metallopeptidase 2 decreases secretion EXP Glutathione results in decreased secretion of MMP2 protein CTD PMID:15147517 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G MMP9 matrix metallopeptidase 9 affects binding
multiple interactions
decreases secretion
EXP
ISO
Glutathione binds to MMP9 protein
Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of MMP9 protein]
Glutathione results in decreased secretion of MMP9 protein
Glutathione inhibits the reaction [4-aminophenylmercuriacetate results in increased activity of MMP9 protein]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glutathione binds to MMP9 protein]
CTD PMID:15147517 PMID:17015178 PMID:17640567 PMID:21722719 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561
JBrowse link
G MPO myeloperoxidase multiple interactions EXP 4'-hydroxydiclofenac promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; [[Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione] which results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide; [Hydrogen Peroxide results in increased activity of MPO protein] which results in increased oxidation of Glutathione; [MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in decreased abundance of Glutathione; desmethylnaproxen promotes the reaction [[Hydrogen Peroxide co-treated with MPO protein co-treated with Glutathione] results in increased glutathionylation of 5,5-dimethyl-1-pyrroline-1-oxide]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Albuterol]; Glutathione inhibits the reaction [[MPO protein co-treated with Hydrogen Peroxide] results in increased oxidation of Fenoterol]; Glutathione promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Glutathione promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile] CTD PMID:19462961 PMID:25614581 PMID:28754375 PMID:31288001 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G MST1R macrophage stimulating 1 receptor multiple interactions ISO MST1R protein affects the reaction [Acetaminophen results in decreased abundance of Glutathione] CTD PMID:22575169 NCBI chr 3:49,886,471...49,903,873
Ensembl chr 3:49,887,002...49,903,873
JBrowse link
G MT1A metallothionein 1A increases expression ISO Glutathione deficiency results in increased expression of MT1A mRNA CTD PMID:15345336 NCBI chr16:56,638,666...56,640,087
Ensembl chr16:56,638,666...56,640,087
JBrowse link
G MT1X metallothionein 1X multiple interactions ISO [MT1 protein co-treated with MT2 protein] affects the reaction [Glutathione affects the susceptibility to Doxorubicin] CTD PMID:20600803 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MT2A metallothionein 2A multiple interactions ISO [MT1 protein co-treated with MT2 protein] affects the reaction [Glutathione affects the susceptibility to Doxorubicin] CTD PMID:20600803 NCBI chr16:56,608,584...56,609,497
Ensembl chr16:56,608,584...56,609,497
JBrowse link
G MTF1 metal regulatory transcription factor 1 multiple interactions ISO
EXP
Glutathione inhibits the reaction [Cadmium inhibits the reaction [Zinc results in increased activity of MTF1 protein]] CTD PMID:9507026 NCBI chr 1:37,809,570...37,859,614
Ensembl chr 1:37,809,574...37,859,592
JBrowse link
G MTR 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions EXP Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] CTD PMID:26989453 NCBI chr 1:236,794,304...236,903,981
Ensembl chr 1:236,795,292...236,921,278
Ensembl chr 1:236,795,292...236,921,278
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor affects abundance
multiple interactions
EXP
ISO
MYC protein affects the abundance of Glutathione
Glutathione inhibits the reaction [arsenite results in increased expression of MYC mRNA]
CTD PMID:9848127 PMID:12226097 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions
increases abundance
decreases abundance
affects abundance
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [[[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] which results in increased abundance of Glutathione; [[Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which affects the localization of NFE2L2 protein; [Glutathione deficiency results in increased abundance of Reactive Oxygen Species] which results in increased activity of NFE2L2 protein; [KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione; Buthionine Sulfoximine inhibits the reaction [[KEAP1 gene mutant form results in increased activity of NFE2L2] which results in increased abundance of Glutathione]; Glutathione inhibits the reaction [3-O-caffeoyl-1-methylquinic acid affects the localization of NFE2L2 protein]; Glutathione inhibits the reaction [Air Pollutants results in increased expression of NFE2L2 protein]; NFE2L2 promotes the reaction [Chalcone analog results in increased abundance of Glutathione]; NFE2L2 protein affects the reaction [Silver results in increased abundance of Glutathione]
NFE2L2 protein results in increased abundance of Glutathione
NFE2L2 gene mutant form results in decreased abundance of Glutathione
NFE2L2 protein affects the abundance of Glutathione
NFE2L2 protein inhibits the reaction [triptolide results in decreased abundance of Glutathione]
[ATG5 gene mutant form results in increased activity of NFE2L2 protein] affects the reaction [Acetaminophen affects the abundance of Glutathione]; [ATG5 gene mutant form results in increased activity of NFE2L2 protein] which affects the abundance of Glutathione; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased abundance of Glutathione; Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased expression of NFE2L2 protein]; NFE2L2 gene mutant form promotes the reaction [Diquat results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [cinnamic aldehyde results in decreased abundance of Glutathione]; NFE2L2 protein inhibits the reaction [Dinitrochlorobenzene results in decreased abundance of Glutathione]; sulforafan affects the reaction [NFE2L2 affects the abundance of Glutathione]
NFE2L2 affects the abundance of Glutathione; NFE2L2 protein affects the abundance of Glutathione
CTD PMID:11287661 PMID:16524372 PMID:16631525 PMID:19303893 PMID:19608619 PMID:20124447 PMID:20800667 PMID:21728338 PMID:21971136 PMID:22491424 PMID:22546375 PMID:22762311 PMID:22820427 PMID:23649983 PMID:23764462 PMID:24211276 PMID:27633142 PMID:28219650 PMID:29618784 PMID:31299238 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions EXP Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]] CTD PMID:16219905 PMID:17640567 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO Glutathione inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased phosphorylation of NFKBIA protein]] CTD PMID:17067557 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NGF nerve growth factor multiple interactions
affects reduction
affects oxidation
affects activity
ISO N-acetylsphingosine affects the reaction [Glutathione affects the activity of NGF protein]
NGF protein affects the reduction of Glutathione
NGF protein affects the oxidation of Glutathione
CTD PMID:12381813 PMID:23472850 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
JBrowse link
G NLGN3 neuroligin 3 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of NLGN3 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased methylation of NLGN3 promoter]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NLGN3 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased methylation of NLGN3 promoter] CTD PMID:27624276 NCBI chr  X:71,144,389...71,175,307
Ensembl chr  X:71,144,831...71,171,201
JBrowse link
G NNMT nicotinamide N-methyltransferase increases abundance EXP NNMT protein results in increased abundance of Glutathione CTD PMID:31909875 NCBI chr11:114,257,806...114,313,536
Ensembl chr11:114,257,787...114,313,536
Ensembl chr11:114,257,787...114,313,536
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions EXP
ISO
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]
Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of NOS2 protein]; Glutathione inhibits the reaction [orazipone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
CTD PMID:17640567 PMID:18039960 PMID:21722719 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
decreases expression
ISO
EXP
Glutathione deficiency results in increased expression of NQO1 mRNA
Glutathione inhibits the reaction [2-(pro-1-ynyl)-5-(5,6-dihydroxypenta-1,3-diynyl)thiophene results in increased expression of NQO1 protein]
Glutathione results in decreased expression of NQO1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA; NQO1 protein inhibits the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; NQO1 protein polymorphism promotes the reaction [2,6-Dichloroindophenol results in decreased abundance of Glutathione]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
CTD PMID:15345336 PMID:20800667 PMID:21034357 PMID:21971136 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 increases expression ISO Glutathione deficiency results in increased expression of NR0B2 mRNA CTD PMID:15345336 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions ISO NR1I3 gene mutant form inhibits the reaction [pyrene results in decreased abundance of Glutathione] CTD PMID:26160115 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 multiple interactions EXP Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of ATF4 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP7 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of CASP8 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the cleavage of PARP protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of DDIT3 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form]; Glutathione inhibits the reaction [NR4A1 protein affects the phosphorylation of EIF2AK3 protein] CTD PMID:24515801 PMID:26035713 NCBI chr12:52,022,832...52,059,507
Ensembl chr12:52,022,832...52,059,507
JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 multiple interactions ISO Glutathione inhibits the reaction [Permethrin results in increased expression of NR4A2 mRNA] CTD PMID:28943456 NCBI chr 2:156,324,432...156,332,724
Ensembl chr 2:156,324,437...156,342,348
JBrowse link
G NRXN1 neurexin 1 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of NRXN1 mRNA]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased methylation of NRXN1 promoter]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of NRXN1 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased methylation of NRXN1 promoter] CTD PMID:27624276 NCBI chr 2:49,918,503...51,032,132
Ensembl chr 2:49,918,503...51,225,575
JBrowse link
G OAF out at first homolog decreases expression ISO Glutathione deficiency results in decreased expression of OAF mRNA CTD PMID:20621112 NCBI chr11:120,211,032...120,230,334
Ensembl chr11:120,211,032...120,230,334
JBrowse link
G ODC1 ornithine decarboxylase 1 multiple interactions ISO Glutathione inhibits the reaction [mezerein results in increased activity of ODC1 protein]; Glutathione inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] CTD PMID:3098411 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G OGDH oxoglutarate dehydrogenase multiple interactions ISO [GLRX protein co-treated with Glutathione] inhibits the reaction [tert-Butylhydroperoxide results in decreased activity of OGDH protein]; Glutathione promotes the reaction [Diamide results in decreased activity of OGDH protein] CTD PMID:12680778 NCBI chr 7:44,606,572...44,709,066
Ensembl chr 7:44,606,572...44,709,066
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase multiple interactions ISO [diethyl maleate results in decreased abundance of Glutathione] which results in increased expression of OGG1 mRNA CTD PMID:22564015 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G PANX1 pannexin 1 decreases oxidation ISO PANX1 gene mutant form results in decreased oxidation of Glutathione CTD PMID:29246445 NCBI chr11:94,128,841...94,185,596
Ensembl chr11:94,128,841...94,181,968
JBrowse link
G PARK7 Parkinsonism associated deglycase increases abundance EXP PARK7 protein results in increased abundance of Glutathione CTD PMID:18331584 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP Glutathione deficiency promotes the reaction [antimony trioxide results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [2'-benzoyloxycinnamaldehyde results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [3-oxo-29-noroleana-1,9(11),12-trien-2,20-dicarbonitrile results in increased cleavage of PARP1 protein]; Glutathione inhibits the reaction [N-methylisoindigotin results in increased cleavage of PARP1 protein] CTD PMID:14660655 PMID:16112521 PMID:24036456 PMID:24515801 PMID:26887594 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PCSK9 proprotein convertase subtilisin/kexin type 9 decreases expression ISO Glutathione deficiency results in decreased expression of PCSK9 mRNA CTD PMID:20621112 NCBI chr 1:55,039,548...55,064,852
Ensembl chr 1:55,039,447...55,064,852
Ensembl chr 1:55,039,447...55,064,852
JBrowse link
G PDGFRB platelet derived growth factor receptor beta increases abundance EXP PDGFRB protein results in increased abundance of Glutathione CTD PMID:29857117 NCBI chr 5:150,113,839...150,155,845
Ensembl chr 5:150,113,839...150,155,872
JBrowse link
G PDK1 pyruvate dehydrogenase kinase 1 multiple interactions EXP Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PDK1 protein] CTD PMID:17171638 NCBI chr 2:172,555,373...172,672,698
Ensembl chr 2:172,555,373...172,608,669
JBrowse link
G PGR progesterone receptor multiple interactions ISO Glutathione inhibits the reaction [LHB protein results in increased abundance of PGR mRNA] CTD PMID:21220312 NCBI chr11:101,029,624...101,130,681
Ensembl chr11:101,029,624...101,129,813
JBrowse link
G PLIN2 perilipin 2 multiple interactions ISO SOD1 gene mutant form promotes the reaction [Glutathione results in increased expression of PLIN2 protein modified form] CTD PMID:27349771 NCBI chr 9:19,108,391...19,127,518
Ensembl chr 9:19,108,375...19,149,290
JBrowse link
G PON1 paraoxonase 1 multiple interactions EXP PON1 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] CTD PMID:20079818 NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532
JBrowse link
G PON3 paraoxonase 3 multiple interactions EXP PON3 protein inhibits the reaction [Carbon Tetrachloride results in decreased abundance of Glutathione] CTD PMID:20079818 NCBI chr 7:95,359,872...95,396,375
Ensembl chr 7:95,359,872...95,396,375
JBrowse link
G PPAN peter pan homolog increases expression ISO Glutathione deficiency results in increased expression of PPAN mRNA CTD PMID:20621112 NCBI chr19:10,106,223...10,112,012
Ensembl chr19:10,106,362...10,112,012
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression
multiple interactions
ISO Glutathione results in increased expression of PPARA mRNA
Glutathione inhibits the reaction [Alcohols results in decreased expression of PPARA protein]; Quercetin promotes the reaction [Glutathione results in increased expression of PPARA mRNA]
CTD PMID:25204422 PMID:28803762 NCBI chr22:46,150,526...46,243,756
Ensembl chr22:46,150,521...46,243,756
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP Glutathione analog results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase increases expression ISO Glutathione deficiency results in increased expression of PPAT mRNA CTD PMID:20621112 NCBI chr 4:56,393,362...56,435,615
Ensembl chr 4:56,393,362...56,435,615
JBrowse link
G PPP1R3C protein phosphatase 1 regulatory subunit 3C increases expression ISO Glutathione deficiency results in increased expression of PPP1R3C mRNA CTD PMID:20621112 NCBI chr10:91,628,442...91,633,071
Ensembl chr10:91,628,442...91,633,071
JBrowse link
G PRDX1 peroxiredoxin 1 multiple interactions EXP [frenolicin B results in decreased activity of PRDX1 protein] which results in decreased abundance of Glutathione CTD PMID:30661989 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,511,036...45,523,047
Ensembl chr 1:45,511,036...45,523,047
JBrowse link
G PRDX2 peroxiredoxin 2 multiple interactions ISO SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of PRDX2 protein] CTD PMID:27349771 NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800
JBrowse link
G PRDX6 peroxiredoxin 6 increases expression ISO Glutathione deficiency results in increased expression of PRDX6 mRNA CTD PMID:15345336 NCBI chr 1:173,477,335...173,488,815
Ensembl chr 1:173,477,330...173,488,815
JBrowse link
G PRIM2 DNA primase subunit 2 increases expression ISO Glutathione deficiency results in increased expression of PRIM2 mRNA CTD PMID:20621112 NCBI chr 6:57,314,805...57,646,852
Ensembl chr 6:57,314,805...57,646,850
JBrowse link
G PRKCD protein kinase C delta multiple interactions
affects abundance
EXP
ISO
Glutathione inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased phosphorylation of PRKCD protein]; Glutathione inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]
PRKCD protein affects the abundance of Glutathione
CTD PMID:15131007 PMID:15707588 PMID:17171638 NCBI chr 3:53,161,209...53,192,717
Ensembl chr 3:53,156,009...53,192,717
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase affects abundance ISO PRKN protein affects the abundance of Glutathione CTD PMID:12915482 NCBI chr 6:161,347,417...162,727,802
Ensembl chr 6:161,347,417...162,727,771
Ensembl chr 6:161,347,417...162,727,771
JBrowse link
G PRNP prion protein multiple interactions ISO PRNP protein inhibits the reaction [manganese chloride results in decreased abundance of Glutathione] CTD PMID:17483122 NCBI chr20:4,686,456...4,701,588
Ensembl chr20:4,686,350...4,701,590
JBrowse link
G PROCR protein C receptor multiple interactions EXP Glutathione inhibits the reaction [Doxorubicin results in decreased expression of PROCR protein] CTD PMID:17172434 NCBI chr20:35,172,072...35,215,989
Ensembl chr20:35,172,072...35,216,240
JBrowse link
G PTBP1 polypyrimidine tract binding protein 1 increases expression ISO Glutathione deficiency results in increased expression of PTBP1 mRNA CTD PMID:15345336 NCBI chr19:797,452...812,316
Ensembl chr19:797,075...812,327
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]
Glutathione inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 mRNA]; Glutathione inhibits the reaction [cadmium sulfate results in increased expression of PTGS2 protein]
Glutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of PTGS2 protein]; Glutathione inhibits the reaction [LHB protein results in increased abundance of PTGS2 mRNA]
CTD PMID:17640567 PMID:21220312 PMID:21722719 PMID:22767315 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,423
JBrowse link
G PTMA prothymosin alpha increases abundance
multiple interactions
decreases abundance
EXP
ISO
PTMA protein alternative form results in increased abundance of Glutathione
PTMA protein inhibits the reaction [Dexamethasone results in decreased abundance of Glutathione]
PTMA protein alternative form results in decreased abundance of Glutathione
CTD PMID:9147362 PMID:19442654 NCBI chr 2:231,708,525...231,713,551
Ensembl chr 2:231,706,895...231,713,541
Ensembl chr 2:231,706,895...231,713,541
JBrowse link
G PTPN2 protein tyrosine phosphatase non-receptor type 2 multiple interactions EXP Glutathione inhibits the reaction [quinone results in decreased activity of PTPN2 protein] CTD PMID:31248982 NCBI chr18:12,785,478...12,884,351
Ensembl chr18:12,785,478...12,929,643
JBrowse link
G PTPRF protein tyrosine phosphatase receptor type F decreases expression ISO Glutathione deficiency results in decreased expression of PTPRF mRNA CTD PMID:20621112 NCBI chr 1:43,522,238...43,623,666
Ensembl chr 1:43,525,187...43,623,666
JBrowse link
G PTPRS protein tyrosine phosphatase receptor type S decreases expression ISO Glutathione deficiency results in decreased expression of PTPRS mRNA CTD PMID:20621112 NCBI chr19:5,205,503...5,340,812
Ensembl chr19:5,158,495...5,340,803
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions EXP Glutathione inhibits the reaction [Doxorubicin results in decreased phosphorylation of RB1 protein]; Glutathione inhibits the reaction [Levamisole results in decreased expression of RB1 protein] CTD PMID:11139434 PMID:22927544 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RBM27 RNA binding motif protein 27 decreases expression ISO Glutathione deficiency results in decreased expression of RBM27 mRNA CTD PMID:20621112 NCBI chr 5:146,203,550...146,289,223
Ensembl chr 5:146,203,550...146,339,251
Ensembl chr 5:146,203,550...146,339,251
JBrowse link
G RDH16 retinol dehydrogenase 16 increases expression ISO Glutathione deficiency results in increased expression of RDH2 mRNA CTD PMID:15345336 NCBI chr12:56,951,431...56,957,608
Ensembl chr12:56,951,431...56,959,374
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases glutathionylation
affects abundance
EXP
ISO
[Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [cinnamic aldehyde results in increased glutathionylation of RELA protein]; [cinnamic aldehyde results in increased abundance of Glutathione] which results in increased glutathionylation of RELA protein; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]; [Glutathione co-treated with Hydrogen Peroxide] results in increased glutathionylation of RELA protein; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]
Glutathione results in increased glutathionylation of RELA protein
RELA protein affects the abundance of Glutathione
Glutathione affects the reaction [Sodium Selenite results in increased expression of RELA mRNA]; Glutathione inhibits the reaction [Alcohols results in increased expression of RELA protein]
CTD PMID:16219905 PMID:17640567 PMID:18449455 PMID:20116392 PMID:20159942 PMID:20351055 PMID:28803762 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G RELN reelin decreases expression ISO Glutathione deficiency results in decreased expression of RELN mRNA CTD PMID:20621112 NCBI chr 7:103,471,789...103,989,658
Ensembl chr 7:103,471,784...103,989,658
Ensembl chr 7:103,471,784...103,989,658
JBrowse link
G RETREG1 reticulophagy regulator 1 increases expression ISO Glutathione deficiency results in increased expression of RETREG1 mRNA CTD PMID:20621112 NCBI chr 5:16,473,038...16,617,096
Ensembl chr 5:16,473,038...16,617,058
Ensembl chr 5:16,473,038...16,617,058
JBrowse link
G RFK riboflavin kinase increases abundance EXP RFK protein results in increased abundance of Glutathione CTD PMID:21308351 NCBI chr 9:76,385,526...76,394,426
Ensembl chr 9:76,385,526...76,394,517
JBrowse link
G RPS6 ribosomal protein S6 increases expression ISO Glutathione deficiency results in increased expression of RPS6 mRNA CTD PMID:15345336 NCBI chr 9:19,375,715...19,380,236
Ensembl chr 9:19,375,715...19,380,236
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 increases expression ISO Glutathione deficiency results in increased expression of RPS6KB1 mRNA CTD PMID:15345336 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574
JBrowse link
G RREB1 ras responsive element binding protein 1 decreases expression ISO Glutathione deficiency results in decreased expression of RREB1 mRNA CTD PMID:20621112 NCBI chr 6:7,107,743...7,251,980
Ensembl chr 6:7,107,597...7,251,980
JBrowse link
G RXRA retinoid X receptor alpha multiple interactions
affects abundance
ISO GCLC protein affects the reaction [RXRA protein affects the abundance of Glutathione] CTD PMID:14978233 NCBI chr 9:134,326,455...134,440,585
Ensembl chr 9:134,317,098...134,440,585
JBrowse link
G SAMD4A sterile alpha motif domain containing 4A increases expression ISO Glutathione deficiency results in increased expression of SAMD4A mRNA CTD PMID:20621112 NCBI chr14:54,567,097...54,793,315
Ensembl chr14:54,566,117...54,793,315
Ensembl chr14:54,566,117...54,793,315
JBrowse link
G SCD stearoyl-CoA desaturase decreases expression ISO Glutathione deficiency results in decreased expression of SCD1 mRNA CTD PMID:20621112 NCBI chr10:100,347,233...100,364,826
Ensembl chr10:100,347,233...100,364,826
JBrowse link
G SDF2L1 stromal cell derived factor 2 like 1 increases expression ISO Glutathione deficiency results in increased expression of SDF2L1 mRNA CTD PMID:20621112 NCBI chr22:21,642,302...21,644,299
Ensembl chr22:21,642,302...21,644,299
JBrowse link
G SELE selectin E multiple interactions EXP [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA] CTD PMID:21971136 NCBI chr 1:169,722,640...169,734,079
Ensembl chr 1:169,722,640...169,764,705
JBrowse link
G SELENOW selenoprotein W multiple interactions EXP [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased expression of SELENOW mRNA; Glutathione deficiency promotes the reaction [Methylmercury Compounds results in decreased expression of SELENOW mRNA] CTD PMID:15823556 NCBI chr19:47,778,703...47,784,682
Ensembl chr19:47,778,585...47,784,686
JBrowse link
G SESN2 sestrin 2 increases expression
multiple interactions
ISO
EXP
Glutathione deficiency results in increased expression of SESN2 mRNA
Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of SESN2 protein]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of SESN2 protein]; Glutathione inhibits the reaction [p-carboxymethylphenyl 1,1-bis(3'-indolyl)-1-(p-carboxymethylphenyl)methane results in increased expression of SESN2 protein]
CTD PMID:20621112 PMID:26035713 NCBI chr 1:28,259,452...28,282,491
Ensembl chr 1:28,259,518...28,282,491
JBrowse link
G SFXN1 sideroflexin 1 increases expression ISO Glutathione deficiency results in increased expression of SFXN1 mRNA CTD PMID:15345336 NCBI chr 5:175,478,560...175,529,742
Ensembl chr 5:175,477,062...175,529,742
JBrowse link
G SGK2 serum/glucocorticoid regulated kinase 2 increases expression ISO Glutathione deficiency results in increased expression of SGK2 mRNA CTD PMID:20621112 NCBI chr20:43,559,027...43,585,627
Ensembl chr20:43,558,968...43,588,237
JBrowse link
G SIRT1 sirtuin 1 multiple interactions
decreases abundance
EXP
ISO
[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]; GLRX protein inhibits the reaction [[Palmitic Acid co-treated with Glucose] promotes the reaction [Glutathione binds to SIRT1 protein]]
SIRT1 protein results in decreased abundance of Glutathione
CTD PMID:24451382 PMID:29134718 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP SLC22A6 protein results in increased susceptibility to [mercuric oxide co-treated with Glutathione] CTD PMID:12606766 NCBI chr11:62,976,597...62,984,967
Ensembl chr11:62,936,385...62,984,967
Ensembl chr11:62,936,385...62,984,967
JBrowse link
G SLC25A10 solute carrier family 25 member 10 multiple interactions
increases uptake
ISO [SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to S-(1,2-dichlorovinyl)cysteine; [SLC25A10 protein co-treated with Glutathione] results in decreased susceptibility to tert-Butylhydroperoxide
SLC25A10 protein results in increased uptake of Glutathione
CTD PMID:12388626 NCBI chr17:81,712,284...81,721,012
Ensembl chr17:81,712,236...81,721,016
JBrowse link
G SLC25A20 solute carrier family 25 member 20 multiple interactions EXP Glutathione inhibits the reaction [Mercuric Chloride results in decreased activity of SLC25A20 protein]; Glutathione inhibits the reaction [methylmercuric chloride results in decreased activity of SLC25A20 protein] CTD PMID:25849418 NCBI chr 3:48,856,926...48,898,882
Ensembl chr 3:48,856,926...48,898,904
JBrowse link
G SLC25A33 solute carrier family 25 member 33 increases expression ISO Glutathione deficiency results in increased expression of SLC25A33 mRNA CTD PMID:20621112 NCBI chr 1:9,539,465...9,585,173
Ensembl chr 1:9,539,465...9,585,173
JBrowse link
G SLC31A1 solute carrier family 31 member 1 multiple interactions EXP [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [SLC31A1 protein results in increased import of Copper] CTD PMID:23426973 NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492
JBrowse link
G SLC39A2 solute carrier family 39 member 2 multiple interactions EXP [SLC39A2 protein co-treated with zinc chloride] results in increased abundance of Glutathione CTD PMID:18385089 NCBI chr14:20,999,293...21,001,871
Ensembl chr14:20,999,255...21,001,871
JBrowse link
G SLC3A2 solute carrier family 3 member 2 multiple interactions EXP [[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione CTD PMID:22216172 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,102...62,888,875
Ensembl chr11:62,856,102...62,888,875
JBrowse link
G SLC5A6 solute carrier family 5 member 6 increases expression ISO Glutathione deficiency results in increased expression of SLC5A6 mRNA CTD PMID:15345336 NCBI chr 2:27,199,587...27,212,342
Ensembl chr 2:27,199,587...27,212,958
JBrowse link
G SLC7A11 solute carrier family 7 member 11 increases abundance
multiple interactions
ISO
EXP
SLC7A11 results in increased abundance of Glutathione
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione
[[Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione] which results in increased abundance of Reactive Oxygen Species; [SLC7A11 gene mutant form results in increased susceptibility to Paraquat] which results in decreased abundance of Glutathione; [SLC7A11 results in increased abundance of Glutathione] which results in decreased abundance of Reactive Oxygen Species; [Sulfasalazine results in decreased activity of SLC7A11 protein] which results in decreased abundance of Glutathione
CTD PMID:19015640 PMID:22216172 PMID:23085521 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SLC9A9 solute carrier family 9 member A9 increases expression ISO Glutathione deficiency results in increased expression of SLC9A9 mRNA CTD PMID:20621112 NCBI chr 3:143,265,222...143,848,492
Ensembl chr 3:143,265,222...143,848,485
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 increases import EXP SLCO1B1 protein results in increased import of Glutathione analog CTD PMID:16479312 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SNCA synuclein alpha multiple interactions
decreases abundance
ISO
EXP
Glutathione inhibits the reaction [manganese chloride promotes the reaction [SNCA protein binds to SNCA protein binds to SNCA protein]]
Dopamine inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; ferrous sulfate inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]; geraniol inhibits the reaction [SNCA protein results in decreased abundance of Glutathione]
CTD PMID:23353026 PMID:27026137 PMID:27424009 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
increases abundance
affects activity
affects abundance
EXP
ISO
[Glutathione results in increased reduction of SOD1 protein] promotes the reaction [Hydrogen Peroxide results in increased oxidation of SOD1 protein modified form]; [Glutathione results in increased reduction of SOD1 protein] which results in increased susceptibility to Hydrogen Peroxide; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD1 mRNA]; Glutathione promotes the reaction [SOD1 protein binds to Oligodeoxyribonucleotides]; Glutathione results in increased reduction of and results in decreased activity of SOD1 protein
SOD1 gene mutant form results in increased abundance of Glutathione
Glutathione deficiency affects the activity of SOD1 protein
[GPX1 protein co-treated with SOD1 protein] affects the reaction [Acetaminophen results in decreased abundance of Glutathione]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of ATF6 protein modified form]; SOD1 gene mutant form inhibits the reaction [Glutathione results in increased expression of PRDX2 protein]; SOD1 gene mutant form promotes the reaction [Glutathione results in increased expression of PLIN2 protein modified form]; Thioacetamide promotes the reaction [SOD1 gene mutant form results in increased abundance of Glutathione]
SOD1 protein affects the abundance of Glutathione
CTD PMID:15707499 PMID:16101137 PMID:16377630 PMID:16636302 PMID:22867017 PMID:27349771 PMID:31162603 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 increases abundance
multiple interactions
EXP
ISO
SOD2 protein results in increased abundance of Glutathione
[Streptozocin co-treated with INS1 protein co-treated with Glutathione] affects the expression of SOD2 mRNA
Glutathione affects the reaction [SOD2 protein affects the activity of CASP9 protein]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin]; Glutathione affects the reaction [SOD2 protein results in decreased susceptibility to Paclitaxel]; Glutathione promotes the reaction [Eugenol results in decreased expression of SOD2 mRNA]
CTD PMID:15130278 PMID:16101137 PMID:18594523 PMID:25362599 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SP1 Sp1 transcription factor multiple interactions
decreases expression
EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP1 protein]
Glutathione results in decreased expression of SP1
CTD PMID:18556457 PMID:20435036 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G SP3 Sp3 transcription factor multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP3 protein] CTD PMID:20435036 NCBI chr 2:173,900,775...173,965,702
Ensembl chr 2:173,880,850...173,965,702
JBrowse link
G SP4 Sp4 transcription factor multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in decreased expression of SP4 protein] CTD PMID:20435036 NCBI chr 7:21,428,083...21,514,822
Ensembl chr 7:21,428,043...21,514,822
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions EXP Glutathione inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein] CTD PMID:22927544 NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Glutathione inhibits the reaction [Alcohols results in increased expression of SREBF1 protein] CTD PMID:28803762 NCBI chr17:17,811,334...17,837,017
Ensembl chr17:17,810,399...17,837,011
JBrowse link
G SREK1IP1 SREK1 interacting protein 1 decreases expression ISO Glutathione deficiency results in decreased expression of SREK1IP1 mRNA CTD PMID:20621112 NCBI chr 5:64,718,148...64,768,839
Ensembl chr 5:64,718,148...64,768,691
JBrowse link
G SRXN1 sulfiredoxin 1 increases expression ISO Glutathione deficiency results in increased expression of SRXN1 mRNA CTD PMID:20621112 NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,370
Ensembl chr20:646,615...653,370
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions ISO
EXP
Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione promotes the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]
Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]
CTD PMID:12847270 PMID:16896058 NCBI chr 2:190,968,989...191,014,197
Ensembl chr 2:190,908,460...191,020,960
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
affects abundance
EXP
ISO
Glutathione inhibits the reaction [Mercuric Chloride inhibits the reaction [CNTF protein results in increased phosphorylation of STAT3 protein]]
STAT3 protein affects the abundance of Glutathione
CTD PMID:16896058 PMID:20224768 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
Ensembl chr17:42,313,324...42,388,482
JBrowse link
G SULT1C2 sulfotransferase family 1C member 2 increases expression ISO Glutathione deficiency results in increased expression of SULT1C2 mRNA CTD PMID:15345336 NCBI chr 2:108,288,895...108,309,915
Ensembl chr 2:108,288,639...108,309,915
JBrowse link
G SYN1 synapsin I multiple interactions EXP Glutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 mRNA]; Glutathione inhibits the reaction [Particulate Matter results in decreased expression of SYN1 protein] CTD PMID:27624276 PMID:28153600 NCBI chr  X:47,571,901...47,619,857
Ensembl chr  X:47,571,901...47,619,857
JBrowse link
G TALDO1 transaldolase 1 multiple interactions
decreases abundance
ISO Acetylcysteine inhibits the reaction [TALDO1 gene mutant form results in decreased abundance of Glutathione] CTD PMID:19436114 NCBI chr11:747,464...765,012
Ensembl chr11:747,415...765,012
JBrowse link
G TERT telomerase reverse transcriptase multiple interactions
increases expression
EXP Glutathione inhibits the reaction [Camptothecin results in increased expression of TERT protein]
Glutathione results in increased expression of TERT protein
CTD PMID:30851366 NCBI chr 5:1,253,167...1,295,068
Ensembl chr 5:1,253,147...1,295,068
Ensembl chr 5:1,253,147...1,295,068
JBrowse link
G TES testin LIM domain protein increases expression ISO Glutathione deficiency results in increased expression of TES mRNA CTD PMID:20621112 NCBI chr 7:116,210,539...116,258,786
Ensembl chr 7:116,210,506...116,258,783
JBrowse link
G TET1 tet methylcytosine dioxygenase 1 multiple interactions EXP Glutathione inhibits the reaction [Particulate Matter results in increased expression of TET1 mRNA] CTD PMID:28153600 NCBI chr10:68,560,337...68,700,794
Ensembl chr10:68,560,337...68,694,487
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions
decreases abundance
ISO diphenyleneiodonium inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione]; Rotenone inhibits the reaction [TGFB1 protein results in decreased abundance of Glutathione] CTD PMID:11260395 PMID:14732287 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G THPO thrombopoietin decreases expression ISO Glutathione deficiency results in decreased expression of THPO mRNA CTD PMID:20621112 NCBI chr 3:184,371,935...184,379,688
Ensembl chr 3:184,371,935...184,381,968
JBrowse link
G TLR2 toll like receptor 2 decreases expression EXP Glutathione results in decreased expression of TLR2 mRNA CTD PMID:22385246 NCBI chr 4:153,684,080...153,710,643
Ensembl chr 4:153,684,070...153,706,260
Ensembl chr 4:153,684,070...153,706,260
JBrowse link
G TLR4 toll like receptor 4 decreases expression EXP Glutathione results in decreased expression of TLR4 mRNA CTD PMID:22385246 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735
JBrowse link
G TMCC1 transmembrane and coiled-coil domain family 1 increases expression ISO Glutathione deficiency results in increased expression of TMCC1 mRNA CTD PMID:20621112 NCBI chr 3:129,647,792...129,893,711
Ensembl chr 3:129,647,792...129,893,606
JBrowse link
G TNF tumor necrosis factor multiple interactions
decreases abundance
decreases expression
increases chemical synthesis
affects abundance
increases abundance
EXP
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein]; [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in decreased susceptibility to TNF protein; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein affects the localization of RELA protein]; [Glutathione co-treated with Hydrogen Peroxide] inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Acetylcysteine inhibits the reaction [TNF protein results in decreased abundance of Glutathione]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of NFKB1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased activity of RELA protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BCL2L1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Glutathione inhibits the reaction [Curcumin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; inhibits the reaction [TNF protein results in decreased abundance of Glutathione]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of HMOX1 mRNA]; TNF protein inhibits the reaction [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which results in increased expression of NQO1 mRNA]
Glutathione affects the reaction [Alcohols results in increased expression of TNF protein]
Glutathione results in decreased expression of TNF mRNA
TNF protein results in increased chemical synthesis of Glutathione
TNF protein affects the abundance of Glutathione
TNF protein results in increased abundance of Glutathione
CTD PMID:9374527 PMID:9535218 PMID:10802230 PMID:16219905 PMID:16271621 PMID:17079650 PMID:17640567 PMID:19900513 PMID:20351055 PMID:20626112 PMID:21971136 PMID:22385246 PMID:27793764 PMID:28803762 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 multiple interactions ISO Glutathione inhibits the reaction [LHB protein results in increased abundance of TNFAIP6 mRNA] CTD PMID:21220312 NCBI chr 2:151,357,592...151,380,046
Ensembl chr 2:151,357,592...151,380,046
JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b multiple interactions EXP Glutathione inhibits the reaction [rosiglitazone results in increased expression of TNFRSF10B protein] CTD PMID:18164688 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A affects abundance ISO TNFRSF1A protein affects the abundance of Glutathione CTD PMID:20159942 NCBI chr12:6,328,771...6,342,076
Ensembl chr12:6,328,757...6,342,114
JBrowse link
G TOP2A DNA topoisomerase II alpha multiple interactions EXP Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of TOP2A protein] CTD PMID:21497582 NCBI chr17:40,388,525...40,417,902
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases glutathionylation
decreases abundance
increases expression
EXP [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [Benzo(a)pyrene results in increased activity of TP53 protein]; Dithiothreitol inhibits the reaction [Glutathione results in increased glutathionylation of TP53 protein]; Glutathione inhibits the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of TP53 protein]; Glutathione inhibits the reaction [diallyl disulfide results in increased expression of TP53 protein]; Glutathione inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
TP53 protein results in decreased abundance of Glutathione
Glutathione results in increased expression of TP53 protein
CTD PMID:10897038 PMID:12807757 PMID:12967322 PMID:17555331 PMID:19202565 PMID:22927544 PMID:27634759 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TPO thyroid peroxidase multiple interactions
decreases activity
EXP Arsenic Trioxide promotes the reaction [Glutathione results in decreased activity of TPO protein]; Glutathione promotes the reaction [Arsenic Trioxide results in decreased activity of TPO protein] CTD PMID:25595679 NCBI chr 2:1,413,288...1,543,673
Ensembl chr 2:1,374,066...1,543,711
JBrowse link
G TRIB3 tribbles pseudokinase 3 increases expression ISO Glutathione deficiency results in increased expression of TRIB3 mRNA CTD PMID:20621112 NCBI chr20:380,760...397,559
Ensembl chr20:362,835...397,559
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 multiple interactions EXP Glutathione inhibits the reaction [agathic acid results in increased activity of TRPA1 protein]; Glutathione inhibits the reaction [Particulate Matter results in increased activity of TRPA1 protein]; Glutathione inhibits the reaction [phenalen-1-one results in increased activity of TRPA1 protein] CTD PMID:23541125 PMID:30945539 NCBI chr 8:72,021,250...72,094,885
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TSKU tsukushi, small leucine rich proteoglycan increases expression ISO Glutathione deficiency results in increased expression of TSKU mRNA CTD PMID:20621112 NCBI chr11:76,782,280...76,798,144
Ensembl chr11:76,782,251...76,798,153
JBrowse link
G TUBB3 tubulin beta 3 class III multiple interactions EXP Glutathione inhibits the reaction [Particulate Matter results in decreased expression of TUBB3 mRNA] CTD PMID:28153600 NCBI chr16:89,921,925...89,936,097
Ensembl chr16:89,921,392...89,938,761
JBrowse link
G TXNRD1 thioredoxin reductase 1 multiple interactions ISO Glutathione affects the reaction [arsenic trioxide results in decreased activity of TXNRD1 protein]; Glutathione inhibits the reaction [[Mitomycin co-treated with NADP] results in decreased activity of TXNRD1 protein]; Glutathione inhibits the reaction [N-acetyl-4-benzoquinoneimine results in decreased activity of TXNRD1 protein] CTD PMID:17640917 PMID:22694104 PMID:24661219 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G TYR tyrosinase multiple interactions EXP [TYR protein affects the susceptibility to caffeic acid phenethyl ester] which affects the abundance of Glutathione; [TYR protein results in increased oxidation of 3,4-dihydroxyphenylpropionic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of 3-phenylpropionic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of caffeic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of Chlorogenic Acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of cinnamic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of ferulic acid] which results in decreased abundance of Glutathione; [TYR protein results in increased oxidation of trans-3-(4'-hydroxyphenyl)-2-propenoic acid] which results in decreased abundance of Glutathione; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of Ascorbic Acid]; Glutathione inhibits the reaction [[TYR protein results in increased oxidation of caffeic acid phenethyl ester] which results in increased oxidation of NAD]; Glutathione inhibits the reaction [TYR protein results in increased oxidation of caffeic acid phenethyl ester] CTD PMID:20685355 NCBI chr11:89,177,565...89,295,759
Ensembl chr11:89,177,875...89,295,759
JBrowse link
G UCHL1 ubiquitin C-terminal hydrolase L1 multiple interactions EXP Glutathione inhibits the reaction [1,2-naphthoquinone results in increased metabolism of and results in decreased activity of UCHL1 protein] CTD PMID:24582816 NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455
JBrowse link
G UCP1 uncoupling protein 1 multiple interactions ISO Glutathione inhibits the reaction [alitretinoin results in increased expression of UCP1 mRNA]; Glutathione inhibits the reaction [rosiglitazone results in increased expression of UCP1 mRNA] CTD PMID:12414803 NCBI chr 4:140,555,770...140,568,961
Ensembl chr 4:140,559,431...140,568,961
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO Glutathione inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased abundance of Hydrogen Peroxide] CTD PMID:19361538 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
Ensembl chr11:73,974,672...73,983,246
JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 increases expression ISO Glutathione deficiency results in increased expression of UGT1A2 mRNA; Glutathione deficiency results in increased expression of UGT1A3 mRNA CTD PMID:15345336 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,108...233,773,299
JBrowse link
G UGT1A5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO Glutathione deficiency results in increased expression of UGT1A5 mRNA CTD PMID:15345336 NCBI chr 2:233,712,907...233,773,300
Ensembl chr 2:233,712,992...233,773,299
JBrowse link
G UGT1A6 UDP glucuronosyltransferase family 1 member A6 increases expression ISO Glutathione deficiency results in increased expression of UGT1A6 mRNA CTD PMID:15345336 NCBI chr 2:233,691,670...233,773,300
Ensembl chr 2:233,691,607...233,773,300
JBrowse link
G UGT1A8 UDP glucuronosyltransferase family 1 member A8 increases expression ISO Glutathione deficiency results in increased expression of UGT1A8 mRNA CTD PMID:15345336 NCBI chr 2:233,617,633...233,773,300
Ensembl chr 2:233,617,645...233,773,310
JBrowse link
G UGT2B17 UDP glucuronosyltransferase family 2 member B17 increases expression ISO Glutathione deficiency results in increased expression of UGT2B1 mRNA CTD PMID:15345336 NCBI chr 4:68,537,173...68,576,322
Ensembl chr 4:68,537,184...68,568,527
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP [[Buthionine Sulfoximine results in decreased abundance of Glutathione] which co-treated with arsenite] inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; [Buthionine Sulfoximine results in decreased abundance of Glutathione] inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] CTD PMID:16271621 PMID:21971136 NCBI chr 1:100,719,742...100,739,045
Ensembl chr 1:100,719,742...100,739,045
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP Glutathione inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA] CTD PMID:11641398 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VNN1 vanin 1 affects abundance ISO VNN1 affects the abundance of Glutathione CTD PMID:15282320 NCBI chr 6:132,680,849...132,714,055
Ensembl chr 6:132,680,849...132,714,055
JBrowse link
G XBP1 X-box binding protein 1 multiple interactions EXP Glutathione inhibits the reaction [1,1-bis(3'-indolyl)-1-(4-hydroxyphenyl)methane results in increased expression of XBP1 protein alternative form]; Glutathione inhibits the reaction [NR4A1 protein affects the expression of XBP1 protein alternative form] CTD PMID:24515801 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
G XDH xanthine dehydrogenase multiple interactions ISO [Xanthine co-treated with XDH protein] results in increased abundance of Glutathione CTD PMID:7743507 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
G XIAP X-linked inhibitor of apoptosis multiple interactions EXP Glutathione inhibits the reaction [Thimerosal results in decreased expression of XIAP protein] CTD PMID:12140745 NCBI chr  X:123,859,708...123,913,972
Ensembl chr  X:123,859,724...123,913,976
Ensembl chr  X:123,859,724...123,913,976
JBrowse link
G XK X-linked Kx blood group decreases expression ISO Glutathione deficiency results in decreased expression of XK mRNA CTD PMID:20621112 NCBI chr  X:37,685,686...37,732,130
Ensembl chr  X:37,685,791...37,732,130
JBrowse link
G XRCC1 X-ray repair cross complementing 1 multiple interactions
decreases oxidation
increases oxidation
ISO Acetylcysteine promotes the reaction [XRCC1 protein results in decreased oxidation of Glutathione]
XRCC1 gene mutant form results in increased oxidation of Glutathione
CTD PMID:30998386 NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,040...43,580,473
Ensembl chr19:43,543,040...43,580,473
JBrowse link
G YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma increases expression ISO Glutathione deficiency results in increased expression of YWHAG mRNA CTD PMID:15345336 NCBI chr 7:76,326,799...76,358,991
Ensembl chr 7:76,326,799...76,358,991
JBrowse link
G ZBTB7B zinc finger and BTB domain containing 7B decreases expression ISO Glutathione deficiency results in decreased expression of ZBTB7B mRNA CTD PMID:20621112 NCBI chr 1:155,002,628...155,018,523
Ensembl chr 1:155,002,630...155,018,522
JBrowse link
G ZNF367 zinc finger protein 367 increases expression ISO Glutathione deficiency results in increased expression of ZFP367 mRNA CTD PMID:20621112 NCBI chr 9:96,385,941...96,418,639
Ensembl chr 9:96,385,941...96,418,370
JBrowse link
glutathione disulfide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 increases export
increases activity
multiple interactions
EXP
ISO
ABCC1 protein results in increased export of Glutathione Disulfide
Glutathione Disulfide results in increased activity of ABCC1 protein
[Epinephrine co-treated with [verlukast results in decreased activity of ABCC1 protein]] results in increased abundance of Glutathione Disulfide
Glutathione Disulfide inhibits the reaction [Glutathione promotes the reaction [ABCC1 results in increased transport of methylarsine analog]]; Glutathione Disulfide promotes the reaction [Leukotriene C4 analog binds to ABCC1 protein]
ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide]
CTD PMID:11306701 PMID:15628876 PMID:17272743 PMID:19053318 PMID:21918036 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases transport
multiple interactions
ISO ABCC2 protein results in increased transport of Glutathione Disulfide
Acetaminophen promotes the reaction [ABCC2 protein results in increased transport of Glutathione Disulfide]
CTD PMID:15276087 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G AGT angiotensinogen multiple interactions
increases export
decreases abundance
ISO ABCC1 protein affects the reaction [AGT protein results in decreased abundance of Glutathione Disulfide]
AGT protein results in increased export of Glutathione Disulfide
CTD PMID:17272743 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G ALOX12 arachidonate 12-lipoxygenase, 12S type affects response to substance
increases glutathionylation
increases activity
ISO ALOX12 protein affects the susceptibility to Glutathione Disulfide
Glutathione Disulfide results in increased glutathionylation of ALOX12 protein
Glutathione Disulfide results in increased activity of ALOX12 protein
CTD PMID:19373248 NCBI chr17:6,993,791...7,010,754
Ensembl chr17:6,996,049...7,010,754
JBrowse link
G AR androgen receptor multiple interactions
affects localization
EXP Glutathione Disulfide binds to and results in increased activity of AR protein
Glutathione Disulfide affects the localization of AR protein
CTD PMID:28478275 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Glutathione Disulfide results in increased expression of CDKN1A protein CTD PMID:15993333 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,339
Ensembl chr 6:36,676,460...36,687,339
JBrowse link
G CFTR CF transmembrane conductance regulator decreases activity EXP Glutathione Disulfide results in decreased activity of CFTR protein CTD PMID:15657297 NCBI chr 7:117,480,025...117,668,665
Ensembl chr 7:117,287,120...117,715,971
Ensembl chr 7:117,287,120...117,715,971
JBrowse link
G CRYGD crystallin gamma D increases oxidation EXP Glutathione Disulfide results in increased oxidation of CRYGD protein mutant form CTD PMID:30242128 NCBI chr 2:208,121,607...208,124,524
Ensembl chr 2:208,121,607...208,124,524
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP [Benzo(a)pyrene co-treated with CXCL8 protein] results in increased abundance of Glutathione Disulfide CTD PMID:28238931 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G FAS Fas cell surface death receptor decreases activity ISO Glutathione Disulfide results in decreased activity of FAS protein CTD PMID:10385654 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,990,531...89,017,059
JBrowse link
G FNDC5 fibronectin type III domain containing 5 decreases abundance ISO FNDC5 protein results in decreased abundance of Glutathione Disulfide CTD PMID:32165127 NCBI chr 1:32,862,268...32,872,484
Ensembl chr 1:32,862,268...32,872,482
JBrowse link
G GLRX glutaredoxin affects response to substance ISO GLRX protein affects the susceptibility to Glutathione Disulfide CTD PMID:19373248 NCBI chr 5:95,813,849...95,822,726
Ensembl chr 5:95,751,319...95,822,726
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP
ISO
Glutathione Disulfide inhibits the reaction [Carmustine results in decreased activity of GSR protein]
arsenic trioxide inhibits the reaction [GSR protein results in increased reduction of Glutathione Disulfide]; arsenic trioxide promotes the reaction [GSR protein binds to Glutathione Disulfide]; GSR protein binds to and results in increased reduction of Glutathione Disulfide
[[Carmustine results in decreased activity of GSR protein] which co-treated with Oligodeoxyribonucleotides analog] results in increased abundance of Glutathione Disulfide; [[Cyclophosphamide co-treated with Cisplatin co-treated with Carmustine] results in decreased activity of GSR protein] which results in increased abundance of Glutathione Disulfide
CTD PMID:12114195 PMID:12477282 PMID:19668867 PMID:24634002 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP Glutathione Disulfide analog promotes the reaction [cobaltous chloride results in increased activity of HIF1A protein]; Glutathione Disulfide analog promotes the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19374849 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G MPO myeloperoxidase multiple interactions EXP [MPO protein results in increased oxidation of Phenolsulfonphthalein] which results in increased abundance of Glutathione Disulfide CTD PMID:31288001 NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to NFKB1 protein]]; Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]]
Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein]
CTD PMID:12433058 PMID:12477282 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NGF nerve growth factor affects abundance ISO NGF protein affects the abundance of Glutathione Disulfide CTD PMID:23472850 NCBI chr 1:115,285,915...115,338,253
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
Ensembl chr 1:115,285,917...115,338,256
JBrowse link
G NNMT nicotinamide N-methyltransferase increases abundance EXP NNMT protein results in increased abundance of Glutathione Disulfide CTD PMID:31909875 NCBI chr11:114,257,806...114,313,536
Ensembl chr11:114,257,787...114,313,536
Ensembl chr11:114,257,787...114,313,536
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO Glutathione Disulfide promotes the reaction [Oligodeoxyribonucleotides analog results in increased activity of [NFKB1 protein binds to RELA protein]]
Glutathione Disulfide results in decreased activity of [NFKB1 protein binds to RELA protein]
CTD PMID:12433058 PMID:12477282 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SLC2A4 solute carrier family 2 member 4 multiple interactions
increases abundance
ISO manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [SLC2A4 gene mutant form results in increased abundance of Glutathione Disulfide] CTD PMID:22221582 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257
JBrowse link
G SNCA synuclein alpha decreases abundance EXP SNCA protein results in decreased abundance of Glutathione Disulfide CTD PMID:27424009 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD2 superoxide dismutase 2 increases abundance EXP SOD2 protein results in increased abundance of Glutathione Disulfide CTD PMID:15130278 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G SULT1A1 sulfotransferase family 1A member 1 multiple interactions ISO Glutathione Disulfide affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog affects the reaction [adenosine 3'-phosphate-5'-phosphate binds to SULT1A1 protein]]; Glutathione Disulfide affects the reaction [Polychlorinated Biphenyls analog binds to SULT1A1 protein] CTD PMID:21130751 NCBI chr16:28,605,587...28,623,395
Ensembl chr16:28,605,196...28,623,625
Ensembl chr16:28,605,196...28,623,625
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases glutathionylation
EXP Dithiothreitol inhibits the reaction [Glutathione Disulfide results in increased glutathionylation of TP53 protein]; Glutathione Disulfide results in increased expression of and results in increased phosphorylation of and results in increased activity of TP53 protein CTD PMID:15993333 PMID:17555331 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
L-cystine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KYAT1 kynurenine aminotransferase 1 increases amination EXP KYAT1 protein results in increased amination of Cystine CTD PMID:22093698 NCBI chr 9:128,832,942...128,882,523
Ensembl chr 9:128,819,663...128,881,931
Ensembl chr 9:128,819,663...128,881,931
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK1 protein] CTD PMID:19850060 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO Cystine affects the reaction [Homocysteine results in increased phosphorylation of MAPK3 protein] CTD PMID:19850060 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G SLC3A1 solute carrier family 3 member 1 increases uptake
multiple interactions
EXP SLC3A1 protein results in increased uptake of Cystine
[SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine
CTD PMID:14978168 PMID:18845132 NCBI chr 2:44,275,464...44,321,494
Ensembl chr 2:44,275,458...44,321,494
JBrowse link
G SLC3A2 solute carrier family 3 member 2 multiple interactions ISO
EXP
[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933 PMID:22216172 NCBI chr11:62,856,109...62,888,860
Ensembl chr11:62,856,102...62,888,875
Ensembl chr11:62,856,102...62,888,875
JBrowse link
G SLC7A11 solute carrier family 7 member 11 multiple interactions ISO
EXP
[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine; Sulfasalazine inhibits the reaction [[SLC3A2 protein co-treated with SLC7A11 protein] results in increased uptake of Cystine]
[[[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione] which results in decreased susceptibility to Hydrogen Peroxide; [[Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine] which results in increased abundance of Glutathione; [Bilirubin results in increased activity of [SLC7A11 protein co-treated with SLC3A2 protein]] which results in increased uptake of Cystine
CTD PMID:19576933 PMID:22216172 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SLC7A9 solute carrier family 7 member 9 multiple interactions EXP [SLC3A1 protein co-treated with SLC7A9 protein] results in increased uptake of Cystine CTD PMID:14978168 NCBI chr19:32,830,511...32,870,957
Ensembl chr19:32,830,509...32,869,767
JBrowse link
lactacystin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions ISO lactacystin inhibits the reaction [AGT protein results in increased degradation of SYP protein] CTD PMID:18487452 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AHR aryl hydrocarbon receptor multiple interactions
affects localization
EXP
ISO
lactacystin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
lactacystin inhibits the reaction [geldanamycin results in increased degradation of AHR protein]; lactacystin inhibits the reaction [Tetrachlorodibenzodioxin results in increased degradation of AHR protein]
lactacystin affects the localization of AHR protein
CTD PMID:10722677 PMID:12237327 PMID:17445780 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 increases localization
affects localization
multiple interactions
ISO lactacystin results in increased localization of AIFM1 protein
lactacystin affects the localization of AIFM1 protein
ATRN protein affects the reaction [lactacystin affects the localization of AIFM1 protein]; U 0126 inhibits the reaction [lactacystin results in increased localization of AIFM1 protein]
CTD PMID:16860906 PMID:21683092 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G APOB apolipoprotein B multiple interactions
increases secretion
increases expression
EXP acetylleucyl-leucyl-norleucinal inhibits the reaction [lactacystin results in decreased expression of and results in decreased secretion of APOB protein]; HSPA5 promotes the reaction [lactacystin results in increased expression of APOB protein]; HSPA5 promotes the reaction [lactacystin results in increased secretion of APOB protein]; lactacystin inhibits the reaction [HSPA5 results in increased degradation of APOB protein]; lactacystin results in increased expression of and results in increased secretion of APOB protein CTD PMID:15618547 PMID:19383982 NCBI chr 2:21,001,429...21,044,073
Ensembl chr 2:21,001,429...21,044,073
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP lactacystin inhibits the reaction [resveratrol results in decreased secretion of APP protein] CTD PMID:16162502 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO lactacystin inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein] CTD PMID:10506578 NCBI chr 1:116,372,986...116,410,259
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
G ATRN attractin decreases response to substance
multiple interactions
ISO ATRN protein results in decreased susceptibility to lactacystin
ATRN protein affects the reaction [lactacystin affects the localization of AIFM1 protein]
CTD PMID:16860906 NCBI chr20:3,471,018...3,651,118
Ensembl chr20:3,471,018...3,651,118
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
ISO
EXP
lactacystin results in decreased expression of BCL2 protein
lactacystin inhibits the reaction [sodium bichromate results in decreased expression of BCL2 protein]
lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein]; Sirolimus inhibits the reaction [lactacystin results in decreased expression of BCL2 protein]
CTD PMID:18544562 PMID:18640276 PMID:19361538 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions ISO lactacystin inhibits the reaction [Acetaminophen results in decreased expression of BCL2L1 protein] CTD PMID:15673306 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G CASP3 caspase 3 increases activity
increases expression
multiple interactions
ISO lactacystin results in increased activity of CASP3 protein
lactacystin results in increased expression of CASP3 protein modified form
[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein; calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein]
CTD PMID:15618349 PMID:20649845 PMID:21683092 PMID:29944914 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP8 caspase 8 multiple interactions ISO lactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]] CTD PMID:20671745 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CCND1 cyclin D1 multiple interactions EXP lactacystin inhibits the reaction [Curcumin results in increased degradation of CCND1 protein] CTD PMID:18156803 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCNE1 cyclin E1 multiple interactions EXP lactacystin inhibits the reaction [Curcumin results in increased degradation of CCNE1 protein] CTD PMID:18156803 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312
JBrowse link
G CCS copper chaperone for superoxide dismutase multiple interactions ISO lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein]
lactacystin inhibits the reaction [[Copper Sulfate co-treated with 2,3,2-tetramine] results in increased degradation of CCS protein]
CTD PMID:12832419 PMID:19039664 NCBI chr11:66,593,162...66,606,019
Ensembl chr11:66,593,153...66,606,019
JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression
multiple interactions
EXP lactacystin results in increased expression of CDKN1B protein
lactacystin inhibits the reaction [Estradiol results in increased degradation of CDKN1B protein]
CTD PMID:12149143 PMID:17283133 PMID:23029392 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,715,058...12,722,369
JBrowse link
G CEBPB CCAAT enhancer binding protein beta increases expression EXP lactacystin results in increased expression of CEBPB protein CTD PMID:11779194 NCBI chr20:50,190,583...50,192,690
Ensembl chr20:50,190,830...50,192,668
JBrowse link
G CEBPD CCAAT enhancer binding protein delta increases expression EXP lactacystin results in increased expression of CEBPD protein CTD PMID:11779194 NCBI chr 8:47,736,913...47,738,164
Ensembl chr 8:47,736,913...47,738,164
JBrowse link
G COMT catechol-O-methyltransferase multiple interactions EXP lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein] CTD PMID:17138778 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G CP ceruloplasmin decreases degradation ISO lactacystin results in decreased degradation of CP protein CTD PMID:16405854 NCBI chr 3:149,162,410...149,222,008
Ensembl chr 3:149,162,410...149,221,829
JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP lactacystin inhibits the reaction [Indomethacin results in decreased expression of CTNNB1 protein]; lactacystin inhibits the reaction [resveratrol results in increased degradation of CTNNB1 protein] CTD PMID:11756231 PMID:26040106 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [lactacystin results in increased expression of CXCL8 mRNA]; Antimycin A inhibits the reaction [lactacystin results in increased expression of CXCL8 mRNA]; diphenyleneiodonium inhibits the reaction [lactacystin results in increased expression of CXCL8 mRNA]; Glutathione inhibits the reaction [lactacystin results in increased expression of CXCL8 mRNA]; Rotenone inhibits the reaction [lactacystin results in increased expression of CXCL8 mRNA] CTD PMID:12208513 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions ISO lactacystin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] CTD PMID:10722677 PMID:10777561 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP24A1 cytochrome P450 family 24 subfamily A member 1 multiple interactions EXP lactacystin promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA] CTD PMID:24792400 NCBI chr20:54,145,731...54,174,032
Ensembl chr20:54,153,446...54,173,986
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 multiple interactions EXP lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]; lactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA] CTD PMID:24224465 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 multiple interactions EXP lactacystin inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP3A4 mRNA]; lactacystin inhibits the reaction [Phenobarbital results in increased expression of CYP3A4 mRNA] CTD PMID:24224465 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP lactacystin results in increased expression of DDIT3 mRNA CTD PMID:19135031 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DIO2 iodothyronine deiodinase 2 multiple interactions EXP lactacystin inhibits the reaction [Cycloheximide results in decreased activity of DIO2 protein]; lactacystin inhibits the reaction [Thyroxine results in decreased activity of DIO2 protein]; lactacystin results in increased expression of and results in increased activity of DIO2 protein CTD PMID:11425850 NCBI chr14:80,197,526...80,231,057
Ensembl chr14:80,197,527...80,387,757
Ensembl chr14:80,197,527...80,387,757
JBrowse link
G EIF4E eukaryotic translation initiation factor 4E multiple interactions EXP lactacystin inhibits the reaction [Cadmium Chloride results in decreased expression of EIF4E protein] CTD PMID:15878868 NCBI chr 4:98,879,276...98,929,133
Ensembl chr 4:98,871,684...98,930,637
Ensembl chr 4:98,871,684...98,930,637
JBrowse link
G ERBB2 erb-b2 receptor tyrosine kinase 2 multiple interactions EXP lactacystin inhibits the reaction [Dronabinol results in decreased expression of ERBB2 protein] CTD PMID:30733293 NCBI chr17:39,688,094...39,728,660
Ensembl chr17:39,687,914...39,730,426
JBrowse link
G FZR1 fizzy and cell division cycle 20 related 1 multiple interactions EXP lactacystin inhibits the reaction [Estradiol affects the localization of FZR1 protein] CTD PMID:23029392 NCBI chr19:3,506,263...3,538,334
Ensembl chr19:3,506,273...3,538,330
Ensembl chr19:3,506,273...3,538,330
JBrowse link
G GJA1 gap junction protein alpha 1 multiple interactions ISO lactacystin inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein] CTD PMID:22150760 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727
JBrowse link
G GLS glutaminase multiple interactions EXP lactacystin inhibits the reaction [diphenylarsinic acid results in increased degradation of GLS protein alternative form] CTD PMID:22493432 NCBI chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
Ensembl chr 2:190,880,821...190,965,552
JBrowse link
G GRIA1 glutamate ionotropic receptor AMPA type subunit 1 increases localization ISO lactacystin results in increased localization of GRIA1 protein CTD PMID:19674091 NCBI chr 5:153,490,670...153,813,873
Ensembl chr 5:153,489,615...153,813,869
JBrowse link
G GRIA2 glutamate ionotropic receptor AMPA type subunit 2 increases localization ISO lactacystin results in increased localization of GRIA2 protein CTD PMID:19674091 NCBI chr 4:157,220,120...157,370,583
Ensembl chr 4:157,204,182...157,366,075
JBrowse link
G GSTA2 glutathione S-transferase alpha 2 increases expression EXP lactacystin results in increased expression of GSTA2 mRNA CTD PMID:12446695 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP lactacystin inhibits the reaction [geldanamycin results in increased degradation of HIF1A protein] CTD PMID:11980636 NCBI chr14:61,695,513...61,748,259
Ensembl chr14:61,695,513...61,748,259
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
ISO lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; lactacystin promotes the reaction [manganese chloride results in increased expression of HMOX1 protein]
lactacystin results in increased expression of HMOX1 mRNA
CTD PMID:12441344 PMID:21384399 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HPX hemopexin multiple interactions ISO lactacystin inhibits the reaction [[cobaltiprotoporphyrin binds to HPX protein] which results in increased degradation of CCS protein]; lactacystin inhibits the reaction [[Heme binds to HPX protein] which results in increased degradation of CCS protein] CTD PMID:19039664 NCBI chr11:6,431,049...6,440,987
Ensembl chr11:6,431,049...6,442,617
JBrowse link
G HSF1 heat shock transcription factor 1 increases activity EXP lactacystin results in increased activity of HSF1 protein CTD PMID:11893605 NCBI chr 8:144,291,603...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G HSF2 heat shock transcription factor 2 increases activity EXP lactacystin results in increased activity of HSF2 protein CTD PMID:11893605 NCBI chr 6:122,399,551...122,433,119
Ensembl chr 6:122,399,551...122,433,119
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP HSPA5 promotes the reaction [lactacystin results in increased expression of APOB protein]; HSPA5 promotes the reaction [lactacystin results in increased secretion of APOB protein]; lactacystin inhibits the reaction [HSPA5 results in increased degradation of APOB protein] CTD PMID:15618547 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,343
JBrowse link
G IFNG interferon gamma multiple interactions ISO
EXP
lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG mRNA]
lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]
CTD PMID:22398747 PMID:25766886 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL13 interleukin 13 multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL13 mRNA] CTD PMID:22398747 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein] CTD PMID:25766886 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 mRNA] CTD PMID:22398747 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G IL2RA interleukin 2 receptor subunit alpha multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2RA mRNA] CTD PMID:22398747 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370
JBrowse link
G IL4 interleukin 4 multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 mRNA] CTD PMID:22398747 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
EXP lactacystin results in increased expression of IL6 mRNA; lactacystin results in increased expression of IL6 protein
Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 mRNA]; Quercetin inhibits the reaction [lactacystin results in increased expression of IL6 protein]
CTD PMID:11893605 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions EXP lactacystin promotes the reaction [Tretinoin results in increased expression of ITGAM protein] CTD PMID:20945414 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G LAMB1 laminin subunit beta 1 multiple interactions ISO lactacystin inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein] CTD PMID:22150760 NCBI chr 7:107,923,799...108,003,176
Ensembl chr 7:107,923,799...108,003,187
Ensembl chr 7:107,923,799...108,003,187
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases activity
multiple interactions
ISO lactacystin results in increased activity of MAPK1 protein
U 0126 inhibits the reaction [lactacystin results in increased activity of MAPK1 protein]
CTD PMID:21683092 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases activity
multiple interactions
ISO lactacystin results in increased activity of MAPK3 protein
U 0126 inhibits the reaction [lactacystin results in increased activity of MAPK3 protein]
CTD PMID:21683092 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases activity
increases phosphorylation
ISO lactacystin results in increased activity of MAPK8 protein
lactacystin results in increased phosphorylation of MAPK8 protein
CTD PMID:15618349 PMID:18463101 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MAPK8IP1 mitogen-activated protein kinase 8 interacting protein 1 increases expression ISO lactacystin results in increased expression of MAPK8IP1 protein CTD PMID:15618349 NCBI chr11:45,885,651...45,906,465
Ensembl chr11:45,885,651...45,906,465
JBrowse link
G MTTP microsomal triglyceride transfer protein increases ubiquitination ISO lactacystin results in increased ubiquitination of MTTP protein CTD PMID:17405876 NCBI chr 4:99,564,130...99,623,997
Ensembl chr 4:99,563,761...99,623,999
Ensembl chr 4:99,563,761...99,623,999
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 increases expression
decreases degradation
multiple interactions
EXP
ISO
lactacystin results in increased expression of NFE2L2 protein
lactacystin results in decreased degradation of NFE2L2 protein
lactacystin promotes the reaction [Cadmium Chloride results in increased expression of NFE2L2 protein]
lactacystin promotes the reaction [manganese chloride affects the localization of and results in increased activity of NFE2L2 protein]; lactacystin promotes the reaction [manganese chloride promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]
CTD PMID:12441344 PMID:12446695 PMID:15322212 PMID:21384399 PMID:26598004 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP lactacystin promotes the reaction [Deoxycholic Acid results in increased phosphorylation of NFKBIA protein] CTD PMID:17644113 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NOL3 nucleolar protein 3 multiple interactions ISO lactacystin affects the reaction [Doxorubicin results in increased degradation of NOL3 protein] CTD PMID:19139834 NCBI chr16:67,170,538...67,175,737
Ensembl chr16:67,170,154...67,175,735
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions ISO
EXP
lactacystin inhibits the reaction [GW 7647 inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [pirinixic acid inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [zinc protoporphyrin inhibits the reaction [Peptidoglycan results in increased expression of NOS2 protein]]
lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [deoxynivalenol results in increased degradation of NOS2 protein]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]
CTD PMID:17891158 PMID:19376148 PMID:25766886 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 decreases activity
multiple interactions
EXP lactacystin results in decreased activity of NR1I3 protein
lactacystin inhibits the reaction [Phenobarbital affects the localization of NR1I3 protein]
CTD PMID:24224465 NCBI chr 1:161,229,666...161,238,623
Ensembl chr 1:161,229,666...161,238,302
Ensembl chr 1:161,229,666...161,238,302
JBrowse link
G OPTN optineurin increases expression
multiple interactions
ISO lactacystin results in increased expression of OPTN protein
lactacystin results in increased expression of and results in increased ubiquitination of OPTN protein
CTD PMID:21059646 NCBI chr10:13,100,082...13,138,308
Ensembl chr10:13,099,449...13,138,308
JBrowse link
G OTC ornithine transcarbamylase multiple interactions
decreases metabolic processing
EXP lactacystin inhibits the reaction [Oxygen results in decreased metabolism of OTC protein]
lactacystin results in decreased metabolism of OTC protein
CTD PMID:11161710 NCBI chr  X:38,352,528...38,421,446
Ensembl chr  X:38,352,586...38,421,446
JBrowse link
G PARK7 Parkinsonism associated deglycase decreases response to substance EXP PARK7 protein results in decreased susceptibility to lactacystin CTD PMID:18331584 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
G PDIA2 protein disulfide isomerase family A member 2 increases expression EXP lactacystin results in increased expression of PDIA2 mRNA; lactacystin results in increased expression of PDIA2 protein CTD PMID:15353226 NCBI chr16:283,164...287,215
Ensembl chr16:283,152...287,215
Ensembl chr16:283,152...287,215
JBrowse link
G PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 increases expression ISO lactacystin results in increased expression of PFKFB3 protein CTD PMID:19448625 NCBI chr10:6,144,918...6,254,648
Ensembl chr10:6,144,934...6,254,644
JBrowse link
G PPP1R15A protein phosphatase 1 regulatory subunit 15A increases expression EXP lactacystin results in increased expression of PPP1R15A mRNA CTD PMID:19135031 NCBI chr19:48,872,421...48,876,058
Ensembl chr19:48,872,421...48,876,058
JBrowse link
G PRKCB protein kinase C beta multiple interactions EXP lactacystin inhibits the reaction [Deoxycholic Acid results in increased expression of PRKCB protein] CTD PMID:17644113 NCBI chr16:23,835,983...24,220,611
Ensembl chr16:23,835,983...24,220,611
JBrowse link
G PSMB10 proteasome 20S subunit beta 10 multiple interactions ISO [PSMB8 protein co-treated with PSMB10 protein] affects the susceptibility to lactacystin CTD PMID:22398747 NCBI chr16:67,934,506...67,936,850
Ensembl chr16:67,934,506...67,936,864
JBrowse link
G PSMB8 proteasome 20S subunit beta 8 multiple interactions ISO [PSMB8 protein co-treated with PSMB10 protein] affects the susceptibility to lactacystin CTD PMID:22398747 NCBI chr 6:32,840,717...32,844,679
Ensembl chr 6:32,840,717...32,844,679
JBrowse link
G PSMD4 proteasome 26S subunit, non-ATPase 4 multiple interactions EXP lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] CTD PMID:15362974 NCBI chr 1:151,254,734...151,267,479
Ensembl chr 1:151,254,703...151,267,479
Ensembl chr 1:151,254,703...151,267,479
JBrowse link
G RBPJ recombination signal binding protein for immunoglobulin kappa J region increases expression EXP lactacystin results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr 4:26,163,458...26,435,131
Ensembl chr 4:26,163,455...26,435,131
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP lactacystin inhibits the reaction [Deoxycholic Acid results in increased localization of RELA protein] CTD PMID:17644113 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,597...65,663,090
JBrowse link
G SERPINE1 serpin family E member 1 multiple interactions EXP lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]] CTD PMID:18344023 NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247
JBrowse link
G SKP2 S-phase kinase associated protein 2 multiple interactions
decreases expression
EXP lactacystin inhibits the reaction [Estradiol results in increased expression of SKP2 protein]
lactacystin results in decreased expression of SKP2 protein
CTD PMID:23029392 NCBI chr 5:36,152,067...36,184,319
Ensembl chr 5:36,151,989...36,184,319
Ensembl chr 5:36,151,989...36,184,319
JBrowse link
G SLC10A2 solute carrier family 10 member 2 multiple interactions EXP lactacystin inhibits the reaction [resveratrol results in decreased expression of SLC10A2 protein] CTD PMID:24498857 NCBI chr13:103,043,998...103,066,417
Ensembl chr13:103,043,998...103,066,417
JBrowse link
G SLC31A1 solute carrier family 31 member 1 multiple interactions EXP lactacystin inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] CTD PMID:17108132 NCBI chr 9:113,221,544...113,264,492
Ensembl chr 9:113,221,544...113,264,492
JBrowse link
G SLC38A3 solute carrier family 38 member 3 multiple interactions ISO lactacystin inhibits the reaction [manganese chloride results in increased degradation of SLC38A3 protein] CTD PMID:20737472 NCBI chr 3:50,205,268...50,221,486
Ensembl chr 3:50,205,246...50,221,486
JBrowse link
G SNCA synuclein alpha multiple interactions
decreases expression
EXP
ISO
lactacystin promotes the reaction [SNCA protein mutant form binds to SNCA protein mutant form]
lactacystin results in decreased expression of SNCA protein
CTD PMID:16584840 PMID:18818210 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
affects localization
EXP
ISO
lactacystin inhibits the reaction [Glucose deficiency results in increased degradation of SOD1 protein]
lactacystin affects the localization of SOD1 protein mutant form
Copper promotes the reaction [lactacystin affects the localization of SOD1 protein mutant form]; Ditiocarb inhibits the reaction [lactacystin affects the localization of SOD1 protein mutant form]
CTD PMID:15034941 PMID:17309078 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SPTAN1 spectrin alpha, non-erythrocytic 1 multiple interactions
increases cleavage
ISO [lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein; calpain inhibitor III inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein] CTD PMID:21683092 NCBI chr 9:128,552,564...128,633,662
Ensembl chr 9:128,552,558...128,633,662
JBrowse link
G STK11 serine/threonine kinase 11 multiple interactions EXP lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein] CTD PMID:21191146 NCBI chr19:1,205,778...1,228,431
Ensembl chr19:1,177,558...1,228,431
Ensembl chr19:1,177,558...1,228,431
JBrowse link
G SYP synaptophysin multiple interactions ISO lactacystin inhibits the reaction [AGT protein results in increased degradation of SYP protein] CTD PMID:18487452 NCBI chr  X:49,187,815...49,200,193
Ensembl chr  X:49,187,815...49,200,199
Ensembl chr  X:49,187,815...49,200,199
JBrowse link
G TBX21 T-box transcription factor 21 multiple interactions ISO lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA] CTD PMID:22398747 NCBI chr17:47,733,236...47,746,122
Ensembl chr17:47,733,236...47,746,122
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP lactacystin inhibits the reaction [tin protoporphyrin IX inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]] CTD PMID:18344023 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TIPARP TCDD inducible poly(ADP-ribose) polymerase multiple interactions ISO lactacystin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of TIPARP mRNA] CTD PMID:12147270 NCBI chr 3:156,674,590...156,706,770
Ensembl chr 3:156,673,235...156,706,770
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP
ISO
lactacystin inhibits the reaction [deoxynivalenol inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]]; lactacystin inhibits the reaction [TNF protein results in increased expression of COMT protein]; lactacystin promotes the reaction [[IFNG protein co-treated with TNF protein co-treated with IL1B protein] results in increased expression of NOS2 protein]
lactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF mRNA]; lactacystin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:17138778 PMID:18809656 PMID:22398747 PMID:25766886 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TOMM20 translocase of outer mitochondrial membrane 20 affects localization EXP lactacystin affects the localization of TOMM20 protein CTD PMID:11161710 NCBI chr 1:235,109,341...235,128,837
Ensembl chr 1:235,109,341...235,128,837
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases ubiquitination
ISO lactacystin inhibits the reaction [Acetaminophen results in increased degradation of TP53 protein]; lactacystin results in increased phosphorylation of and results in increased expression of TP53 protein
lactacystin results in increased ubiquitination of TP53 protein
CTD PMID:16330492 PMID:18463101 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TP63 tumor protein p63 multiple interactions EXP lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of STK11 protein]; lactacystin inhibits the reaction [[Cisplatin results in increased phosphorylation of TP63 protein alternative form] which results in increased degradation of TP63 protein alternative form] CTD PMID:21191146 NCBI chr 3:189,596,746...189,897,276
Ensembl chr 3:189,631,389...189,897,276
JBrowse link
G TSC22D3 TSC22 domain family member 3 multiple interactions ISO lactacystin inhibits the reaction [[benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone results in decreased activity of CASP8 protein] inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]] CTD PMID:20671745 NCBI chr  X:107,713,221...107,777,329
Ensembl chr  X:107,713,221...107,777,342
JBrowse link
G UBXN1 UBX domain protein 1 multiple interactions EXP lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein] CTD PMID:15362974 NCBI chr11:62,676,500...62,679,116
Ensembl chr11:62,676,498...62,679,117
JBrowse link
G UCP2 uncoupling protein 2 multiple interactions ISO lactacystin inhibits the reaction [[pirinixic acid results in increased expression of UCP2 protein] which results in increased degradation of BCL2 protein] CTD PMID:19361538 NCBI chr11:73,974,671...73,983,202
Ensembl chr11:73,974,672...73,983,246
Ensembl chr11:73,974,672...73,983,246
JBrowse link
G VCP valosin containing protein multiple interactions
increases expression
EXP lactacystin promotes the reaction [VCP protein binds to UBXN1 protein binds to PSMD4 protein]
lactacystin results in increased expression of VCP protein
CTD PMID:15362974 NCBI chr 9:35,056,064...35,072,625
Ensembl chr 9:35,056,064...35,072,627
Ensembl chr 9:35,056,064...35,072,627
Ensembl chr 9:35,056,064...35,072,627
JBrowse link
G VDR vitamin D receptor decreases degradation EXP lactacystin results in decreased degradation of VDR protein CTD PMID:24792400 NCBI chr12:47,841,537...47,905,022
Ensembl chr12:47,841,537...47,943,048
JBrowse link
G XBP1 X-box binding protein 1 decreases response to substance EXP XBP1 protein results in decreased susceptibility to lactacystin CTD PMID:19135031 NCBI chr22:28,794,560...28,800,569
Ensembl chr22:28,794,555...28,800,597
JBrowse link
leukotriene E4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase multiple interactions ISO
EXP
ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [Ovalbumin results in increased abundance of Leukotriene E4]]
[zileuton results in decreased activity of ALOX5 protein] which results in decreased abundance of Leukotriene E4
CTD PMID:8621850 PMID:10764316 PMID:12794006 NCBI chr10:45,374,209...45,446,121
Ensembl chr10:45,374,176...45,446,119
JBrowse link
G CYSLTR1 cysteinyl leukotriene receptor 1 affects binding
multiple interactions
EXP
ISO
Leukotriene E4 binds to CYSLTR1 protein
[Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein; montelukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]; zafirlukast inhibits the reaction [Leukotriene E4 binds to and results in increased activity of CYSLTR1 protein]
Leukotriene E4 inhibits the reaction [Leukotriene D4 binds to CYSLTR1 protein]
CTD PMID:8384568 PMID:9620942 PMID:10462554 PMID:11705452 PMID:12853847 NCBI chr  X:78,271,468...78,327,611
Ensembl chr  X:78,271,468...78,327,691
JBrowse link
G CYSLTR2 cysteinyl leukotriene receptor 2 multiple interactions
increases activity
EXP [Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; [Leukotriene E4 results in increased activity of CYSLTR2 protein] which results in increased abundance of Calcium; Leukotriene E4 binds to and results in increased activity of CYSLTR2 protein CTD PMID:10851239 PMID:11093801 NCBI chr13:48,653,929...48,711,226
Ensembl chr13:48,653,711...48,711,226
JBrowse link
G GPR17 G protein-coupled receptor 17 increases activity ISO Leukotriene E4 results in increased activity of GPR17 protein CTD PMID:18974869 NCBI chr 2:127,646,153...127,652,639
Ensembl chr 2:127,645,864...127,652,639
JBrowse link
G IL13 interleukin 13 increases abundance ISO IL13 protein results in increased abundance of Leukotriene E4 CTD PMID:12654629 NCBI chr 5:132,656,522...132,661,110
Ensembl chr 5:132,656,263...132,661,110
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 decreases activity ISO Leukotriene E4 results in decreased activity of MGST1 protein CTD PMID:9890956 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MUC5AC mucin 5AC, oligomeric mucus/gel-forming increases expression ISO Leukotriene E4 results in increased expression of MUC5AC protein CTD PMID:12654629 NCBI chr11:1,157,953...1,201,138
Ensembl chr11:1,157,953...1,201,138
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 gene mutant form promotes the reaction [Carbon Tetrachloride results in increased abundance of Leukotriene E4] CTD PMID:25432964 NCBI chr 9:122,369,906...122,395,703
Ensembl chr 9:122,370,530...122,395,703
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A1BG alpha-1-B glycoprotein multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of A1BG mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of A1BG mRNA] CTD PMID:22129741 NCBI chr19:58,345,183...58,353,492
Ensembl chr19:58,345,178...58,353,492
JBrowse link
G ABCA1 ATP binding cassette subfamily A member 1 multiple interactions EXP Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 mRNA]; Acetylcysteine inhibits the reaction [sodium arsenite results in decreased expression of ABCA1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased methylation of ABCA1 promoter] CTD PMID:31150806 NCBI chr 9:104,781,006...104,928,232
Ensembl chr 9:104,781,006...104,928,155
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP
ISO
Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of CASP7 protein]; Acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]] which affects the cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in increased expression of ABCB1 mRNA]
Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ABCB1]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of and results in increased activity of ABCB1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased expression of and results in increased activity of ABCB1 protein]
CTD PMID:10636889 PMID:18474546 PMID:22914566 PMID:23867903 PMID:25824409 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 multiple interactions EXP Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC1 mRNA]; Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC1 protein]; Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]; Buthionine Sulfoximine analog inhibits the reaction [Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to Doxorubicin]] CTD PMID:11820781 PMID:15473893 PMID:22914566 PMID:23867903 NCBI chr16:15,949,616...16,143,062
Ensembl chr16:15,949,577...16,143,074
Ensembl chr16:15,949,577...16,143,074
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions EXP Acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCC2 mRNA]; Acetylcysteine inhibits the reaction [formononetin results in decreased expression of ABCC2 mRNA] CTD PMID:22914566 PMID:23867903 NCBI chr10:99,782,602...99,853,741
Ensembl chr10:99,782,640...99,852,594
JBrowse link
G ABCC3 ATP binding cassette subfamily C member 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Sulindac results in increased expression of ABCC3 protein] CTD PMID:11820781 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253
JBrowse link
G ABCG1 ATP binding cassette subfamily G member 1 decreases expression EXP Acetylcysteine results in decreased expression of ABCG1 mRNA CTD PMID:16084531 NCBI chr21:42,199,689...42,304,387
Ensembl chr21:42,199,689...42,297,244
JBrowse link
G ABCG4 ATP binding cassette subfamily G member 4 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ABCG4 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ABCG4 mRNA] CTD PMID:22129741 NCBI chr11:119,149,052...119,162,666
Ensembl chr11:119,149,052...119,162,653
JBrowse link
G ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO Acetylcysteine inhibits the reaction [NSC 680410 results in decreased phosphorylation of ABL1 protein] CTD PMID:16481037 NCBI chr 9:130,713,881...130,887,675
Ensembl chr 9:130,713,016...130,887,675
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions
affects response to substance
ISO [Zinc co-treated with Selenium co-treated with Acetylcysteine] inhibits the reaction [dimethyl mercury results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Cadmium results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased activity of ACHE protein]; Acetylcysteine inhibits the reaction [Fenitrothion results in decreased expression of ACHE protein]
ACHE protein affects the susceptibility to Acetylcysteine
Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased expression of ACHE mRNA alternative form]; Acetylcysteine inhibits the reaction [Streptozocin results in increased activity of ACHE protein]
CTD PMID:20399762 PMID:20688495 PMID:26769589 PMID:27087133 PMID:27163631 PMID:28499986 PMID:29253600 PMID:30639957 PMID:31173782 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACP3 acid phosphatase 3 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACP3 mRNA CTD PMID:22129741 NCBI chr 3:132,317,403...132,368,765
Ensembl chr 3:132,317,369...132,368,298
JBrowse link
G ACSM5 acyl-CoA synthetase medium chain family member 5 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSM5 mRNA; Acetylcysteine inhibits the reaction [[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of ACSM5 mRNA] CTD PMID:22129741 NCBI chr16:20,409,534...20,441,336
Ensembl chr16:20,409,534...20,441,336
JBrowse link
G ACSS1 acyl-CoA synthetase short chain family member 1 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ACSS1 mRNA CTD PMID:22129741 NCBI chr20:25,006,232...25,058,143
Ensembl chr20:25,006,230...25,058,980
JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions EXP
ISO
Acetylcysteine inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ACTA2 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]
CTD PMID:16757516 PMID:21134390 PMID:32659284 NCBI chr10:88,935,074...88,991,397
Ensembl chr10:88,935,074...88,991,339
JBrowse link
G ADAM33 ADAM metallopeptidase domain 33 multiple interactions EXP Acetylcysteine inhibits the reaction [Particulate Matter results in increased expression of ADAM33 mRNA] CTD PMID:29753051 NCBI chr20:3,667,973...3,682,108
Ensembl chr20:3,667,965...3,682,246
JBrowse link
G ADGRB2 adhesion G protein-coupled receptor B2 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ADGRB2 mRNA CTD PMID:22129741 NCBI chr 1:31,727,105...31,764,340
Ensembl chr 1:31,727,117...31,764,893
JBrowse link
G ADGRB3 adhesion G protein-coupled receptor B3 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ADGRB3 mRNA CTD PMID:22129741 NCBI chr 6:68,635,282...69,389,506
Ensembl chr 6:68,635,282...69,389,506
JBrowse link
G ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide multiple interactions ISO Acetylcysteine inhibits the reaction [Ethanol results in increased expression of ADH1 mRNA] CTD PMID:20705415 NCBI chr 4:99,336,497...99,352,746
Ensembl chr 4:99,336,497...99,352,746
JBrowse link
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions ISO Acetylcysteine inhibits the reaction [Palmitates results in decreased expression of ADIPOQ mRNA]; Acetylcysteine inhibits the reaction [Palmitates results in decreased expression of ADIPOQ protein]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]; Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ mRNA]]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOQ protein]] CTD PMID:17471172 PMID:21912612 NCBI chr 3:186,842,710...186,858,463
Ensembl chr 3:186,842,704...186,858,463
JBrowse link
G ADIPOR2 adiponectin receptor 2 multiple interactions ISO Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]; Allopurinol promotes the reaction [Acetylcysteine inhibits the reaction [Streptozocin results in decreased expression of ADIPOR2 protein]] CTD PMID:21912612 NCBI chr12:1,691,059...1,788,674
Ensembl chr12:1,688,574...1,788,674
JBrowse link
G AGT angiotensinogen multiple interactions ISO Acetylcysteine inhibits the reaction [AGT protein results in increased phosphorylation of and results in increased activity of EGFR protein]
Acetylcysteine inhibits the reaction [AGT protein modified form results in increased abundance of Reactive Oxygen Species]
CTD PMID:15849355 PMID:30703374 NCBI chr 1:230,702,523...230,745,583
Ensembl chr 1:230,702,523...230,714,122
Ensembl chr 1:230,702,523...230,714,122
JBrowse link
G AGTR1 angiotensin II receptor type 1 multiple interactions ISO Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of AGTR1 mRNA] CTD PMID:23603059 NCBI chr 3:148,697,903...148,743,003
Ensembl chr 3:148,697,784...148,743,008
JBrowse link
G AHR aryl hydrocarbon receptor increases expression
multiple interactions
ISO
EXP
Acetylcysteine results in increased expression of AHR protein
Acetylcysteine inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of and affects the localization of AHR protein]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1A enhancer]; Acetylcysteine promotes the reaction [AHR protein binds to CDKN1B enhancer]
CTD PMID:18022818 PMID:21569840 PMID:31551408 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions ISO
EXP
Acetylcysteine inhibits the reaction [Cadmium Chloride affects the localization of AIFM1 protein]
Acetylcysteine inhibits the reaction [bisphenol A affects the localization of AIFM1 protein]
Acetylcysteine inhibits the reaction [1,12-benzoperylene results in increased expression of AIFM1 protein]; Acetylcysteine inhibits the reaction [2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide affects the localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [perfosfamide results in increased localization of AIFM1 protein]; Acetylcysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone affects the localization of AIFM1 protein]
CTD PMID:18034189 PMID:18412143 PMID:18506790 PMID:18951928 PMID:19679660 PMID:21741372 PMID:27189055 PMID:31518672 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AIMP1 aminoacyl tRNA synthetase complex interacting multifunctional protein 1 decreases expression EXP Acetylcysteine results in decreased expression of AIMP1 mRNA CTD PMID:16084531 NCBI chr 4:106,315,544...106,349,456
Ensembl chr 4:106,315,544...106,349,456
JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 multiple interactions EXP Acetylcysteine inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein]; Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AKR1C3 mRNA] CTD PMID:18829485 PMID:21787718 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein]; [Acetylcysteine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein; Acetylcysteine inhibits the reaction [1,4-naphthoquinone analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic analog results in increased phosphorylation of and affects the localization of AKT1 protein]; Acetylcysteine inhibits the reaction [arsenic trichloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased activity of AKT1 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Butyric Acid results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cadmium acetate results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cholix toxin, Vibrio cholerae results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cucurbitacin E affects the phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [diallyl trisulfide results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [divinyl sulfone analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Fingolimod Hydrochloride results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [ginsenoside Rk1 results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Morpholines analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [N-arachidonoylalanine results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [oenothein B results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Patulin results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [synaptamide results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [titanium dioxide results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]; Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein
Acetylcysteine inhibits the reaction [4-nonylphenol results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]
Acetylcysteine inhibits the reaction [cadmium acetate results in decreased expression of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of AKT1 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in increased expression of AKT1 mRNA]
CTD PMID:12168106 PMID:12614848 PMID:16137721 PMID:16731823 PMID:21055460 PMID:21195169 PMID:21787718 PMID:22427991 PMID:22867088 PMID:23000059 PMID:23159718 PMID:23948867 PMID:24299490 PMID:24449419 PMID:24489685 PMID:24582688 PMID:24875536 PMID:24933620 PMID:25199686 PMID:25471227 PMID:25939952 PMID:25944616 PMID:26514923 PMID:26804764 PMID:26942697 PMID:27106530 PMID:27117918 PMID:27411387 PMID:27658547 PMID:28087840 PMID:28600122 PMID:29604266 PMID:30265530 PMID:30452899 PMID:30797898 PMID:30871965 PMID:31068539 PMID:31157476 PMID:32305283 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALAD aminolevulinate dehydratase multiple interactions ISO Acetylcysteine promotes the reaction [Zinc Sulfate inhibits the reaction [sodium arsenite results in decreased activity of ALAD protein]] CTD PMID:16959597 NCBI chr 9:113,386,312...113,401,301
Ensembl chr 9:113,386,312...113,401,290
JBrowse link
G ALB albumin multiple interactions ISO Acetylcysteine inhibits the reaction [Acetaminophen results in decreased expression of ALB protein]; Acetylcysteine inhibits the reaction [ALB protein modified form results in decreased expression of MFN2 protein]; Acetylcysteine inhibits the reaction [ALB protein modified form results in increased abundance of Hydrogen Peroxide]; Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]; Acetylcysteine inhibits the reaction [Mustard Gas results in increased expression of ALB protein]; Acetylcysteine promotes the reaction [Selenium inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]]; Selenium promotes the reaction [Acetylcysteine inhibits the reaction [Mercuric Chloride results in decreased expression of ALB protein]] CTD PMID:11428623 PMID:20804811 PMID:24485406 PMID:27997345 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member multiple interactions EXP Acetylcysteine inhibits the reaction [Nitroglycerin results in decreased activity of ALDH2 protein] CTD PMID:17585900 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
JBrowse link
G ALK ALK receptor tyrosine kinase multiple interactions EXP Acetylcysteine affects the phosphorylation of and affects the activity of ALK protein mutant form CTD PMID:19503098 NCBI chr 2:29,190,992...29,921,589
Ensembl chr 2:29,192,774...29,921,586
JBrowse link
G AMACR alpha-methylacyl-CoA racemase multiple interactions EXP Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of AMACR mRNA] CTD PMID:18829485 NCBI chr 5:33,986,165...34,008,050
Ensembl chr 5:33,986,165...34,008,104
JBrowse link
G ANG angiogenin multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased secretion of ANG protein] CTD PMID:26138014 NCBI chr14:20,684,177...20,694,186
Ensembl chr14:20,684,177...20,698,971
JBrowse link
G ANGPT1 angiopoietin 1 decreases secretion EXP Acetylcysteine results in decreased secretion of ANGPT1 protein CTD PMID:19622383 NCBI chr 8:107,249,482...107,497,918
Ensembl chr 8:107,249,482...107,498,055
JBrowse link
G ANGPTL4 angiopoietin like 4 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANGPTL4 mRNA CTD PMID:22129741 NCBI chr19:8,364,129...8,374,373
Ensembl chr19:8,363,289...8,374,370
JBrowse link
G ANKRD29 ankyrin repeat domain 29 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ANKRD29 mRNA CTD PMID:22129741 NCBI chr18:23,598,926...23,662,914
Ensembl chr18:23,598,926...23,662,911
JBrowse link
G AOC1 amine oxidase copper containing 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Methotrexate results in increased activity of AOC1 protein] CTD PMID:20885979 NCBI chr 7:150,824,875...150,861,504
Ensembl chr 7:150,824,627...150,861,504
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Cholesterol analog results in increased expression of APAF1 mRNA]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide results in increased expression of APAF1 protein] CTD PMID:15877105 PMID:19477266 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
Ensembl chr12:98,645,141...98,735,433
JBrowse link
G APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions EXP
ISO
Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein]
Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of APEX1 mRNA]
CTD PMID:12231548 PMID:17938202 NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772
JBrowse link
G APEX2 apurinic/apyrimidinic endodeoxyribonuclease 2 multiple interactions
decreases expression
ISO Acetylcysteine inhibits the reaction [Acrylonitrile results in increased expression of APEX2 mRNA]
Acetylcysteine results in decreased expression of APEX2 mRNA
CTD PMID:26332274 NCBI chr  X:55,000,363...55,009,057
Ensembl chr  X:55,000,363...55,009,057
JBrowse link
G APH1B aph-1 homolog B, gamma-secretase subunit multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of APH1B mRNA CTD PMID:22129741 NCBI chr15:63,277,550...63,309,126
Ensembl chr15:63,276,018...63,309,126
JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP Acetylcysteine inhibits the reaction [APP protein affects the localization of RELA protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK14 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased activity of MAPK8 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of CASP1 protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of and results in increased cleavage of IL1B protein]; Acetylcysteine inhibits the reaction [APP protein results in increased expression of NLRP3 protein] CTD PMID:12684028 PMID:28004443 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AQP2 aquaporin 2 increases expression ISO Acetylcysteine results in increased expression of AQP2 protein CTD PMID:23183129 NCBI chr12:49,950,737...49,958,878
Ensembl chr12:49,950,737...49,958,878
Ensembl chr12:49,950,737...49,958,878
JBrowse link
G AR androgen receptor multiple interactions EXP Acetylcysteine inhibits the reaction [SOD2 protein affects the activity of AR protein]; Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of AR mRNA]; Acetylcysteine inhibits the reaction [Sodium Selenite results in decreased expression of AR protein] CTD PMID:16928829 PMID:18829485 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ARL13A ADP ribosylation factor like GTPase 13A multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARL13A mRNA CTD PMID:22129741 NCBI chr  X:100,969,011...100,990,831
Ensembl chr  X:100,969,708...100,990,831
JBrowse link
G ARNT aryl hydrocarbon receptor nuclear translocator multiple interactions EXP Acetylcysteine inhibits the reaction [Curcumin results in increased degradation of ARNT protein] CTD PMID:16880289 NCBI chr 1:150,809,713...150,876,737
Ensembl chr 1:150,809,713...150,876,708
JBrowse link
G ARNTL aryl hydrocarbon receptor nuclear translocator like multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARNTL mRNA CTD PMID:22129741 NCBI chr11:13,276,552...13,387,268
Ensembl chr11:13,276,652...13,387,266
JBrowse link
G ARRDC3 arrestin domain containing 3 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ARRDC3 mRNA CTD PMID:22129741 NCBI chr 5:91,368,631...91,383,332
Ensembl chr 5:91,368,631...91,383,317
JBrowse link
G ART4 ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) decreases expression EXP Acetylcysteine results in decreased expression of ART4 mRNA CTD PMID:16084531 NCBI chr12:14,825,569...14,843,526
Ensembl chr12:14,825,569...14,843,526
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ASNS mRNA CTD PMID:22129741 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G ASTL astacin like metalloendopeptidase multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ASTL mRNA CTD PMID:22129741 NCBI chr 2:96,122,817...96,143,059
Ensembl chr 2:96,123,850...96,138,436
JBrowse link
G ATF2 activating transcription factor 2 multiple interactions ISO
EXP
Acetylcysteine inhibits the reaction [chromium hexavalent ion results in increased phosphorylation of ATF2 protein]
Acetylcysteine inhibits the reaction [2-aminodiphenyl results in increased phosphorylation of ATF2 protein]
CTD PMID:19654923 PMID:22288910 NCBI chr 2:175,072,259...175,168,203
Ensembl chr 2:175,072,250...175,168,382
JBrowse link
G ATF3 activating transcription factor 3 multiple interactions ISO Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of and affects the localization of ATF3 protein] CTD PMID:25531190 NCBI chr 1:212,565,407...212,620,777
Ensembl chr 1:212,565,334...212,620,777
JBrowse link
G ATF4 activating transcription factor 4 multiple interactions
decreases expression
increases expression
EXP
ISO
Acetylcysteine inhibits the reaction [Acrylamide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [fangchinoline results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution analog results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [withaferin A results in increased expression of ATF4 protein]
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [tetrachlorobenzoquinone results in increased expression of ATF4 protein]
Acetylcysteine results in decreased expression of ATF4 protein
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of ATF4 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of ATF4 protein]; Acetylcysteine promotes the reaction [perfluorooctanoic acid results in increased expression of ATF4 mRNA]
Acetylcysteine results in increased expression of ATF4 protein
CTD PMID:15788408 PMID:19722195 PMID:21266191 PMID:24291486 PMID:25451595 PMID:25568320 PMID:27484784 PMID:27634458 PMID:27816613 PMID:28754437 PMID:31330229 PMID:32578922 NCBI chr22:39,514,494...39,522,686
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
Ensembl chr22:39,519,672...39,522,683
JBrowse link
G ATF6 activating transcription factor 6 multiple interactions EXP
ISO
Acetylcysteine results in increased metabolism of and results in increased activity of ATF6 protein
Acetylcysteine inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of ATF6 protein modified form]; Acetylcysteine inhibits the reaction [arsenite results in increased expression of ATF6 protein]; Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]
Acetylcysteine inhibits the reaction [chloroacetic acid results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased cleavage of ATF6 protein]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of ATF6 protein]
CTD PMID:18077580 PMID:19722195 PMID:21198628 PMID:21911445 PMID:24291486 PMID:25451595 PMID:31330229 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,320...161,964,070
JBrowse link
G ATG10 autophagy related 10 multiple interactions ISO Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG10 mRNA] CTD PMID:24614525 NCBI chr 5:81,972,021...82,258,502
Ensembl chr 5:81,972,023...82,276,857
JBrowse link
G ATG12 autophagy related 12 multiple interactions EXP
ISO
Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG12 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG12 mRNA]; Acetylcysteine inhibits the reaction [Vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG12 mRNA]
CTD PMID:20543569 PMID:24614525 PMID:29307831 PMID:30205151 NCBI chr 5:115,828,200...115,841,565
Ensembl chr 5:115,828,200...115,841,837
JBrowse link
G ATG16L1 autophagy related 16 like 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG16L1 protein] CTD PMID:30205151 NCBI chr 2:233,251,647...233,295,674
Ensembl chr 2:233,210,051...233,295,674
JBrowse link
G ATG4A autophagy related 4A cysteine peptidase multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of ATG4A protein] CTD PMID:29179951 NCBI chr  X:108,091,778...108,154,671
Ensembl chr  X:108,091,668...108,154,671
JBrowse link
G ATG5 autophagy related 5 multiple interactions EXP
ISO
Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG5 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG5 mRNA]; Acetylcysteine inhibits the reaction [Butyric Acid results in increased expression of ATG5 protein]; Acetylcysteine inhibits the reaction [Vorinostat promotes the reaction [ATG5 protein binds to ATG12 protein]]
Acetylcysteine inhibits the reaction [Zinc Oxide analog results in increased expression of ATG5 mRNA]
CTD PMID:20543569 PMID:24614525 PMID:28600122 PMID:29307831 PMID:30205151 NCBI chr 6:106,184,476...106,325,789
Ensembl chr 6:106,045,423...106,325,791
JBrowse link
G ATG7 autophagy related 7 multiple interactions EXP Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATG7 mRNA]; Acetylcysteine inhibits the reaction [Acrolein results in increased expression of ATG7 protein]; Acetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG7 mRNA] CTD PMID:29247770 PMID:29307831 PMID:30205151 PMID:31319114 NCBI chr 3:11,272,348...11,564,652
Ensembl chr 3:11,272,309...11,557,665
JBrowse link
G ATM ATM serine/threonine kinase multiple interactions
increases phosphorylation
EXP
ISO
Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATM protein]; Acetylcysteine inhibits the reaction [Aristolochic Acids results in increased expression of ATM protein modified form]; Acetylcysteine inhibits the reaction [ATM protein promotes the reaction [Doxorubicin results in increased activity of TP53 protein]]; Acetylcysteine inhibits the reaction [dorsomorphin results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK1 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of CHEK2 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of NBN protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of SMC1A protein]]; Acetylcysteine inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Acetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [polyhexamethyleneguanidine results in increased phosphorylation of ATM protein]; Acetylcysteine inhibits the reaction [usnic acid results in increased phosphorylation of ATM protein]
Acetylcysteine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased expression of ATM protein]
Acetylcysteine results in increased phosphorylation of ATM protein
CTD PMID:15489221 PMID:23274516 PMID:24792323 PMID:26451628 PMID:31168028 PMID:31715134 PMID:32142722 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,222,832...108,369,102
Ensembl chr11:108,222,832...108,369,102
JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions ISO Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein] CTD PMID:10506578 NCBI chr 1:116,372,986...116,410,259
Ensembl chr 1:116,372,668...116,410,261
JBrowse link
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression
multiple interactions
EXP
ISO
Acetylcysteine results in increased expression of ATP2A2 mRNA
Acetylcysteine inhibits the reaction [Doxorubicin results in decreased expression of ATP2A2 mRNA]; Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of ATP2A2 protein]
CTD PMID:10625299 PMID:16084531 PMID:17005195 NCBI chr12:110,281,247...110,351,093
Ensembl chr12:110,280,756...110,351,093
JBrowse link
G ATP6V0D1 ATPase H+ transporting V0 subunit d1 multiple interactions EXP Acetylcysteine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of ATP6V0D1 mRNA]; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of ATP6V0D1 mRNA] CTD PMID:29307831 PMID:31319114 NCBI chr16:67,438,019...67,481,157
Ensembl chr16:67,438,014...67,481,181
JBrowse link
G ATP6V0D2 ATPase H+ transporting V0 subunit d2 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of ATP6V0D2 mRNA
[Acetylcysteine co-treated with CSF1R protein co-treated with TNFSF11 protein] results in decreased expression of ATP6V0D2 mRNA; Acetylcysteine affects the reaction [[NFE2L2 protein affects the susceptibility to sodium arsenite] affects the reaction [[CSF1R protein co-treated with TNFSF11 protein] affects the expression of ATP6V0D2 mRNA]]; Acetylcysteine inhibits the reaction [[sodium arsenite co-treated with CSF1R protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 mRNA]
CTD PMID:22129741 PMID:30742845 NCBI chr 8:86,098,910...86,154,225
Ensembl chr 8:85,987,323...86,154,225
JBrowse link
G ATR ATR serine/threonine kinase multiple interactions EXP Acetylcysteine inhibits the reaction [2,3,5-trichloro-6-phenyl-(1,4)benzoquinone results in increased expression of ATR protein] CTD PMID:26451628 NCBI chr 3:142,449,235...142,578,793
Ensembl chr 3:142,449,007...142,578,733
JBrowse link
G ATXN1 ataxin 1 affects localization
multiple interactions
EXP Acetylcysteine affects the localization of ATXN1 protein mutant form
Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of ATXN1 protein mutant form]; Acetylcysteine inhibits the reaction [tert-Butylhydroperoxide affects the localization of ATXN1 protein mutant form]
CTD PMID:12893416 NCBI chr 6:16,299,112...16,761,490
Ensembl chr 6:16,299,112...16,761,491
JBrowse link
G AURKB aurora kinase B multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide affects the localization of AURKB protein] CTD PMID:28343997 NCBI chr17:8,204,731...8,210,767
Ensembl chr17:8,204,733...8,210,600
JBrowse link
G B2M beta-2-microglobulin decreases response to substance
multiple interactions
EXP Acetylcysteine results in decreased susceptibility to B2M protein modified form
Acetylcysteine inhibits the reaction [B2M protein modified form results in increased abundance of Reactive Oxygen Species]
CTD PMID:21864514 NCBI chr15:44,711,492...44,718,145
Ensembl chr15:44,711,487...44,718,877
Ensembl chr15:44,711,487...44,718,877
JBrowse link
G B3GALT5 beta-1,3-galactosyltransferase 5 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GALT5 mRNA CTD PMID:22129741 NCBI chr21:39,612,940...39,673,137
Ensembl chr21:39,556,442...39,673,137
JBrowse link
G B3GNT9 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 9 multiple interactions ISO [indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of B3GNT9 mRNA CTD PMID:22129741 NCBI chr16:67,148,104...67,150,998
Ensembl chr16:67,148,104...67,150,998
JBrowse link
G BACH1 BTB domain and CNC homolog 1 multiple interactions EXP Acetylcysteine inhibits the reaction [arsenic trioxide affects the localization of BACH1 protein] CTD PMID:19350554 NCBI chr21:29,298,922...29,361,894
Ensembl chr21:29,194,071...29,630,751