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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prednisone
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Accession:CHEBI:8382 term browser browse the term
Definition:A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Synonyms:related_synonym: 1,2-Dehydrocortisone;   1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione;   17,21-Dihydroxypregna-1,4-diene-3,11,20-trione;   Dehydrocortisone;   Formula=C21H26O5;   InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1;   InChIKey=XOFYZVNMUHMLCC-ZPOLXVRWSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])C(=O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   prednison;   prednisona;   prednisonum
 xref: CAS:53-03-2;   DrugBank:DB00635;   Drug_Central:2253;   KEGG:C07370
 xref_mesh: MESH:D011241
 xref: PMID:10438974;   PMID:15859934;   PMID:18971570;   PMID:23093541;   PMID:23395281;   Patent:US2579479;   Patent:US2837464;   Patent:US2897216;   Patent:US3134718;   Reaxys:2065301;   Wikipedia:Prednisone


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prednisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Prednisone results in decreased expression of A2M protein CTD PMID:11304663 NCBI chr 4:156,570,163...156,619,870
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases secretion
affects response to substance		 ISO Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]
ABCB1A protein affects the susceptibility to Prednisone		 CTD PMID:15502009 PMID:22464980 NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Prednisone CTD PMID:15502009 NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases activity		 ISO Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]
Prednisone results in increased activity of ABCC3 protein		 CTD PMID:15979871 NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO Prednisone results in decreased expression of AKT1 mRNA CTD PMID:38439560 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alb albumin decreases expression ISO Prednisone results in decreased expression of ALB mRNA CTD PMID:38439560 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Ar androgen receptor multiple interactions ISO Prednisone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression ISO Prednisone results in decreased expression of BAX mRNA CTD PMID:38439560 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp9 caspase 9 decreases expression ISO Prednisone results in decreased expression of CASP9 mRNA CTD PMID:38439560 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases expression ISO Prednisone results in decreased expression of CCL11 protein CTD PMID:15523430 NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,028,328...67,032,926 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 decreases expression ISO Prednisone results in decreased expression of CCL13 protein CTD PMID:15523430 NCBI chr10:67,567,876...67,569,426
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]; Prednisone inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] CTD PMID:16636307 NCBI chr 9:25,580,071...25,679,968
Ensembl chr 9:18,086,984...18,182,199 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Prednisone results in increased expression of CDKN1A protein CTD PMID:15034294 NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Prednisone results in increased expression of CDKN1B protein CTD PMID:15034294 NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Prednisone results in increased expression of CDKN2A protein CTD PMID:15034294 NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Prednisone results in increased expression of CDKN2B protein CTD PMID:15034294 NCBI chr 5:109,123,308...109,134,906
Ensembl chr 5:104,010,680...104,019,050 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha affects expression
decreases expression		 ISO Prednisone affects the expression of CEBPA mRNA
Prednisone results in decreased expression of CEBPA protein		 CTD PMID:38439560 NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO Prednisone results in decreased expression of CPT1A mRNA CTD PMID:38439560 NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Prednisone results in decreased expression of CXCL12 mRNA CTD PMID:38439560 NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO Prednisone results in increased expression of CYP27A1 mRNA CTD PMID:38439560 NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Dlk1 delta like non-canonical Notch ligand 1 decreases expression ISO Prednisone results in decreased expression of DLK1 mRNA CTD PMID:38439560 NCBI chr 6:134,192,491...134,199,779
Ensembl chr 6:128,410,316...128,417,522 		JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578 		JBrowse link
G Fas Fas cell surface death receptor multiple interactions ISO Prednisone inhibits the reaction [FAS protein mutant form results in decreased expression of PPARG protein]; Prednisone inhibits the reaction [FAS protein mutant form results in increased expression of IL17A protein]; Prednisone inhibits the reaction [FAS protein mutant form results in increased expression of NFKB1 protein]; Prednisone inhibits the reaction [FAS protein mutant form results in increased expression of STAT3 protein]; Prednisone inhibits the reaction [FAS protein mutant form results in increased expression of TNF protein] CTD PMID:38555047 NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Gcg glucagon multiple interactions
decreases expression		 EXP [Fatty Acids, Unsaturated co-treated with Prednisone] results in increased expression of GCG mRNA
Prednisone results in decreased expression of GCG mRNA		 CTD PMID:12524409 PMID:14705828 NCBI chr 3:67,522,489...67,531,533
Ensembl chr 3:47,113,914...47,122,929 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Prednisone results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression ISO Prednisone results in decreased expression of HNF4A mRNA; Prednisone results in decreased expression of HNF4A protein CTD PMID:38439560 NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Ifng interferon gamma multiple interactions ISO [zafirlukast co-treated with Prednisone co-treated with Budesonide] inhibits the reaction [Antigens results in increased secretion of IFNG protein] CTD PMID:16160912 NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO Prednisone results in decreased expression of IGF1 mRNA CTD PMID:38439560 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il12a interleukin 12A multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 decreases expression ISO Prednisone results in decreased expression of IL13 protein CTD PMID:15523430 NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il17a interleukin 17A multiple interactions ISO Prednisone inhibits the reaction [FAS protein mutant form results in increased expression of IL17A protein] CTD PMID:38555047 NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il4 interleukin 4 decreases expression ISO Prednisone results in decreased expression of IL4 protein CTD PMID:19584951 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 decreases expression ISO Prednisone results in decreased expression of IL5 protein CTD PMID:12722970 PMID:15523430 NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO Prednisone results in decreased expression of ITGB1 mRNA CTD PMID:38439560 NCBI chr19:73,602,277...73,650,271
Ensembl chr19:56,705,171...56,753,195 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Prednisone results in decreased expression of JUN mRNA CTD PMID:12524409 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Krt19 keratin 19 increases expression ISO Prednisone results in increased expression of KRT19 mRNA CTD PMID:38439560 NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,066,802...85,171,799 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression ISO Prednisone results in decreased expression of MAP2K1 mRNA CTD PMID:38439560 NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO Prednisone results in decreased expression of MAP2K2 mRNA CTD PMID:38439560 NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression ISO Prednisone results in decreased expression of MAPK1 mRNA CTD PMID:38439560 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression ISO Prednisone results in decreased expression of MAPK3 mRNA CTD PMID:38439560 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Prednisone results in decreased expression of MKI67 mRNA CTD PMID:38439560 NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Prednisone inhibits the reaction [FAS protein mutant form results in increased expression of NFKB1 protein] CTD PMID:38555047 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Prednisone inhibits the reaction [Doxorubicin results in decreased phosphorylation of NPHS1 protein]; Prednisone inhibits the reaction [Doxorubicin results in increased expression of NPHS1 protein] CTD PMID:16636307 PMID:19293598 NCBI chr 1:94,848,261...94,876,522
Ensembl chr 1:85,720,812...85,749,078 		JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP Prednisone inhibits the reaction [Doxorubicin results in increased expression of NPHS2 mRNA] CTD PMID:16636307 NCBI chr13:70,993,622...71,011,585
Ensembl chr13:68,448,926...68,461,313 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Prednisone binds to and results in increased activity of NR3C1 protein CTD PMID:28973534 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Prednisone results in increased expression of PCK1 mRNA CTD PMID:38439560 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191 		JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression ISO Prednisone results in decreased expression of PCNA mRNA; Prednisone results in decreased expression of PCNA protein CTD PMID:38439560 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Prednisone results in increased expression of PLAT protein CTD PMID:10452346 NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Prednisone results in decreased expression of POMC protein modified form CTD PMID:1977371 NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Prednisone results in decreased expression of PPARA mRNA CTD PMID:38439560 NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO Prednisone inhibits the reaction [FAS protein mutant form results in decreased expression of PPARG protein] CTD PMID:38555047 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prom1 prominin 1 decreases expression ISO Prednisone results in decreased expression of PROM mRNA CTD PMID:38439560 NCBI chr14:71,202,303...71,307,008
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Ptprc protein tyrosine phosphatase, receptor type, C decreases expression ISO Prednisone results in decreased expression of PTPRC mRNA CTD PMID:38439560 NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692 		JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Prednisone results in decreased expression of PYGM protein CTD PMID:8815173 NCBI chr 1:213,119,805...213,134,622
Ensembl chr 1:203,690,533...203,705,368 		JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Prednisone results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:15034294 NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302 		JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Prednisone results in increased expression of SERPINC1 protein CTD PMID:11304663 NCBI chr13:75,790,558...75,804,826
Ensembl chr13:73,257,179...73,284,293 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Prednisone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Sox9 SRY-box transcription factor 9 affects expression ISO Prednisone affects the expression of SOX9 mRNA CTD PMID:38439560 NCBI chr10:98,305,744...98,311,250
Ensembl chr10:97,806,485...97,811,994 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Prednisone inhibits the reaction [FAS protein mutant form results in increased expression of STAT3 protein] CTD PMID:38555047 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Prednisone results in decreased expression of TGFB1 protein CTD PMID:12722970 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO Prednisone results in increased expression of TNF protein
Prednisone inhibits the reaction [FAS protein mutant form results in increased expression of TNF protein]		 CTD PMID:19584951 PMID:38555047 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tyms thymidylate synthetase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536 		JBrowse link
G Vdr vitamin D receptor increases expression
affects response to substance		 ISO Prednisone results in increased expression of VDR protein
VDR gene polymorphism affects the susceptibility to Prednisone		 CTD PMID:7662588 PMID:15713801 NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in decreased expression of VEGFA protein] CTD PMID:19293598 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19909
    role 19880
      application 19720
        anti-inflammatory agent 16695
          anti-inflammatory drug 14977
            prednisone 68
              20alpha-dihydroprednisone 0
              20beta-dihydroprednisone 0
              6alpha-hydroxyprednisone 0
              6beta-hydroxyprednisone 0
              Delta(6)-prednisone 0
              cortancyl 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19909
    subatomic particle 19907
      composite particle 19907
        hadron 19907
          baryon 19907
            nucleon 19907
              atomic nucleus 19907
                atom 19907
                  main group element atom 19846
                    p-block element atom 19846
                      carbon group element atom 19784
                        carbon atom 19781
                          organic molecular entity 19781
                            heteroorganic entity 19540
                              organochalcogen compound 19301
                                organooxygen compound 19216
                                  carbonyl compound 18947
                                    ketone 17281
                                      oxo steroid 10547
                                        3-oxo steroid 9935
                                          3-oxo-Delta(1) steroid 5234
                                            3-oxo-Delta(1),Delta(4)-steroid 5234
                                              prednisone 68
                                                20alpha-dihydroprednisone 0
                                                20beta-dihydroprednisone 0
                                                6alpha-hydroxyprednisone 0
                                                6beta-hydroxyprednisone 0
                                                Delta(6)-prednisone 0
                                                cortancyl 0
paths to the root