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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prednisone
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Accession:CHEBI:8382 term browser browse the term
Definition:A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead of the oxo group at position 11), which is the active drug and also a steroid.
Synonyms:related_synonym: 1,2-Dehydrocortisone;   1,4-Pregnadiene-17alpha,21-diol-3,11,20-trione;   17,21-Dihydroxypregna-1,4-diene-3,11,20-trione;   Dehydrocortisone;   Formula=C21H26O5;   InChI=1S/C21H26O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-15,18,22,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1;   InChIKey=XOFYZVNMUHMLCC-ZPOLXVRWSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])C(=O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   prednison;   prednisona;   prednisonum
 xref: Beilstein:2065301;   CAS:53-03-2;   DrugBank:DB00635;   Drug_Central:2253;   KEGG:C07370
 xref_mesh: MESH:D011241
 xref: PMID:10438974;   PMID:15859934;   PMID:18971570;   PMID:23093541;   PMID:23395281;   Patent:US2579479;   Patent:US2837464;   Patent:US2897216;   Patent:US3134718;   Reaxys:2065301;   Wikipedia:Prednisone


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prednisone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin decreases expression ISO Prednisone results in decreased expression of A2M protein CTD PMID:11304663 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
affects response to substance
increases secretion
ISO Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Prednisone]
ABCB1A protein affects the susceptibility to Prednisone
CTD PMID:15502009 PMID:22464980 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Prednisone CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 multiple interactions
increases activity
ISO Prednisone promotes the reaction [ABCC3 protein affects the transport of calcein AM]
Prednisone results in increased activity of ABCC3 protein
CTD PMID:15979871 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein CTD PMID:29782964 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ar androgen receptor multiple interactions ISO Prednisone binds to and results in increased activity of AR protein mutant form CTD PMID:11956172 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases expression ISO Prednisone results in decreased expression of CCL11 protein CTD PMID:15523430 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl12 chemokine (C-C motif) ligand 12 decreases expression ISO Prednisone results in decreased expression of CCL13 protein CTD PMID:15523430 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780
JBrowse link
G Cd2ap CD2-associated protein multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in increased expression of CD2AP mRNA]; Prednisone inhibits the reaction [Doxorubicin results in increased expression of CD2AP protein] CTD PMID:16636307 NCBI chr 9:18,086,744...18,182,744
Ensembl chr 9:18,086,984...18,182,199
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Prednisone results in increased expression of CDKN1A protein CTD PMID:15034294 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO Prednisone results in increased expression of CDKN1B protein CTD PMID:15034294 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Prednisone results in increased expression of CDKN2A protein CTD PMID:15034294 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Cdkn2b cyclin-dependent kinase inhibitor 2B increases expression ISO Prednisone results in increased expression of CDKN2B protein CTD PMID:15034294 NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Gcg glucagon multiple interactions
decreases expression
EXP [Fatty Acids, Unsaturated co-treated with Prednisone] results in increased expression of GCG mRNA
Prednisone results in decreased expression of GCG mRNA
CTD PMID:12524409 PMID:14705828 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases activity ISO Prednisone results in increased activity of HIF1A protein CTD PMID:19502547 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Ifng interferon gamma multiple interactions ISO [zafirlukast co-treated with Prednisone co-treated with Budesonide] inhibits the reaction [Antigens results in increased secretion of IFNG protein] CTD PMID:16160912 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Prednisone results in increased expression of [IL12A protein binds to IL12B protein] CTD PMID:19584951 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13 interleukin 13 decreases expression ISO Prednisone results in decreased expression of IL13 protein CTD PMID:15523430 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il4 interleukin 4 decreases expression ISO Prednisone results in decreased expression of IL4 protein CTD PMID:19584951 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases expression ISO Prednisone results in decreased expression of IL5 protein CTD PMID:12722970 PMID:15523430 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Ins2 insulin 2 multiple interactions ISO [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of and results in increased secretion of ADIPOQ protein; [Prednisone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of FABP4 protein CTD PMID:29782964 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Prednisone results in decreased expression of JUN mRNA CTD PMID:12524409 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions EXP Prednisone inhibits the reaction [Doxorubicin results in increased expression of NPHS2 mRNA] CTD PMID:16636307 NCBI chr13:68,448,720...68,461,312
Ensembl chr13:68,448,926...68,461,313
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Prednisone binds to and results in increased activity of NR3C1 protein CTD PMID:28973534 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Plat plasminogen activator, tissue type increases expression ISO Prednisone results in increased expression of PLAT protein CTD PMID:10452346 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO Prednisone results in decreased expression of POMC protein modified form CTD PMID:1977371 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pygm glycogen phosphorylase, muscle associated decreases expression ISO Prednisone results in decreased expression of PYGM protein CTD PMID:8815173 NCBI chr 1:203,690,550...203,705,369
Ensembl chr 1:203,690,533...203,705,368
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO Prednisone results in decreased phosphorylation of and results in decreased activity of RB1 protein CTD PMID:15034294 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Serpinc1 serpin family C member 1 increases expression ISO Prednisone results in increased expression of SERPINC1 protein CTD PMID:11304663 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Prednisone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression ISO Prednisone results in decreased expression of TGFB1 protein CTD PMID:12722970 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Prednisone results in increased expression of TNF protein CTD PMID:19584951 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tyms thymidylate synthetase affects response to substance ISO TYMS gene polymorphism affects the susceptibility to Prednisone CTD PMID:15713801 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Vdr vitamin D receptor increases expression
affects response to substance
ISO Prednisone results in increased expression of VDR protein
VDR gene polymorphism affects the susceptibility to Prednisone
CTD PMID:7662588 PMID:15713801 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP Prednisone affects the reaction [Doxorubicin results in decreased expression of VEGFA protein] CTD PMID:19293598 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      application 19471
        anti-inflammatory agent 15836
          anti-inflammatory drug 13622
            prednisone 38
              carboxyspermidine 0
              cortancyl 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      ketone 16924
                                        oxyketone 8656
                                          alpha-oxyketone 8656
                                            alpha-hydroxy ketone 8656
                                              primary alpha-hydroxy ketone 7537
                                                prednisone 38
                                                  carboxyspermidine 0
                                                  cortancyl 0
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