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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:non-proteinogenic amino acid derivative
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Accession:CHEBI:83812 term browser browse the term
Definition:Any derivative of a non-proteinogenic amino acid resulting from reaction at an amino group or carboxy group, or from the replacement of any hydrogen by a heteroatom.
Synonyms:related_synonym: non-canonical amino acid derivative;   non-canonical amino-acid derivatives;   non-proteinogenic amino-acid derivatives

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(R)-pantothenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh8 atonal bHLH transcription factor 8 increases expression ISO Pantothenic Acid results in increased expression of ATOH8 mRNA CTD PMID:19397697 NCBI chr 4:100,067,341...100,099,517
Ensembl chr 4:100,067,341...100,099,517 		JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid] CTD PMID:24709313 NCBI chr 7:139,454,945...139,484,403
Ensembl chr 7:139,455,242...139,483,997 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO Pantothenic Acid results in increased expression of CYP1B1 mRNA CTD PMID:19397697 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Fam43a family with sequence similarity 43, member A increases expression ISO Pantothenic Acid results in increased expression of FAM43A mRNA CTD PMID:19397697 NCBI chr11:73,676,601...73,679,003
Ensembl chr11:73,676,601...73,678,984 		JBrowse link
G Fut7 fucosyltransferase 7 decreases expression ISO Pantothenic Acid results in decreased expression of FUT7 mRNA CTD PMID:19397697 NCBI chr 3:2,637,281...2,646,497
Ensembl chr 3:2,642,531...2,646,648 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Pantothenic Acid results in increased expression of HMOX1 mRNA; Pantothenic Acid results in increased expression of HMOX1 protein CTD PMID:19397697 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspb7 heat shock protein family B (small) member 7 increases expression ISO Pantothenic Acid results in increased expression of HSPB7 mRNA CTD PMID:19397697 NCBI chr 5:159,968,077...159,971,563
Ensembl chr 5:159,967,839...159,971,562 		JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO Pantothenic Acid results in increased expression of ID1 mRNA CTD PMID:19397697 NCBI chr 3:148,214,623...148,216,715
Ensembl chr 3:148,215,540...148,216,718 		JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Pantothenic Acid results in increased expression of ID3 mRNA CTD PMID:19397697 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions		 ISO IDH2 protein mutant form results in increased abundance of Pantothenic Acid
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid]		 CTD PMID:27469509 NCBI chr 1:141,874,354...141,893,674
Ensembl chr 1:141,866,283...141,893,705 		JBrowse link
G Il6 interleukin 6 increases expression ISO Pantothenic Acid results in increased expression of IL6 mRNA CTD PMID:19397697 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Pantothenic Acid CTD PMID:20567778 NCBI chr 5:120,503,475...120,682,281
Ensembl chr 5:120,564,645...120,682,221 		JBrowse link
G Marchf2 membrane associated ring-CH-type finger 2 increases expression ISO Pantothenic Acid results in increased expression of MARCHF2 mRNA CTD PMID:19397697 NCBI chr 7:18,559,301...18,585,351
Ensembl chr 7:18,559,205...18,585,313 		JBrowse link
G Mtres1 mitochondrial transcription rescue factor 1 increases expression ISO Pantothenic Acid results in increased expression of MTRES1 mRNA CTD PMID:19397697 NCBI chr20:48,276,101...48,294,975
Ensembl chr20:48,275,762...48,294,948 		JBrowse link
G Myb MYB proto-oncogene, transcription factor multiple interactions ISO Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein] CTD PMID:16112698 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817 		JBrowse link
G Mycn MYCN proto-oncogene, bHLH transcription factor increases expression ISO Pantothenic Acid results in increased expression of MYCN mRNA CTD PMID:19397697 NCBI chr 6:38,222,554...38,228,419
Ensembl chr 6:38,222,555...38,228,379 		JBrowse link
G Nhlrc1 NHL repeat containing E3 ubiquitin protein ligase 1 increases expression ISO Pantothenic Acid results in increased expression of NHLRC1 mRNA CTD PMID:19397697 NCBI chr17:18,059,382...18,060,572
Ensembl chr17:18,059,382...18,060,572 		JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA CTD PMID:20505214 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216 		JBrowse link
G Nrep neuronal regeneration related protein increases expression ISO Pantothenic Acid results in increased expression of NREP mRNA CTD PMID:19397697 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445 		JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of PIM1 protein] CTD PMID:16112698 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555 		JBrowse link
G Pou3f4 POU class 3 homeobox 4 increases expression ISO Pantothenic Acid results in increased expression of POU3F4 mRNA CTD PMID:19397697 NCBI chr  X:82,143,789...82,145,066
Ensembl chr  X:82,143,789...82,145,066 		JBrowse link
G Ptprcap protein tyrosine phosphatase, receptor type, C-associated protein increases expression ISO Pantothenic Acid results in increased expression of PTPRCAP mRNA CTD PMID:19397697 NCBI chr 1:219,403,970...219,406,129
Ensembl chr 1:219,403,970...219,406,128 		JBrowse link
G Slc51b solute carrier family 51 subunit beta increases expression ISO Pantothenic Acid results in increased expression of SLC51B mRNA CTD PMID:19397697 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986 		JBrowse link
G Slc5a6 solute carrier family 5 member 6 increases transport
multiple interactions		 EXP
ISO		 SLC5A6 results in increased transport of Pantothenic Acid
Sodium affects the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]		 CTD PMID:9516450 PMID:10329687 NCBI chr 6:26,685,823...26,697,110
Ensembl chr 6:26,686,033...26,697,116 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Pantothenic Acid results in decreased expression of SOX2 mRNA CTD PMID:19397697 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545 		JBrowse link
G Tmem18 transmembrane protein 18 increases expression ISO Pantothenic Acid results in increased expression of TMEM18 mRNA CTD PMID:19397697 NCBI chr 6:49,529,228...49,534,960
Ensembl chr 6:49,529,228...49,536,648 		JBrowse link
G Zfp575 zinc finger protein 575 decreases expression ISO Pantothenic Acid results in decreased expression of ZNF575 mRNA CTD PMID:19397697 NCBI chr 1:81,447,987...81,450,156
Ensembl chr 1:81,447,987...81,450,094 		JBrowse link
dabigatran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 decreases expression ISO Dabigatran results in decreased expression of AIF1 protein CTD PMID:27397090 NCBI chr20:5,161,350...5,167,176
Ensembl chr20:5,161,333...5,166,448 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 decreases expression ISO Dabigatran results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 8:77,640,234...77,719,488
Ensembl chr 8:77,640,222...77,719,489 		JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Dabigatran results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 5:4,275,728...4,495,525
Ensembl chr 5:4,373,626...4,513,142 		JBrowse link
G F2 coagulation factor II decreases activity ISO Dabigatran results in decreased activity of F2 protein CTD PMID:17911567 PMID:25138021 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031 		JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763 		JBrowse link
G Fgb fibrinogen beta chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 2:182,028,044...182,035,026
Ensembl chr 2:182,027,115...182,038,178 		JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Dabigatran results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr 1:265,492,949...265,498,965
Ensembl chr 1:265,493,124...265,498,831 		JBrowse link
G Fgg fibrinogen gamma chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 2:181,987,080...181,994,523
Ensembl chr 2:181,987,217...181,994,514 		JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Dabigatran results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr19:53,044,379...53,047,081
Ensembl chr19:53,044,379...53,047,081 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA] CTD PMID:28585189 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238 		JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Dabigatran results in decreased expression of GFAP protein CTD PMID:27397090 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Hoxb9 homeo box B9 increases expression ISO Dabigatran results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390 		JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Dabigatran results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr10:89,797,011...89,817,009
Ensembl chr10:89,797,038...89,816,491 		JBrowse link
G Mertk MER proto-oncogene, tyrosine kinase increases expression ISO Dabigatran results in increased expression of MERTK mRNA CTD PMID:27397090 NCBI chr 3:121,235,230...121,340,932
Ensembl chr 3:121,235,119...121,342,444 		JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Dabigatran results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 2:231,962,517...231,963,441
Ensembl chr 2:231,962,517...231,963,308 		JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of NR4A2 mRNA] CTD PMID:28585189 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159 		JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Dabigatran results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 1:14,797,766...14,799,835
Ensembl chr 1:14,797,766...14,799,835 		JBrowse link
G Pax3 paired box 3 decreases expression ISO Dabigatran results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 9:84,004,004...84,101,226
Ensembl chr 9:84,005,183...84,101,172 		JBrowse link
G Pax6 paired box 6 increases expression ISO Dabigatran results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 3:95,700,241...95,728,682
Ensembl chr 3:95,707,386...95,728,624 		JBrowse link
G Plp1 proteolipid protein 1 increases expression ISO Dabigatran results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:107,494,326...107,511,355
Ensembl chr  X:107,496,072...107,511,348 		JBrowse link
G Rcor2 REST corepressor 2 multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of RCOR2 mRNA] CTD PMID:28585189 NCBI chr 1:222,513,970...222,525,356
Ensembl chr 1:222,519,615...222,524,779 		JBrowse link
G Ret ret proto-oncogene multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of RET protein] CTD PMID:28585189 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA] CTD PMID:28585189 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
G Snca synuclein alpha multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in increased expression of SNCA mRNA] CTD PMID:28585189 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285 		JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Dabigatran results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 3:147,643,250...147,649,511
Ensembl chr 3:147,643,250...147,649,504 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in decreased expression of TH mRNA] CTD PMID:28585189 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Dabigatran inhibits the reaction [Rotenone results in increased expression of TNF mRNA] CTD PMID:28585189 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Uncx UNC homeobox decreases expression ISO Dabigatran results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr12:17,182,158...17,186,679
Ensembl chr12:17,182,163...17,186,679 		JBrowse link
metalaxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO metalaxyl results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO metalaxyl results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431 		JBrowse link
methylphenidate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b1 aldo-keto reductase family 1 member B decreases expression ISO Methylphenidate results in decreased expression of AKR1B3 mRNA CTD PMID:22470460 NCBI chr 4:61,706,866...61,720,959
Ensembl chr 4:61,706,864...61,720,956 		JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 increases expression ISO Methylphenidate results in increased expression of AP2B1 mRNA CTD PMID:22470460 NCBI chr10:70,516,462...70,621,973
Ensembl chr10:70,520,206...70,621,977 		JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 decreases expression ISO Methylphenidate results in decreased expression of ARAP1 mRNA CTD PMID:22470460 NCBI chr 1:166,459,062...166,525,200
Ensembl chr 1:166,478,005...166,525,255 		JBrowse link
G Arc activity-regulated cytoskeleton-associated protein affects expression EXP Methylphenidate affects the expression of ARC mRNA CTD PMID:19222557 NCBI chr 7:115,907,097...115,911,059
Ensembl chr 7:115,907,097...115,910,541 		JBrowse link
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 decreases expression ISO Methylphenidate results in decreased expression of ARIH2 mRNA CTD PMID:22470460 NCBI chr 8:117,387,004...117,446,085
Ensembl chr 8:117,387,010...117,446,019 		JBrowse link
G Armc9 armadillo repeat containing 9 decreases expression ISO Methylphenidate results in decreased expression of ARMC9 mRNA CTD PMID:22470460 NCBI chr 9:93,172,718...93,299,119
Ensembl chr 9:93,172,673...93,296,750 		JBrowse link
G B4galt4 beta-1,4-galactosyltransferase 4 decreases expression ISO Methylphenidate results in decreased expression of B4GALT4 mRNA CTD PMID:22470460 NCBI chr11:64,558,006...64,584,054
Ensembl chr11:64,557,977...64,583,994 		JBrowse link
G Bcl9 BCL9, transcription coactivator decreases expression ISO Methylphenidate results in decreased expression of BCL9 mRNA CTD PMID:22470460 NCBI chr 2:199,334,644...199,420,083
Ensembl chr 2:199,334,664...199,354,793 		JBrowse link
G Bdnf brain-derived neurotrophic factor affects expression
multiple interactions
decreases expression		 EXP
ISO		 Methylphenidate affects the expression of BDNF mRNA
[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]
Methylphenidate results in decreased expression of BDNF mRNA		 CTD PMID:19222557 PMID:22470460 PMID:24394491 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210 		JBrowse link
G C2 complement C2 increases expression ISO Methylphenidate results in increased expression of C2 mRNA CTD PMID:22470460 NCBI chr20:4,542,340...4,561,152
Ensembl chr20:4,542,340...4,561,152 		JBrowse link
G Cald1 caldesmon 1 increases expression ISO Methylphenidate results in increased expression of CALD1 mRNA CTD PMID:22470460 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489 		JBrowse link
G Cbr3 carbonyl reductase 3 increases expression ISO Methylphenidate results in increased expression of CBR3 mRNA CTD PMID:22470460 NCBI chr11:33,909,417...33,917,674
Ensembl chr11:33,909,439...33,917,674 		JBrowse link
G Ccdc166 coiled-coil domain containing 166 decreases expression ISO Methylphenidate results in decreased expression of CCDC166 mRNA CTD PMID:22470460 NCBI chr 7:117,039,890...117,041,693
Ensembl chr 7:117,039,892...117,041,693 		JBrowse link
G Ccdc91 coiled-coil domain containing 91 decreases expression ISO Methylphenidate results in decreased expression of CCDC91 mRNA CTD PMID:22470460 NCBI chr 4:181,873,465...182,043,593
Ensembl chr 4:181,874,861...182,043,593 		JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 increases expression ISO Methylphenidate results in increased expression of CDK5R1 mRNA CTD PMID:22470460 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255 		JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis
increases metabolic processing		 ISO [CES1 protein results in increased hydrolysis of Methylphenidate] which results in increased chemical synthesis of ritalinic acid; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; CES1 gene mutant form results in decreased metabolism of and results in increased abundance of Methylphenidate; Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CES1 protein results in increased metabolism of Methylphenidate		 CTD PMID:15082749 PMID:18485328 PMID:20097249 PMID:25445008 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821 		JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression ISO Methylphenidate results in increased expression of CHD2 mRNA CTD PMID:22470460 NCBI chr 1:134,757,934...134,873,053
Ensembl chr 1:134,757,934...134,871,167 		JBrowse link
G Chga chromogranin A decreases expression ISO Methylphenidate results in decreased expression of CHGA mRNA CTD PMID:22470460 NCBI chr 6:126,434,226...126,445,569
Ensembl chr 6:126,434,226...126,445,568 		JBrowse link
G Chid1 chitinase domain containing 1 decreases expression ISO Methylphenidate results in decreased expression of CHID1 mRNA CTD PMID:22470460 NCBI chr 1:214,476,418...214,511,569
Ensembl chr 1:214,476,387...214,511,529 		JBrowse link
G Chrna6 cholinergic receptor nicotinic alpha 6 subunit decreases expression ISO Methylphenidate results in decreased expression of CHRNA6 mRNA CTD PMID:22470460 NCBI chr16:68,860,018...68,866,718
Ensembl chr16:68,860,018...68,866,718 		JBrowse link
G Chst8 carbohydrate sulfotransferase 8 decreases expression ISO Methylphenidate results in decreased expression of CHST8 mRNA CTD PMID:22470460 NCBI chr 1:90,542,095...90,685,257
Ensembl chr 1:90,542,096...90,685,257 		JBrowse link
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X increases expression ISO Methylphenidate results in increased expression of CLPX mRNA CTD PMID:22470460 NCBI chr 8:70,789,137...70,843,133
Ensembl chr 8:70,789,256...70,843,123 		JBrowse link
G Cnnm1 cyclin and CBS domain divalent metal cation transport mediator 1 increases expression ISO Methylphenidate results in increased expression of CNNM1 mRNA CTD PMID:22470460 NCBI chr 1:263,184,361...263,243,912
Ensembl chr 1:263,186,235...263,242,468 		JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like decreases expression ISO Methylphenidate results in decreased expression of CNOT6L mRNA CTD PMID:22470460 NCBI chr14:15,059,101...15,148,255
Ensembl chr14:15,059,387...15,146,586 		JBrowse link
G Cnr1 cannabinoid receptor 1 increases expression ISO Methylphenidate results in increased expression of CNR1 mRNA CTD PMID:22470460 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056 		JBrowse link
G Comtd1 catechol-O-methyltransferase domain containing 1 decreases expression ISO Methylphenidate results in decreased expression of COMTD1 mRNA CTD PMID:22470460 NCBI chr15:2,631,529...2,634,640
Ensembl chr15:2,631,529...2,634,640 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases expression		 EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of CREB mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of CREB protein
Methylphenidate results in decreased expression of CREB mRNA		 CTD PMID:21753012 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase decreases expression ISO Methylphenidate results in decreased expression of D2HGDH mRNA CTD PMID:22470460 NCBI chr 9:100,956,570...100,974,393
Ensembl chr 9:100,956,477...100,974,551 		JBrowse link
G Dab2 DAB adaptor protein 2 increases expression ISO Methylphenidate results in increased expression of DAB2 mRNA CTD PMID:22470460 NCBI chr 2:55,747,353...55,768,848
Ensembl chr 2:55,747,318...55,768,270 		JBrowse link
G Dapk3 death-associated protein kinase 3 decreases expression ISO Methylphenidate results in decreased expression of DAPK3 mRNA CTD PMID:22470460 NCBI chr 7:11,392,436...11,400,855
Ensembl chr 7:11,392,437...11,400,805 		JBrowse link
G Dhx35 DEAH-box helicase 35 decreases expression ISO Methylphenidate results in decreased expression of DHX35 mRNA CTD PMID:22470460 NCBI chr 3:155,297,545...155,354,857
Ensembl chr 3:155,297,566...155,356,462 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methylphenidate CTD PMID:11454915 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases expression
affects expression		 EXP
ISO		 [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate
Methylphenidate results in decreased expression of DRD2 mRNA
Methylphenidate affects the expression of DRD2 protein		 CTD PMID:11454915 PMID:17599397 PMID:22470460 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642 		JBrowse link
G Drd4 dopamine receptor D4 affects response to substance ISO DRD4 promoter mutant form affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr 1:214,278,296...214,282,818
Ensembl chr 1:214,278,296...214,281,483 		JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression		 EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of EGR1 mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of EGR1 mRNA]; Methylphenidate promotes the reaction [Amphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of EGR1 mRNA] CTD PMID:16549270 PMID:19931852 PMID:20020108 PMID:21753012 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429 		JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 decreases expression ISO Methylphenidate results in decreased expression of ENTPD5 mRNA CTD PMID:22470460 NCBI chr 6:108,087,677...108,123,811
Ensembl chr 6:108,087,418...108,120,579 		JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1-like 1 decreases expression ISO Methylphenidate results in decreased expression of EPB41L1 mRNA CTD PMID:22470460 NCBI chr 3:152,492,725...152,622,047
Ensembl chr 3:152,552,822...152,619,722 		JBrowse link
G Epha10 EPH receptor A10 decreases expression ISO Methylphenidate results in decreased expression of EPHA10 mRNA CTD PMID:22470460 NCBI chr 5:142,875,171...142,910,537
Ensembl chr 5:142,875,773...142,908,395 		JBrowse link
G Exog exo/endonuclease G decreases expression ISO Methylphenidate results in decreased expression of EXOG mRNA CTD PMID:22470460 NCBI chr 8:128,133,398...128,153,110
Ensembl chr 8:128,133,431...128,153,110 		JBrowse link
G Fank1 fibronectin type III and ankyrin repeat domains 1 decreases expression ISO Methylphenidate results in decreased expression of FANK1 mRNA CTD PMID:22470460 NCBI chr 1:205,842,469...205,954,152
Ensembl chr 1:205,842,489...205,950,371 		JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb increases expression ISO Methylphenidate results in increased expression of FCGR2B mRNA CTD PMID:22470460 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression		 ISO
EXP		 [Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of FOS mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of FOS mRNA]
Methylphenidate results in increased expression of FOS protein
Methylphenidate results in decreased expression of FOS protein
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA; Methylphenidate results in increased expression of FOS protein		 CTD PMID:12112414 PMID:12699766 PMID:15916815 PMID:19931852 PMID:21753012 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression EXP Methylphenidate results in increased expression of FOSB protein CTD PMID:15916815 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710 		JBrowse link
G Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 decreases expression ISO Methylphenidate results in decreased expression of GALNT10 mRNA CTD PMID:22470460 NCBI chr10:43,067,316...43,208,992
Ensembl chr10:43,067,299...43,210,427 		JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases expression ISO Methylphenidate results in decreased expression of GCH1 mRNA CTD PMID:22470460 NCBI chr15:23,935,011...23,968,971
Ensembl chr15:23,934,585...23,969,011 		JBrowse link
G Gdnf glial cell derived neurotrophic factor decreases expression ISO Methylphenidate results in decreased expression of GDNF mRNA CTD PMID:22470460 NCBI chr 2:56,884,181...56,912,964
Ensembl chr 2:56,887,987...56,910,238 		JBrowse link
G Ghdc GH3 domain containing decreases expression ISO Methylphenidate results in decreased expression of GHDC mRNA CTD PMID:22470460 NCBI chr10:88,672,834...88,677,055
Ensembl chr10:88,672,843...88,677,055 		JBrowse link
G Grik3 glutamate ionotropic receptor kainate type subunit 3 decreases expression ISO Methylphenidate results in decreased expression of GRIK3 mRNA CTD PMID:22470460 NCBI chr 5:143,500,441...143,715,546
Ensembl chr 5:143,500,441...143,715,546 		JBrowse link
G Gucy2c guanylate cyclase 2C decreases expression ISO Methylphenidate results in decreased expression of GUCY2C mRNA CTD PMID:22470460 NCBI chr 4:170,659,993...170,740,274
Ensembl chr 4:170,659,998...170,740,274 		JBrowse link
G Hbp1 HMG-box transcription factor 1 decreases expression ISO Methylphenidate results in decreased expression of HBP1 mRNA CTD PMID:22470460 NCBI chr 6:51,231,479...51,257,699
Ensembl chr 6:51,231,480...51,257,625 		JBrowse link
G Homer1 homer scaffold protein 1 increases expression
multiple interactions		 EXP Methylphenidate results in increased expression of HOMER1 mRNA
SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of HOMER1 mRNA]		 CTD PMID:16549270 NCBI chr 2:22,909,550...23,012,303
Ensembl chr 2:22,909,569...23,009,678 		JBrowse link
G Hspb6 heat shock protein family B (small) member 6 decreases expression ISO Methylphenidate results in decreased expression of HSPB6 mRNA CTD PMID:22470460 NCBI chr 1:89,008,117...89,010,256
Ensembl chr 1:89,008,117...89,010,256 		JBrowse link
G Il6 interleukin 6 increases expression ISO Methylphenidate results in increased expression of IL6 mRNA CTD PMID:22470460 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ip6k1 inositol hexakisphosphate kinase 1 increases expression ISO Methylphenidate results in increased expression of IP6K1 mRNA CTD PMID:22470460 NCBI chr 8:116,781,957...116,826,152
Ensembl chr 8:116,804,451...116,823,540 		JBrowse link
G Jak3 Janus kinase 3 decreases expression ISO Methylphenidate results in decreased expression of JAK3 mRNA CTD PMID:22470460 NCBI chr16:20,107,471...20,120,678
Ensembl chr16:20,109,200...20,120,668 		JBrowse link
G Kifc3 kinesin family member C3 decreases expression ISO Methylphenidate results in decreased expression of KIFC3 mRNA CTD PMID:22470460 NCBI chr19:10,305,405...10,339,186
Ensembl chr19:10,320,604...10,339,178 		JBrowse link
G Lad1 ladinin 1 decreases expression ISO Methylphenidate results in decreased expression of LAD1 mRNA CTD PMID:22470460 NCBI chr13:52,645,257...52,659,619
Ensembl chr13:52,645,257...52,659,619 		JBrowse link
G Lama3 laminin subunit alpha 3 decreases expression ISO Methylphenidate results in decreased expression of LAMA3 mRNA CTD PMID:22470460 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838 		JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 decreases expression ISO Methylphenidate results in decreased expression of LARGE1 mRNA CTD PMID:22470460 NCBI chr19:12,481,563...12,945,320
Ensembl chr19:12,481,540...12,942,963 		JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression ISO Methylphenidate results in increased expression of LASP1 mRNA CTD PMID:22470460 NCBI chr10:85,744,662...85,785,130
Ensembl chr10:85,744,568...85,785,133 		JBrowse link
G Lgals3bp galectin 3 binding protein decreases expression ISO Methylphenidate results in decreased expression of LGALS3BP mRNA CTD PMID:22470460 NCBI chr10:107,415,334...107,424,672
Ensembl chr10:107,415,326...107,424,710 		JBrowse link
G Lhfpl5 LHFPL tetraspan subfamily member 5 decreases expression ISO Methylphenidate results in decreased expression of LHFPL5 mRNA CTD PMID:22470460 NCBI chr20:5,815,837...5,826,137
Ensembl chr20:5,815,837...5,826,137 		JBrowse link
G Lrrc27 leucine rich repeat containing 27 decreases expression ISO Methylphenidate results in decreased expression of LRRC27 mRNA CTD PMID:22470460 NCBI chr 1:211,543,751...211,575,823
Ensembl chr 1:211,543,751...211,575,820 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases expression ISO Methylphenidate results in decreased expression of MAP1LC3B mRNA CTD PMID:22470460 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
multiple interactions		 EXP Methylphenidate results in decreased expression of MAPK1 mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of MAPK1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MAPK1 protein		 CTD PMID:21753012 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression ISO Methylphenidate results in increased expression of MAPK8 mRNA CTD PMID:22470460 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mlc1 modulator of VRAC current 1 decreases expression ISO Methylphenidate results in decreased expression of MLC1 mRNA CTD PMID:22470460 NCBI chr 7:129,949,984...129,970,314
Ensembl chr 7:129,949,967...129,970,550 		JBrowse link
G Morn2 MORN repeat containing 2 decreases expression ISO Methylphenidate results in decreased expression of MORN2 mRNA CTD PMID:22470460 NCBI chr 6:2,969,290...2,974,419
Ensembl chr 6:2,969,333...2,974,418 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
affects expression		 EXP [Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein
Methylphenidate affects the expression of MTOR mRNA		 CTD PMID:21753012 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967 		JBrowse link
G Mvp major vault protein decreases expression ISO Methylphenidate results in decreased expression of MVP mRNA CTD PMID:22470460 NCBI chr 1:198,420,813...198,448,612
Ensembl chr 1:198,420,806...198,450,047 		JBrowse link
G Nabp1 nucleic acid binding protein 1 increases expression ISO Methylphenidate results in increased expression of NABP1 mRNA CTD PMID:22470460 NCBI chr 9:55,049,893...55,057,784
Ensembl chr 9:55,050,203...55,057,658 		JBrowse link
G Nacad NAC alpha domain containing decreases expression ISO Methylphenidate results in decreased expression of NACAD mRNA CTD PMID:22470460 NCBI chr14:86,860,607...86,868,605
Ensembl chr14:86,860,608...86,868,598 		JBrowse link
G Ncor2 nuclear receptor co-repressor 2 decreases expression ISO Methylphenidate results in decreased expression of NCOR2 mRNA CTD PMID:22470460 NCBI chr12:36,871,917...37,033,701
Ensembl chr12:36,871,999...37,033,701 		JBrowse link
G Neto2 neuropilin and tolloid like 2 increases expression ISO Methylphenidate results in increased expression of NETO2 mRNA CTD PMID:22470460 NCBI chr19:22,450,579...22,486,530
Ensembl chr19:22,450,030...22,486,531 		JBrowse link
G Nol3 nucleolar protein 3 decreases expression ISO Methylphenidate results in decreased expression of NOL3 mRNA CTD PMID:22470460 NCBI chr19:37,232,567...37,236,668
Ensembl chr19:37,235,001...37,236,649 		JBrowse link
G Nsun4 NOP2/Sun RNA methyltransferase 4 increases expression ISO Methylphenidate results in increased expression of NSUN4 mRNA CTD PMID:22470460 NCBI chr 5:134,885,377...134,905,492
Ensembl chr 5:134,886,497...134,905,588 		JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 NCBI chr17:5,934,651...6,245,778
Ensembl chr17:5,933,729...6,244,676 		JBrowse link
G Parp3 poly (ADP-ribose) polymerase family, member 3 increases expression ISO Methylphenidate results in increased expression of PARP3 mRNA CTD PMID:22470460 NCBI chr 8:115,173,440...115,179,543
Ensembl chr 8:115,173,453...115,179,191 		JBrowse link
G Pear1 platelet endothelial aggregation receptor 1 increases expression ISO Methylphenidate results in increased expression of PEAR1 mRNA CTD PMID:22470460 NCBI chr 2:187,114,219...187,134,209
Ensembl chr 2:187,114,217...187,133,993 		JBrowse link
G Peds1 plasmanylethanolamine desaturase 1 decreases expression ISO Methylphenidate results in decreased expression of TMEM189 mRNA CTD PMID:22470460 NCBI chr 3:164,376,621...164,388,213
Ensembl chr 3:164,376,630...164,388,492 		JBrowse link
G Pisd phosphatidylserine decarboxylase decreases expression ISO Methylphenidate results in decreased expression of PISD mRNA CTD PMID:22470460 NCBI chr14:83,298,630...83,347,697
Ensembl chr14:83,298,674...83,346,738 		JBrowse link
G Pkn1 protein kinase N1 decreases expression ISO Methylphenidate results in decreased expression of PKN1 mRNA CTD PMID:22470460 NCBI chr19:24,803,524...24,832,305
Ensembl chr19:24,803,524...24,831,500 		JBrowse link
G Pnma8b PNMA family member 8B increases expression ISO Methylphenidate results in increased expression of PNMAL2 mRNA CTD PMID:22470460 NCBI chr 1:78,876,205...78,878,779
Ensembl chr 1:78,876,205...78,878,779 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 increases expression ISO Methylphenidate results in increased expression of PRKG2 mRNA CTD PMID:22470460 NCBI chr14:12,217,121...12,313,616
Ensembl chr14:12,218,553...12,315,229 		JBrowse link
G Prlr prolactin receptor decreases expression ISO Methylphenidate results in decreased expression of PRLR mRNA CTD PMID:22470460 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692 		JBrowse link
G Prpf39 pre-mRNA processing factor 39 increases expression ISO Methylphenidate results in increased expression of PRPF39 mRNA CTD PMID:22470460 NCBI chr 6:86,785,793...86,810,806
Ensembl chr 6:86,785,771...86,810,316 		JBrowse link
G Ptdss2 phosphatidylserine synthase 2 decreases expression ISO Methylphenidate results in decreased expression of PTDSS2 mRNA CTD PMID:22470460 NCBI chr 1:214,122,981...214,148,011
Ensembl chr 1:214,123,044...214,149,729 		JBrowse link
G Ptpn21 protein tyrosine phosphatase, non-receptor type 21 increases expression ISO Methylphenidate results in increased expression of PTPN21 mRNA CTD PMID:22470460 NCBI chr 6:122,656,500...122,721,496
Ensembl chr 6:122,656,500...122,721,496 		JBrowse link
G Pus7l pseudouridine synthase 7 like decreases expression ISO Methylphenidate results in decreased expression of PUS7L mRNA CTD PMID:22470460 NCBI chr 7:135,765,307...135,803,818
Ensembl chr 7:135,765,303...135,800,481 		JBrowse link
G Rab38 RAB38, member RAS oncogene family increases expression ISO Methylphenidate results in increased expression of RAB38 mRNA CTD PMID:22470460 NCBI chr 1:152,072,716...152,153,449
Ensembl chr 1:152,072,665...152,153,449 		JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression ISO Methylphenidate results in decreased expression of RACGAP1 mRNA CTD PMID:22470460 NCBI chr 7:141,277,303...141,308,849
Ensembl chr 7:141,277,312...141,307,233 		JBrowse link
G Rbfox1 RNA binding fox-1 homolog 1 increases expression ISO Methylphenidate results in increased expression of RBFOX1 mRNA CTD PMID:22470460 NCBI chr10:8,312,961...10,437,778
Ensembl chr10:8,312,961...8,654,892 		JBrowse link
G Rcc2 regulator of chromosome condensation 2 decreases expression ISO Methylphenidate results in decreased expression of RCC2 mRNA CTD PMID:22470460 NCBI chr 5:159,220,531...159,236,313
Ensembl chr 5:159,220,979...159,234,320 		JBrowse link
G Ret ret proto-oncogene decreases expression ISO Methylphenidate results in decreased expression of RET mRNA CTD PMID:22470460 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372 		JBrowse link
G Rgma repulsive guidance molecule BMP co-receptor a decreases expression ISO Methylphenidate results in decreased expression of RGMA mRNA CTD PMID:22470460 NCBI chr 1:134,699,053...134,742,512
Ensembl chr 1:134,699,299...134,742,514 		JBrowse link
G Rgs20 regulator of G-protein signaling 20 decreases expression ISO Methylphenidate results in decreased expression of RGS20 mRNA CTD PMID:22470460 NCBI chr 5:14,367,498...14,494,048
Ensembl chr 5:14,415,606...14,494,756 		JBrowse link
G Rhbdd2 rhomboid domain containing 2 decreases expression ISO Methylphenidate results in decreased expression of RHBDD2 mRNA CTD PMID:22470460 NCBI chr12:24,091,132...24,102,081
Ensembl chr12:24,092,004...24,102,084 		JBrowse link
G Sdc3 syndecan 3 decreases expression ISO Methylphenidate results in decreased expression of SDC3 mRNA CTD PMID:22470460 NCBI chr 5:148,923,098...148,956,404
Ensembl chr 5:148,923,098...148,956,404 		JBrowse link
G Siae sialic acid acetylesterase decreases expression ISO Methylphenidate results in decreased expression of SIAE mRNA CTD PMID:22470460 NCBI chr 8:40,078,269...40,113,514
Ensembl chr 8:40,078,269...40,113,514 		JBrowse link
G Slc10a4 solute carrier family 10, member 4 decreases expression ISO Methylphenidate results in decreased expression of SLC10A4 mRNA CTD PMID:22470460 NCBI chr14:37,764,839...37,770,059
Ensembl chr14:37,764,839...37,770,059 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 decreases expression ISO Methylphenidate results in decreased expression of SLC18A2 mRNA CTD PMID:22470460 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
G Slc2a12 solute carrier family 2 member 12 increases expression ISO Methylphenidate results in increased expression of SLC2A12 mRNA CTD PMID:22470460 NCBI chr 1:24,003,625...24,056,373
Ensembl chr 1:24,003,625...24,056,373 		JBrowse link
G Slc6a3 solute carrier family 6 member 3 multiple interactions
decreases expression
increases response to substance
affects response to substance		 ISO [Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; [SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate] which affects the uptake of Dopamine; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Methylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Methylphenidate results in decreased expression of SLC6A3 mRNA
Methylphenidate results in decreased expression of SLC6A3 protein
SLC6A3 protein results in increased susceptibility to Methylphenidate
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
SLC6A3 3' UTR polymorphism affects the susceptibility to Methylphenidate; SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate		 CTD PMID:12112414 PMID:12699766 PMID:15059031 PMID:16139732 PMID:17234900 PMID:18614672 PMID:19462300 PMID:22470460 PMID:31009648 NCBI chr 1:32,323,011...32,363,983
Ensembl chr 1:32,321,580...32,363,983 		JBrowse link
G Snap25 synaptosome associated protein 25 affects response to substance ISO SNAP25 gene polymorphism affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr 3:129,697,408...129,788,417
Ensembl chr 3:129,599,353...129,788,400 		JBrowse link
G Sncaip synuclein, alpha interacting protein increases expression ISO Methylphenidate results in increased expression of SNCAIP mRNA CTD PMID:22470460 NCBI chr18:47,739,284...47,877,679
Ensembl chr18:47,739,140...47,877,676 		JBrowse link
G Sncg synuclein, gamma decreases expression ISO Methylphenidate results in decreased expression of SNCG mRNA CTD PMID:22470460 NCBI chr16:10,722,110...10,726,648
Ensembl chr16:10,722,106...10,726,707 		JBrowse link
G Snx22 sorting nexin 22 decreases expression ISO Methylphenidate results in decreased expression of SNX22 mRNA CTD PMID:22470460 NCBI chr 8:71,725,405...71,728,729
Ensembl chr 8:71,725,771...71,728,685 		JBrowse link
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 decreases expression ISO Methylphenidate results in decreased expression of SORCS3 mRNA CTD PMID:22470460 NCBI chr 1:267,986,305...268,620,331
Ensembl chr 1:268,189,277...268,620,331 		JBrowse link
G Sox11 SRY-box transcription factor 11 increases expression ISO Methylphenidate results in increased expression of SOX11 mRNA CTD PMID:22470460 NCBI chr 6:46,629,967...46,631,988
Ensembl chr 6:46,629,974...46,631,983 		JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases expression ISO Methylphenidate results in decreased expression of STAT5A mRNA CTD PMID:22470460 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057 		JBrowse link
G Stox2 storkhead box 2 increases expression ISO Methylphenidate results in increased expression of STOX2 mRNA CTD PMID:22470460 NCBI chr16:47,994,555...48,233,588
Ensembl chr16:48,120,864...48,228,891 		JBrowse link
G Suds3 SDS3 homolog, SIN3A corepressor complex component decreases expression ISO Methylphenidate results in decreased expression of SUDS3 mRNA CTD PMID:22470460 NCBI chr12:45,199,012...45,221,507
Ensembl chr12:45,199,577...45,221,512 		JBrowse link
G Taar1 trace-amine-associated receptor 1 multiple interactions ISO Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] CTD PMID:17234900 NCBI chr 1:22,595,477...22,596,475
Ensembl chr 1:22,595,477...22,596,475 		JBrowse link
G Th tyrosine hydroxylase decreases expression ISO Methylphenidate results in decreased expression of TH mRNA CTD PMID:22470460 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
G Tmem185b transmembrane protein 185B decreases expression ISO Methylphenidate results in decreased expression of TMEM185B mRNA CTD PMID:22470460 NCBI chr13:35,554,621...35,557,952
Ensembl chr13:35,554,964...35,556,016 		JBrowse link
G Tmem30a transmembrane protein 30A decreases expression ISO Methylphenidate results in decreased expression of TMEM30A mRNA CTD PMID:22470460 NCBI chr 8:87,222,107...87,245,953
Ensembl chr 8:87,223,948...87,245,951 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO Methylphenidate results in increased expression of TNF mRNA CTD PMID:22470460 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Traf5 TNF receptor-associated factor 5 decreases expression ISO Methylphenidate results in decreased expression of TRAF5 mRNA CTD PMID:22470460 NCBI chr13:110,758,556...110,801,871
Ensembl chr13:110,758,761...110,784,209 		JBrowse link
G Trim25 tripartite motif-containing 25 increases expression ISO Methylphenidate results in increased expression of TRIM25 mRNA CTD PMID:22470460 NCBI chr10:76,343,847...76,362,159
Ensembl chr10:76,343,847...76,362,145 		JBrowse link
G Tspan17 tetraspanin 17 decreases expression ISO Methylphenidate results in decreased expression of TSPAN17 mRNA CTD PMID:22470460 NCBI chr17:10,356,980...10,364,614
Ensembl chr17:10,356,936...10,364,570 		JBrowse link
G Ttf1 transcription termination factor 1 increases expression ISO Methylphenidate results in increased expression of TTF1 mRNA CTD PMID:22470460 NCBI chr 3:7,635,630...7,660,153
Ensembl chr 3:7,635,933...7,660,673 		JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 decreases expression ISO Methylphenidate results in decreased expression of TWSG1 mRNA CTD PMID:22470460 NCBI chr 9:113,699,151...113,732,601
Ensembl chr 9:113,699,170...113,732,622 		JBrowse link
G Ube3d ubiquitin protein ligase E3D decreases expression ISO Methylphenidate results in decreased expression of UBE2CBP mRNA CTD PMID:22470460 NCBI chr 8:93,948,689...94,120,477
Ensembl chr 8:93,948,767...94,120,458 		JBrowse link
G Ubxn10 UBX domain protein 10 decreases expression ISO Methylphenidate results in decreased expression of UBXN10 mRNA CTD PMID:22470460 NCBI chr 5:157,158,129...157,165,767
Ensembl chr 5:157,159,936...157,165,767 		JBrowse link
G Uck2 uridine-cytidine kinase 2 decreases expression ISO Methylphenidate results in decreased expression of UCK2 mRNA CTD PMID:22470460 NCBI chr13:85,376,716...85,443,976
Ensembl chr13:85,376,716...85,443,976 		JBrowse link
G Vash1 vasohibin 1 increases expression ISO Methylphenidate results in increased expression of VASH1 mRNA CTD PMID:22470460 NCBI chr 6:110,624,377...110,640,942
Ensembl chr 6:110,624,856...110,637,382 		JBrowse link
G Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) decreases expression ISO Methylphenidate results in decreased expression of WARS2 mRNA CTD PMID:22470460 NCBI chr 2:201,170,363...201,256,115
Ensembl chr 2:201,172,312...201,255,703 		JBrowse link
G Zfp14 ZFP14 zinc finger protein decreases expression ISO Methylphenidate results in decreased expression of ZFP14 mRNA CTD PMID:22470460 NCBI chr 1:88,350,361...88,367,370
Ensembl chr 1:88,350,361...88,361,851 		JBrowse link
N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elavl1 ELAV like RNA binding protein 1 increases phosphorylation
multiple interactions		 ISO N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]		 CTD PMID:31945382 NCBI chr12:2,461,502...2,502,432
Ensembl chr12:2,461,502...2,502,432 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
multiple interactions		 EXP N-Methylaspartate results in increased expression of MAPK1 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]		 CTD PMID:22639866 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases expression
multiple interactions		 EXP N-Methylaspartate results in increased expression of MAPK3 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]		 CTD PMID:22639866 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases ADP-ribosylation EXP N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression		 ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199 		JBrowse link
nateglinide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP binding cassette subfamily C member 4 affects binding ISO ABCC4 protein binds to nateglinide CTD PMID:17939016 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 affects metabolic processing ISO CYP2C9 protein affects the metabolism of Nateglinide CTD PMID:18159128 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434 		JBrowse link
G Ins2 insulin 2 increases secretion ISO nateglinide results in increased secretion of INS protein CTD PMID:16403453 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577 		JBrowse link
rhodotorulic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity		 ISO Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
S-adenosyl-L-homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy adenosylhomocysteinase increases hydrolysis ISO AHCY results in increased hydrolysis of S-Adenosylhomocysteine CTD PMID:26974671 NCBI chr 3:150,587,833...150,603,057
Ensembl chr 3:150,587,833...150,603,082 		JBrowse link
G Ahr aryl hydrocarbon receptor increases abundance
multiple interactions		 ISO AHR protein results in increased abundance of S-Adenosylhomocysteine
PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]		 CTD PMID:29416063 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Alas2 5'-aminolevulinate synthase 2 multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341 		JBrowse link
G App amyloid beta precursor protein increases expression
decreases methylation
multiple interactions		 ISO S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein		 CTD PMID:19635394 PMID:22064374 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Atp7b ATPase copper transporting beta increases abundance ISO ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine CTD PMID:22945834 NCBI chr16:74,865,516...74,944,935
Ensembl chr16:74,865,516...74,945,286 		JBrowse link
G Bace1 beta-secretase 1 increases expression ISO S-Adenosylhomocysteine results in increased expression of BACE1 protein CTD PMID:19635394 NCBI chr 8:50,140,092...50,162,388
Ensembl chr 8:50,139,997...50,162,361 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 4:31,534,225...31,569,152
Ensembl chr 4:31,534,225...31,569,151 		JBrowse link
G Comt catechol-O-methyltransferase decreases activity EXP S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 NCBI chr11:86,715,981...86,735,630
Ensembl chr11:86,715,981...86,735,622 		JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity
multiple interactions		 ISO S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]		 CTD PMID:16037419 PMID:22064374 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495 		JBrowse link
G Fgf19 fibroblast growth factor 19 decreases abundance ISO FGF19 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 1:218,058,405...218,061,693
Ensembl chr 1:218,058,405...218,061,693 		JBrowse link
G Hbb hemoglobin subunit beta multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725 		JBrowse link
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 8:48,667,278...48,674,673
Ensembl chr 8:48,667,275...48,674,748 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions		 ISO
EXP		 S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]		 CTD PMID:19770485 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression EXP S-Adenosylhomocysteine results in decreased expression of NFKBIA protein CTD PMID:19770485 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance ISO NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions
decreases methylation
decreases expression		 ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein		 CTD PMID:22064374 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Psen1 presenilin 1 multiple interactions
decreases methylation
increases expression		 ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein		 CTD PMID:19635394 NCBI chr 6:107,169,514...107,221,000
Ensembl chr 6:107,169,528...107,216,798 		JBrowse link
G Slc19a1 solute carrier family 19 member 1 affects abundance ISO SLC19A1 protein affects the abundance of S-Adenosylhomocysteine CTD PMID:15705887 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions EXP S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of TIMP2 protein CTD PMID:19770485 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Nos1 nitric oxide synthase 1 multiple interactions
decreases activity		 EXP
ISO		 [S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine		 CTD PMID:11006970 PMID:12511180 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341 		JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr 1:280,397,831...280,457,968
Ensembl chr 1:280,423,079...280,457,148 		JBrowse link
S-nitroso-N-acetyl-D-penicillamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Adenine Nucleotides] CTD PMID:15316071 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]] CTD PMID:21138475 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of AQP3 mRNA CTD PMID:12102619 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245 		JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions		 ISO S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein]		 CTD PMID:21138475 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]		 CTD PMID:21138475 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]
S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 mRNA; S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein		 CTD PMID:17135264 PMID:21138475 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Calca calcitonin-related polypeptide alpha multiple interactions
increases secretion		 EXP Carbon Dioxide inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:18052948 NCBI chr 1:184,184,018...184,188,922
Ensembl chr 1:184,184,020...184,188,911 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased activity of and results in increased cleavage of CASP1 protein CTD PMID:10903723 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
decreases activity		 ISO
EXP		 [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of CASP3 protein]
S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein
S-Nitroso-N-Acetylpenicillamine results in decreased activity of CASP3 protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein]		 CTD PMID:10811113 PMID:12006578 PMID:12220328 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine inhibits the reaction [3,5-dimethoxy-4'-hydroxystilbene results in decreased phosphorylation of CREB1 protein]; S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Quercetin results in decreased phosphorylation of CREB1 protein] CTD PMID:17135264 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Csrp3 cysteine and glycine rich protein 3 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of CSRP3 mRNA CTD PMID:12102619 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367 		JBrowse link
G Drgx dorsal root ganglia homeobox decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of PRRXL1 mRNA CTD PMID:12102619 NCBI chr16:8,823,872...8,853,430
Ensembl chr16:8,823,872...8,853,430 		JBrowse link
G Edn1 endothelin 1 increases secretion EXP S-Nitroso-N-Acetylpenicillamine results in increased secretion of EDN1 protein CTD PMID:15640287 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Eln elastin decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of ELN mRNA CTD PMID:12102619 NCBI chr12:24,978,478...25,021,864
Ensembl chr12:24,978,483...25,021,863 		JBrowse link
G Exoc6 exocyst complex component 6 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of SEC15 mRNA CTD PMID:12102619 NCBI chr 1:256,211,879...256,369,318
Ensembl chr 1:256,226,179...256,368,813 		JBrowse link
G Faslg Fas ligand multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fcgr2a Fc fragment of IgG receptor IIa decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR3 mRNA CTD PMID:12102619 NCBI chr13:91,146,878...91,163,691
Ensembl chr13:91,168,973...91,198,036
Ensembl chr13:91,168,973...91,198,036 		JBrowse link
G Fcgr2b Fc fragment of IgG receptor IIb decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR2B mRNA CTD PMID:12102619 NCBI chr13:89,329,298...89,343,916
Ensembl chr13:89,327,794...89,433,815 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein] CTD PMID:16351512 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681 		JBrowse link
G Ghrh growth hormone releasing hormone decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of GHRH mRNA CTD PMID:12102619 NCBI chr 3:153,449,124...153,468,794
Ensembl chr 3:153,449,125...153,468,794 		JBrowse link
G Gnai2 G protein subunit alpha i2 multiple interactions
decreases expression		 EXP 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 8:116,370,730...116,391,337
Ensembl chr 8:116,370,744...116,391,307 		JBrowse link
G Gnai3 G protein subunit alpha i3 multiple interactions
decreases expression		 EXP 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 2:210,896,779...210,934,733
Ensembl chr 2:210,896,656...210,934,749 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of GOT1 mRNA CTD PMID:12102619 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein] CTD PMID:11672444 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522 		JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP [S-Nitroso-N-Acetylpenicillamine co-treated with 2-tert-butylhydroquinone] results in increased expression of GSTA2 CTD PMID:15357004 NCBI chr 8:85,640,081...85,645,621 JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of HCK mRNA CTD PMID:12102619 NCBI chr 3:148,579,917...148,623,026
Ensembl chr 3:148,579,920...148,623,033 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP S-Nitroso-N-Acetylpenicillamine results in increased expression of HMOX1 protein CTD PMID:16439612 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Ifng interferon gamma multiple interactions ISO S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Streptozocin results in increased expression of IFNG protein] CTD PMID:15892581 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Itpka inositol-trisphosphate 3-kinase A decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of ITPKA mRNA CTD PMID:12102619 NCBI chr 3:111,545,007...111,553,605
Ensembl chr 3:111,545,007...111,553,604 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
multiple interactions
increases phosphorylation
decreases phosphorylation		 EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK1 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK1 protein]		 CTD PMID:15640287 PMID:19252090 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression
decreases phosphorylation
increases phosphorylation
multiple interactions		 EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK3 protein
S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein
S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein]		 CTD PMID:15640287 PMID:19252090 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mme membrane metallo-endopeptidase decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of MME mRNA CTD PMID:12102619 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738 		JBrowse link
G Mtf1 metal-regulatory transcription factor 1 affects localization ISO S-Nitroso-N-Acetylpenicillamine affects the localization of MTF1 protein CTD PMID:16423564 NCBI chr 5:142,797,340...142,843,896
Ensembl chr 5:142,797,366...142,842,122 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of NFKB1 mRNA CTD PMID:12102619 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases activity
decreases expression		 ISO
EXP		 S-Nitroso-N-Acetylpenicillamine results in decreased activity of NOS2 protein
S-Nitroso-N-Acetylpenicillamine results in decreased expression of NOS2 promoter		 CTD PMID:11076874 PMID:15565661 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11799084 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705 		JBrowse link
G Npr3 natriuretic peptide receptor 3 multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of NPR3 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 2:61,883,946...61,950,291
Ensembl chr 2:61,888,950...61,949,926 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] CTD PMID:18652891 PMID:21235400 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948 		JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of PAM mRNA CTD PMID:12102619 NCBI chr 9:111,028,543...111,177,588
Ensembl chr 9:111,028,575...111,177,602 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]] CTD PMID:10811113 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Prkca protein kinase C, alpha multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein] CTD PMID:18652891 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947 		JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein] CTD PMID:18652891 PMID:21235400 NCBI chr 1:64,407,098...64,433,698
Ensembl chr 1:64,407,114...64,433,636 		JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 multiple interactions
increases activity		 EXP [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
S-Nitroso-N-Acetylpenicillamine results in increased activity of PRKG1 protein		 CTD PMID:11799084 NCBI chr 1:248,982,039...250,300,952 JBrowse link
G Rack1 receptor for activated C kinase 1 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of RACK1 mRNA CTD PMID:12102619 NCBI chr10:34,149,717...34,155,198
Ensembl chr10:34,149,717...34,155,198
Ensembl chr12:34,149,717...34,155,198 		JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein] CTD PMID:21235400 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699 		JBrowse link
G Rgs17 regulator of G-protein signaling 17 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr 1:42,491,566...42,587,735
Ensembl chr 1:42,492,761...42,587,721 		JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 decreases expression EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of RPLP0 mRNA CTD PMID:12102619 NCBI chr12:46,791,528...46,794,797
Ensembl chr12:46,791,528...46,794,797 		JBrowse link
G Sftpa1 surfactant protein A1 decreases expression
multiple interactions		 EXP S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA
bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA]		 CTD PMID:15640287 NCBI chr16:18,716,019...18,719,404
Ensembl chr16:18,716,019...18,719,403 		JBrowse link
G Sftpb surfactant protein B multiple interactions
decreases expression		 EXP bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA] CTD PMID:15640287 NCBI chr 4:100,166,855...100,175,941
Ensembl chr 4:100,166,863...100,175,938 		JBrowse link
G Sftpc surfactant protein C multiple interactions
decreases expression		 EXP bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA] CTD PMID:15640287 NCBI chr15:52,211,538...52,214,480
Ensembl chr15:52,211,544...52,214,616 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
affects response to substance		 ISO GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]
SOD1 protein affects the susceptibility to S-Nitroso-N-Acetylpenicillamine		 CTD PMID:10698074 PMID:11672444 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862 		JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO
EXP		 GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA		 CTD PMID:11672444 PMID:14996425 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of TRP53 mRNA
S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein]		 CTD PMID:7673702 PMID:16351512 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions EXP S-Nitroso-N-Acetylpenicillamine inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein] CTD PMID:20177073 NCBI chr 8:6,811,543...6,917,534
Ensembl chr 8:6,811,543...6,917,535 		JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation EXP S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of VASP protein CTD PMID:11799084 NCBI chr 1:80,170,608...80,185,882
Ensembl chr 1:80,170,619...80,185,882 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
increases secretion		 EXP S-Nitroso-N-Acetylpenicillamine results in increased expression of VEGFA mRNA
S-Nitroso-N-Acetylpenicillamine results in increased secretion of VEGFA protein		 CTD PMID:10613739 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19853
    chemical entity 19853
      atom 19851
        nonmetal atom 19733
          nitrogen atom 18620
            nitrogen molecular entity 18620
              organonitrogen compound 18395
                amino acid derivative 10957
                  non-proteinogenic amino acid derivative 262
                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-\{[(S)-1-mesyl-2-piperidyl]carbonyl\}-L-alanine 0
                    3-hydroxynorvaline 0
                    D-alanine derivative + 2
                    D-arginine derivative + 0
                    D-asparagine derivative 0
                    D-aspartic acid derivative + 5
                    D-cysteine derivative + 0
                    D-glutamic acid derivative + 0
                    D-histidine derivative 0
                    D-isoleucine derivative + 0
                    D-leucine derivative + 0
                    D-methionine derivative + 0
                    D-phenylalanine derivative + 0
                    D-proline derivative + 0
                    D-selenocysteine derivative 0
                    D-serine derivative + 0
                    D-threonine derivative 0
                    D-tryptophan derivative + 0
                    D-tyrosine derivative + 0
                    D-valine derivative + 0
                    N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alanine + 0
                    N-(2,6-dichlorobenzoyl)-3-[6-(2,6-dimethoxyphenyl)-2-naphthyl]alanine 0
                    N-acetyl-L-alpha-phenylglycine 0
                    N-acyl-D-amino acid + 61
                    N-formyl-L-kynurenine + 0
                    N-formylkynurenine + 0
                    N-heptanoyl-L-homoserine 0
                    N-nitrososarcosine 0
                    beta-alanine derivative + 55
                    beta-amino acid ester + 128
                    brivaracetam 0
                    delta-amino acid ester + 0
                    homocysteine derivative + 23
                    methyl 3-[2-(2,6-dichlorophenyl)quinolin-6-yl]alaninate + 0
                    methyl 5-(hydroxymethyl)pyrrolidine-2-carboxylate 0
                    methyl N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alaninate 0
                    methyl N-(2,6-dichlorobenzoyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-methylalaninate 0
                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4,4a,8a-hexahydro-6-quinolyl]alaninate 0
                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                    ornithine derivative + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19853
    subatomic particle 19851
      composite particle 19851
        hadron 19851
          baryon 19851
            nucleon 19851
              atomic nucleus 19851
                atom 19851
                  main group element atom 19744
                    main group molecular entity 19744
                      p-block molecular entity 19744
                        carbon group molecular entity 19650
                          organic molecular entity 19639
                            heteroorganic entity 19229
                              organonitrogen compound 18395
                                amino acid derivative 10957
                                  non-proteinogenic amino acid derivative 262
                                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-\{[(S)-1-mesyl-2-piperidyl]carbonyl\}-L-alanine 0
                                    3-hydroxynorvaline 0
                                    D-alanine derivative + 2
                                    D-arginine derivative + 0
                                    D-asparagine derivative 0
                                    D-aspartic acid derivative + 5
                                    D-cysteine derivative + 0
                                    D-glutamic acid derivative + 0
                                    D-histidine derivative 0
                                    D-isoleucine derivative + 0
                                    D-leucine derivative + 0
                                    D-methionine derivative + 0
                                    D-phenylalanine derivative + 0
                                    D-proline derivative + 0
                                    D-selenocysteine derivative 0
                                    D-serine derivative + 0
                                    D-threonine derivative 0
                                    D-tryptophan derivative + 0
                                    D-tyrosine derivative + 0
                                    D-valine derivative + 0
                                    N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alanine + 0
                                    N-(2,6-dichlorobenzoyl)-3-[6-(2,6-dimethoxyphenyl)-2-naphthyl]alanine 0
                                    N-acetyl-L-alpha-phenylglycine 0
                                    N-acyl-D-amino acid + 61
                                    N-formyl-L-kynurenine + 0
                                    N-formylkynurenine + 0
                                    N-heptanoyl-L-homoserine 0
                                    N-nitrososarcosine 0
                                    beta-alanine derivative + 55
                                    beta-amino acid ester + 128
                                    brivaracetam 0
                                    delta-amino acid ester + 0
                                    homocysteine derivative + 23
                                    methyl 3-[2-(2,6-dichlorophenyl)quinolin-6-yl]alaninate + 0
                                    methyl 5-(hydroxymethyl)pyrrolidine-2-carboxylate 0
                                    methyl N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alaninate 0
                                    methyl N-(2,6-dichlorobenzoyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-methylalaninate 0
                                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4,4a,8a-hexahydro-6-quinolyl]alaninate 0
                                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                                    ornithine derivative + 4
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