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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:non-proteinogenic amino acid derivative
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Accession:CHEBI:83812 term browser browse the term
Definition:Any derivative of a non-proteinogenic amino acid resulting from reaction at an amino group or carboxy group, or from the replacement of any hydrogen by a heteroatom.
Synonyms:related_synonym: non-canonical amino acid derivative;   non-canonical amino-acid derivatives;   non-proteinogenic amino-acid derivatives


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(R)-pantothenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atoh8 atonal bHLH transcription factor 8 increases expression ISO Pantothenic Acid results in increased expression of ATOH8 mRNA CTD PMID:19397697 NCBI chr 6:72,206,174...72,235,780
Ensembl chr 6:72,206,177...72,235,577
JBrowse link
G Col2a1 collagen, type II, alpha 1 multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid] CTD PMID:24709313 NCBI chr15:97,975,602...98,004,724
Ensembl chr15:97,975,602...98,004,695
JBrowse link
G Cxcl15 chemokine (C-X-C motif) ligand 15 increases expression ISO Pantothenic Acid results in increased expression of CXCL8 mRNA CTD PMID:19397697 NCBI chr 5:90,794,534...90,803,067
Ensembl chr 5:90,794,534...90,803,067
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO Pantothenic Acid results in increased expression of CYP1B1 mRNA CTD PMID:19397697 NCBI chr17:79,706,940...79,715,061
Ensembl chr17:79,701,537...79,715,061
JBrowse link
G Fam43a family with sequence similarity 43, member A increases expression ISO Pantothenic Acid results in increased expression of FAM43A mRNA CTD PMID:19397697 NCBI chr16:30,599,723...30,602,797
Ensembl chr16:30,599,723...30,602,797
JBrowse link
G Fut7 fucosyltransferase 7 decreases expression ISO Pantothenic Acid results in decreased expression of FUT7 mRNA CTD PMID:19397697 NCBI chr 2:25,422,351...25,426,374
Ensembl chr 2:25,423,267...25,426,374
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Pantothenic Acid results in increased expression of HMOX1 mRNA; Pantothenic Acid results in increased expression of HMOX1 protein CTD PMID:19397697 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Hspb7 heat shock protein family, member 7 (cardiovascular) increases expression ISO Pantothenic Acid results in increased expression of HSPB7 mRNA CTD PMID:19397697 NCBI chr 4:141,420,779...141,425,310
Ensembl chr 4:141,420,779...141,425,311
JBrowse link
G Id1 inhibitor of DNA binding 1, HLH protein increases expression ISO Pantothenic Acid results in increased expression of ID1 mRNA CTD PMID:19397697 NCBI chr 2:152,736,251...152,737,410
Ensembl chr 2:152,736,251...152,737,410
JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Pantothenic Acid results in increased expression of ID3 mRNA CTD PMID:19397697 NCBI chr 4:136,143,822...136,145,392
Ensembl chr 4:136,143,497...136,145,755
JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial multiple interactions
increases abundance
EXP Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid] CTD PMID:27469509 NCBI chr 7:80,094,845...80,118,608
Ensembl chr 7:80,094,846...80,115,392
JBrowse link
G Il6 interleukin 6 increases expression ISO Pantothenic Acid results in increased expression of IL6 mRNA CTD PMID:19397697 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Lepr leptin receptor affects abundance EXP LEPR affects the abundance of Pantothenic Acid CTD PMID:20567778 NCBI chr 4:101,717,137...101,815,352
Ensembl chr 4:101,717,404...101,815,352
JBrowse link
G Marchf2 membrane associated ring-CH-type finger 2 increases expression ISO Pantothenic Acid results in increased expression of MARCHF2 mRNA CTD PMID:19397697 NCBI chr17:33,685,692...33,718,677
Ensembl chr17:33,685,692...33,718,670
JBrowse link
G Mtres1 mitochondrial transcription rescue factor 1 increases expression ISO Pantothenic Acid results in increased expression of MTRES1 mRNA CTD PMID:19397697 NCBI chr10:43,525,119...43,541,041
Ensembl chr10:43,525,133...43,540,994
JBrowse link
G Myb myeloblastosis oncogene multiple interactions EXP Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein] CTD PMID:16112698 NCBI chr10:21,124,930...21,160,984
Ensembl chr10:21,124,935...21,160,984
JBrowse link
G Mycn v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived increases expression ISO Pantothenic Acid results in increased expression of MYCN mRNA CTD PMID:19397697 NCBI chr12:12,936,093...12,941,836
Ensembl chr12:12,936,093...12,941,914
JBrowse link
G Nhlrc1 NHL repeat containing 1 increases expression ISO Pantothenic Acid results in increased expression of NHLRC1 mRNA CTD PMID:19397697 NCBI chr13:47,012,557...47,014,850
Ensembl chr13:47,012,557...47,014,850
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP [Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA CTD PMID:20505214 NCBI chr15:101,253,902...101,274,795
Ensembl chr15:101,254,269...101,274,795
JBrowse link
G Nrep neuronal regeneration related protein increases expression ISO Pantothenic Acid results in increased expression of NREP mRNA CTD PMID:19397697 NCBI chr18:33,437,019...33,464,365
Ensembl chr18:33,437,019...33,464,029
JBrowse link
G Pim1 proviral integration site 1 multiple interactions EXP Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of PIM1 protein] CTD PMID:16112698 NCBI chr17:29,490,785...29,496,111
Ensembl chr17:29,490,753...29,496,112
JBrowse link
G Pou3f4 POU domain, class 3, transcription factor 4 increases expression ISO Pantothenic Acid results in increased expression of POU3F4 mRNA CTD PMID:19397697 NCBI chr  X:110,814,379...110,819,108
Ensembl chr  X:110,814,280...110,817,207
JBrowse link
G Ptprcap protein tyrosine phosphatase, receptor type, C polypeptide-associated protein increases expression ISO Pantothenic Acid results in increased expression of PTPRCAP mRNA CTD PMID:19397697 NCBI chr19:4,154,646...4,156,710
Ensembl chr19:4,153,604...4,156,751
JBrowse link
G Rpl13a-ps1 ribosomal protein 13A, pseudogene 1 increases expression ISO Pantothenic Acid results in increased expression of RPL13AP3 mRNA CTD PMID:19397697 NCBI chr19:50,030,100...50,030,756
Ensembl chr19:50,030,124...50,030,735
JBrowse link
G Slc51b solute carrier family 51, beta subunit increases expression ISO Pantothenic Acid results in increased expression of SLC51B mRNA CTD PMID:19397697 NCBI chr 9:65,412,753...65,422,773
Ensembl chr 9:65,412,714...65,422,955
JBrowse link
G Slc5a6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 increases transport
multiple interactions
ISO SLC5A6 results in increased transport of Pantothenic Acid
Sodium affects the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
CTD PMID:9516450 PMID:10329687 NCBI chr 5:31,036,036...31,048,924
Ensembl chr 5:31,036,036...31,048,924
JBrowse link
G Sox2 SRY (sex determining region Y)-box 2 decreases expression ISO Pantothenic Acid results in decreased expression of SOX2 mRNA CTD PMID:19397697 NCBI chr 3:34,649,995...34,652,461
Ensembl chr 3:34,650,405...34,652,461
JBrowse link
G Tmem18 transmembrane protein 18 increases expression ISO Pantothenic Acid results in increased expression of TMEM18 mRNA CTD PMID:19397697 NCBI chr12:30,584,443...30,591,219
Ensembl chr12:30,584,426...30,591,215
JBrowse link
G Zfp575 zinc finger protein 575 decreases expression ISO Pantothenic Acid results in decreased expression of ZNF575 mRNA CTD PMID:19397697 NCBI chr 7:24,583,838...24,587,840
Ensembl chr 7:24,583,838...24,587,641
JBrowse link
dabigatran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aif1 allograft inflammatory factor 1 decreases expression EXP Dabigatran results in decreased expression of AIF1 protein CTD PMID:27397090 NCBI chr17:35,170,986...35,176,083
Ensembl chr17:35,170,991...35,176,068
JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 decreases expression ISO Dabigatran results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr 9:71,215,789...71,296,243
Ensembl chr 9:71,215,789...71,296,243
JBrowse link
G Eya1 EYA transcriptional coactivator and phosphatase 1 decreases expression ISO Dabigatran results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 1:14,168,953...14,311,035
Ensembl chr 1:14,168,954...14,310,235
JBrowse link
G F2 coagulation factor II decreases activity EXP
ISO
Dabigatran results in decreased activity of F2 protein CTD PMID:17911567 PMID:25138021 NCBI chr 2:91,612,397...91,636,457
Ensembl chr 2:91,625,320...91,636,414
JBrowse link
G Fga fibrinogen alpha chain multiple interactions EXP Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 3:83,026,153...83,033,627
Ensembl chr 3:83,026,076...83,033,627
JBrowse link
G Fgb fibrinogen beta chain multiple interactions EXP Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 3:83,042,246...83,049,863
Ensembl chr 3:83,040,141...83,049,863
JBrowse link
G Fgf8 fibroblast growth factor 8 increases expression ISO Dabigatran results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr19:45,736,491...45,742,941
Ensembl chr19:45,736,798...45,742,915
JBrowse link
G Fgg fibrinogen gamma chain multiple interactions EXP Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 3:83,007,724...83,015,056
Ensembl chr 3:83,007,724...83,015,049
JBrowse link
G Foxc2 forkhead box C2 decreases expression ISO Dabigatran results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr 8:121,116,171...121,118,895
Ensembl chr 8:121,116,171...121,118,895
JBrowse link
G Gdnf glial cell line derived neurotrophic factor multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA] CTD PMID:28585189 NCBI chr15:7,810,048...7,837,580
Ensembl chr15:7,810,846...7,837,575
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression EXP Dabigatran results in decreased expression of GFAP protein CTD PMID:27397090 NCBI chr11:102,887,336...102,897,200
Ensembl chr11:102,887,336...102,900,912
JBrowse link
G Hoxb9 homeobox B9 increases expression ISO Dabigatran results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr11:96,271,330...96,276,595
Ensembl chr11:96,271,457...96,276,595
JBrowse link
G Meox1 mesenchyme homeobox 1 decreases expression ISO Dabigatran results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr11:101,877,510...101,894,354
Ensembl chr11:101,877,510...101,894,374
JBrowse link
G Mertk MER proto-oncogene tyrosine kinase increases expression EXP Dabigatran results in increased expression of MERTK mRNA CTD PMID:27397090 NCBI chr 2:128,698,915...128,803,162
Ensembl chr 2:128,698,956...128,802,894
JBrowse link
G Neurog2 neurogenin 2 increases expression ISO Dabigatran results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 3:127,632,733...127,635,636
Ensembl chr 3:127,633,135...127,635,631
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of NR4A2 mRNA] CTD PMID:28585189 NCBI chr 2:57,106,830...57,124,003
Ensembl chr 2:57,106,830...57,124,003
JBrowse link
G Olig3 oligodendrocyte transcription factor 3 increases expression ISO Dabigatran results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr10:19,356,539...19,358,604
Ensembl chr10:19,356,533...19,358,604
JBrowse link
G Pax3 paired box 3 decreases expression ISO Dabigatran results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 1:78,101,267...78,197,136
Ensembl chr 1:78,101,267...78,197,134
JBrowse link
G Pax6 paired box 6 increases expression ISO Dabigatran results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr 2:105,668,896...105,698,410
Ensembl chr 2:105,668,900...105,697,364
JBrowse link
G Plp1 proteolipid protein (myelin) 1 increases expression EXP Dabigatran results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:136,820,148...136,838,582
Ensembl chr  X:136,822,671...136,839,733
JBrowse link
G Rcor2 REST corepressor 2 multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of RCOR2 mRNA] CTD PMID:28585189 NCBI chr19:7,267,394...7,275,225
Ensembl chr19:7,267,325...7,275,225
JBrowse link
G Ret ret proto-oncogene multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of RET protein] CTD PMID:28585189 NCBI chr 6:118,151,748...118,197,744
Ensembl chr 6:118,151,745...118,197,718
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA] CTD PMID:28585189 NCBI chr19:59,260,878...59,296,012
Ensembl chr19:59,260,896...59,296,012
JBrowse link
G Snca synuclein, alpha multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in increased expression of SNCA mRNA] CTD PMID:28585189 NCBI chr 6:60,731,573...60,829,855
Ensembl chr 6:60,731,575...60,829,855
JBrowse link
G Tcf15 transcription factor 15 decreases expression ISO Dabigatran results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr 2:152,143,056...152,149,097
Ensembl chr 2:152,143,561...152,149,097
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of TH mRNA] CTD PMID:28585189 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in increased expression of TNF mRNA] CTD PMID:28585189 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Uncx UNC homeobox decreases expression ISO Dabigatran results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr 5:139,543,865...139,548,179
Ensembl chr 5:139,543,494...139,548,179
JBrowse link
metalaxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c38 cytochrome P450, family 2, subfamily c, polypeptide 38 decreases expression ISO metalaxyl results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr19:39,389,556...39,463,103
Ensembl chr19:39,389,556...39,463,075
JBrowse link
G Cyp7a1 cytochrome P450, family 7, subfamily a, polypeptide 1 decreases expression ISO metalaxyl results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 4:6,265,612...6,275,632
Ensembl chr 4:6,265,612...6,275,633
JBrowse link
G Gm40318 predicted gene, 40318 increases expression ISO metalaxyl results in increased expression of S100P protein CTD PMID:32194361 NCBI chr 5:36,762,504...36,767,419
Ensembl chr 5:36,762,617...36,766,695
JBrowse link
methylphenidate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtpbp1 ATP/GTP binding protein 1 increases expression EXP Methylphenidate results in increased expression of AGTPBP1 mRNA CTD PMID:22470460 NCBI chr13:59,449,534...59,557,370
Ensembl chr13:59,445,742...59,585,227
JBrowse link
G Akr1b3 aldo-keto reductase family 1, member B3 (aldose reductase) decreases expression EXP Methylphenidate results in decreased expression of AKR1B3 mRNA CTD PMID:22470460 NCBI chr 6:34,303,930...34,317,489
Ensembl chr 6:34,302,434...34,317,478
JBrowse link
G Ap2b1 adaptor-related protein complex 2, beta 1 subunit increases expression EXP Methylphenidate results in increased expression of AP2B1 mRNA CTD PMID:22470460 NCBI chr11:83,298,719...83,405,035
Ensembl chr11:83,299,024...83,405,035
JBrowse link
G Arap1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 decreases expression EXP Methylphenidate results in decreased expression of ARAP1 mRNA CTD PMID:22470460 NCBI chr 7:101,347,921...101,412,586
Ensembl chr 7:101,348,067...101,412,586
JBrowse link
G Arc activity regulated cytoskeletal-associated protein affects expression ISO Methylphenidate affects the expression of ARC mRNA CTD PMID:19222557 NCBI chr15:74,669,081...74,672,570
Ensembl chr15:74,669,083...74,672,570
JBrowse link
G Arih2 ariadne RBR E3 ubiquitin protein ligase 2 decreases expression EXP Methylphenidate results in decreased expression of ARIH2 mRNA CTD PMID:22470460 NCBI chr 9:108,602,942...108,653,681
Ensembl chr 9:108,602,942...108,649,386
JBrowse link
G Armc9 armadillo repeat containing 9 decreases expression EXP Methylphenidate results in decreased expression of ARMC9 mRNA CTD PMID:22470460 NCBI chr 1:86,154,729...86,278,284
Ensembl chr 1:86,154,780...86,278,284
JBrowse link
G B4galt4 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 4 decreases expression EXP Methylphenidate results in decreased expression of B4GALT4 mRNA CTD PMID:22470460 NCBI chr16:38,742,220...38,769,054
Ensembl chr16:38,742,264...38,769,049
JBrowse link
G Bcl9 B cell CLL/lymphoma 9 decreases expression EXP Methylphenidate results in decreased expression of BCL9 mRNA CTD PMID:22470460 NCBI chr 3:97,203,658...97,298,402
Ensembl chr 3:97,203,662...97,297,917
JBrowse link
G Bdnf brain derived neurotrophic factor affects expression
multiple interactions
decreases expression
ISO
EXP
Methylphenidate affects the expression of BDNF mRNA
[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]
Methylphenidate results in decreased expression of BDNF mRNA
CTD PMID:19222557 PMID:22470460 PMID:24394491 NCBI chr 2:109,674,700...109,727,043
Ensembl chr 2:109,674,700...109,727,007
JBrowse link
G C2 complement component 2 (within H-2S) increases expression EXP Methylphenidate results in increased expression of C2 mRNA CTD PMID:22470460 NCBI chr17:34,862,602...34,882,100
Ensembl chr17:34,862,604...34,898,265
JBrowse link
G Cald1 caldesmon 1 increases expression EXP Methylphenidate results in increased expression of CALD1 mRNA CTD PMID:22470460 NCBI chr 6:34,598,495...34,775,469
Ensembl chr 6:34,598,500...34,775,473
JBrowse link
G Cbr3 carbonyl reductase 3 increases expression EXP Methylphenidate results in increased expression of CBR3 mRNA CTD PMID:22470460 NCBI chr16:93,683,219...93,690,991
Ensembl chr16:93,683,215...93,690,990
JBrowse link
G Ccdc166 coiled-coil domain containing 166 decreases expression EXP Methylphenidate results in decreased expression of CCDC166 mRNA CTD PMID:22470460 NCBI chr15:75,979,872...75,982,285
Ensembl chr15:75,979,872...75,982,455
JBrowse link
G Ccdc91 coiled-coil domain containing 91 decreases expression EXP Methylphenidate results in decreased expression of CCDC91 mRNA CTD PMID:22470460 NCBI chr 6:147,475,871...147,632,613
Ensembl chr 6:147,475,828...147,632,612
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5, regulatory subunit 1 (p35) increases expression EXP Methylphenidate results in increased expression of CDK5R1 mRNA CTD PMID:22470460 NCBI chr11:80,477,023...80,481,184
Ensembl chr11:80,477,023...80,481,184
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions
increases hydrolysis
increases metabolic processing
ISO
EXP
[CES1 protein results in increased hydrolysis of Methylphenidate] which results in increased chemical synthesis of ritalinic acid; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; CES1 gene mutant form results in decreased metabolism of and results in increased abundance of Methylphenidate; Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CES1 protein results in increased metabolism of Methylphenidate
CTD PMID:15082749 PMID:18485328 PMID:20097249 PMID:25445008 NCBI chr 8:93,166,072...93,197,804
Ensembl chr 8:93,166,068...93,197,838
JBrowse link
G Chd2 chromodomain helicase DNA binding protein 2 increases expression EXP Methylphenidate results in increased expression of CHD2 mRNA CTD PMID:22470460 NCBI chr 7:73,426,652...73,541,746
Ensembl chr 7:73,426,638...73,541,830
JBrowse link
G Chga chromogranin A decreases expression EXP Methylphenidate results in decreased expression of CHGA mRNA CTD PMID:22470460 NCBI chr12:102,554,941...102,565,027
Ensembl chr12:102,554,969...102,565,028
JBrowse link
G Chid1 chitinase domain containing 1 decreases expression EXP Methylphenidate results in decreased expression of CHID1 mRNA CTD PMID:22470460 NCBI chr 7:141,493,136...141,539,905
Ensembl chr 7:141,493,136...141,539,857
JBrowse link
G Chrna6 cholinergic receptor, nicotinic, alpha polypeptide 6 decreases expression EXP Methylphenidate results in decreased expression of CHRNA6 mRNA CTD PMID:22470460 NCBI chr 8:27,403,212...27,413,944
Ensembl chr 8:27,403,212...27,413,944
JBrowse link
G Chst8 carbohydrate sulfotransferase 8 decreases expression EXP Methylphenidate results in decreased expression of CHST8 mRNA CTD PMID:22470460 NCBI chr 7:34,674,468...34,812,711
Ensembl chr 7:34,674,468...34,812,711
JBrowse link
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit increases expression EXP Methylphenidate results in increased expression of CLPX mRNA CTD PMID:22470460 NCBI chr 9:65,294,251...65,330,658
Ensembl chr 9:65,294,260...65,330,658
JBrowse link
G Cnnm1 cyclin M1 increases expression EXP Methylphenidate results in increased expression of CNNM1 mRNA CTD PMID:22470460 NCBI chr19:43,439,069...43,497,210
Ensembl chr19:43,440,436...43,497,210
JBrowse link
G Cnot6l CCR4-NOT transcription complex, subunit 6-like decreases expression EXP Methylphenidate results in decreased expression of CNOT6L mRNA CTD PMID:22470460 NCBI chr 5:96,070,333...96,164,198
Ensembl chr 5:96,070,333...96,164,171
JBrowse link
G Cnr1 cannabinoid receptor 1 (brain) increases expression EXP Methylphenidate results in increased expression of CNR1 mRNA CTD PMID:22470460 NCBI chr 4:33,923,171...33,948,831
Ensembl chr 4:33,924,593...33,948,831
JBrowse link
G Comtd1 catechol-O-methyltransferase domain containing 1 decreases expression EXP Methylphenidate results in decreased expression of COMTD1 mRNA CTD PMID:22470460 NCBI chr14:21,845,861...21,848,910
Ensembl chr14:21,845,855...21,848,977
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions
decreases expression
ISO [Fluoxetine co-treated with Methylphenidate] results in increased expression of CREB mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of CREB protein
Methylphenidate results in decreased expression of CREB mRNA
CTD PMID:21753012 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Cyp4f13 cytochrome P450, family 4, subfamily f, polypeptide 13 decreases expression EXP Methylphenidate results in decreased expression of CYP4F13 mRNA CTD PMID:22470460 NCBI chr17:32,924,688...32,947,415
Ensembl chr17:32,924,688...32,947,402
JBrowse link
G D2hgdh D-2-hydroxyglutarate dehydrogenase decreases expression EXP Methylphenidate results in decreased expression of D2HGDH mRNA CTD PMID:22470460 NCBI chr 1:93,823,195...93,853,857
Ensembl chr 1:93,824,909...93,852,348
JBrowse link
G Dab2 disabled 2, mitogen-responsive phosphoprotein increases expression EXP Methylphenidate results in increased expression of DAB2 mRNA CTD PMID:22470460 NCBI chr15:6,299,788...6,440,715
Ensembl chr15:6,299,788...6,440,712
JBrowse link
G Dapk3 death-associated protein kinase 3 decreases expression EXP Methylphenidate results in decreased expression of DAPK3 mRNA CTD PMID:22470460 NCBI chr10:81,182,987...81,193,197
Ensembl chr10:81,183,005...81,193,197
JBrowse link
G Dhx35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 decreases expression EXP Methylphenidate results in decreased expression of DHX35 mRNA CTD PMID:22470460 NCBI chr 2:158,794,745...158,858,220
Ensembl chr 2:158,794,807...158,858,214
JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methylphenidate CTD PMID:11454915 NCBI chr13:54,051,183...54,055,658
Ensembl chr13:54,051,183...54,055,705
JBrowse link
G Drd2 dopamine receptor D2 multiple interactions
decreases expression
affects expression
ISO
EXP
[Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate
Methylphenidate results in decreased expression of DRD2 mRNA
Methylphenidate affects the expression of DRD2 protein
CTD PMID:11454915 PMID:17599397 PMID:22470460 NCBI chr 9:49,340,360...49,408,177
Ensembl chr 9:49,340,627...49,408,177
JBrowse link
G Drd4 dopamine receptor D4 affects response to substance ISO DRD4 promoter mutant form affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr 7:141,291,974...141,296,464
Ensembl chr 7:141,292,006...141,296,464
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO [Fluoxetine co-treated with Methylphenidate] results in increased expression of EGR1 mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of EGR1 mRNA]; Methylphenidate promotes the reaction [Amphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of EGR1 mRNA] CTD PMID:16549270 PMID:19931852 PMID:20020108 PMID:21753012 NCBI chr18:34,861,207...34,864,956
Ensembl chr18:34,859,823...34,864,984
JBrowse link
G Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 decreases expression EXP Methylphenidate results in decreased expression of ENTPD5 mRNA CTD PMID:22470460 NCBI chr12:84,373,875...84,409,029
Ensembl chr12:84,373,857...84,409,029
JBrowse link
G Epb41l1 erythrocyte membrane protein band 4.1 like 1 decreases expression EXP Methylphenidate results in decreased expression of EPB41L1 mRNA CTD PMID:22470460 NCBI chr 2:156,417,595...156,543,214
Ensembl chr 2:156,420,909...156,543,214
JBrowse link
G Epha10 Eph receptor A10 decreases expression EXP Methylphenidate results in decreased expression of EPHA10 mRNA CTD PMID:22470460 NCBI chr 4:124,881,530...124,917,801
Ensembl chr 4:124,880,899...124,917,800
JBrowse link
G Exog endo/exonuclease (5'-3'), endonuclease G-like decreases expression EXP Methylphenidate results in decreased expression of EXOG mRNA CTD PMID:22470460 NCBI chr 9:119,444,925...119,465,518
Ensembl chr 9:119,444,943...119,465,517
JBrowse link
G Fank1 fibronectin type 3 and ankyrin repeat domains 1 decreases expression EXP Methylphenidate results in decreased expression of FANK1 mRNA CTD PMID:22470460 NCBI chr 7:133,776,836...133,881,536
Ensembl chr 7:133,776,861...133,881,532
JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb increases expression EXP Methylphenidate results in increased expression of FCGR2B mRNA CTD PMID:22470460 NCBI chr 1:170,960,558...170,976,071
Ensembl chr 1:170,958,617...170,976,547
JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions
increases expression
decreases expression
ISO
EXP
[Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of FOS mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of FOS mRNA]
Methylphenidate results in increased expression of FOS protein
Methylphenidate results in decreased expression of FOS protein
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA; Methylphenidate results in increased expression of FOS protein
CTD PMID:12112414 PMID:12699766 PMID:15916815 PMID:19931852 PMID:21753012 NCBI chr12:85,473,890...85,477,274
Ensembl chr12:85,473,890...85,477,273
JBrowse link
G Fosb FBJ osteosarcoma oncogene B increases expression ISO Methylphenidate results in increased expression of FOSB protein CTD PMID:15916815 NCBI chr 7:19,302,696...19,310,118
Ensembl chr 7:19,302,696...19,310,051
JBrowse link
G Galnt10 polypeptide N-acetylgalactosaminyltransferase 10 decreases expression EXP Methylphenidate results in decreased expression of GALNT10 mRNA CTD PMID:22470460 NCBI chr11:57,645,442...57,787,514
Ensembl chr11:57,645,442...57,787,514
JBrowse link
G Gch1 GTP cyclohydrolase 1 decreases expression EXP Methylphenidate results in decreased expression of GCH1 mRNA CTD PMID:22470460 NCBI chr14:47,153,895...47,189,413
Ensembl chr14:47,153,895...47,189,413
JBrowse link
G Gdnf glial cell line derived neurotrophic factor decreases expression EXP Methylphenidate results in decreased expression of GDNF mRNA CTD PMID:22470460 NCBI chr15:7,810,048...7,837,580
Ensembl chr15:7,810,846...7,837,575
JBrowse link
G Ghdc GH3 domain containing decreases expression EXP Methylphenidate results in decreased expression of GHDC mRNA CTD PMID:22470460 NCBI chr11:100,766,026...100,770,973
Ensembl chr11:100,766,032...100,770,957
JBrowse link
G Grik3 glutamate receptor, ionotropic, kainate 3 decreases expression EXP Methylphenidate results in decreased expression of GRIK3 mRNA CTD PMID:22470460 NCBI chr 4:125,490,259...125,714,173
Ensembl chr 4:125,490,700...125,714,173
JBrowse link
G Gucy2c guanylate cyclase 2c decreases expression EXP Methylphenidate results in decreased expression of GUCY2C mRNA CTD PMID:22470460 NCBI chr 6:136,697,284...136,781,742
Ensembl chr 6:136,697,284...136,781,765
JBrowse link
G Hbp1 high mobility group box transcription factor 1 decreases expression EXP Methylphenidate results in decreased expression of HBP1 mRNA CTD PMID:22470460 NCBI chr12:31,926,452...31,950,530
Ensembl chr12:31,926,254...31,950,535
JBrowse link
G Homer1 homer scaffolding protein 1 increases expression
multiple interactions
ISO Methylphenidate results in increased expression of HOMER1 mRNA
SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of HOMER1 mRNA]
CTD PMID:16549270 NCBI chr13:93,303,757...93,405,129
Ensembl chr13:93,299,635...93,405,129
JBrowse link
G Hspb6 heat shock protein, alpha-crystallin-related, B6 decreases expression EXP Methylphenidate results in decreased expression of HSPB6 mRNA CTD PMID:22470460 NCBI chr 7:30,552,535...30,555,443
Ensembl chr 7:30,552,178...30,555,443
JBrowse link
G Il6 interleukin 6 increases expression EXP Methylphenidate results in increased expression of IL6 mRNA CTD PMID:22470460 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
G Ip6k1 inositol hexaphosphate kinase 1 increases expression EXP Methylphenidate results in increased expression of IP6K1 mRNA CTD PMID:22470460 NCBI chr 9:108,002,648...108,048,782
Ensembl chr 9:108,002,501...108,048,782
JBrowse link
G Jak3 Janus kinase 3 decreases expression EXP Methylphenidate results in decreased expression of JAK3 mRNA CTD PMID:22470460 NCBI chr 8:71,676,383...71,690,577
Ensembl chr 8:71,676,296...71,690,575
JBrowse link
G Kifc3 kinesin family member C3 decreases expression EXP Methylphenidate results in decreased expression of KIFC3 mRNA CTD PMID:22470460 NCBI chr 8:95,099,828...95,202,826
Ensembl chr 8:95,099,828...95,202,812
JBrowse link
G Lad1 ladinin decreases expression EXP Methylphenidate results in decreased expression of LAD1 mRNA CTD PMID:22470460 NCBI chr 1:135,818,598...135,833,341
Ensembl chr 1:135,818,598...135,833,342
JBrowse link
G Lama3 laminin, alpha 3 decreases expression EXP Methylphenidate results in decreased expression of LAMA3 mRNA CTD PMID:22470460 NCBI chr18:12,333,417...12,583,013
Ensembl chr18:12,333,819...12,583,013
JBrowse link
G Large1 LARGE xylosyl- and glucuronyltransferase 1 decreases expression EXP Methylphenidate results in decreased expression of LARGE1 mRNA CTD PMID:22470460 NCBI chr 8:72,814,598...73,353,721
Ensembl chr 8:72,814,599...73,353,540
JBrowse link
G Lasp1 LIM and SH3 protein 1 increases expression EXP Methylphenidate results in increased expression of LASP1 mRNA CTD PMID:22470460 NCBI chr11:97,799,005...97,838,765
Ensembl chr11:97,799,000...97,838,764
JBrowse link
G Lgals3bp lectin, galactoside-binding, soluble, 3 binding protein decreases expression EXP Methylphenidate results in decreased expression of LGALS3BP mRNA CTD PMID:22470460 NCBI chr11:118,392,747...118,401,959
Ensembl chr11:118,392,751...118,402,092
JBrowse link
G Lhfpl5 lipoma HMGIC fusion partner-like 5 decreases expression EXP Methylphenidate results in decreased expression of LHFPL5 mRNA CTD PMID:22470460 NCBI chr17:28,575,369...28,583,593
Ensembl chr17:28,575,641...28,585,679
JBrowse link
G Lrrc27 leucine rich repeat containing 27 decreases expression EXP Methylphenidate results in decreased expression of LRRC27 mRNA CTD PMID:22470460 NCBI chr 7:139,211,632...139,242,979
Ensembl chr 7:139,212,988...139,242,979
JBrowse link
G Lyz1 lysozyme 1 decreases expression EXP Methylphenidate results in decreased expression of LYZ1 mRNA CTD PMID:22470460 NCBI chr10:117,287,795...117,292,868
Ensembl chr10:117,287,797...117,292,868
JBrowse link
G Malat1 metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA) increases expression EXP Methylphenidate results in increased expression of MALAT1 mRNA CTD PMID:22470460 NCBI chr19:5,795,690...5,802,672
Ensembl chr19:5,795,690...5,802,672
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta decreases expression EXP Methylphenidate results in decreased expression of MAP1LC3B mRNA CTD PMID:22470460 NCBI chr 8:121,590,438...121,598,760
Ensembl chr 8:121,590,361...121,598,760
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases expression
multiple interactions
ISO Methylphenidate results in decreased expression of MAPK1 mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of MAPK1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MAPK1 protein
CTD PMID:21753012 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases expression EXP Methylphenidate results in increased expression of MAPK8 mRNA CTD PMID:22470460 NCBI chr14:33,377,898...33,447,353
Ensembl chr14:33,377,898...33,447,158
JBrowse link
G Mlc1 megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human) decreases expression EXP Methylphenidate results in decreased expression of MLC1 mRNA CTD PMID:22470460 NCBI chr15:88,955,884...88,982,693
Ensembl chr15:88,955,884...88,979,007
JBrowse link
G Morn2 MORN repeat containing 2 decreases expression EXP Methylphenidate results in decreased expression of MORN2 mRNA CTD PMID:22470460 NCBI chr17:80,290,203...80,300,096
Ensembl chr17:80,290,203...80,297,476
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
affects expression
ISO [Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein
Methylphenidate affects the expression of MTOR mRNA
CTD PMID:21753012 NCBI chr 4:148,448,582...148,557,685
Ensembl chr 4:148,448,611...148,557,683
JBrowse link
G Mvp major vault protein decreases expression EXP Methylphenidate results in decreased expression of MVP mRNA CTD PMID:22470460 NCBI chr 7:126,986,860...127,014,594
Ensembl chr 7:126,986,860...127,014,621
JBrowse link
G Nabp1 nucleic acid binding protein 1 increases expression EXP Methylphenidate results in increased expression of NABP1 mRNA CTD PMID:22470460 NCBI chr 1:51,464,968...51,478,475
Ensembl chr 1:51,465,862...51,478,425
JBrowse link
G Nacad NAC alpha domain containing decreases expression EXP Methylphenidate results in decreased expression of NACAD mRNA CTD PMID:22470460 NCBI chr11:6,597,814...6,606,059
Ensembl chr11:6,597,823...6,606,053
JBrowse link
G Ncor2 nuclear receptor co-repressor 2 decreases expression EXP Methylphenidate results in decreased expression of NCOR2 mRNA CTD PMID:22470460 NCBI chr 5:125,017,153...125,179,238
Ensembl chr 5:125,017,153...125,179,219
JBrowse link
G Neto2 neuropilin (NRP) and tolloid (TLL)-like 2 increases expression EXP Methylphenidate results in increased expression of NETO2 mRNA CTD PMID:22470460 NCBI chr 8:85,636,718...85,700,952
Ensembl chr 8:85,636,588...85,700,924
JBrowse link
G Nol3 nucleolar protein 3 (apoptosis repressor with CARD domain) decreases expression EXP Methylphenidate results in decreased expression of NOL3 mRNA CTD PMID:22470460 NCBI chr 8:105,276,145...105,281,939
Ensembl chr 8:105,276,140...105,281,939
JBrowse link
G Nsun4 NOL1/NOP2/Sun domain family, member 4 increases expression EXP Methylphenidate results in increased expression of NSUN4 mRNA CTD PMID:22470460 NCBI chr 4:116,033,002...116,053,879
Ensembl chr 4:116,032,842...116,053,876
JBrowse link
G Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 multiple interactions ISO [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 NCBI chr13:58,806,472...59,133,970
Ensembl chr13:58,806,569...59,133,970
JBrowse link
G Parp3 poly (ADP-ribose) polymerase family, member 3 increases expression EXP Methylphenidate results in increased expression of PARP3 mRNA CTD PMID:22470460 NCBI chr 9:106,470,322...106,476,949
Ensembl chr 9:106,470,322...106,476,949
JBrowse link
G Pear1 platelet endothelial aggregation receptor 1 increases expression EXP Methylphenidate results in increased expression of PEAR1 mRNA CTD PMID:22470460 NCBI chr 3:87,749,097...87,769,110
Ensembl chr 3:87,747,890...87,824,306
JBrowse link
G Pisd phosphatidylserine decarboxylase decreases expression EXP Methylphenidate results in decreased expression of PISD mRNA CTD PMID:22470460 NCBI chr 5:32,736,301...32,785,642
Ensembl chr 5:32,736,301...32,785,646
JBrowse link
G Pkn1 protein kinase N1 decreases expression EXP Methylphenidate results in decreased expression of PKN1 mRNA CTD PMID:22470460 NCBI chr 8:83,666,533...83,699,181
Ensembl chr 8:83,666,536...83,699,179
JBrowse link
G Pnmal2 PNMA-like 2 increases expression EXP Methylphenidate results in increased expression of PNMAL2 mRNA CTD PMID:22470460 NCBI chr 7:16,944,682...16,948,828
Ensembl chr 7:16,944,682...16,948,828
JBrowse link
G Prkg2 protein kinase, cGMP-dependent, type II increases expression EXP Methylphenidate results in increased expression of PRKG2 mRNA CTD PMID:22470460 NCBI chr 5:98,929,773...99,037,375
Ensembl chr 5:98,929,773...99,037,351
JBrowse link
G Prlr prolactin receptor decreases expression EXP Methylphenidate results in decreased expression of PRLR mRNA CTD PMID:22470460 NCBI chr15:10,177,238...10,349,190
Ensembl chr15:10,177,238...10,349,180
JBrowse link
G Prpf39 pre-mRNA processing factor 39 increases expression EXP Methylphenidate results in increased expression of PRPF39 mRNA CTD PMID:22470460 NCBI chr12:65,036,334...65,063,386
Ensembl chr12:65,036,333...65,063,386
JBrowse link
G Ptdss2 phosphatidylserine synthase 2 decreases expression EXP Methylphenidate results in decreased expression of PTDSS2 mRNA CTD PMID:22470460 NCBI chr 7:141,131,267...141,156,158
Ensembl chr 7:141,122,382...141,157,606
JBrowse link
G Ptpn21 protein tyrosine phosphatase, non-receptor type 21 increases expression EXP Methylphenidate results in increased expression of PTPN21 mRNA CTD PMID:22470460 NCBI chr12:98,676,741...98,737,613
Ensembl chr12:98,676,741...98,737,405
JBrowse link
G Pus7l pseudouridylate synthase 7-like decreases expression EXP Methylphenidate results in decreased expression of PUS7L mRNA CTD PMID:22470460 NCBI chr15:94,522,640...94,543,534
Ensembl chr15:94,522,688...94,543,547
JBrowse link
G Rab38 RAB38, member RAS oncogene family increases expression EXP Methylphenidate results in increased expression of RAB38 mRNA CTD PMID:22470460 NCBI chr 7:88,430,273...88,491,572
Ensembl chr 7:88,430,273...88,491,572
JBrowse link
G Racgap1 Rac GTPase-activating protein 1 decreases expression EXP Methylphenidate results in decreased expression of RACGAP1 mRNA CTD PMID:22470460 NCBI chr15:99,620,496...99,651,656
Ensembl chr15:99,620,496...99,651,656
JBrowse link
G Rbfox1 RNA binding protein, fox-1 homolog (C. elegans) 1 increases expression EXP Methylphenidate results in increased expression of RBFOX1 mRNA CTD PMID:22470460 NCBI chr16:5,884,793...7,412,480
Ensembl chr16:5,885,355...7,411,526
JBrowse link
G Rcc2 regulator of chromosome condensation 2 decreases expression EXP Methylphenidate results in decreased expression of RCC2 mRNA CTD PMID:22470460 NCBI chr 4:140,701,473...140,723,220
Ensembl chr 4:140,700,541...140,723,220
JBrowse link
G Ret ret proto-oncogene decreases expression EXP Methylphenidate results in decreased expression of RET mRNA CTD PMID:22470460 NCBI chr 6:118,151,748...118,197,744
Ensembl chr 6:118,151,745...118,197,718
JBrowse link
G Rgma repulsive guidance molecule family member A decreases expression EXP Methylphenidate results in decreased expression of RGMA mRNA CTD PMID:22470460 NCBI chr 7:73,375,520...73,419,899
Ensembl chr 7:73,375,509...73,419,899
JBrowse link
G Rgs20 regulator of G-protein signaling 20 decreases expression EXP Methylphenidate results in decreased expression of RGS20 mRNA CTD PMID:22470460 NCBI chr 1:4,909,573...5,070,299
Ensembl chr 1:4,909,576...5,070,285
JBrowse link
G Rhbdd2 rhomboid domain containing 2 decreases expression EXP Methylphenidate results in decreased expression of RHBDD2 mRNA CTD PMID:22470460 NCBI chr 5:135,632,654...135,646,376
Ensembl chr 5:135,632,618...135,646,448
JBrowse link
G Sdc3 syndecan 3 decreases expression EXP Methylphenidate results in decreased expression of SDC3 mRNA CTD PMID:22470460 NCBI chr 4:130,792,537...130,826,318
Ensembl chr 4:130,792,537...130,826,319
JBrowse link
G Siae sialic acid acetylesterase decreases expression EXP Methylphenidate results in decreased expression of SIAE mRNA CTD PMID:22470460 NCBI chr 9:37,613,821...37,648,258
Ensembl chr 9:37,555,698...37,649,655
JBrowse link
G Slc10a4 solute carrier family 10 (sodium/bile acid cotransporter family), member 4 decreases expression EXP Methylphenidate results in decreased expression of SLC10A4 mRNA CTD PMID:22470460 NCBI chr 5:73,006,904...73,012,955
Ensembl chr 5:73,006,883...73,012,955
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 decreases expression EXP Methylphenidate results in decreased expression of SLC18A2 mRNA CTD PMID:22470460 NCBI chr19:59,260,878...59,296,012
Ensembl chr19:59,260,896...59,296,012
JBrowse link
G Slc2a12 solute carrier family 2 (facilitated glucose transporter), member 12 increases expression EXP Methylphenidate results in increased expression of SLC2A12 mRNA CTD PMID:22470460 NCBI chr10:22,644,990...22,703,880
Ensembl chr10:22,645,011...22,704,285
JBrowse link
G Slc6a3 solute carrier family 6 (neurotransmitter transporter, dopamine), member 3 multiple interactions
decreases expression
increases response to substance
affects response to substance
ISO
EXP
[Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; [SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate] which affects the uptake of Dopamine; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Methylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Methylphenidate results in decreased expression of SLC6A3 mRNA
Methylphenidate results in decreased expression of SLC6A3 protein
SLC6A3 protein results in increased susceptibility to Methylphenidate
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
SLC6A3 3' UTR polymorphism affects the susceptibility to Methylphenidate; SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate
CTD PMID:12112414 PMID:12699766 PMID:15059031 PMID:16139732 PMID:17234900 PMID:18614672 PMID:19462300 PMID:22470460 PMID:31009648 NCBI chr13:73,536,128...73,578,672
Ensembl chr13:73,536,747...73,578,672
JBrowse link
G Snap25 synaptosomal-associated protein 25 affects response to substance ISO SNAP25 gene polymorphism affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr 2:136,713,439...136,782,428
Ensembl chr 2:136,713,453...136,782,428
JBrowse link
G Sncaip synuclein, alpha interacting protein (synphilin) increases expression EXP Methylphenidate results in increased expression of SNCAIP mRNA CTD PMID:22470460 NCBI chr18:52,767,811...52,915,935
Ensembl chr18:52,767,709...52,915,935
JBrowse link
G Sncg synuclein, gamma decreases expression EXP Methylphenidate results in decreased expression of SNCG mRNA CTD PMID:22470460 NCBI chr14:34,370,274...34,374,669
Ensembl chr14:34,370,274...34,374,789
JBrowse link
G Snx22 sorting nexin 22 decreases expression EXP Methylphenidate results in decreased expression of SNX22 mRNA CTD PMID:22470460 NCBI chr 9:66,065,174...66,069,759
Ensembl chr 9:66,065,176...66,069,719
JBrowse link
G Sorcs3 sortilin-related VPS10 domain containing receptor 3 decreases expression EXP Methylphenidate results in decreased expression of SORCS3 mRNA CTD PMID:22470460 NCBI chr19:48,206,025...48,805,505
Ensembl chr19:48,206,025...48,805,505
JBrowse link
G Sox11 SRY (sex determining region Y)-box 11 increases expression EXP Methylphenidate results in increased expression of SOX11 mRNA CTD PMID:22470460 NCBI chr12:27,334,268...27,342,718
Ensembl chr12:27,334,264...27,342,574
JBrowse link
G Stat5a signal transducer and activator of transcription 5A decreases expression EXP Methylphenidate results in decreased expression of STAT5A mRNA CTD PMID:22470460 NCBI chr11:100,859,351...100,885,169
Ensembl chr11:100,859,351...100,885,169
JBrowse link
G Stox2 storkhead box 2 increases expression EXP Methylphenidate results in increased expression of STOX2 mRNA CTD PMID:22470460 NCBI chr 8:47,180,048...47,413,847
Ensembl chr 8:47,180,048...47,446,362
JBrowse link
G Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) decreases expression EXP Methylphenidate results in decreased expression of SUDS3 mRNA CTD PMID:22470460 NCBI chr 5:117,091,678...117,115,993
Ensembl chr 5:117,091,680...117,116,113
JBrowse link
G Taar1 trace amine-associated receptor 1 multiple interactions ISO Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] CTD PMID:17234900 NCBI chr10:23,920,406...23,921,404
Ensembl chr10:23,920,356...23,921,469
JBrowse link
G Tcl1b1 T cell leukemia/lymphoma 1B, 1 increases expression EXP Methylphenidate results in increased expression of TCL1B1 mRNA CTD PMID:22470460 NCBI chr12:105,159,704...105,166,625
Ensembl chr12:105,159,690...105,166,625
JBrowse link
G Th tyrosine hydroxylase decreases expression EXP Methylphenidate results in decreased expression of TH mRNA CTD PMID:22470460 NCBI chr 7:142,892,779...142,899,995
Ensembl chr 7:142,892,752...142,931,128
JBrowse link
G Tmem185b transmembrane protein 185B decreases expression EXP Methylphenidate results in decreased expression of TMEM185B mRNA CTD PMID:22470460 NCBI chr 1:119,526,154...119,528,983
Ensembl chr 1:119,526,160...119,528,983
JBrowse link
G Tmem189 transmembrane protein 189 decreases expression EXP Methylphenidate results in decreased expression of TMEM189 mRNA CTD PMID:22470460 NCBI chr 2:167,643,225...167,661,544
Ensembl chr 2:167,642,608...167,689,822
JBrowse link
G Tmem30a transmembrane protein 30A decreases expression EXP Methylphenidate results in decreased expression of TMEM30A mRNA CTD PMID:22470460 NCBI chr 9:79,768,941...79,793,430
Ensembl chr 9:79,768,943...79,793,507
JBrowse link
G Tnf tumor necrosis factor increases expression EXP Methylphenidate results in increased expression of TNF mRNA CTD PMID:22470460 NCBI chr17:35,199,367...35,202,007
Ensembl chr17:35,199,381...35,202,007
JBrowse link
G Traf5 TNF receptor-associated factor 5 decreases expression EXP Methylphenidate results in decreased expression of TRAF5 mRNA CTD PMID:22470460 NCBI chr 1:191,997,203...192,092,599
Ensembl chr 1:191,997,205...192,092,559
JBrowse link
G Trim25 tripartite motif-containing 25 increases expression EXP Methylphenidate results in increased expression of TRIM25 mRNA CTD PMID:22470460 NCBI chr11:88,999,403...89,020,294
Ensembl chr11:88,999,376...89,020,293
JBrowse link
G Tspan17 tetraspanin 17 decreases expression EXP Methylphenidate results in decreased expression of TSPAN17 mRNA CTD PMID:22470460 NCBI chr13:54,789,102...54,796,775
Ensembl chr13:54,789,377...54,796,776
JBrowse link
G Ttf1 transcription termination factor, RNA polymerase I increases expression EXP Methylphenidate results in increased expression of TTF1 mRNA CTD PMID:22470460 NCBI chr 2:29,060,199...29,087,656
Ensembl chr 2:29,060,262...29,087,656
JBrowse link
G Twsg1 twisted gastrulation BMP signaling modulator 1 decreases expression EXP Methylphenidate results in decreased expression of TWSG1 mRNA CTD PMID:22470460 NCBI chr17:65,923,065...65,951,187
Ensembl chr17:65,921,972...65,951,226
JBrowse link
G Ube2cbp ubiquitin-conjugating enzyme E2C binding protein decreases expression EXP Methylphenidate results in decreased expression of UBE2CBP mRNA CTD PMID:22470460 NCBI chr 9:86,307,234...86,464,976
Ensembl chr 9:86,307,306...86,464,950
JBrowse link
G Ubxn10 UBX domain protein 10 decreases expression EXP Methylphenidate results in decreased expression of UBXN10 mRNA CTD PMID:22470460 NCBI chr 4:138,709,837...138,738,438
Ensembl chr 4:138,709,837...138,737,167
JBrowse link
G Uck2 uridine-cytidine kinase 2 decreases expression EXP Methylphenidate results in decreased expression of UCK2 mRNA CTD PMID:22470460 NCBI chr 1:167,222,895...167,285,933
Ensembl chr 1:167,222,883...167,285,320
JBrowse link
G Vash1 vasohibin 1 increases expression EXP Methylphenidate results in increased expression of VASH1 mRNA CTD PMID:22470460 NCBI chr12:86,678,700...86,695,688
Ensembl chr12:86,678,700...86,692,091
JBrowse link
G Wars2 tryptophanyl tRNA synthetase 2 (mitochondrial) decreases expression EXP Methylphenidate results in decreased expression of WARS2 mRNA CTD PMID:22470460 NCBI chr 3:99,140,107...99,221,230
Ensembl chr 3:99,141,068...99,239,186
JBrowse link
G Zfp14 zinc finger protein 14 decreases expression EXP Methylphenidate results in decreased expression of ZFP14 mRNA CTD PMID:22470460 NCBI chr 7:30,036,357...30,051,396
Ensembl chr 7:30,036,359...30,051,380
JBrowse link
N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Elavl1 ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) increases phosphorylation
multiple interactions
ISO N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]
CTD PMID:31945382 NCBI chr 8:4,284,781...4,325,140
Ensembl chr 8:4,285,382...4,325,413
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions
increases expression
ISO thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form] CTD PMID:22639866 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions
increases expression
ISO thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form] CTD PMID:22639866 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 increases ADP-ribosylation ISO N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
decreases expression
ISO 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr10:63,319,005...63,339,035
Ensembl chr10:63,319,005...63,381,704
JBrowse link
nateglinide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 affects binding ISO ABCC4 protein binds to nateglinide CTD PMID:17939016 NCBI chr14:118,482,692...118,707,856
Ensembl chr14:118,482,692...118,706,219
JBrowse link
G Cyp2c65 cytochrome P450, family 2, subfamily c, polypeptide 65 affects metabolic processing ISO CYP2C9 protein affects the metabolism of nateglinide CTD PMID:18159128 NCBI chr19:39,061,006...39,093,948
Ensembl chr19:39,061,015...39,093,944
JBrowse link
G Cyp2c66 cytochrome P450, family 2, subfamily c, polypeptide 66 affects metabolic processing ISO CYP2C9 protein affects the metabolism of nateglinide CTD PMID:18159128 NCBI chr19:39,113,898...39,186,756
Ensembl chr19:39,113,898...39,187,072
JBrowse link
G Ins2 insulin II increases secretion ISO nateglinide results in increased secretion of INS protein CTD PMID:16403453 NCBI chr 7:142,678,656...142,679,726
Ensembl chr 7:142,678,656...142,743,381
JBrowse link
G Slco1b2 solute carrier organic anion transporter family, member 1b2 multiple interactions ISO Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 6:141,629,452...141,686,646
Ensembl chr 6:141,629,518...141,686,646
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 multiple interactions ISO Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr 7:99,657,804...99,711,340
Ensembl chr 7:99,657,804...99,711,340
JBrowse link
rhodotorulic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases activity
ISO Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
S-adenosyl-L-homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahcy S-adenosylhomocysteine hydrolase increases hydrolysis ISO AHCY results in increased hydrolysis of S-Adenosylhomocysteine CTD PMID:26974671 NCBI chr 2:155,059,310...155,074,497
Ensembl chr 2:155,059,310...155,074,497
JBrowse link
G Ahr aryl-hydrocarbon receptor multiple interactions
increases abundance
EXP PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr12:35,497,979...35,534,989
Ensembl chr12:35,497,974...35,535,038
JBrowse link
G Alas2 aminolevulinic acid synthase 2, erythroid multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:150,547,417...150,570,622
Ensembl chr  X:150,547,375...150,570,638
JBrowse link
G App amyloid beta (A4) precursor protein increases expression
decreases methylation
multiple interactions
EXP S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein
CTD PMID:19635394 PMID:22064374 NCBI chr16:84,952,666...85,175,255
Ensembl chr16:84,949,685...85,173,766
JBrowse link
G Atp7b ATPase, Cu++ transporting, beta polypeptide increases abundance EXP ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine CTD PMID:22945834 NCBI chr 8:21,992,783...22,060,074
Ensembl chr 8:21,992,785...22,060,305
JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 increases expression EXP S-Adenosylhomocysteine results in increased expression of BACE1 protein CTD PMID:19635394 NCBI chr 9:45,838,545...45,862,484
Ensembl chr 9:45,838,580...45,864,399
JBrowse link
G Col1a1 collagen, type I, alpha 1 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr11:94,936,224...94,953,042
Ensembl chr11:94,936,224...94,953,042
JBrowse link
G Col1a2 collagen, type I, alpha 2 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 6:4,505,618...4,541,543
Ensembl chr 6:4,504,814...4,541,544
JBrowse link
G Comt catechol-O-methyltransferase decreases activity ISO S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 NCBI chr16:18,406,882...18,426,716
Ensembl chr16:18,406,886...18,426,852
JBrowse link
G Dnmt1 DNA methyltransferase (cytosine-5) 1 decreases activity
multiple interactions
ISO
EXP
S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
CTD PMID:16037419 PMID:22064374 NCBI chr 9:20,907,206...20,959,888
Ensembl chr 9:20,907,209...20,959,888
JBrowse link
G Fgf15 fibroblast growth factor 15 decreases abundance EXP FGF19 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 7:144,896,532...144,900,953
Ensembl chr 7:144,896,531...144,900,953
JBrowse link
G Hbb-b1 hemoglobin, beta adult major chain multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029
G Hmbs hydroxymethylbilane synthase multiple interactions ISO [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr 9:44,336,348...44,344,228
Ensembl chr 9:44,336,339...44,344,228
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression
multiple interactions
EXP
ISO
S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]
CTD PMID:19770485 NCBI chr 8:92,827,290...92,853,421
Ensembl chr 8:92,827,291...92,853,420
JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha decreases expression ISO S-Adenosylhomocysteine results in decreased expression of NFKBIA protein CTD PMID:19770485 NCBI chr12:55,489,409...55,492,647
Ensembl chr12:55,489,410...55,492,647
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance EXP NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 4:133,553,376...133,556,686
Ensembl chr 4:133,553,376...133,556,536
JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 multiple interactions
decreases methylation
decreases expression
EXP Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein
CTD PMID:22064374 NCBI chr 6:113,326,972...113,334,877
Ensembl chr 6:113,326,972...113,335,068
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions EXP PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr11:59,970,614...60,046,561
Ensembl chr11:59,970,614...60,046,489
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,454,249...52,115,853
Ensembl chr 5:51,454,250...51,567,726
JBrowse link
G Psen1 presenilin 1 multiple interactions
decreases methylation
increases expression
EXP Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein
CTD PMID:19635394 NCBI chr12:83,688,152...83,735,095
Ensembl chr12:83,688,152...83,735,199
JBrowse link
G Slc19a1 solute carrier family 19 (folate transporter), member 1 affects abundance EXP SLC19A1 protein affects the abundance of S-Adenosylhomocysteine CTD PMID:15705887 NCBI chr10:77,032,269...77,050,432
Ensembl chr10:77,032,241...77,061,002
JBrowse link
G Sp1 trans-acting transcription factor 1 multiple interactions ISO S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 NCBI chr15:102,406,316...102,436,404
Ensembl chr15:102,406,143...102,436,404
JBrowse link
G Timp2 tissue inhibitor of metalloproteinase 2 decreases expression EXP S-Adenosylhomocysteine results in decreased expression of TIMP2 protein CTD PMID:19770485 NCBI chr11:118,301,061...118,355,411
Ensembl chr11:118,301,069...118,355,740
JBrowse link
S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Edn1 endothelin 1 multiple interactions ISO S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Nos1 nitric oxide synthase 1, neuronal multiple interactions
decreases activity
ISO
EXP
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine
CTD PMID:11006970 PMID:12511180 NCBI chr 5:117,866,839...117,958,840
Ensembl chr 5:117,781,032...117,958,840
JBrowse link
G Slc18a2 solute carrier family 18 (vesicular monoamine), member 2 multiple interactions ISO S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr19:59,260,878...59,296,012
Ensembl chr19:59,260,896...59,296,012
JBrowse link
S-nitroso-N-acetyl-D-penicillamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 multiple interactions ISO AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Adenine Nucleotides] CTD PMID:15316071 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Akt1 thymoma viral proto-oncogene 1 multiple interactions
decreases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]] CTD PMID:21138475 NCBI chr12:112,653,821...112,674,884
Ensembl chr12:112,653,821...112,674,884
JBrowse link
G Aqp3 aquaporin 3 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of AQP3 mRNA CTD PMID:12102619 NCBI chr 4:41,092,724...41,098,183
Ensembl chr 4:41,092,722...41,098,183
JBrowse link
G Bad BCL2-associated agonist of cell death decreases phosphorylation
multiple interactions
EXP S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein]
CTD PMID:21138475 NCBI chr19:6,941,861...6,951,905
Ensembl chr19:6,941,861...6,951,899
JBrowse link
G Bax BCL2-associated X protein increases expression
multiple interactions
EXP S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]
CTD PMID:21138475 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions
decreases expression
EXP Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]
S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 mRNA; S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein
CTD PMID:17135264 PMID:21138475 NCBI chr 1:106,538,176...106,714,290
Ensembl chr 1:106,538,178...106,714,274
JBrowse link
G Calca calcitonin/calcitonin-related polypeptide, alpha multiple interactions
increases secretion
ISO Carbon Dioxide inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:18052948 NCBI chr 7:114,625,981...114,636,910
Ensembl chr 7:114,631,478...114,636,357
JBrowse link
G Casp1 caspase 1 multiple interactions EXP [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased activity of and results in increased cleavage of CASP1 protein CTD PMID:10903723 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
decreases activity
ISO
EXP
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of CASP3 protein]
S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein
S-Nitroso-N-Acetylpenicillamine results in decreased activity of CASP3 protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein]
CTD PMID:10811113 PMID:12006578 PMID:12220328 NCBI chr 8:46,617,291...46,639,698
Ensembl chr 8:46,617,291...46,639,689
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP S-Nitroso-N-Acetylpenicillamine inhibits the reaction [3,5-dimethoxy-4'-hydroxystilbene results in decreased phosphorylation of CREB1 protein]; S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Quercetin results in decreased phosphorylation of CREB1 protein] CTD PMID:17135264 NCBI chr 1:64,532,794...64,604,548
Ensembl chr 1:64,532,645...64,604,548
JBrowse link
G Csrp3 cysteine and glycine-rich protein 3 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of CSRP3 mRNA CTD PMID:12102619 NCBI chr 7:48,830,398...48,848,051
Ensembl chr 7:48,830,398...48,848,033
JBrowse link
G Edn1 endothelin 1 increases secretion ISO S-Nitroso-N-Acetylpenicillamine results in increased secretion of EDN1 protein CTD PMID:15640287 NCBI chr13:42,301,476...42,307,990
Ensembl chr13:42,301,476...42,307,990
JBrowse link
G Eln elastin decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of ELN mRNA CTD PMID:12102619 NCBI chr 5:134,702,595...134,747,368
Ensembl chr 5:134,702,593...134,747,323
JBrowse link
G Exoc6 exocyst complex component 6 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of SEC15 mRNA CTD PMID:12102619 NCBI chr19:37,536,763...37,684,052
Ensembl chr19:37,520,879...37,684,059
JBrowse link
G Fasl Fas ligand (TNF superfamily, member 6) multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr 1:161,780,691...161,788,495
Ensembl chr 1:161,780,689...161,788,495
JBrowse link
G Fcgr2b Fc receptor, IgG, low affinity IIb decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR2B mRNA CTD PMID:12102619 NCBI chr 1:170,960,558...170,976,071
Ensembl chr 1:170,958,617...170,976,547
JBrowse link
G Fcgr3 Fc receptor, IgG, low affinity III decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR3 mRNA CTD PMID:12102619 NCBI chr 1:171,051,169...171,065,915
Ensembl chr 1:171,051,174...171,064,935
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein] CTD PMID:16351512 NCBI chr 3:37,348,477...37,410,106
Ensembl chr 3:37,348,346...37,410,108
JBrowse link
G Ghrh growth hormone releasing hormone decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of GHRH mRNA CTD PMID:12102619 NCBI chr 2:157,329,496...157,348,725
Ensembl chr 2:157,329,497...157,347,506
JBrowse link
G Gnai2 guanine nucleotide binding protein (G protein), alpha inhibiting 2 multiple interactions
decreases expression
ISO 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 9:107,614,125...107,635,391
Ensembl chr 9:107,614,125...107,635,367
JBrowse link
G Gnai3 guanine nucleotide binding protein (G protein), alpha inhibiting 3 multiple interactions
decreases expression
ISO 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 3:108,107,275...108,146,152
Ensembl chr 3:108,107,280...108,146,146
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of GOT1 mRNA CTD PMID:12102619 NCBI chr19:43,499,752...43,524,605
Ensembl chr19:43,499,752...43,524,605
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein] CTD PMID:11672444 NCBI chr 9:108,339,080...108,340,342
Ensembl chr 9:108,338,903...108,340,343
JBrowse link
G Gsta2 glutathione S-transferase, alpha 2 (Yc2) multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine co-treated with 2-tert-butylhydroquinone] results in increased expression of GSTA2 CTD PMID:15357004 NCBI chr 9:78,331,018...78,347,192
Ensembl chr 9:78,331,018...78,355,788
JBrowse link
G Hck hemopoietic cell kinase decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of HCK mRNA CTD PMID:12102619 NCBI chr 2:153,108,468...153,151,441
Ensembl chr 2:153,108,468...153,151,441
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO S-Nitroso-N-Acetylpenicillamine results in increased expression of HMOX1 protein CTD PMID:16439612 NCBI chr 8:75,093,618...75,100,593
Ensembl chr 8:75,093,621...75,100,589
JBrowse link
G Ifng interferon gamma multiple interactions EXP S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Streptozocin results in increased expression of IFNG protein] CTD PMID:15892581 NCBI chr10:118,441,046...118,445,894
Ensembl chr10:118,441,046...118,445,892
JBrowse link
G Itpka inositol 1,4,5-trisphosphate 3-kinase A decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of ITPKA mRNA CTD PMID:12102619 NCBI chr 2:119,742,337...119,751,253
Ensembl chr 2:119,742,337...119,751,263
JBrowse link
G Mapk1 mitogen-activated protein kinase 1 decreases expression
multiple interactions
increases phosphorylation
decreases phosphorylation
ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK1 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK1 protein]
CTD PMID:15640287 PMID:19252090 NCBI chr16:16,983,382...17,047,453
Ensembl chr16:16,983,382...17,047,453
JBrowse link
G Mapk3 mitogen-activated protein kinase 3 decreases expression
decreases phosphorylation
increases phosphorylation
multiple interactions
ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK3 protein
S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein
S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein]
CTD PMID:15640287 PMID:19252090 NCBI chr 7:126,759,626...126,765,816
Ensembl chr 7:126,759,601...126,765,819
JBrowse link
G Mme membrane metallo endopeptidase decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of MME mRNA CTD PMID:12102619 NCBI chr 3:63,295,211...63,383,713
Ensembl chr 3:63,241,537...63,386,030
JBrowse link
G Mtf1 metal response element binding transcription factor 1 affects localization EXP S-Nitroso-N-Acetylpenicillamine affects the localization of MTF1 protein CTD PMID:16423564 NCBI chr 4:124,802,549...124,849,800
Ensembl chr 4:124,802,104...124,849,800
JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of NFKB1 mRNA CTD PMID:12102619 NCBI chr 3:135,584,655...135,691,969
Ensembl chr 3:135,584,655...135,691,547
JBrowse link
G Nos2 nitric oxide synthase 2, inducible decreases activity
decreases expression
ISO S-Nitroso-N-Acetylpenicillamine results in decreased activity of NOS2 protein
S-Nitroso-N-Acetylpenicillamine results in decreased expression of NOS2 promoter
CTD PMID:11076874 PMID:15565661 NCBI chr11:78,920,787...78,960,226
Ensembl chr11:78,920,787...78,960,254
JBrowse link
G Nppa natriuretic peptide type A multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11799084 NCBI chr 4:148,000,722...148,002,074
Ensembl chr 4:148,000,722...148,002,079
JBrowse link
G Npr3 natriuretic peptide receptor 3 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of NPR3 protein] CTD PMID:16962941 PMID:19252090 NCBI chr15:11,839,896...11,907,837
Ensembl chr15:11,839,896...11,907,287
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] CTD PMID:18652891 PMID:21235400 NCBI chr10:6,758,593...7,038,209
Ensembl chr10:6,758,506...7,038,198
JBrowse link
G Pam peptidylglycine alpha-amidating monooxygenase decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of PAM mRNA CTD PMID:12102619 NCBI chr 1:97,821,091...98,095,853
Ensembl chr 1:97,795,114...98,095,646
JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]] CTD PMID:10811113 NCBI chr 1:180,568,891...180,600,999
Ensembl chr 1:180,568,924...180,601,254
JBrowse link
G Prkca protein kinase C, alpha multiple interactions EXP S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein] CTD PMID:18652891 NCBI chr11:107,933,387...108,343,888
Ensembl chr11:107,933,387...108,343,928
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein] CTD PMID:18652891 PMID:21235400 NCBI chr 7:3,303,532...3,331,099
Ensembl chr 7:3,289,179...3,331,099
JBrowse link
G Prkg1 protein kinase, cGMP-dependent, type I multiple interactions
increases activity
ISO [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
S-Nitroso-N-Acetylpenicillamine results in increased activity of PRKG1 protein
CTD PMID:11799084 NCBI chr19:30,564,487...31,765,268
Ensembl chr19:30,564,489...31,765,033
JBrowse link
G Prrxl1 paired related homeobox protein-like 1 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of PRRXL1 mRNA CTD PMID:12102619 NCBI chr14:32,595,867...32,649,246
Ensembl chr14:32,599,407...32,649,246
JBrowse link
G Rack1 receptor for activated C kinase 1 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of RACK1 mRNA CTD PMID:12102619 NCBI chr11:48,800,360...48,806,241
Ensembl chr11:48,800,332...48,806,434
JBrowse link
G Raf1 v-raf-leukemia viral oncogene 1 multiple interactions EXP S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein] CTD PMID:21235400 NCBI chr 6:115,618,569...115,676,635
Ensembl chr 6:115,618,067...115,676,635
JBrowse link
G Rgs17 regulator of G-protein signaling 17 multiple interactions EXP S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr10:5,825,663...5,922,412
Ensembl chr10:5,825,663...5,922,400
JBrowse link
G Rplp0 ribosomal protein, large, P0 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of RPLP0 mRNA CTD PMID:12102619 NCBI chr 5:115,559,467...115,563,729
Ensembl chr 5:115,559,467...115,563,727
JBrowse link
G Sftpa1 surfactant associated protein A1 decreases expression
multiple interactions
ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA
bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA]
CTD PMID:15640287 NCBI chr14:41,131,788...41,136,373
Ensembl chr14:41,131,782...41,136,452
JBrowse link
G Sftpb surfactant associated protein B multiple interactions
decreases expression
ISO bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA] CTD PMID:15640287 NCBI chr 6:72,304,610...72,314,373
Ensembl chr 6:72,304,610...72,314,371
JBrowse link
G Sftpc surfactant associated protein C multiple interactions
decreases expression
ISO bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA] CTD PMID:15640287 NCBI chr14:70,520,941...70,524,081
Ensembl chr14:70,520,949...70,524,081
JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions
affects response to substance
EXP GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]
SOD1 protein affects the susceptibility to S-Nitroso-N-Acetylpenicillamine
CTD PMID:10698074 PMID:11672444 NCBI chr16:90,220,762...90,226,333
Ensembl chr16:90,220,754...90,226,329
JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial multiple interactions EXP
ISO
GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA
CTD PMID:11672444 PMID:14996425 NCBI chr17:13,007,839...13,018,119
Ensembl chr17:13,006,846...13,040,063
JBrowse link
G Trp53 transformation related protein 53 multiple interactions EXP
ISO
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of TRP53 mRNA
S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein]
CTD PMID:7673702 PMID:16351512 NCBI chr11:69,580,348...69,591,873
Ensembl chr11:69,580,359...69,591,873
JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein] CTD PMID:20177073 NCBI chr 9:8,543,867...8,680,752
Ensembl chr 9:8,544,142...8,680,741
JBrowse link
G Vasp vasodilator-stimulated phosphoprotein increases phosphorylation ISO S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of VASP protein CTD PMID:11799084 NCBI chr 7:19,256,929...19,271,854
Ensembl chr 7:19,256,929...19,271,817
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
increases secretion
ISO S-Nitroso-N-Acetylpenicillamine results in increased expression of VEGFA mRNA
S-Nitroso-N-Acetylpenicillamine results in increased secretion of VEGFA protein
CTD PMID:10613739 NCBI chr17:46,016,993...46,032,377
Ensembl chr17:46,016,993...46,032,369
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 21560
    chemical entity 21558
      atom 21546
        nonmetal atom 21426
          nitrogen atom 19235
            nitrogen molecular entity 19235
              organonitrogen compound 19009
                amino acid derivative 11366
                  non-proteinogenic amino acid derivative 271
                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-\{[(S)-1-mesyl-2-piperidyl]carbonyl\}-L-alanine 0
                    3-hydroxynorvaline 0
                    D-alanine derivative + 3
                    D-arginine derivative + 0
                    D-asparagine derivative 0
                    D-aspartic acid derivative + 5
                    D-cysteine derivative + 0
                    D-glutamic acid derivative + 0
                    D-histidine derivative 0
                    D-isoleucine derivative + 0
                    D-leucine derivative + 0
                    D-methionine derivative + 0
                    D-phenylalanine derivative + 0
                    D-proline derivative + 0
                    D-selenocysteine derivative 0
                    D-serine derivative + 0
                    D-threonine derivative 0
                    D-tryptophan derivative + 0
                    D-tyrosine derivative + 0
                    D-valine derivative + 0
                    N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alanine + 0
                    N-(2,6-dichlorobenzoyl)-3-[6-(2,6-dimethoxyphenyl)-2-naphthyl]alanine 0
                    N-acetyl-L-alpha-phenylglycine 0
                    N-acyl-D-amino acid + 62
                    N-formyl-L-kynurenine + 0
                    N-formylkynurenine + 0
                    N-heptanoyl-L-homoserine 0
                    N-nitrososarcosine 0
                    beta-alanine derivative + 57
                    beta-amino acid ester + 133
                    brivaracetam 0
                    delta-amino acid ester + 0
                    homocysteine derivative + 23
                    methyl 3-[2-(2,6-dichlorophenyl)quinolin-6-yl]alaninate + 0
                    methyl 5-(hydroxymethyl)pyrrolidine-2-carboxylate 0
                    methyl N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alaninate 0
                    methyl N-(2,6-dichlorobenzoyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-methylalaninate 0
                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4,4a,8a-hexahydro-6-quinolyl]alaninate 0
                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                    ornithine derivative + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 21560
    subatomic particle 21546
      composite particle 21546
        hadron 21546
          baryon 21546
            nucleon 21546
              atomic nucleus 21546
                atom 21546
                  main group element atom 21449
                    main group molecular entity 21449
                      p-block molecular entity 21448
                        carbon group molecular entity 21240
                          organic molecular entity 21135
                            heteroorganic entity 20769
                              organonitrogen compound 19009
                                amino acid derivative 11366
                                  non-proteinogenic amino acid derivative 271
                                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-\{[(S)-1-mesyl-2-piperidyl]carbonyl\}-L-alanine 0
                                    3-hydroxynorvaline 0
                                    D-alanine derivative + 3
                                    D-arginine derivative + 0
                                    D-asparagine derivative 0
                                    D-aspartic acid derivative + 5
                                    D-cysteine derivative + 0
                                    D-glutamic acid derivative + 0
                                    D-histidine derivative 0
                                    D-isoleucine derivative + 0
                                    D-leucine derivative + 0
                                    D-methionine derivative + 0
                                    D-phenylalanine derivative + 0
                                    D-proline derivative + 0
                                    D-selenocysteine derivative 0
                                    D-serine derivative + 0
                                    D-threonine derivative 0
                                    D-tryptophan derivative + 0
                                    D-tyrosine derivative + 0
                                    D-valine derivative + 0
                                    N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alanine + 0
                                    N-(2,6-dichlorobenzoyl)-3-[6-(2,6-dimethoxyphenyl)-2-naphthyl]alanine 0
                                    N-acetyl-L-alpha-phenylglycine 0
                                    N-acyl-D-amino acid + 62
                                    N-formyl-L-kynurenine + 0
                                    N-formylkynurenine + 0
                                    N-heptanoyl-L-homoserine 0
                                    N-nitrososarcosine 0
                                    beta-alanine derivative + 57
                                    beta-amino acid ester + 133
                                    brivaracetam 0
                                    delta-amino acid ester + 0
                                    homocysteine derivative + 23
                                    methyl 3-[2-(2,6-dichlorophenyl)quinolin-6-yl]alaninate + 0
                                    methyl 5-(hydroxymethyl)pyrrolidine-2-carboxylate 0
                                    methyl N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alaninate 0
                                    methyl N-(2,6-dichlorobenzoyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-methylalaninate 0
                                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4,4a,8a-hexahydro-6-quinolyl]alaninate 0
                                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                                    ornithine derivative + 4
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