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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:non-proteinogenic amino acid derivative
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Accession:CHEBI:83812 term browser browse the term
Definition:Any derivative of a non-proteinogenic amino acid resulting from reaction at an amino group or carboxy group, or from the replacement of any hydrogen by a heteroatom.
Synonyms:related_synonym: non-canonical amino acid derivative;   non-canonical amino-acid derivatives;   non-proteinogenic amino-acid derivatives


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(R)-pantothenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOH8 atonal bHLH transcription factor 8 increases expression EXP Pantothenic Acid results in increased expression of ATOH8 mRNA CTD PMID:19397697 NCBI chr 2:85,753,786...85,791,383
Ensembl chr 2:85,751,344...85,791,383
JBrowse link
G COL2A1 collagen type II alpha 1 chain multiple interactions ISO [COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid] CTD PMID:24709313 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Pantothenic Acid results in increased expression of CXCL8 mRNA CTD PMID:19397697 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYP1B1 cytochrome P450 family 1 subfamily B member 1 increases expression EXP Pantothenic Acid results in increased expression of CYP1B1 mRNA CTD PMID:19397697 NCBI chr 2:38,067,509...38,076,151
Ensembl chr 2:38,066,973...38,109,902
JBrowse link
G FAM43A family with sequence similarity 43 member A increases expression EXP Pantothenic Acid results in increased expression of FAM43A mRNA CTD PMID:19397697 NCBI chr 3:194,685,883...194,689,037
Ensembl chr 3:194,685,883...194,689,037
JBrowse link
G FUT7 fucosyltransferase 7 decreases expression EXP Pantothenic Acid results in decreased expression of FUT7 mRNA CTD PMID:19397697 NCBI chr 9:137,030,174...137,032,088
Ensembl chr 9:137,030,174...137,032,088
Ensembl chr 9:137,030,174...137,032,088
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Pantothenic Acid results in increased expression of HMOX1 mRNA; Pantothenic Acid results in increased expression of HMOX1 protein CTD PMID:19397697 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G HSPB7 heat shock protein family B (small) member 7 increases expression EXP Pantothenic Acid results in increased expression of HSPB7 mRNA CTD PMID:19397697 NCBI chr 1:16,014,029...16,019,594
Ensembl chr 1:16,014,028...16,019,594
JBrowse link
G ID1 inhibitor of DNA binding 1, HLH protein increases expression EXP Pantothenic Acid results in increased expression of ID1 mRNA CTD PMID:19397697 NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,605,283...31,606,515
JBrowse link
G ID3 inhibitor of DNA binding 3, HLH protein increases expression EXP Pantothenic Acid results in increased expression of ID3 mRNA CTD PMID:19397697 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 increases abundance
multiple interactions
ISO IDH2 protein mutant form results in increased abundance of Pantothenic Acid
Triazines inhibits the reaction [IDH2 protein mutant form results in increased abundance of Pantothenic Acid]
CTD PMID:27469509 NCBI chr15:90,083,045...90,102,468
Ensembl chr15:90,083,045...90,102,504
Ensembl chr15:90,083,045...90,102,504
JBrowse link
G IL6 interleukin 6 increases expression EXP Pantothenic Acid results in increased expression of IL6 mRNA CTD PMID:19397697 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G KRTAP10-3 keratin associated protein 10-3 decreases expression EXP Pantothenic Acid results in decreased expression of KRTAP10-3 mRNA CTD PMID:19397697 NCBI chr21:44,557,790...44,558,795
Ensembl chr21:44,557,790...44,558,795
JBrowse link
G LEPR leptin receptor affects abundance ISO LEPR affects the abundance of Pantothenic Acid CTD PMID:20567778 NCBI chr 1:65,420,652...65,641,559
Ensembl chr 1:65,420,652...65,641,559
JBrowse link
G MARCHF2 membrane associated ring-CH-type finger 2 increases expression EXP Pantothenic Acid results in increased expression of MARCHF2 mRNA CTD PMID:19397697 NCBI chr19:8,413,305...8,439,017
Ensembl chr19:8,413,270...8,439,017
JBrowse link
G MTRES1 mitochondrial transcription rescue factor 1 increases expression EXP Pantothenic Acid results in increased expression of MTRES1 mRNA CTD PMID:19397697 NCBI chr 6:107,028,199...107,051,586
Ensembl chr 6:107,028,199...107,051,586
JBrowse link
G MYB MYB proto-oncogene, transcription factor multiple interactions ISO Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of MYB protein] CTD PMID:16112698 NCBI chr 6:135,181,308...135,219,172
Ensembl chr 6:135,181,308...135,219,173
JBrowse link
G MYCN MYCN proto-oncogene, bHLH transcription factor increases expression EXP Pantothenic Acid results in increased expression of MYCN mRNA CTD PMID:19397697 NCBI chr 2:15,940,550...15,947,004
Ensembl chr 2:15,940,550...15,947,007
JBrowse link
G NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 increases expression EXP Pantothenic Acid results in increased expression of NHLRC1 mRNA CTD PMID:19397697 NCBI chr 6:18,120,440...18,122,677
Ensembl chr 6:18,120,440...18,122,677
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 multiple interactions ISO [Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA CTD PMID:20505214 NCBI chr12:52,022,832...52,059,507
Ensembl chr12:52,022,832...52,059,507
JBrowse link
G NREP neuronal regeneration related protein increases expression EXP Pantothenic Acid results in increased expression of NREP mRNA CTD PMID:19397697 NCBI chr 5:111,728,802...111,976,932
Ensembl chr 5:111,662,621...111,997,464
JBrowse link
G PIM1 Pim-1 proto-oncogene, serine/threonine kinase multiple interactions ISO Pantothenic Acid inhibits the reaction [Valproic Acid results in decreased expression of PIM1 protein] CTD PMID:16112698 NCBI chr 6:37,170,152...37,175,428
Ensembl chr 6:37,170,152...37,175,428
JBrowse link
G POU3F4 POU class 3 homeobox 4 increases expression EXP Pantothenic Acid results in increased expression of POU3F4 mRNA CTD PMID:19397697 NCBI chr  X:83,508,290...83,512,127
Ensembl chr  X:83,508,290...83,512,127
JBrowse link
G PTPRCAP protein tyrosine phosphatase receptor type C associated protein increases expression EXP Pantothenic Acid results in increased expression of PTPRCAP mRNA CTD PMID:19397697 NCBI chr11:67,435,510...67,437,682
Ensembl chr11:67,435,510...67,437,682
JBrowse link
G RPL13AP3 ribosomal protein L13a pseudogene 3 increases expression EXP Pantothenic Acid results in increased expression of RPL13AP3 mRNA CTD PMID:19397697 NCBI chr14:55,766,245...55,767,717
Ensembl chr14:55,766,177...55,767,717
JBrowse link
G SLC51B solute carrier family 51 subunit beta increases expression EXP Pantothenic Acid results in increased expression of SLC51B mRNA CTD PMID:19397697 NCBI chr15:65,045,387...65,053,397
Ensembl chr15:65,045,387...65,053,397
JBrowse link
G SLC5A6 solute carrier family 5 member 6 increases transport
multiple interactions
ISO
EXP
SLC5A6 results in increased transport of Pantothenic Acid
Sodium affects the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
Thioctic Acid inhibits the reaction [SLC5A6 results in increased transport of Pantothenic Acid]
CTD PMID:9516450 PMID:10329687 NCBI chr 2:27,199,587...27,212,342
Ensembl chr 2:27,199,587...27,212,958
JBrowse link
G SOX2 SRY-box transcription factor 2 decreases expression EXP Pantothenic Acid results in decreased expression of SOX2 mRNA CTD PMID:19397697 NCBI chr 3:181,711,925...181,714,436
Ensembl chr 3:181,711,925...181,714,436
JBrowse link
G TMEM18 transmembrane protein 18 increases expression EXP Pantothenic Acid results in increased expression of TMEM18 mRNA CTD PMID:19397697 NCBI chr 2:663,877...677,406
Ensembl chr 2:663,877...677,406
JBrowse link
G ZNF575 zinc finger protein 575 decreases expression EXP Pantothenic Acid results in decreased expression of ZNF575 mRNA CTD PMID:19397697 NCBI chr19:43,531,574...43,536,090
Ensembl chr19:43,525,497...43,536,130
JBrowse link
dabigatran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIF1 allograft inflammatory factor 1 decreases expression ISO Dabigatran results in decreased expression of AIF1 protein CTD PMID:27397090 NCBI chr 6:31,615,212...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G ALDH1A2 aldehyde dehydrogenase 1 family member A2 decreases expression EXP Dabigatran results in decreased expression of ALDH1A2 mRNA CTD PMID:31711903 NCBI chr15:57,953,429...58,065,711
Ensembl chr15:57,953,424...58,497,866
JBrowse link
G EYA1 EYA transcriptional coactivator and phosphatase 1 decreases expression EXP Dabigatran results in decreased expression of EYA1 mRNA CTD PMID:31711903 NCBI chr 8:71,197,433...71,548,104
Ensembl chr 8:71,197,433...71,592,025
JBrowse link
G F2 coagulation factor II, thrombin decreases activity ISO
EXP
Dabigatran results in decreased activity of F2 protein CTD PMID:17911567 PMID:25138021 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G FGA fibrinogen alpha chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 4:154,583,126...154,590,742
Ensembl chr 4:154,583,128...154,590,745
JBrowse link
G FGB fibrinogen beta chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 4:154,562,980...154,572,807
Ensembl chr 4:154,563,011...154,572,807
Ensembl chr 4:154,563,011...154,572,807
JBrowse link
G FGF8 fibroblast growth factor 8 increases expression EXP Dabigatran results in increased expression of FGF8 mRNA CTD PMID:31711903 NCBI chr10:101,770,109...101,780,369
Ensembl chr10:101,770,130...101,780,369
JBrowse link
G FGG fibrinogen gamma chain multiple interactions ISO Dabigatran inhibits the reaction [Dietary Fats results in increased cleavage of [FGA protein binds to FGB protein binds to FGG protein]] CTD PMID:25138021 NCBI chr 4:154,604,136...154,612,656
Ensembl chr 4:154,604,134...154,612,967
JBrowse link
G FOXC2 forkhead box C2 decreases expression EXP Dabigatran results in decreased expression of FOXC2 mRNA CTD PMID:31711903 NCBI chr16:86,566,829...86,569,728
Ensembl chr16:86,566,829...86,569,728
JBrowse link
G GDNF glial cell derived neurotrophic factor multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA] CTD PMID:28585189 NCBI chr 5:37,812,677...37,840,044
Ensembl chr 5:37,812,677...37,840,041
JBrowse link
G GFAP glial fibrillary acidic protein decreases expression ISO Dabigatran results in decreased expression of GFAP protein CTD PMID:27397090 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G HOXB9 homeobox B9 increases expression EXP Dabigatran results in increased expression of HOXB9 mRNA CTD PMID:31711903 NCBI chr17:48,621,156...48,626,358
Ensembl chr17:48,621,156...48,626,358
JBrowse link
G MEOX1 mesenchyme homeobox 1 decreases expression EXP Dabigatran results in decreased expression of MEOX1 mRNA CTD PMID:31711903 NCBI chr17:43,640,389...43,661,977
Ensembl chr17:43,640,389...43,661,922
JBrowse link
G MERTK MER proto-oncogene, tyrosine kinase increases expression ISO Dabigatran results in increased expression of MERTK mRNA CTD PMID:27397090 NCBI chr 2:111,898,607...112,029,561
Ensembl chr 2:111,898,607...112,029,561
JBrowse link
G NEUROG2 neurogenin 2 increases expression EXP Dabigatran results in increased expression of NEUROG2 mRNA CTD PMID:31711903 NCBI chr 4:112,513,516...112,516,180
Ensembl chr 4:112,513,516...112,516,180
JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of NR4A2 mRNA] CTD PMID:28585189 NCBI chr 2:156,324,432...156,332,724
Ensembl chr 2:156,324,437...156,342,348
JBrowse link
G OLIG3 oligodendrocyte transcription factor 3 increases expression EXP Dabigatran results in increased expression of OLIG3 mRNA CTD PMID:31711903 NCBI chr 6:137,492,199...137,494,394
Ensembl chr 6:137,492,199...137,494,394
JBrowse link
G PAX3 paired box 3 decreases expression EXP Dabigatran results in decreased expression of PAX3 mRNA CTD PMID:31711903 NCBI chr 2:222,199,887...222,298,998
Ensembl chr 2:222,199,888...222,298,996
Ensembl chr 2:222,199,888...222,298,996
JBrowse link
G PAX6 paired box 6 increases expression EXP Dabigatran results in increased expression of PAX6 mRNA CTD PMID:31711903 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961
JBrowse link
G PLP1 proteolipid protein 1 increases expression ISO Dabigatran results in increased expression of PLP1 mRNA CTD PMID:27397090 NCBI chr  X:103,776,506...103,792,619
Ensembl chr  X:103,773,718...103,792,619
JBrowse link
G RCOR2 REST corepressor 2 multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of RCOR2 mRNA] CTD PMID:28585189 NCBI chr11:63,911,230...63,917,164
Ensembl chr11:63,911,230...63,917,164
JBrowse link
G RET ret proto-oncogene multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of RET protein] CTD PMID:28585189 NCBI chr10:43,077,069...43,130,351
Ensembl chr10:43,077,064...43,130,351
JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of SLC18A2 mRNA] CTD PMID:28585189 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430
JBrowse link
G SNCA synuclein alpha multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in increased expression of SNCA mRNA] CTD PMID:28585189 NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G TCF15 transcription factor 15 decreases expression EXP Dabigatran results in decreased expression of TCF15 mRNA CTD PMID:31711903 NCBI chr20:604,257...610,309
Ensembl chr20:603,797...610,398
JBrowse link
G TH tyrosine hydroxylase multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in decreased expression of TH mRNA] CTD PMID:28585189 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO Dabigatran inhibits the reaction [Rotenone results in increased expression of TNF mRNA] CTD PMID:28585189 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G UNCX UNC homeobox decreases expression EXP Dabigatran results in decreased expression of UNCX mRNA CTD PMID:31711903 NCBI chr 7:1,232,872...1,237,326
Ensembl chr 7:1,232,872...1,237,326
JBrowse link
metalaxyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases expression EXP metalaxyl results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP metalaxyl results in decreased expression of CYP7A1 protein CTD PMID:32194361 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G S100P S100 calcium binding protein P increases expression EXP metalaxyl results in increased expression of S100P protein CTD PMID:32194361 NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170
JBrowse link
methylphenidate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGTPBP1 ATP/GTP binding protein 1 increases expression ISO Methylphenidate results in increased expression of AGTPBP1 mRNA CTD PMID:22470460 NCBI chr 9:85,546,539...85,742,029
Ensembl chr 9:85,546,539...85,742,029
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B decreases expression ISO Methylphenidate results in decreased expression of AKR1B3 mRNA CTD PMID:22470460 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AP2B1 adaptor related protein complex 2 subunit beta 1 increases expression ISO Methylphenidate results in increased expression of AP2B1 mRNA CTD PMID:22470460 NCBI chr17:35,587,265...35,726,413
Ensembl chr17:35,578,046...35,726,413
JBrowse link
G ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 decreases expression ISO Methylphenidate results in decreased expression of ARAP1 mRNA CTD PMID:22470460 NCBI chr11:72,685,069...72,752,408
Ensembl chr11:72,685,069...72,793,599
JBrowse link
G ARC activity regulated cytoskeleton associated protein affects expression ISO Methylphenidate affects the expression of ARC mRNA CTD PMID:19222557 NCBI chr 8:142,611,049...142,614,479
Ensembl chr 8:142,611,049...142,614,479
JBrowse link
G ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 decreases expression ISO Methylphenidate results in decreased expression of ARIH2 mRNA CTD PMID:22470460 NCBI chr 3:48,918,821...48,986,382
Ensembl chr 3:48,918,821...48,986,382
JBrowse link
G ARMC9 armadillo repeat containing 9 decreases expression ISO Methylphenidate results in decreased expression of ARMC9 mRNA CTD PMID:22470460 NCBI chr 2:231,198,628...231,394,991
Ensembl chr 2:231,198,546...231,376,848
Ensembl chr 2:231,198,546...231,376,848
JBrowse link
G B4GALT4 beta-1,4-galactosyltransferase 4 decreases expression ISO Methylphenidate results in decreased expression of B4GALT4 mRNA CTD PMID:22470460 NCBI chr 3:119,211,742...119,240,907
Ensembl chr 3:119,211,732...119,240,946
JBrowse link
G BCL9 BCL9 transcription coactivator decreases expression ISO Methylphenidate results in decreased expression of BCL9 mRNA CTD PMID:22470460 NCBI chr 1:147,541,501...147,626,217
Ensembl chr 1:147,541,501...147,626,216
JBrowse link
G BDNF brain derived neurotrophic factor affects expression
multiple interactions
decreases expression
ISO
EXP
Methylphenidate affects the expression of BDNF mRNA
[staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]]; Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]
Methylphenidate results in decreased expression of BDNF mRNA
CTD PMID:19222557 PMID:22470460 PMID:24394491 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G C2 complement C2 increases expression ISO Methylphenidate results in increased expression of C2 mRNA CTD PMID:22470460 NCBI chr 6:31,897,783...31,945,672
Ensembl chr 6:31,897,785...31,945,672
JBrowse link
G CALD1 caldesmon 1 increases expression ISO Methylphenidate results in increased expression of CALD1 mRNA CTD PMID:22470460 NCBI chr 7:134,779,629...134,970,729
Ensembl chr 7:134,744,252...134,970,729
JBrowse link
G CBR3 carbonyl reductase 3 increases expression ISO Methylphenidate results in increased expression of CBR3 mRNA CTD PMID:22470460 NCBI chr21:36,134,901...36,146,562
Ensembl chr21:36,135,079...36,146,562
JBrowse link
G CCDC166 coiled-coil domain containing 166 decreases expression ISO Methylphenidate results in decreased expression of CCDC166 mRNA CTD PMID:22470460 NCBI chr 8:143,706,694...143,708,109
Ensembl chr 8:143,706,694...143,708,109
JBrowse link
G CCDC91 coiled-coil domain containing 91 decreases expression ISO Methylphenidate results in decreased expression of CCDC91 mRNA CTD PMID:22470460 NCBI chr12:28,190,446...28,550,166
Ensembl chr12:28,133,249...28,581,511
JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 increases expression ISO Methylphenidate results in increased expression of CDK5R1 mRNA CTD PMID:22470460 NCBI chr17:32,485,028...32,491,256
Ensembl chr17:32,486,993...32,491,253
JBrowse link
G CES1 carboxylesterase 1 multiple interactions
increases hydrolysis
increases metabolic processing
EXP
ISO
[CES1 protein results in increased hydrolysis of Methylphenidate] which results in increased chemical synthesis of ritalinic acid; Aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; CES1 gene mutant form results in decreased metabolism of and results in increased abundance of Methylphenidate; Fluoxetine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Perphenazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
aripiprazole inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate]
CES1 protein results in increased metabolism of Methylphenidate
CTD PMID:15082749 PMID:18485328 PMID:20097249 PMID:25445008 NCBI chr16:55,802,851...55,833,127
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CHD2 chromodomain helicase DNA binding protein 2 increases expression ISO Methylphenidate results in increased expression of CHD2 mRNA CTD PMID:22470460 NCBI chr15:92,900,324...93,027,996
Ensembl chr15:92,900,189...93,027,996
JBrowse link
G CHGA chromogranin A decreases expression ISO Methylphenidate results in decreased expression of CHGA mRNA CTD PMID:22470460 NCBI chr14:92,922,594...92,935,293
Ensembl chr14:92,923,150...92,935,285
JBrowse link
G CHID1 chitinase domain containing 1 decreases expression ISO Methylphenidate results in decreased expression of CHID1 mRNA CTD PMID:22470460 NCBI chr11:867,859...914,845
Ensembl chr11:867,859...915,058
JBrowse link
G CHRNA6 cholinergic receptor nicotinic alpha 6 subunit decreases expression ISO Methylphenidate results in decreased expression of CHRNA6 mRNA CTD PMID:22470460 NCBI chr 8:42,752,620...42,768,786
Ensembl chr 8:42,752,620...42,796,392
JBrowse link
G CHST8 carbohydrate sulfotransferase 8 decreases expression ISO Methylphenidate results in decreased expression of CHST8 mRNA CTD PMID:22470460 NCBI chr19:33,621,953...33,773,509
Ensembl chr19:33,621,953...33,773,509
JBrowse link
G CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit X increases expression ISO Methylphenidate results in increased expression of CLPX mRNA CTD PMID:22470460 NCBI chr15:65,148,219...65,185,374
Ensembl chr15:65,148,219...65,185,342
JBrowse link
G CNNM1 cyclin and CBS domain divalent metal cation transport mediator 1 increases expression ISO Methylphenidate results in increased expression of CNNM1 mRNA CTD PMID:22470460 NCBI chr10:99,329,101...99,394,330
Ensembl chr10:99,329,356...99,394,330
JBrowse link
G CNOT6L CCR4-NOT transcription complex subunit 6 like decreases expression ISO Methylphenidate results in decreased expression of CNOT6L mRNA CTD PMID:22470460 NCBI chr 4:77,713,387...77,820,269
Ensembl chr 4:77,713,387...77,819,615
JBrowse link
G CNR1 cannabinoid receptor 1 increases expression ISO Methylphenidate results in increased expression of CNR1 mRNA CTD PMID:22470460 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,359
JBrowse link
G COMTD1 catechol-O-methyltransferase domain containing 1 decreases expression ISO Methylphenidate results in decreased expression of COMTD1 mRNA CTD PMID:22470460 NCBI chr10:75,233,641...75,236,027
Ensembl chr10:75,233,641...75,236,030
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions
decreases expression
ISO [Fluoxetine co-treated with Methylphenidate] results in increased expression of CREB mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of CREB protein
Methylphenidate results in decreased expression of CREB mRNA
CTD PMID:21753012 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G D2HGDH D-2-hydroxyglutarate dehydrogenase decreases expression ISO Methylphenidate results in decreased expression of D2HGDH mRNA CTD PMID:22470460 NCBI chr 2:241,734,629...241,768,816
Ensembl chr 2:241,734,602...241,768,816
JBrowse link
G DAB2 DAB adaptor protein 2 increases expression ISO Methylphenidate results in increased expression of DAB2 mRNA CTD PMID:22470460 NCBI chr 5:39,460,870...39,462,304
Ensembl chr 5:39,371,675...39,462,300
JBrowse link
G DAPK3 death associated protein kinase 3 decreases expression ISO Methylphenidate results in decreased expression of DAPK3 mRNA CTD PMID:22470460 NCBI chr19:3,958,453...3,971,099
Ensembl chr19:3,958,453...3,971,123
JBrowse link
G DHX35 DEAH-box helicase 35 decreases expression ISO Methylphenidate results in decreased expression of DHX35 mRNA CTD PMID:22470460 NCBI chr20:38,962,344...39,039,723
Ensembl chr20:38,962,299...39,039,723
JBrowse link
G DRD1 dopamine receptor D1 multiple interactions ISO [SCH 23390 binds to and results in decreased activity of DRD1 protein] which results in decreased susceptibility to Methylphenidate CTD PMID:11454915 NCBI chr 5:175,440,036...175,444,182
Ensembl chr 5:175,440,036...175,444,182
JBrowse link
G DRD2 dopamine receptor D2 multiple interactions
decreases expression
affects expression
ISO [Raclopride binds to and results in decreased activity of DRD2 protein] which results in decreased susceptibility to Methylphenidate
Methylphenidate results in decreased expression of DRD2 mRNA
Methylphenidate affects the expression of DRD2 protein
CTD PMID:11454915 PMID:17599397 PMID:22470460 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DRD4 dopamine receptor D4 affects response to substance EXP DRD4 promoter mutant form affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706
JBrowse link
G EGR1 early growth response 1 multiple interactions
increases expression
ISO [Fluoxetine co-treated with Methylphenidate] results in increased expression of EGR1 mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of EGR1 mRNA]; Methylphenidate promotes the reaction [Amphetamine results in increased expression of EGR1 mRNA]; SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of EGR1 mRNA] CTD PMID:16549270 PMID:19931852 PMID:20020108 PMID:21753012 NCBI chr 5:138,465,479...138,469,303
Ensembl chr 5:138,465,479...138,469,303
JBrowse link
G ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 (inactive) decreases expression ISO Methylphenidate results in decreased expression of ENTPD5 mRNA CTD PMID:22470460 NCBI chr14:73,955,329...74,019,326
Ensembl chr14:73,958,010...74,019,399
JBrowse link
G EPB41L1 erythrocyte membrane protein band 4.1 like 1 decreases expression ISO Methylphenidate results in decreased expression of EPB41L1 mRNA CTD PMID:22470460 NCBI chr20:36,064,891...36,232,799
Ensembl chr20:36,091,504...36,232,799
JBrowse link
G EPHA10 EPH receptor A10 decreases expression ISO Methylphenidate results in decreased expression of EPHA10 mRNA CTD PMID:22470460 NCBI chr 1:37,713,888...37,765,120
Ensembl chr 1:37,713,880...37,765,133
JBrowse link
G EXOG exo/endonuclease G decreases expression ISO Methylphenidate results in decreased expression of EXOG mRNA CTD PMID:22470460 NCBI chr 3:38,496,127...38,526,304
Ensembl chr 3:38,496,127...38,542,161
JBrowse link
G FANK1 fibronectin type III and ankyrin repeat domains 1 decreases expression ISO Methylphenidate results in decreased expression of FANK1 mRNA CTD PMID:22470460 NCBI chr10:125,896,223...126,009,599
Ensembl chr10:125,896,564...126,009,592
Ensembl chr10:125,896,564...126,009,592
JBrowse link
G FCGR2B Fc fragment of IgG receptor IIb increases expression ISO Methylphenidate results in increased expression of FCGR2B mRNA CTD PMID:22470460 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,147...161,678,654
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
decreases expression
EXP
ISO
[Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of FOS mRNA; Fluoxetine promotes the reaction [Methylphenidate results in increased expression of FOS mRNA]
Methylphenidate results in increased expression of FOS protein
Methylphenidate results in decreased expression of FOS protein
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
Methylphenidate results in increased expression of FOS mRNA; Methylphenidate results in increased expression of FOS protein
CTD PMID:12112414 PMID:12699766 PMID:15916815 PMID:19931852 PMID:21753012 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOSB FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Methylphenidate results in increased expression of FOSB protein CTD PMID:15916815 NCBI chr19:45,467,996...45,475,179
Ensembl chr19:45,467,995...45,475,179
JBrowse link
G GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 decreases expression ISO Methylphenidate results in decreased expression of GALNT10 mRNA CTD PMID:22470460 NCBI chr 5:154,190,733...154,420,984
Ensembl chr 5:154,190,730...154,420,984
JBrowse link
G GCH1 GTP cyclohydrolase 1 decreases expression ISO Methylphenidate results in decreased expression of GCH1 mRNA CTD PMID:22470460 NCBI chr14:54,842,016...54,902,826
Ensembl chr14:54,842,008...54,902,826
JBrowse link
G GDNF glial cell derived neurotrophic factor decreases expression ISO Methylphenidate results in decreased expression of GDNF mRNA CTD PMID:22470460 NCBI chr 5:37,812,677...37,840,044
Ensembl chr 5:37,812,677...37,840,041
JBrowse link
G GHDC GH3 domain containing decreases expression ISO Methylphenidate results in decreased expression of GHDC mRNA CTD PMID:22470460 NCBI chr17:42,189,087...42,194,494
Ensembl chr17:42,188,799...42,194,532
JBrowse link
G GRIK3 glutamate ionotropic receptor kainate type subunit 3 decreases expression ISO Methylphenidate results in decreased expression of GRIK3 mRNA CTD PMID:22470460 NCBI chr 1:36,795,527...37,034,515
Ensembl chr 1:36,795,527...37,034,515
JBrowse link
G GUCY2C guanylate cyclase 2C decreases expression ISO Methylphenidate results in decreased expression of GUCY2C mRNA CTD PMID:22470460 NCBI chr12:14,612,632...14,696,625
Ensembl chr12:14,612,632...14,696,599
JBrowse link
G HBP1 HMG-box transcription factor 1 decreases expression ISO Methylphenidate results in decreased expression of HBP1 mRNA CTD PMID:22470460 NCBI chr 7:107,168,987...107,202,523
Ensembl chr 7:107,168,961...107,202,522
JBrowse link
G HOMER1 homer scaffold protein 1 increases expression
multiple interactions
ISO Methylphenidate results in increased expression of HOMER1 mRNA
SCH 23390 inhibits the reaction [Methylphenidate results in increased expression of HOMER1 mRNA]
CTD PMID:16549270 NCBI chr 5:79,372,636...79,514,134
Ensembl chr 5:79,372,636...79,514,134
JBrowse link
G HSPB6 heat shock protein family B (small) member 6 decreases expression ISO Methylphenidate results in decreased expression of HSPB6 mRNA CTD PMID:22470460 NCBI chr19:35,754,566...35,757,029
Ensembl chr19:35,754,566...35,758,079
JBrowse link
G IL6 interleukin 6 increases expression ISO Methylphenidate results in increased expression of IL6 mRNA CTD PMID:22470460 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G IP6K1 inositol hexakisphosphate kinase 1 increases expression ISO Methylphenidate results in increased expression of IP6K1 mRNA CTD PMID:22470460 NCBI chr 3:49,724,294...49,786,542
Ensembl chr 3:49,724,294...49,786,542
JBrowse link
G JAK3 Janus kinase 3 decreases expression ISO Methylphenidate results in decreased expression of JAK3 mRNA CTD PMID:22470460 NCBI chr19:17,824,782...17,848,071
Ensembl chr19:17,824,780...17,848,071
JBrowse link
G KIFC3 kinesin family member C3 decreases expression ISO Methylphenidate results in decreased expression of KIFC3 mRNA CTD PMID:22470460 NCBI chr16:57,758,217...57,863,053
Ensembl chr16:57,758,217...57,863,053
JBrowse link
G LAD1 ladinin 1 decreases expression ISO Methylphenidate results in decreased expression of LAD1 mRNA CTD PMID:22470460 NCBI chr 1:201,380,833...201,399,324
Ensembl chr 1:201,380,833...201,399,915
JBrowse link
G LAMA3 laminin subunit alpha 3 decreases expression ISO Methylphenidate results in decreased expression of LAMA3 mRNA CTD PMID:22470460 NCBI chr18:23,689,443...23,955,066
Ensembl chr18:23,689,443...23,956,222
Ensembl chr18:23,689,443...23,956,222
JBrowse link
G LARGE1 LARGE xylosyl- and glucuronyltransferase 1 decreases expression ISO Methylphenidate results in decreased expression of LARGE1 mRNA CTD PMID:22470460 NCBI chr22:33,162,237...33,922,824
Ensembl chr22:33,162,226...33,922,841
JBrowse link
G LASP1 LIM and SH3 protein 1 increases expression ISO Methylphenidate results in increased expression of LASP1 mRNA CTD PMID:22470460 NCBI chr17:38,870,058...38,921,770
Ensembl chr17:38,869,859...38,921,770
JBrowse link
G LGALS3BP galectin 3 binding protein decreases expression ISO Methylphenidate results in decreased expression of LGALS3BP mRNA CTD PMID:22470460 NCBI chr17:78,971,255...78,979,923
Ensembl chr17:78,971,238...78,979,947
JBrowse link
G LHFPL5 LHFPL tetraspan subfamily member 5 decreases expression ISO Methylphenidate results in decreased expression of LHFPL5 mRNA CTD PMID:22470460 NCBI chr 6:35,805,352...35,824,070
Ensembl chr 6:35,797,206...35,845,397
JBrowse link
G LRRC27 leucine rich repeat containing 27 decreases expression ISO Methylphenidate results in decreased expression of LRRC27 mRNA CTD PMID:22470460 NCBI chr10:132,330,063...132,381,508
Ensembl chr10:132,332,154...132,381,508
JBrowse link
G MALAT1 metastasis associated lung adenocarcinoma transcript 1 increases expression ISO Methylphenidate results in increased expression of MALAT1 mRNA CTD PMID:22470460 NCBI chr11:65,497,738...65,506,516
Ensembl chr11:65,497,688...65,506,516
JBrowse link
G MAP1LC3B microtubule associated protein 1 light chain 3 beta decreases expression ISO Methylphenidate results in decreased expression of MAP1LC3B mRNA CTD PMID:22470460 NCBI chr16:87,392,336...87,404,774
Ensembl chr16:87,383,953...87,404,779
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases expression
multiple interactions
ISO Methylphenidate results in decreased expression of MAPK1 mRNA
[Fluoxetine co-treated with Methylphenidate] results in increased expression of MAPK1 mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MAPK1 protein
CTD PMID:21753012 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases expression ISO Methylphenidate results in increased expression of MAPK8 mRNA CTD PMID:22470460 NCBI chr10:48,306,673...48,439,360
Ensembl chr10:48,306,639...48,439,360
JBrowse link
G MLC1 modulator of VRAC current 1 decreases expression ISO Methylphenidate results in decreased expression of MLC1 mRNA CTD PMID:22470460 NCBI chr22:50,059,391...50,085,875
Ensembl chr22:50,059,391...50,085,902
Ensembl chr22:50,059,391...50,085,902
JBrowse link
G MORN2 MORN repeat containing 2 decreases expression ISO Methylphenidate results in decreased expression of MORN2 mRNA CTD PMID:22470460 NCBI chr 2:38,875,976...38,882,649
Ensembl chr 2:38,875,962...38,929,072
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions
affects expression
ISO [Fluoxetine co-treated with Methylphenidate] results in increased expression of MTOR mRNA; [Fluoxetine co-treated with Methylphenidate] results in increased phosphorylation of MTOR protein
Methylphenidate affects the expression of MTOR mRNA
CTD PMID:21753012 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G MVP major vault protein decreases expression ISO Methylphenidate results in decreased expression of MVP mRNA CTD PMID:22470460 NCBI chr16:29,820,394...29,848,039
Ensembl chr16:29,820,394...29,848,039
JBrowse link
G NABP1 nucleic acid binding protein 1 increases expression ISO Methylphenidate results in increased expression of NABP1 mRNA CTD PMID:22470460 NCBI chr 2:191,678,136...191,686,943
Ensembl chr 2:191,678,068...191,696,664
Ensembl chr 2:191,678,068...191,696,664
JBrowse link
G NACAD NAC alpha domain containing decreases expression ISO Methylphenidate results in decreased expression of NACAD mRNA CTD PMID:22470460 NCBI chr 7:45,080,432...45,089,452
Ensembl chr 7:45,080,437...45,088,969
JBrowse link
G NCOR2 nuclear receptor corepressor 2 decreases expression ISO Methylphenidate results in decreased expression of NCOR2 mRNA CTD PMID:22470460 NCBI chr12:124,324,415...124,567,612
Ensembl chr12:124,324,415...124,567,589
JBrowse link
G NETO2 neuropilin and tolloid like 2 increases expression ISO Methylphenidate results in increased expression of NETO2 mRNA CTD PMID:22470460 NCBI chr16:47,077,703...47,144,025
Ensembl chr16:47,077,703...47,143,945
JBrowse link
G NOL3 nucleolar protein 3 decreases expression ISO Methylphenidate results in decreased expression of NOL3 mRNA CTD PMID:22470460 NCBI chr16:67,170,538...67,175,737
Ensembl chr16:67,170,154...67,175,735
JBrowse link
G NSUN4 NOP2/Sun RNA methyltransferase 4 increases expression ISO Methylphenidate results in increased expression of NSUN4 mRNA CTD PMID:22470460 NCBI chr 1:46,340,807...46,385,199
Ensembl chr 1:46,340,177...46,365,152
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 multiple interactions EXP [staurosporine aglycone binds to and results in decreased activity of NTRK2 protein] inhibits the reaction [Methylphenidate inhibits the reaction [Chlorodiphenyl (54% Chlorine) results in decreased expression of BDNF protein]] CTD PMID:24394491 NCBI chr 9:84,668,458...85,027,070
Ensembl chr 9:84,668,551...85,027,070
Ensembl chr 9:84,668,551...85,027,070
JBrowse link
G PARP3 poly(ADP-ribose) polymerase family member 3 increases expression ISO Methylphenidate results in increased expression of PARP3 mRNA CTD PMID:22470460 NCBI chr 3:51,942,290...51,948,867
Ensembl chr 3:51,942,345...51,948,867
JBrowse link
G PEAR1 platelet endothelial aggregation receptor 1 increases expression ISO Methylphenidate results in increased expression of PEAR1 mRNA CTD PMID:22470460 NCBI chr 1:156,893,697...156,916,429
Ensembl chr 1:156,893,698...156,916,434
JBrowse link
G PEDS1 plasmanylethanolamine desaturase 1 decreases expression ISO Methylphenidate results in decreased expression of TMEM189 mRNA CTD PMID:22470460 NCBI chr20:50,118,254...50,153,723
Ensembl chr20:50,118,254...50,153,734
JBrowse link
G PISD phosphatidylserine decarboxylase decreases expression ISO Methylphenidate results in decreased expression of PISD mRNA CTD PMID:22470460 NCBI chr22:31,618,491...31,662,564
Ensembl chr22:31,618,491...31,662,432
JBrowse link
G PKN1 protein kinase N1 decreases expression ISO Methylphenidate results in decreased expression of PKN1 mRNA CTD PMID:22470460 NCBI chr19:14,433,306...14,471,859
Ensembl chr19:14,433,053...14,471,867
JBrowse link
G PNMA8B PNMA family member 8B increases expression ISO Methylphenidate results in increased expression of PNMAL2 mRNA CTD PMID:22470460 NCBI chr19:46,491,191...46,495,867
Ensembl chr19:46,486,906...46,495,879
JBrowse link
G PRKG2 protein kinase cGMP-dependent 2 increases expression ISO Methylphenidate results in increased expression of PRKG2 mRNA CTD PMID:22470460 NCBI chr 4:81,087,370...81,217,837
Ensembl chr 4:81,087,370...81,215,117
JBrowse link
G PRLR prolactin receptor decreases expression ISO Methylphenidate results in decreased expression of PRLR mRNA CTD PMID:22470460 NCBI chr 5:35,048,756...35,230,724
Ensembl chr 5:35,048,756...35,230,487
JBrowse link
G PRPF39 pre-mRNA processing factor 39 increases expression ISO Methylphenidate results in increased expression of PRPF39 mRNA CTD PMID:22470460 NCBI chr14:45,084,116...45,116,282
Ensembl chr14:45,084,107...45,116,282
JBrowse link
G PTDSS2 phosphatidylserine synthase 2 decreases expression ISO Methylphenidate results in decreased expression of PTDSS2 mRNA CTD PMID:22470460 NCBI chr11:448,215...491,399
Ensembl chr11:448,268...491,399
JBrowse link
G PTPN21 protein tyrosine phosphatase non-receptor type 21 increases expression ISO Methylphenidate results in increased expression of PTPN21 mRNA CTD PMID:22470460 NCBI chr14:88,465,778...88,555,007
Ensembl chr14:88,465,778...88,555,007
JBrowse link
G PUS7L pseudouridine synthase 7 like decreases expression ISO Methylphenidate results in decreased expression of PUS7L mRNA CTD PMID:22470460 NCBI chr12:43,718,992...43,758,790
Ensembl chr12:43,718,993...43,758,817
Ensembl chr12:43,718,993...43,758,817
JBrowse link
G RAB38 RAB38, member RAS oncogene family increases expression ISO Methylphenidate results in increased expression of RAB38 mRNA CTD PMID:22470460 NCBI chr11:87,809,490...88,175,504
Ensembl chr11:88,113,251...88,175,443
JBrowse link
G RACGAP1 Rac GTPase activating protein 1 decreases expression ISO Methylphenidate results in decreased expression of RACGAP1 mRNA CTD PMID:22470460 NCBI chr12:49,989,162...50,033,206
Ensembl chr12:49,976,923...50,033,136
JBrowse link
G RBFOX1 RNA binding fox-1 homolog 1 increases expression ISO Methylphenidate results in increased expression of RBFOX1 mRNA CTD PMID:22470460 NCBI chr16:5,239,752...7,713,343
Ensembl chr16:5,239,802...7,713,340
JBrowse link
G RCC2 regulator of chromosome condensation 2 decreases expression ISO Methylphenidate results in decreased expression of RCC2 mRNA CTD PMID:22470460 NCBI chr 1:17,406,760...17,439,677
Ensembl chr 1:17,406,760...17,439,677
JBrowse link
G RET ret proto-oncogene decreases expression ISO Methylphenidate results in decreased expression of RET mRNA CTD PMID:22470460 NCBI chr10:43,077,069...43,130,351
Ensembl chr10:43,077,064...43,130,351
JBrowse link
G RGMA repulsive guidance molecule BMP co-receptor a decreases expression ISO Methylphenidate results in decreased expression of RGMA mRNA CTD PMID:22470460 NCBI chr15:93,035,271...93,089,211
Ensembl chr15:93,035,273...93,089,204
JBrowse link
G RGS20 regulator of G protein signaling 20 decreases expression ISO Methylphenidate results in decreased expression of RGS20 mRNA CTD PMID:22470460 NCBI chr 8:53,851,795...53,959,304
Ensembl chr 8:53,851,795...53,959,303
JBrowse link
G RHBDD2 rhomboid domain containing 2 decreases expression ISO Methylphenidate results in decreased expression of RHBDD2 mRNA CTD PMID:22470460 NCBI chr 7:75,879,015...75,888,926
Ensembl chr 7:75,842,602...75,888,926
JBrowse link
G SDC3 syndecan 3 decreases expression ISO Methylphenidate results in decreased expression of SDC3 mRNA CTD PMID:22470460 NCBI chr 1:30,869,466...30,909,735
Ensembl chr 1:30,869,466...30,908,758
JBrowse link
G SIAE sialic acid acetylesterase decreases expression ISO Methylphenidate results in decreased expression of SIAE mRNA CTD PMID:22470460 NCBI chr11:124,633,113...124,676,303
Ensembl chr11:124,633,113...124,695,707
JBrowse link
G SLC10A4 solute carrier family 10 member 4 decreases expression ISO Methylphenidate results in decreased expression of SLC10A4 mRNA CTD PMID:22470460 NCBI chr 4:48,483,343...48,489,526
Ensembl chr 4:48,483,343...48,489,526
JBrowse link
G SLC18A2 solute carrier family 18 member A2 decreases expression ISO Methylphenidate results in decreased expression of SLC18A2 mRNA CTD PMID:22470460 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430
JBrowse link
G SLC2A12 solute carrier family 2 member 12 increases expression ISO Methylphenidate results in increased expression of SLC2A12 mRNA CTD PMID:22470460 NCBI chr 6:133,987,581...134,052,651
Ensembl chr 6:133,987,581...134,052,624
JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions
decreases expression
increases response to substance
affects response to substance
EXP
ISO
[Methylphenidate co-treated with SLC6A3 protein] results in increased expression of FOS protein; [SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate] which affects the uptake of Dopamine; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS mRNA]; Methylphenidate inhibits the reaction [[Dopamine co-treated with SLC6A3 protein] results in increased expression of FOS protein]; Methylphenidate inhibits the reaction [SLC6A3 protein mutant form results in increased export of Dopamine]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
Methylphenidate results in decreased expression of SLC6A3 mRNA
Methylphenidate results in decreased expression of SLC6A3 protein
SLC6A3 protein results in increased susceptibility to Methylphenidate
SLC6A3 protein affects the reaction [Methylphenidate results in increased expression of FOS protein]
SLC6A3 3' UTR polymorphism affects the susceptibility to Methylphenidate; SLC6A3 protein polymorphism affects the susceptibility to Methylphenidate
CTD PMID:12112414 PMID:12699766 PMID:15059031 PMID:16139732 PMID:17234900 PMID:18614672 PMID:19462300 PMID:22470460 PMID:31009648 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link
G SNAP25 synaptosome associated protein 25 affects response to substance EXP SNAP25 gene polymorphism affects the susceptibility to Methylphenidate CTD PMID:17023870 NCBI chr20:10,218,830...10,307,420
Ensembl chr20:10,218,830...10,307,418
JBrowse link
G SNCAIP synuclein alpha interacting protein increases expression ISO Methylphenidate results in increased expression of SNCAIP mRNA CTD PMID:22470460 NCBI chr 5:122,311,354...122,464,219
Ensembl chr 5:122,311,354...122,464,219
JBrowse link
G SNCG synuclein gamma decreases expression ISO Methylphenidate results in decreased expression of SNCG mRNA CTD PMID:22470460 NCBI chr10:86,955,759...86,963,260
Ensembl chr10:86,958,599...86,963,258
JBrowse link
G SNX22 sorting nexin 22 decreases expression ISO Methylphenidate results in decreased expression of SNX22 mRNA CTD PMID:22470460 NCBI chr15:64,151,698...64,157,481
Ensembl chr15:64,151,715...64,157,481
JBrowse link
G SORCS3 sortilin related VPS10 domain containing receptor 3 decreases expression ISO Methylphenidate results in decreased expression of SORCS3 mRNA CTD PMID:22470460 NCBI chr10:104,641,290...105,265,242
Ensembl chr10:104,641,290...105,265,242
JBrowse link
G SOX11 SRY-box transcription factor 11 increases expression ISO Methylphenidate results in increased expression of SOX11 mRNA CTD PMID:22470460 NCBI chr 2:5,692,384...5,701,385
Ensembl chr 2:5,692,384...5,701,385
JBrowse link
G STAT5A signal transducer and activator of transcription 5A decreases expression ISO Methylphenidate results in decreased expression of STAT5A mRNA CTD PMID:22470460 NCBI chr17:42,287,547...42,311,943
Ensembl chr17:42,287,547...42,311,943
JBrowse link
G STOX2 storkhead box 2 increases expression ISO Methylphenidate results in increased expression of STOX2 mRNA CTD PMID:22470460 NCBI chr 4:183,796,331...184,023,530
Ensembl chr 4:183,797,692...184,023,526
JBrowse link
G SUDS3 SDS3 homolog, SIN3A corepressor complex component decreases expression ISO Methylphenidate results in decreased expression of SUDS3 mRNA CTD PMID:22470460 NCBI chr12:118,373,189...118,418,033
Ensembl chr12:118,376,555...118,418,033
JBrowse link
G TAAR1 trace amine associated receptor 1 multiple interactions EXP Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Dopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Methamphetamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Octopamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [tryptamine results in increased activity of TAAR1 protein]]; Methylphenidate inhibits the reaction [SLC6A3 protein promotes the reaction [Tyramine results in increased activity of TAAR1 protein]] CTD PMID:17234900 NCBI chr 6:132,643,312...132,659,182
Ensembl chr 6:132,644,898...132,646,051
Ensembl chr 6:132,644,898...132,646,051
JBrowse link
G TCL1B TCL1 family AKT coactivator B increases expression ISO Methylphenidate results in increased expression of TCL1B1 mRNA CTD PMID:22470460 NCBI chr14:95,686,426...95,692,628
Ensembl chr14:95,686,426...95,692,628
JBrowse link
G TH tyrosine hydroxylase decreases expression ISO Methylphenidate results in decreased expression of TH mRNA CTD PMID:22470460 NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,877
Ensembl chr11:2,163,929...2,171,877
JBrowse link
G TMEM185B transmembrane protein 185B decreases expression ISO Methylphenidate results in decreased expression of TMEM185B mRNA CTD PMID:22470460 NCBI chr 2:120,217,479...120,223,400
Ensembl chr 2:120,217,479...120,223,400
JBrowse link
G TMEM30A transmembrane protein 30A decreases expression ISO Methylphenidate results in decreased expression of TMEM30A mRNA CTD PMID:22470460 NCBI chr 6:75,252,924...75,284,792
Ensembl chr 6:75,252,924...75,284,948
JBrowse link
G TNF tumor necrosis factor increases expression ISO Methylphenidate results in increased expression of TNF mRNA CTD PMID:22470460 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TRAF5 TNF receptor associated factor 5 decreases expression ISO Methylphenidate results in decreased expression of TRAF5 mRNA CTD PMID:22470460 NCBI chr 1:211,326,594...211,374,946
Ensembl chr 1:211,326,615...211,374,946
JBrowse link
G TRIM25 tripartite motif containing 25 increases expression ISO Methylphenidate results in increased expression of TRIM25 mRNA CTD PMID:22470460 NCBI chr17:56,887,909...56,914,049
Ensembl chr17:56,836,387...56,914,080
JBrowse link
G TSPAN17 tetraspanin 17 decreases expression ISO Methylphenidate results in decreased expression of TSPAN17 mRNA CTD PMID:22470460 NCBI chr 5:176,647,484...176,659,051
Ensembl chr 5:176,647,387...176,659,054
JBrowse link
G TTF1 transcription termination factor 1 increases expression ISO Methylphenidate results in increased expression of TTF1 mRNA CTD PMID:22470460 NCBI chr 9:132,375,548...132,406,840
Ensembl chr 9:132,375,548...132,406,851
JBrowse link
G TWSG1 twisted gastrulation BMP signaling modulator 1 decreases expression ISO Methylphenidate results in decreased expression of TWSG1 mRNA CTD PMID:22470460 NCBI chr18:9,334,773...9,402,420
Ensembl chr18:9,334,767...9,402,420
JBrowse link
G UBE3D ubiquitin protein ligase E3D decreases expression ISO Methylphenidate results in decreased expression of UBE2CBP mRNA CTD PMID:22470460 NCBI chr 6:82,880,834...83,065,841
Ensembl chr 6:82,892,390...83,065,841
JBrowse link
G UBXN10 UBX domain protein 10 decreases expression ISO Methylphenidate results in decreased expression of UBXN10 mRNA CTD PMID:22470460 NCBI chr 1:20,183,007...20,196,050
Ensembl chr 1:20,186,096...20,196,050
JBrowse link
G UCK2 uridine-cytidine kinase 2 decreases expression ISO Methylphenidate results in decreased expression of UCK2 mRNA CTD PMID:22470460 NCBI chr 1:165,827,614...165,911,618
Ensembl chr 1:165,827,614...165,911,618
JBrowse link
G VASH1 vasohibin 1 increases expression ISO Methylphenidate results in increased expression of VASH1 mRNA CTD PMID:22470460 NCBI chr14:76,761,457...76,783,017
Ensembl chr14:76,761,468...76,783,015
JBrowse link
G WARS2 tryptophanyl tRNA synthetase 2, mitochondrial decreases expression ISO Methylphenidate results in decreased expression of WARS2 mRNA CTD PMID:22470460 NCBI chr 1:119,031,216...119,140,788
Ensembl chr 1:119,031,216...119,140,654
Ensembl chr 1:119,031,216...119,140,654
JBrowse link
G ZFP14 ZFP14 zinc finger protein decreases expression ISO Methylphenidate results in decreased expression of ZFP14 mRNA CTD PMID:22470460 NCBI chr19:36,334,453...36,379,201
Ensembl chr19:36,334,453...36,379,201
JBrowse link
N-methyl-D-aspartic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ELAVL1 ELAV like RNA binding protein 1 increases phosphorylation
multiple interactions
EXP N-Methylaspartate results in increased phosphorylation of ELAVL1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in increased phosphorylation of ELAVL1 protein]
CTD PMID:31945382 NCBI chr19:7,958,573...8,005,641
Ensembl chr19:7,958,573...8,005,659
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases expression
multiple interactions
ISO N-Methylaspartate results in increased expression of MAPK1 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK1 protein modified form]
CTD PMID:22639866 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases expression
multiple interactions
ISO N-Methylaspartate results in increased expression of MAPK3 protein modified form
thieno(2,3-c)isoquinolin-5-one inhibits the reaction [N-Methylaspartate results in increased expression of MAPK3 protein modified form]
CTD PMID:22639866 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases ADP-ribosylation ISO N-Methylaspartate results in increased ADP-ribosylation of PARP1 protein CTD PMID:16903875 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G SIRT1 sirtuin 1 multiple interactions
decreases expression
EXP 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Dizocilpine Maleate inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; ELAV1 protein mutant form inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein]; Go 6976 inhibits the reaction [N-Methylaspartate results in decreased expression of SIRT1 mRNA]; N-Methylaspartate results in decreased expression of and results in decreased activity of SIRT1 protein CTD PMID:31945382 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
nateglinide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC4 ATP binding cassette subfamily C member 4 affects binding EXP ABCC4 protein binds to nateglinide CTD PMID:17939016 NCBI chr13:95,019,835...95,301,451
Ensembl chr13:95,019,835...95,301,475
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 affects metabolic processing EXP CYP2C9 protein affects the metabolism of nateglinide CTD PMID:18159128 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G INS insulin increases secretion EXP nateglinide results in increased secretion of INS protein CTD PMID:16403453 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,341
Ensembl chr11:2,159,779...2,161,341
JBrowse link
G SLCO1B1 solute carrier organic anion transporter family member 1B1 multiple interactions EXP Nateglinide inhibits the reaction [SLCO1B1 protein results in increased uptake of Atorvastatin] CTD PMID:23121773 NCBI chr12:21,131,194...21,239,796
Ensembl chr12:21,131,194...21,239,796
JBrowse link
G SLCO1B3 solute carrier organic anion transporter family member 1B3 multiple interactions EXP Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO1B3 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr12:20,810,705...20,916,911
Ensembl chr12:20,810,702...20,916,911
JBrowse link
G SLCO2B1 solute carrier organic anion transporter family member 2B1 multiple interactions EXP Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Atorvastatin]; Nateglinide inhibits the reaction [SLCO2B1 protein results in increased uptake of Sulfobromophthalein] CTD PMID:23121773 NCBI chr11:75,151,107...75,206,549
Ensembl chr11:75,100,563...75,206,549
JBrowse link
rhodotorulic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases activity
EXP Calcium Chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein]; ferric chloride inhibits the reaction [rhodotorulic acid results in decreased activity of MMP2 protein] CTD PMID:10086886 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
S-adenosyl-L-homocysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHCY adenosylhomocysteinase increases hydrolysis EXP AHCY results in increased hydrolysis of S-Adenosylhomocysteine CTD PMID:26974671 NCBI chr20:34,235,012...34,311,976
Ensembl chr20:34,280,268...34,311,802
JBrowse link
G AHR aryl hydrocarbon receptor increases abundance
multiple interactions
ISO AHR protein results in increased abundance of S-Adenosylhomocysteine
PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine]
CTD PMID:29416063 NCBI chr 7:17,298,652...17,346,147
Ensembl chr 7:16,916,359...17,346,152
JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 multiple interactions EXP [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of ALAS2 mRNA] CTD PMID:24141029 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977
JBrowse link
G APP amyloid beta precursor protein increases expression
decreases methylation
multiple interactions
ISO S-Adenosylhomocysteine results in increased expression of APP protein
S-Adenosylhomocysteine results in decreased methylation of APP promoter
Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of APP promoter]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein]; S-Adenosylhomocysteine results in increased expression of and results in increased cleavage of APP protein
CTD PMID:19635394 PMID:22064374 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G ATP7B ATPase copper transporting beta increases abundance ISO ATP7B protein mutant form results in increased abundance of S-Adenosylhomocysteine CTD PMID:22945834 NCBI chr13:51,932,669...52,012,130
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G BACE1 beta-secretase 1 increases expression ISO S-Adenosylhomocysteine results in increased expression of BACE1 protein CTD PMID:19635394 NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,207...117,316,259
JBrowse link
G COL1A1 collagen type I alpha 1 chain decreases expression EXP S-Adenosylhomocysteine results in decreased expression of COL1A1 mRNA CTD PMID:15983038 NCBI chr17:50,184,096...50,201,649
Ensembl chr17:50,183,289...50,201,632
Ensembl chr17:50,183,289...50,201,632
JBrowse link
G COL1A2 collagen type I alpha 2 chain decreases expression EXP S-Adenosylhomocysteine results in decreased expression of COL1A2 mRNA CTD PMID:15983038 NCBI chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
Ensembl chr 7:94,394,895...94,431,227
JBrowse link
G COMT catechol-O-methyltransferase decreases activity ISO S-Adenosylhomocysteine results in decreased activity of COMT protein CTD PMID:10064789 NCBI chr22:19,941,772...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
Ensembl chr22:19,941,733...19,969,975
JBrowse link
G DNMT1 DNA methyltransferase 1 decreases activity
multiple interactions
EXP
ISO
S-Adenosylhomocysteine results in decreased activity of DNMT1 protein
S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
CTD PMID:16037419 PMID:22064374 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,345...10,231,286
Ensembl chr19:10,133,345...10,231,286
JBrowse link
G FGF19 fibroblast growth factor 19 decreases abundance ISO FGF19 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr11:69,698,238...69,704,022
Ensembl chr11:69,698,238...69,704,022
JBrowse link
G HBB hemoglobin subunit beta multiple interactions EXP [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HBB mRNA] CTD PMID:24141029 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
JBrowse link
G HMBS hydroxymethylbilane synthase multiple interactions EXP [S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA; catechol inhibits the reaction [[S-Adenosylhomocysteine co-treated with Hemin] results in increased expression of HMBS mRNA] CTD PMID:24141029 NCBI chr11:119,084,864...119,093,549
Ensembl chr11:119,084,866...119,093,549
JBrowse link
G MMP2 matrix metallopeptidase 2 increases expression
multiple interactions
ISO S-Adenosylhomocysteine results in increased expression of MMP2 mRNA; S-Adenosylhomocysteine results in increased expression of MMP2 protein
S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter]
U 0126 inhibits the reaction [S-Adenosylhomocysteine results in increased expression of MMP2 protein]
CTD PMID:19770485 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691
JBrowse link
G NFKBIA NFKB inhibitor alpha decreases expression ISO S-Adenosylhomocysteine results in decreased expression of NFKBIA protein CTD PMID:19770485 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,511...35,404,749
Ensembl chr14:35,401,511...35,404,749
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 decreases abundance ISO NR0B2 protein results in decreased abundance of S-Adenosylhomocysteine CTD PMID:29416063 NCBI chr 1:26,911,489...26,914,110
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase multiple interactions
decreases methylation
decreases expression
ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased expression of OGG1 protein]; Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of OGG1 promoter]; S-Adenosylhomocysteine inhibits the reaction [DNMT1 protein binds to OGG1 promoter]
S-Adenosylhomocysteine results in decreased expression of OGG1 mRNA; S-Adenosylhomocysteine results in decreased expression of OGG1 protein
CTD PMID:22064374 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G PEMT phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in increased abundance of S-Adenosylhomocysteine] CTD PMID:29416063 NCBI chr17:17,505,561...17,591,987
Ensembl chr17:17,505,563...17,591,708
JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP S-Adenosylhomocysteine results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089
JBrowse link
G PSEN1 presenilin 1 multiple interactions
decreases methylation
increases expression
ISO Betaine inhibits the reaction [S-Adenosylhomocysteine results in decreased methylation of PSEN1 promoter]
S-Adenosylhomocysteine results in increased expression of PSEN1 protein
CTD PMID:19635394 NCBI chr14:73,136,436...73,223,691
Ensembl chr14:73,136,418...73,223,691
JBrowse link
G SLC19A1 solute carrier family 19 member 1 affects abundance ISO SLC19A1 protein affects the abundance of S-Adenosylhomocysteine CTD PMID:15705887 NCBI chr21:45,502,517...45,563,140
Ensembl chr21:45,493,572...45,573,365
JBrowse link
G SP1 Sp1 transcription factor multiple interactions ISO S-Adenosylhomocysteine promotes the reaction [SP1 protein binds to MMP2 promoter] CTD PMID:19770485 NCBI chr12:53,380,176...53,416,446
Ensembl chr12:53,380,176...53,416,446
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 decreases expression ISO S-Adenosylhomocysteine results in decreased expression of TIMP2 protein CTD PMID:19770485 NCBI chr17:78,852,977...78,925,387
Ensembl chr17:78,852,977...78,925,387
JBrowse link
S-methyl-L-thiocitrulline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions ISO S-methylthiocitrulline inhibits the reaction [EDN1 protein results in increased abundance of Nitric Oxide] CTD PMID:16380457 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G NOS1 nitric oxide synthase 1 multiple interactions
decreases activity
ISO [S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine
[S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the abundance of Sodium
CTD PMID:11006970 PMID:12511180 NCBI chr12:117,208,142...117,361,626
Ensembl chr12:117,208,142...117,452,170
JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions ISO S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased activity of SLC18A2 protein]; S-methylthiocitrulline inhibits the reaction [Methamphetamine results in decreased expression of SLC18A2 protein] CTD PMID:17683483 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430
JBrowse link
S-nitroso-N-acetyl-D-penicillamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AIFM1 apoptosis inducing factor mitochondria associated 1 multiple interactions EXP AIFM1 protein inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Glutathione]; AIFM1 protein promotes the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased reduction of Adenine Nucleotides] CTD PMID:15316071 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879
Ensembl chr  X:130,124,666...130,165,879
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]; wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]] CTD PMID:21138475 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G AQP3 aquaporin 3 (Gill blood group) decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of AQP3 mRNA CTD PMID:12102619 NCBI chr 9:33,441,154...33,447,596
Ensembl chr 9:33,441,156...33,447,596
JBrowse link
G BAD BCL2 associated agonist of cell death decreases phosphorylation
multiple interactions
ISO S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of BAD protein]
CTD PMID:21138475 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased expression of BAX protein]
CTD PMID:21138475 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
ISO Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein]
S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 mRNA; S-Nitroso-N-Acetylpenicillamine results in decreased expression of BCL2 protein
CTD PMID:17135264 PMID:21138475 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G CALCA calcitonin related polypeptide alpha multiple interactions
increases secretion
ISO Carbon Dioxide inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased secretion of CALCA protein] CTD PMID:18052948 NCBI chr11:14,966,668...14,972,361
Ensembl chr11:14,966,668...14,972,354
Ensembl chr11:14,966,668...14,972,354
JBrowse link
G CASP1 caspase 1 multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased activity of and results in increased cleavage of CASP1 protein CTD PMID:10903723 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
decreases activity
EXP
ISO
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of CASP3 protein]
S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein
S-Nitroso-N-Acetylpenicillamine results in decreased activity of CASP3 protein
Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased activity of CASP3 protein]
CTD PMID:10811113 PMID:12006578 PMID:12220328 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine inhibits the reaction [3,5-dimethoxy-4'-hydroxystilbene results in decreased phosphorylation of CREB1 protein]; S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Quercetin results in decreased phosphorylation of CREB1 protein] CTD PMID:17135264 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CSRP3 cysteine and glycine rich protein 3 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of CSRP3 mRNA CTD PMID:12102619 NCBI chr11:19,182,030...19,201,983
Ensembl chr11:19,182,030...19,210,571
JBrowse link
G DRGX dorsal root ganglia homeobox decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of PRRXL1 mRNA CTD PMID:12102619 NCBI chr10:49,364,066...49,396,089
Ensembl chr10:49,364,181...49,396,016
JBrowse link
G EDN1 endothelin 1 increases secretion ISO S-Nitroso-N-Acetylpenicillamine results in increased secretion of EDN1 protein CTD PMID:15640287 NCBI chr 6:12,256,463...12,297,194
Ensembl chr 6:12,290,361...12,297,194
JBrowse link
G ELN elastin decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of ELN mRNA CTD PMID:12102619 NCBI chr 7:74,027,772...74,069,907
Ensembl chr 7:74,027,789...74,069,907
JBrowse link
G EXOC6 exocyst complex component 6 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of SEC15 mRNA CTD PMID:12102619 NCBI chr10:92,826,831...93,059,490
Ensembl chr10:92,826,831...93,059,493
JBrowse link
G FASLG Fas ligand multiple interactions EXP [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [Etoposide results in increased activity of FASLG promoter]; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine results in increased activity of FASLG promoter] CTD PMID:10811113 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G FCGR2A Fc fragment of IgG receptor IIa decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR3 mRNA CTD PMID:12102619 NCBI chr 1:161,505,430...161,524,048
Ensembl chr 1:161,505,430...161,524,013
JBrowse link
G FCGR2B Fc fragment of IgG receptor IIb decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of FCGR2B mRNA CTD PMID:12102619 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,147...161,678,654
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein] CTD PMID:16351512 NCBI chr 4:122,826,708...122,898,236
Ensembl chr 4:122,826,708...122,898,236
JBrowse link
G GHRH growth hormone releasing hormone decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of GHRH mRNA CTD PMID:12102619 NCBI chr20:37,251,086...37,261,814
Ensembl chr20:37,251,082...37,261,835
JBrowse link
G GNAI2 G protein subunit alpha i2 multiple interactions
decreases expression
ISO 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI2 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 3:50,227,068...50,259,362
Ensembl chr 3:50,226,292...50,259,362
JBrowse link
G GNAI3 G protein subunit alpha i3 multiple interactions
decreases expression
ISO 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein]; Uric Acid inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of GNAI3 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195
JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of GOT1 mRNA CTD PMID:12102619 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions ISO GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; GPX1 protein affects the susceptibility to [Diquat co-treated with S-Nitroso-N-Acetylpenicillamine]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased expression of GPX1 protein] CTD PMID:11672444 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GSTA2 glutathione S-transferase alpha 2 multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine co-treated with 2-tert-butylhydroquinone] results in increased expression of GSTA2 CTD PMID:15357004 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
JBrowse link
G HCK HCK proto-oncogene, Src family tyrosine kinase decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of HCK mRNA CTD PMID:12102619 NCBI chr20:32,052,242...32,101,856
Ensembl chr20:32,052,197...32,101,856
Ensembl chr20:32,052,197...32,101,856
JBrowse link
G HMOX1 heme oxygenase 1 increases expression ISO S-Nitroso-N-Acetylpenicillamine results in increased expression of HMOX1 protein CTD PMID:16439612 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,207
Ensembl chr22:35,380,361...35,394,207
JBrowse link
G IFNG interferon gamma multiple interactions ISO S-Nitroso-N-Acetylpenicillamine inhibits the reaction [Streptozocin results in increased expression of IFNG protein] CTD PMID:15892581 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G ITPKA inositol-trisphosphate 3-kinase A decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of ITPKA mRNA CTD PMID:12102619 NCBI chr15:41,493,874...41,503,555
Ensembl chr15:41,493,393...41,503,551
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 decreases expression
multiple interactions
increases phosphorylation
decreases phosphorylation
ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK1 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK1 protein]
CTD PMID:15640287 PMID:19252090 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,754,500...21,867,680
Ensembl chr22:21,754,500...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 decreases expression
decreases phosphorylation
increases phosphorylation
multiple interactions
ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of MAPK3 protein
S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein
S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of MAPK3 protein]; 8-Bromo Cyclic Adenosine Monophosphate inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of MAPK3 protein]
CTD PMID:15640287 PMID:19252090 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MME membrane metalloendopeptidase decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of MME mRNA CTD PMID:12102619 NCBI chr 3:155,024,202...155,183,729
Ensembl chr 3:155,024,124...155,183,704
Ensembl chr 3:155,024,124...155,183,704
JBrowse link
G MTF1 metal regulatory transcription factor 1 affects localization ISO S-Nitroso-N-Acetylpenicillamine affects the localization of MTF1 protein CTD PMID:16423564 NCBI chr 1:37,809,570...37,859,614
Ensembl chr 1:37,809,574...37,859,592
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of NFKB1 mRNA CTD PMID:12102619 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NOS2 nitric oxide synthase 2 decreases activity
decreases expression
EXP
ISO
S-Nitroso-N-Acetylpenicillamine results in decreased activity of NOS2 protein
S-Nitroso-N-Acetylpenicillamine results in decreased expression of NOS2 promoter
CTD PMID:11076874 PMID:15565661 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NPPA natriuretic peptide A multiple interactions ISO [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA] CTD PMID:11799084 NCBI chr 1:11,845,709...11,847,783
Ensembl chr 1:11,845,709...11,848,345
JBrowse link
G NPR3 natriuretic peptide receptor 3 multiple interactions
decreases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of NPR3 protein] CTD PMID:16962941 PMID:19252090 NCBI chr 5:32,689,076...32,791,720
Ensembl chr 5:32,689,070...32,791,724
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] CTD PMID:18652891 PMID:21235400 NCBI chr 6:154,010,496...154,246,867
Ensembl chr 6:154,010,496...154,246,867
JBrowse link
G PAM peptidylglycine alpha-amidating monooxygenase decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of PAM mRNA CTD PMID:12102619 NCBI chr 5:102,754,783...103,031,105
Ensembl chr 5:102,753,981...103,031,105
JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions EXP [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] inhibits the reaction [N-caproylsphingosine promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]] CTD PMID:10811113 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,691...226,408,093
JBrowse link
G PRKCA protein kinase C alpha multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCA protein] CTD PMID:18652891 NCBI chr17:66,302,613...66,810,743
Ensembl chr17:66,302,613...66,810,743
JBrowse link
G PRKCG protein kinase C gamma multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein] CTD PMID:18652891 PMID:21235400 NCBI chr19:53,882,197...53,907,652
Ensembl chr19:53,879,190...53,907,652
JBrowse link
G PRKG1 protein kinase cGMP-dependent 1 multiple interactions
increases activity
ISO [S-Nitroso-N-Acetylpenicillamine co-treated with PRKG1 protein alternative form] inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]
S-Nitroso-N-Acetylpenicillamine results in increased activity of PRKG1 protein
CTD PMID:11799084 NCBI chr10:50,990,888...52,298,350
Ensembl chr10:50,990,888...52,298,423
JBrowse link
G RACK1 receptor for activated C kinase 1 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of RACK1 mRNA CTD PMID:12102619 NCBI chr 5:181,236,897...181,243,906
Ensembl chr 5:181,236,897...181,248,096
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RAF1 protein] CTD PMID:21235400 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,583,601...12,664,226
Ensembl chr 3:12,583,601...12,664,226
JBrowse link
G RGS17 regulator of G protein signaling 17 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to RGS17 protein] CTD PMID:18652891 NCBI chr 6:153,004,459...153,131,284
Ensembl chr 6:153,004,459...153,131,282
JBrowse link
G RPLP0 ribosomal protein lateral stalk subunit P0 decreases expression ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of RPLP0 mRNA CTD PMID:12102619 NCBI chr12:120,196,699...120,201,111
Ensembl chr12:120,196,699...120,201,235
JBrowse link
G SFTPA1 surfactant protein A1 decreases expression
multiple interactions
ISO S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA
bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPA1 mRNA]
CTD PMID:15640287 NCBI chr10:79,610,939...79,615,455
Ensembl chr10:79,610,939...79,615,455
JBrowse link
G SFTPB surfactant protein B multiple interactions
decreases expression
ISO bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPB mRNA] CTD PMID:15640287 NCBI chr 2:85,657,307...85,668,741
Ensembl chr 2:85,657,314...85,668,741
JBrowse link
G SFTPC surfactant protein C multiple interactions
decreases expression
ISO bosentan inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA]; PD 156707 inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased expression of SFTPC mRNA] CTD PMID:15640287 NCBI chr 8:22,157,383...22,164,479
Ensembl chr 8:22,156,913...22,164,479
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
affects response to substance
ISO GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in decreased activity of SOD1 protein]
SOD1 protein affects the susceptibility to S-Nitroso-N-Acetylpenicillamine
CTD PMID:10698074 PMID:11672444 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions ISO GPX1 protein affects the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]]; S-Nitroso-N-Acetylpenicillamine promotes the reaction [Diquat results in increased activity of SOD2 protein]
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of and results in increased activity of SOD2 protein; [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of SOD2 mRNA
CTD PMID:11672444 PMID:14996425 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO
EXP
[S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of TRP53 mRNA
S-Nitroso-N-Acetylpenicillamine promotes the reaction [FGF2 protein results in increased expression of TP53 protein]
CTD PMID:7673702 PMID:16351512 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRPC6 transient receptor potential cation channel subfamily C member 6 multiple interactions ISO S-Nitroso-N-Acetylpenicillamine inhibits the reaction [1-oleoyl-2-acetylglycerol results in increased activity of TRPC6 protein] CTD PMID:20177073 NCBI chr11:101,451,470...101,584,007
Ensembl chr11:101,451,564...101,872,562
JBrowse link
G VASP vasodilator stimulated phosphoprotein increases phosphorylation ISO S-Nitroso-N-Acetylpenicillamine results in increased phosphorylation of VASP protein CTD PMID:11799084 NCBI chr19:45,507,459...45,526,989
Ensembl chr19:45,506,579...45,526,983
JBrowse link
G VEGFA vascular endothelial growth factor A increases expression
increases secretion
ISO S-Nitroso-N-Acetylpenicillamine results in increased expression of VEGFA mRNA
S-Nitroso-N-Acetylpenicillamine results in increased secretion of VEGFA protein
CTD PMID:10613739 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 24382
    chemical entity 24350
      atom 24339
        nonmetal atom 24047
          nitrogen atom 20863
            nitrogen molecular entity 20863
              organonitrogen compound 20535
                amino acid derivative 11201
                  non-proteinogenic amino acid derivative 270
                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-\{[(S)-1-mesyl-2-piperidyl]carbonyl\}-L-alanine 0
                    3-hydroxynorvaline 0
                    D-alanine derivative + 3
                    D-arginine derivative + 0
                    D-asparagine derivative 0
                    D-aspartic acid derivative + 5
                    D-cysteine derivative + 0
                    D-glutamic acid derivative + 0
                    D-histidine derivative 0
                    D-isoleucine derivative + 0
                    D-leucine derivative + 0
                    D-methionine derivative + 0
                    D-phenylalanine derivative + 0
                    D-proline derivative + 0
                    D-selenocysteine derivative 0
                    D-serine derivative + 0
                    D-threonine derivative 0
                    D-tryptophan derivative + 0
                    D-tyrosine derivative + 0
                    D-valine derivative + 0
                    N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alanine + 0
                    N-(2,6-dichlorobenzoyl)-3-[6-(2,6-dimethoxyphenyl)-2-naphthyl]alanine 0
                    N-acetyl-L-alpha-phenylglycine 0
                    N-acyl-D-amino acid + 62
                    N-formyl-L-kynurenine + 0
                    N-formylkynurenine + 0
                    N-heptanoyl-L-homoserine 0
                    N-nitrososarcosine 0
                    beta-alanine derivative + 58
                    beta-amino acid ester + 131
                    brivaracetam 0
                    delta-amino acid ester + 0
                    homocysteine derivative + 23
                    methyl 3-[2-(2,6-dichlorophenyl)quinolin-6-yl]alaninate + 0
                    methyl 5-(hydroxymethyl)pyrrolidine-2-carboxylate 0
                    methyl N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alaninate 0
                    methyl N-(2,6-dichlorobenzoyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-methylalaninate 0
                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4,4a,8a-hexahydro-6-quinolyl]alaninate 0
                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                    ornithine derivative + 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 24382
    subatomic particle 24339
      composite particle 24339
        hadron 24339
          baryon 24339
            nucleon 24339
              atomic nucleus 24339
                atom 24339
                  main group element atom 24188
                    main group molecular entity 24188
                      p-block molecular entity 24181
                        carbon group molecular entity 23967
                          organic molecular entity 23924
                            heteroorganic entity 23267
                              organonitrogen compound 20535
                                amino acid derivative 11201
                                  non-proteinogenic amino acid derivative 270
                                    3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-\{[(S)-1-mesyl-2-piperidyl]carbonyl\}-L-alanine 0
                                    3-hydroxynorvaline 0
                                    D-alanine derivative + 3
                                    D-arginine derivative + 0
                                    D-asparagine derivative 0
                                    D-aspartic acid derivative + 5
                                    D-cysteine derivative + 0
                                    D-glutamic acid derivative + 0
                                    D-histidine derivative 0
                                    D-isoleucine derivative + 0
                                    D-leucine derivative + 0
                                    D-methionine derivative + 0
                                    D-phenylalanine derivative + 0
                                    D-proline derivative + 0
                                    D-selenocysteine derivative 0
                                    D-serine derivative + 0
                                    D-threonine derivative 0
                                    D-tryptophan derivative + 0
                                    D-tyrosine derivative + 0
                                    D-valine derivative + 0
                                    N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alanine + 0
                                    N-(2,6-dichlorobenzoyl)-3-[6-(2,6-dimethoxyphenyl)-2-naphthyl]alanine 0
                                    N-acetyl-L-alpha-phenylglycine 0
                                    N-acyl-D-amino acid + 62
                                    N-formyl-L-kynurenine + 0
                                    N-formylkynurenine + 0
                                    N-heptanoyl-L-homoserine 0
                                    N-nitrososarcosine 0
                                    beta-alanine derivative + 58
                                    beta-amino acid ester + 131
                                    brivaracetam 0
                                    delta-amino acid ester + 0
                                    homocysteine derivative + 23
                                    methyl 3-[2-(2,6-dichlorophenyl)quinolin-6-yl]alaninate + 0
                                    methyl 5-(hydroxymethyl)pyrrolidine-2-carboxylate 0
                                    methyl N-(2,6-dichlorobenzoyl)-3-(2-phenoxy-6-quinolyl)alaninate 0
                                    methyl N-(2,6-dichlorobenzoyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]-N-methylalaninate 0
                                    methyl N-(2,6-dichlorobenzyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-4-(phenylsulfanyl)-1,2,3,4,4a,8a-hexahydro-6-quinolyl]alaninate 0
                                    methyl N-(tert-butoxycarbonyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate 0
                                    ornithine derivative + 4
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