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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:proteinogenic amino acid derivative
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Accession:CHEBI:83811 term browser browse the term
Definition:Any derivative of a proteinogenic amino acid resulting from reaction at an amino group, carboxy group, or a side-chain functional group, or from the replacement of any hydrogen by a heteroatom.
Synonyms:related_synonym: canonical amino acid derivative;   canonical amino-acid derivatives;   proteinogenic amino-acid derivatives


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aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
cilastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein] CTD PMID:20435919 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP8 caspase 8 multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein] CTD PMID:20435919 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470
JBrowse link
G FASLG Fas ligand (TNF superfamily, member 6) multiple interactions EXP Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein] CTD PMID:20435919 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,475
JBrowse link
folic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CBS cystathionine beta-synthase multiple interactions
increases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein
Folic Acid deficiency results in increased activity of CBS protein
CTD PMID:16792574 NCBI chr13:206,205,942...206,231,363 JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA CTD PMID:14662146 NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155
JBrowse link
G CTH cystathionine gamma-lyase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of CTH protein CTD PMID:16792574 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,435,690...142,486,367
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA CTD PMID:16792574 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions
increases activity
increases expression
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSR protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSR mRNA
Folic Acid deficiency results in increased activity of GSR protein
Folic Acid deficiency results in increased expression of GSR mRNA
CTD PMID:16792574 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,989
JBrowse link
G GSS glutathione synthetase multiple interactions EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA CTD PMID:16792574 NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,304
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 increases expression
multiple interactions
EXP Folic Acid deficiency results in increased expression of GSTA1 mRNA
[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSTA1 mRNA
CTD PMID:16792574 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,567,728
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,636...71,881,820
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP [Folic Acid co-treated with Glycine] results in decreased expression of PTGS1 CTD PMID:14662146 NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Folic Acid co-treated with Glycine] results in increased expression of PTGS2 CTD PMID:14662146 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,566,343...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity
multiple interactions
EXP Folic Acid deficiency results in decreased activity of SOD1 protein
[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA; [Ethanol co-treated with Folic Acid deficiency] results in decreased activity of SOD1 protein
CTD PMID:16792574, PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
increases activity
EXP [Ethanol co-treated with Folic Acid deficiency] results in increased activity of SOD2 protein
Folic Acid deficiency results in increased activity of SOD2 protein; Folic Acid results in increased activity of SOD2 protein
CTD PMID:16792574, PMID:22889112 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
G LOC100739163 glutathione S-transferase P-like multiple interactions EXP GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione] CTD PMID:14573868 NCBI chr 2:4,978,761...4,982,233 JBrowse link
glycine betaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein CTD PMID:29129240 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G DNMT1 DNA methyltransferase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA CTD PMID:28445388 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA CTD PMID:28445388 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA CTD PMID:29129240 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GYS1 glycogen synthase 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter CTD PMID:29065941 NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261
JBrowse link
G LDHA lactate dehydrogenase A multiple interactions EXP [bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter CTD PMID:29065941 NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,812,453...40,826,715
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA CTD PMID:28445388 NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,636...71,881,820
JBrowse link
G SI sucrase-isomaltase multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA CTD PMID:28445388 NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478
JBrowse link
G SLC15A1 solute carrier family 15 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA CTD PMID:28445388 NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933
JBrowse link
G SLC5A1 solute carrier family 5 member 1 multiple interactions EXP [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA CTD PMID:28445388 NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,566,343...48,705,841
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA CTD PMID:29129240 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAX protein] CTD PMID:19135140 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP [Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]] CTD PMID:19135140, PMID:29109043 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BMP15 bone morphogenetic protein 15 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of BMP15 mRNA] CTD PMID:26386189 NCBI chr  X:44,613,122...44,620,575
Ensembl chr  X:44,613,122...44,620,575
JBrowse link
G CASP3 caspase 3 multiple interactions EXP [Acetylcysteine co-treated with Zearalenone] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]] CTD PMID:17383151, PMID:19135140, PMID:29109043 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP9 caspase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP9 protein] CTD PMID:19135140 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:19265715 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]] CTD PMID:29109043 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G DDIT3 DNA damage inducible transcript 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA] CTD PMID:18086661 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA] CTD PMID:18086661 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]] CTD PMID:29109043 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,989
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA] CTD PMID:18086661 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA] CTD PMID:18086661 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:17383151 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:17383151 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC] CTD PMID:12712633 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G PTX3 pentraxin 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA] CTD PMID:26386189 NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569
JBrowse link
G TNFAIP6 TNF alpha induced protein 6 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of TNFAIP6 mRNA] CTD PMID:26386189 NCBI chr15:862,013...881,352
Ensembl chr15:862,013...881,461
JBrowse link
G TP53 tumor protein p53 multiple interactions EXP Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; Acetylcysteine promotes the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]] CTD PMID:29109043 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G ZP3 zona pellucida glycoprotein 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of ZP3 mRNA] CTD PMID:26386189 NCBI chr 3:9,934,760...9,944,924
Ensembl chr 3:9,934,761...9,944,941
JBrowse link
ochratoxin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of AKT1 protein CTD PMID:30287338
G ANXA5 annexin A5 decreases expression EXP ochratoxin A results in decreased expression of ANXA5 mRNA CTD PMID:14994279 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
JBrowse link
G ATG5 autophagy related 5 multiple interactions
increases expression
EXP ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of ATG5 protein
CTD PMID:28699257, PMID:30287338 NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,453
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
affects expression
multiple interactions
EXP ochratoxin A results in decreased expression of BCL2 mRNA
ochratoxin A affects the expression of BCL2 mRNA
TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]
CTD PMID:28528741, PMID:29080797 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression
EXP BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of BECN1 protein
CTD PMID:30287338 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G BRCA1 BRCA1 DNA repair associated increases expression EXP ochratoxin A results in increased expression of BRCA1 protein CTD PMID:32454083 NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,855,570
JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
EXP 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase decreases expression EXP ochratoxin A results in decreased expression of CAT protein CTD PMID:18547704 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CRYAB crystallin alpha B increases expression EXP ochratoxin A results in increased expression of CRYAB mRNA CTD PMID:14994279 NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,502...39,643,530
JBrowse link
G CYP2A19 cytochrome P450 2A19 decreases expression EXP ochratoxin A results in decreased expression of CYP2A6 mRNA CTD PMID:14994279 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107
JBrowse link
G DAD1 defender against cell death 1 decreases expression EXP ochratoxin A results in decreased expression of DAD1 mRNA CTD PMID:14994279 NCBI chr 7:76,432,040...76,457,403
Ensembl chr 7:76,432,029...76,457,192
JBrowse link
G DNMT1 DNA methyltransferase 1 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of DNMT1 mRNA; ochratoxin A results in increased expression of DNMT1 protein
Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]
CTD PMID:29080797, PMID:30923867 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha increases expression EXP ochratoxin A results in increased expression of DNMT3A mRNA CTD PMID:29080797, PMID:30923867 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of GCLC mRNA
ochratoxin A inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]
CTD PMID:18547363 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GLMN glomulin, FKBP associated protein increases expression EXP ochratoxin A results in increased expression of GLMN mRNA CTD PMID:14994279 NCBI chr 4:124,773,957...124,813,336
Ensembl chr 4:124,773,979...124,813,337
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of GSTA1 mRNA
ochratoxin A inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA]
CTD PMID:18547363 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,567,728
JBrowse link
G HDAC1 histone deacetylase 1 multiple interactions
increases expression
EXP Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein]
ochratoxin A results in increased expression of HDAC1 mRNA; ochratoxin A results in increased expression of HDAC1 protein
CTD PMID:29080797 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,412
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression
decreases expression
EXP ochratoxin A results in increased expression of HSP90B1 mRNA
ochratoxin A results in decreased expression of HSP90B1 mRNA
CTD PMID:14994279 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP ochratoxin A results in increased expression of HSPA5 mRNA; ochratoxin A results in increased expression of HSPA5 protein CTD PMID:28699257 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 decreases expression EXP ochratoxin A results in decreased expression of HSPD1 mRNA CTD PMID:14994279 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527
JBrowse link
G ID2 inhibitor of DNA binding 2 decreases expression EXP ochratoxin A results in decreased expression of ID2 mRNA CTD PMID:14994279 NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,759...127,503,257
JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 increases expression EXP ochratoxin A results in increased expression of IGFBP2 mRNA CTD PMID:14994279 NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]] CTD PMID:28528741 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL2 interleukin 2 decreases secretion EXP ochratoxin A results in decreased secretion of IL2 protein CTD PMID:28699257 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G IL4 interleukin 4 increases expression EXP ochratoxin A results in increased expression of IL4 mRNA CTD PMID:14994279 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of IL6 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]
CTD PMID:28710020 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G JAK2 Janus kinase 2 multiple interactions
increases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein] CTD PMID:30923867 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148
JBrowse link
G LOC100522201 histone H2AX multiple interactions
increases expression
EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP ochratoxin A results in increased phosphorylation of MAPK1 protein
ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:28528741, PMID:28699257 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
ochratoxin A results in increased phosphorylation of MAPK3 protein
CTD PMID:28528741, PMID:28699257 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of MTOR protein CTD PMID:30287338 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:28528741 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109
JBrowse link
G NEIL1 nei like DNA glycosylase 1 decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of NEIL1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]
CTD PMID:30923867 NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,761...58,283,092
JBrowse link
G NEIL3 nei like DNA glycosylase 3 multiple interactions
decreases expression
EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA] CTD PMID:30923867 NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,310
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases activity
multiple interactions
decreases expression
EXP ochratoxin A results in decreased activity of NFE2L2 protein
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein]; ochratoxin A inhibits the reaction [sulforafan affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased expression of NFE2L2 mRNA]
ochratoxin A results in decreased expression of NFE2L2 mRNA
CTD PMID:18547363, PMID:18547704, PMID:28710020 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NPM1 nucleophosmin 1 increases expression EXP ochratoxin A results in increased expression of NPM1 mRNA CTD PMID:14994279 NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,296...52,781,740
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of OGG1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]
CTD PMID:30923867 NCBI chr13:66,038,669...66,045,478 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
increases expression
multiple interactions
EXP ochratoxin A results in increased cleavage of PARP1 protein
ochratoxin A results in increased expression of PARP1 protein
3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
CTD PMID:30287338, PMID:32454083 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP ochratoxin A results in decreased expression of PCK1 mRNA; ochratoxin A results in decreased expression of PCK1 protein CTD PMID:3753873 NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,938,896
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP ochratoxin A results in decreased expression of PCNA protein CTD PMID:32454083 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276
JBrowse link
G PFDN5 prefoldin subunit 5 decreases expression EXP ochratoxin A results in decreased expression of PFDN5 mRNA CTD PMID:14994279 NCBI chr 5:18,512,637...18,516,928
Ensembl chr 5:18,512,719...18,525,877
JBrowse link
G PPIA peptidylprolyl isomerase A increases expression EXP ochratoxin A results in increased expression of PPIA mRNA CTD PMID:14994279 NCBI chr18:50,563,130...50,566,857 JBrowse link
G PRDX1 peroxiredoxin 1 decreases expression EXP ochratoxin A results in decreased expression of PRDX1 mRNA CTD PMID:14994279 NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,520...165,861,442
JBrowse link
G PTMA prothymosin alpha decreases expression EXP ochratoxin A results in decreased expression of PTMA mRNA CTD PMID:14994279 NCBI chr15:132,353,763...132,361,442
Ensembl chr15:132,355,655...132,361,435
JBrowse link
G RAD51 RAD51 recombinase increases expression EXP ochratoxin A results in increased expression of RAD51 protein CTD PMID:32454083 NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,647...130,640,136
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:28528741 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G RPA2 replication protein A2 increases expression EXP ochratoxin A results in increased expression of RPA2 protein CTD PMID:32454083 NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,578...85,045,916
JBrowse link
G RPS5 ribosomal protein S5 increases expression EXP ochratoxin A results in increased expression of RPS5 mRNA CTD PMID:14994279 NCBI chr 6:62,967,955...62,974,353
Ensembl chr 6:62,921,635...62,974,354
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of SOCS3 mRNA; ochratoxin A results in increased expression of SOCS3 protein
Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein]
CTD PMID:30923867 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,012
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity EXP ochratoxin A results in decreased activity of SOD1 protein CTD PMID:18547704 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression
EXP Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein] CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G SUMO1 small ubiquitin like modifier 1 decreases expression EXP ochratoxin A results in decreased expression of SUMO1 mRNA CTD PMID:14994279 NCBI chr15:105,820,237...105,850,099
Ensembl chr15:105,815,281...105,850,943
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of TGFB1 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; sulforafan inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]
CTD PMID:28710020 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP ochratoxin A results in increased expression of TIMP2 mRNA CTD PMID:14994279 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
G TJP1 tight junction protein 1 affects localization EXP ochratoxin A affects the localization of TJP1 protein CTD PMID:14994279 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,368...145,195,836
JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:28528741 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
ochratoxin A results in increased secretion of TNF protein
CTD PMID:28528741, PMID:28699257 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein] CTD PMID:28710020, PMID:32454083 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G XPA XPA, DNA damage recognition and repair factor decreases expression EXP ochratoxin A results in decreased expression of XPA mRNA CTD PMID:14994279 NCBI chr 1:239,532,331...239,568,589
Ensembl chr 1:239,532,246...239,568,649
JBrowse link
G XRCC1 X-ray repair cross complementing 1 increases expression EXP ochratoxin A results in increased expression of XRCC1 protein CTD PMID:32454083 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,686...50,425,710
JBrowse link
ochratoxin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases activity EXP ochratoxin B results in decreased activity of NFE2L2 protein CTD PMID:18547704 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
orlistat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNLIP pancreatic lipase decreases activity EXP Orlistat results in decreased activity of PNLIP protein CTD PMID:21438711 NCBI chr14:126,771,920...126,789,097
Ensembl chr14:126,771,920...126,789,160
JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions
decreases expression
EXP Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]; Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 protein]; Ritonavir results in decreased expression of and results in decreased activity of NOS3 protein
Ritonavir results in decreased expression of NOS3 mRNA; Ritonavir results in decreased expression of NOS3 protein
CTD PMID:15681703, PMID:16123675, PMID:22037733 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link
saquinavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases expression EXP Saquinavir results in decreased expression of NOS3 mRNA CTD PMID:16123675 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 860
    chemical entity 860
      atom 845
        nonmetal atom 823
          nitrogen atom 322
            nitrogen molecular entity 322
              organonitrogen compound 309
                proteinogenic amino acid 97
                  proteinogenic amino acid derivative 97
                    L-alanine derivative + 0
                    L-arginine derivative + 0
                    L-asparagine derivative + 1
                    L-aspartic acid derivative + 0
                    L-cysteine derivative + 27
                    L-glutamic acid derivative + 20
                    L-glutamine derivative + 0
                    L-histidine derivative + 0
                    L-isoleucine derivative + 0
                    L-leucine derivative + 1
                    L-lysine derivative + 0
                    L-methionine derivative + 0
                    L-phenylalanine derivative + 61
                    L-proline derivative + 0
                    L-selenocysteine derivative + 0
                    L-serine derivative + 0
                    L-threonine derivative + 0
                    L-tryptophan derivative + 0
                    L-tyrosine derivative + 0
                    L-valine derivative + 1
                    glycine derivative + 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 860
    subatomic particle 845
      composite particle 845
        hadron 845
          baryon 845
            nucleon 845
              atomic nucleus 845
                atom 845
                  main group element atom 834
                    p-block element atom 831
                      carbon group element atom 805
                        carbon atom 804
                          organic molecular entity 804
                            organic group 380
                              organic divalent group 378
                                organodiyl group 378
                                  carbonyl group 377
                                    carbonyl compound 377
                                      carboxylic acid 255
                                        proteinogenic amino acid 97
                                          proteinogenic amino acid derivative 97
                                            L-alanine derivative + 0
                                            L-arginine derivative + 0
                                            L-asparagine derivative + 1
                                            L-aspartic acid derivative + 0
                                            L-cysteine derivative + 27
                                            L-glutamic acid derivative + 20
                                            L-glutamine derivative + 0
                                            L-histidine derivative + 0
                                            L-isoleucine derivative + 0
                                            L-leucine derivative + 1
                                            L-lysine derivative + 0
                                            L-methionine derivative + 0
                                            L-phenylalanine derivative + 61
                                            L-proline derivative + 0
                                            L-selenocysteine derivative + 0
                                            L-serine derivative + 0
                                            L-threonine derivative + 0
                                            L-tryptophan derivative + 0
                                            L-tyrosine derivative + 0
                                            L-valine derivative + 1
                                            glycine derivative + 11
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.