Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:galaxolide
go back to main search page
Accession:CHEBI:83784 term browser browse the term
Definition:An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.
Synonyms:exact_synonym: 4,6,6,7,8,8-hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene
 related_synonym: 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran;   1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran;   Formula=C18H26O;   InChI=1S/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3;   InChIKey=ONKNPOPIGWHAQC-UHFFFAOYSA-N;   SMILES=CC1C(C)(C)c2cc3COCC(C)c3cc2C1(C)C
 xref: CAS:1222-05-5
 xref_mesh: MESH:C033119
 xref: PMID:22489002;   PMID:24357097;   PMID:24659337;   PMID:24845313;   Patent:CN103784385;   Patent:CN103911214;   Reaxys:8147764;   Wikipedia:Galaxolide



show annotations for term's descendants           Sort by:
 
galaxolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO galaxolide binds to and results in decreased activity of AR protein; galaxolide inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:15537743 PMID:17762842 PMID:29427707 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO galaxolide results in decreased activity of CES1 protein CTD PMID:22489002 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions
increases activity
decreases activity
ISO [galaxolide co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein; [galaxolide co-treated with Cyclic AMP] results in increased activity of CYP17A1 protein
galaxolide results in increased activity of CYP17A1 protein
galaxolide results in decreased activity of CYP17A1 protein
CTD PMID:23084589 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO galaxolide binds to and results in increased activity of ESR1 protein CTD PMID:17762842 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO galaxolide binds to and results in decreased activity of ESR2 protein CTD PMID:15537743 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression
ISO [galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Hydrocortisone; [galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Progesterone
galaxolide results in decreased expression of HSD3B2
CTD PMID:23084589 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852
JBrowse link
G Pgr progesterone receptor multiple interactions ISO galaxolide binds to and results in decreased activity of PGR protein CTD PMID:15537743 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    role 19746
      application 19492
        fragrance 900
          galaxolide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      carbon group element atom 19614
                        carbon atom 19604
                          organic molecular entity 19604
                            organic molecule 19545
                              organic cyclic compound 19339
                                organic heterocyclic compound 18579
                                  oxacycle 17602
                                    benzopyran 11160
                                      2-benzopyran 1383
                                        isochromenes 1383
                                          galaxolide 7
paths to the root