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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:galaxolide
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Accession:CHEBI:83784 term browser browse the term
Definition:An organic heterotricyclic compound that is 1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene substituted by methyl groups at positions 4, 6, 6, 7, 8 and 8 respectively. It is a synthetic musk used as a fragrance in cosmetics.
Synonyms:exact_synonym: 4,6,6,7,8,8-hexamethyl-1,3,4,6,7,8-hexahydrocyclopenta[g]isochromene
 related_synonym: 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl-cyclopenta-gamma-2-benzopyran;   1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylindeno[5,6-c]pyran;   Formula=C18H26O;   InChI=1S/C18H26O/c1-11-9-19-10-13-7-15-16(8-14(11)13)18(5,6)12(2)17(15,3)4/h7-8,11-12H,9-10H2,1-6H3;   InChIKey=ONKNPOPIGWHAQC-UHFFFAOYSA-N;   SMILES=CC1C(C)(C)c2cc3COCC(C)c3cc2C1(C)C
 xref: CAS:1222-05-5
 xref_mesh: MESH:C033119
 xref: PMID:22489002;   PMID:24357097;   PMID:24659337;   PMID:24845313;   Patent:CN103784385;   Patent:CN103911214;   Reaxys:8147764;   Wikipedia:Galaxolide


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galaxolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO galaxolide binds to and results in decreased activity of AR protein; galaxolide inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:15537743 PMID:17762842 PMID:29427707 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ces1d carboxylesterase 1D decreases activity ISO galaxolide results in decreased activity of CES1 protein CTD PMID:22489002 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions
increases activity
decreases activity
ISO [galaxolide co-treated with Cyclic AMP] results in decreased activity of CYP17A1 protein; [galaxolide co-treated with Cyclic AMP] results in increased activity of CYP17A1 protein
galaxolide results in increased activity of CYP17A1 protein
galaxolide results in decreased activity of CYP17A1 protein
CTD PMID:23084589 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO galaxolide binds to and results in increased activity of ESR1 protein CTD PMID:17762842 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO galaxolide binds to and results in decreased activity of ESR2 protein CTD PMID:15537743 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions
decreases expression
ISO [galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Hydrocortisone; [galaxolide results in decreased expression of [HSD3B2 co-treated with CYP21A2]] which results in decreased chemical synthesis of Progesterone
galaxolide results in decreased expression of HSD3B2
CTD PMID:23084589 NCBI chr 2:200,712,895...200,722,429
Ensembl chr 2:202,341,422...202,350,929
JBrowse link
G Pgr progesterone receptor multiple interactions ISO galaxolide binds to and results in decreased activity of PGR protein CTD PMID:15537743 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link

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  CHEBI ontology 19770
    role 19720
      application 19411
        fragrance 868
          galaxolide 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic molecule 19504
                              organic cyclic compound 19331
                                organic heterocyclic compound 18519
                                  oxacycle 17539
                                    benzopyran 10267
                                      2-benzopyran 1353
                                        isochromenes 1353
                                          galaxolide 7
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