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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prednisolone
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Accession:CHEBI:8378 term browser browse the term
Definition:A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Synonyms:exact_synonym: 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
 related_synonym: (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;   1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol;   3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene;   Delta(1)-dehydrocortisol;   Delta(1)-dehydrohydrocortisone;   Delta(1)-hydrocortisone;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1;   InChIKey=OIGNJSKKLXVSLS-VWUMJDOOSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   hydroretrocortine;   metacortandralone;   prednisolona;   prednisolonum
 xref: Beilstein:1354103;   CAS:50-24-8;   DrugBank:DB00860;   Drug_Central:2245;   HMDB:HMDB0014998;   KEGG:C07369;   KEGG:D00472
 xref_mesh: MESH:D011239
 xref: PMID:11294518;   PMID:23625982;   PMID:24392764;   Reaxys:1354103;   VSDB:1848;   Wikipedia:Prednisolone


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prednisolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Prednisolone results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO Prednisolone results in increased expression of ACSL1 mRNA CTD PMID:17379860 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Prednisolone results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Prednisolone results in increased activity of AHR protein CTD PMID:30203046 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of AKR1B7 mRNA] CTD PMID:21149847 NCBI chr 4:61,850,256...61,879,733
Ensembl chr 4:61,850,348...61,862,526
JBrowse link
G Alb albumin increases expression
multiple interactions
decreases secretion
ISO
EXP
Prednisolone results in increased expression of ALB protein
montelukast inhibits the reaction [Prednisolone results in decreased secretion of ALB protein]
CTD PMID:3404815, PMID:30276927 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Prednisolone results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:138,704,124...138,707,221
Ensembl chr 7:138,704,126...138,707,221
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Prednisolone results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:118,946,267...119,131,202
Ensembl chr 4:118,946,268...119,131,202
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Prednisolone results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
ISO Prednisolone binds to and results in decreased activity of AR protein; Prednisolone binds to and results in increased activity of AR protein; Prednisolone binds to and results in increased activity of AR protein mutant form
[Phenytoin co-treated with Prednisolone] results in increased expression of AR protein
Prednisolone results in increased expression of AR mRNA; Prednisolone results in increased expression of AR protein
CTD PMID:11956172, PMID:19490052, PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 decreases expression ISO Prednisolone results in decreased expression of ARHGAP45 mRNA CTD PMID:21621594 NCBI chr 7:12,541,032...12,741,314
Ensembl chr 7:12,541,061...12,741,296
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases expression ISO Prednisolone results in increased expression of ARNTL mRNA CTD PMID:16269518 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Prednisolone results in increased expression of ARRDC3 mRNA CTD PMID:24356939 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Prednisolone results in decreased expression of ASNS mRNA CTD PMID:19192274 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Prednisolone results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Prednisolone results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Prednisolone results in increased expression of CASP3 protein
montelukast inhibits the reaction [Prednisolone results in increased expression of CASP3 protein]
CTD PMID:30276927 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Prednisolone results in decreased activity of CAT protein
[Prednisolone co-treated with pirfenidone] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; montelukast inhibits the reaction [Prednisolone results in decreased activity of CAT protein]
CTD PMID:28921394, PMID:30276927 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cbll1 Cbl proto-oncogene like 1 decreases expression ISO Prednisolone results in decreased expression of CBLL1 mRNA CTD PMID:21621594 NCBI chr 6:50,772,718...50,786,861
Ensembl chr 6:50,772,829...50,786,967
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA] CTD PMID:23133493 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Prednisolone results in decreased expression of CCL2 protein
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL2 mRNA]
CTD PMID:20116850, PMID:23133493 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Prednisolone results in decreased expression of CCL20 mRNA; Prednisolone results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Prednisolone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Prednisolone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Prednisolone results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Prednisolone results in increased expression of CCN2 mRNA CTD PMID:19192274 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Prednisolone results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Prednisolone results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCR3 mRNA] CTD PMID:23133493 NCBI chr 8:133,026,539...133,040,999
Ensembl chr 8:133,029,625...133,040,997
JBrowse link
G Cd34 CD34 molecule multiple interactions ISO [Melphalan co-treated with Prednisolone] results in decreased expression of CD34 protein CTD PMID:10618687 NCBI chr13:113,691,842...113,711,259
Ensembl chr13:113,691,932...113,711,647
JBrowse link
G Cd84 CD84 molecule increases expression ISO Prednisolone results in increased expression of CD84 mRNA CTD PMID:24356939 NCBI chr13:90,241,369...90,283,625
Ensembl chr13:90,244,681...90,277,865
JBrowse link
G Clgn calmegin decreases expression ISO Prednisolone results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:24,545,257...24,578,527
Ensembl chr19:24,545,318...24,576,798
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Prednisolone results in increased expression of COL1A1 mRNA CTD PMID:19192274 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Crh corticotropin releasing hormone decreases expression
multiple interactions
EXP Prednisolone results in decreased expression of CRH protein
sairei-to inhibits the reaction [Prednisolone results in decreased expression of CRH protein]
CTD PMID:9625448 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 increases expression ISO Prednisolone results in increased expression of CRIM1 mRNA CTD PMID:24356939 NCBI chr 6:788,490...962,663
Ensembl chr 6:788,548...960,703
JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Prednisolone results in decreased expression of CRY1 mRNA CTD PMID:16269518 NCBI chr 7:24,534,593...24,634,098
Ensembl chr 7:24,534,615...24,634,097
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Prednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Prednisolone results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Prednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO Prednisolone results in decreased expression of CXCR2 protein CTD PMID:15804745 NCBI chr 9:81,427,275...81,435,065
Ensembl chr 9:81,427,730...81,434,102
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Prednisolone results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of CYP2C19 mRNA] CTD PMID:21149847 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Prednisolone results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression ISO Prednisolone results in decreased expression of DBP mRNA CTD PMID:16269518 NCBI chr 1:101,687,896...101,692,845
Ensembl chr 1:101,687,855...101,692,846
JBrowse link
G Ddx58 DEXD/H-box helicase 58 decreases expression ISO Prednisolone results in decreased expression of DDX58 mRNA CTD PMID:19192274 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Prednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Prednisolone results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014
JBrowse link
G Fbln1 fibulin 1 increases expression ISO Prednisolone results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases expression ISO Prednisolone results in increased expression of FMO2 mRNA CTD PMID:21621594 NCBI chr13:80,752,526...80,775,264
Ensembl chr13:80,755,058...80,775,264
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Prednisolone results in decreased expression of GBP1 mRNA CTD PMID:19192274, PMID:21621594 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gdf5 growth differentiation factor 5 decreases expression ISO Prednisolone results in decreased expression of GDF5 mRNA CTD PMID:18830904 NCBI chr 3:151,482,672...151,487,129
Ensembl chr 3:151,483,249...151,486,693
JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression ISO Prednisolone results in increased expression of GJB1 mRNA CTD PMID:21621594 NCBI chr  X:71,272,030...71,279,973
Ensembl chr  X:71,272,042...71,279,977
JBrowse link
G Gm2a GM2 ganglioside activator increases expression ISO Prednisolone results in increased expression of GM2A mRNA CTD PMID:17379860 NCBI chr10:40,438,394...40,450,927
Ensembl chr10:40,438,356...40,450,930
JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Prednisolone results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:29,604,607...29,751,174
Ensembl chr  X:29,607,075...29,648,403
JBrowse link
G Gsdme gasdermin E decreases expression ISO Prednisolone results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:79,934,075...79,999,678
Ensembl chr 4:79,934,887...79,989,572
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Prednisolone results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Prednisolone results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO Prednisolone results in increased expression of and results in increased activity of HPGD protein CTD PMID:15680906 NCBI chr16:37,457,134...37,495,758
Ensembl chr16:37,457,135...37,495,758
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Prednisolone results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases metabolic processing ISO HSD11B2 protein results in increased metabolism of Prednisolone CTD PMID:16549198 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Prednisolone results in increased expression of ID3 mRNA CTD PMID:19192274 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Prednisolone results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Prednisolone results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Prednisolone results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Prednisolone results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Prednisolone results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO
EXP
Prednisolone results in decreased expression of IFNG protein
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG mRNA]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG protein]
Prednisolone results in decreased expression of IFNG mRNA
CTD PMID:11043609, PMID:15821026, PMID:23133493 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance
increases expression
ISO Prednisolone results in decreased susceptibility to IGF1 protein
Prednisolone results in increased expression of IGF1 protein
CTD PMID:16079165 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Ighe immunoglobulin heavy constant epsilon decreases expression ISO Prednisolone results in decreased expression of IGHE protein CTD PMID:15821026 NCBI chr 6:138,066,728...138,068,606 JBrowse link
G Il10 interleukin 10 decreases expression
decreases secretion
ISO Prednisolone results in decreased expression of IL10 protein
Prednisolone results in decreased secretion of IL10 protein
CTD PMID:15821026, PMID:28003376 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il12b interleukin 12B decreases secretion ISO Prednisolone results in decreased secretion of IL12B protein CTD PMID:28003376 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 protein] CTD PMID:23133493 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL17A mRNA] CTD PMID:23133493 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 NCBI chr 8:55,009,666...55,016,286
Ensembl chr 8:54,993,859...55,016,299
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases secretion
decreases expression
ISO
EXP
Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]
Prednisolone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Prednisolone results in decreased secretion of IL1B protein
Prednisolone results in decreased expression of IL1B mRNA
Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
CTD PMID:9259316, PMID:16442096, PMID:17379860, PMID:22119283 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Prednisolone results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2 interleukin 2 decreases expression ISO Prednisolone results in decreased expression of IL2 protein CTD PMID:15821026 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Prednisolone results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 mRNA]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 protein]; Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]
Prednisolone results in decreased expression of IL4 protein
CTD PMID:15821026, PMID:16442096, PMID:23133493 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 decreases expression
multiple interactions
ISO Prednisolone results in decreased expression of IL5 protein
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL5 mRNA]
CTD PMID:15821026, PMID:23133493 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
Prednisolone inhibits the reaction [Amiodarone results in increased secretion of IL6 protein]
Prednisolone results in decreased expression of IL6 mRNA; Prednisolone results in decreased expression of IL6 protein
Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL6 protein]
CTD PMID:11043609, PMID:11288978, PMID:16442096, PMID:19192274 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Prednisolone results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Prednisolone results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Prednisolone results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Prednisolone results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:84,613,101...84,643,674
Ensembl chr11:84,615,760...84,633,504
JBrowse link
G Kmt2a lysine methyltransferase 2A decreases response to substance ISO KMT2A gene mutant form results in decreased susceptibility to Prednisolone CTD PMID:14712291 NCBI chr 8:49,110,407...49,185,872
Ensembl chr 8:49,114,990...49,158,971
JBrowse link
G Krt8 keratin 8 increases expression ISO Prednisolone results in increased expression of KRT8 mRNA CTD PMID:21621594 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Prednisolone results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186
JBrowse link
G Lcn2 lipocalin 2 decreases secretion ISO Prednisolone results in decreased secretion of LCN2 protein CTD PMID:28003376 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Ltf lactotransferrin decreases expression ISO Prednisolone results in decreased expression of LTF mRNA CTD PMID:21621594 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Prednisolone results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Ly96 lymphocyte antigen 96 decreases expression ISO Prednisolone results in decreased expression of LY96 mRNA CTD PMID:17379860 NCBI chr 5:1,972,212...1,989,448 JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Prednisolone results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Prednisolone results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Prednisolone results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Prednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]]; Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA] CTD PMID:28921394 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein] CTD PMID:22119283 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
Prednisolone inhibits the reaction [Picryl Chloride results in increased activity of MPO protein]
Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD PMID:16442096, PMID:22119283 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Muc16 mucin 16, cell surface associated decreases expression ISO Prednisolone results in decreased expression of MUC16 protein CTD PMID:12169874 NCBI chr 8:18,438,838...18,639,777 JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression ISO Prednisolone results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Prednisolone results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:70,821,904...70,824,085
Ensembl chr 7:70,821,957...70,824,085
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Prednisolone results in increased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nid2 nidogen 2 increases expression ISO Prednisolone results in increased expression of NID2 mRNA CTD PMID:19192274 NCBI chr15:4,893,999...4,951,893
Ensembl chr15:4,894,213...4,951,917
JBrowse link
G Nmb neuromedin B decreases expression ISO Prednisolone results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Prednisolone results in increased expression of NOS2 protein
montelukast inhibits the reaction [Prednisolone results in increased expression of NOS2 protein]
CTD PMID:30276927 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO Prednisolone results in decreased expression of NR1D1 mRNA CTD PMID:16269518 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects response to substance
increases activity
affects binding
multiple interactions
ISO NR3C1 protein alternative form affects the susceptibility to Prednisolone
Prednisolone results in increased activity of NR3C1 protein
Prednisolone binds to NR3C1 protein
NR3C1 protein alternative form inhibits the reaction [Prednisolone results in increased activity of NR3C1 protein alternative form]; Prednisolone binds to and results in increased activity of NR3C1 protein
CTD PMID:11956172, PMID:14694204, PMID:15362971, PMID:15704223, PMID:15705660, PMID:15755863 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Prednisolone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Prednisolone results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Prednisolone results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Prednisolone results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Olfml2b olfactomedin-like 2B increases expression ISO Prednisolone results in increased expression of OLFML2B mRNA CTD PMID:19192274 NCBI chr13:88,995,301...89,032,487
Ensembl chr13:88,995,316...89,032,487
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Prednisolone results in increased expression of PCK1 mRNA CTD PMID:20065017 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Prednisolone results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:274,616,625...274,648,204
Ensembl chr 1:274,625,224...274,648,204
JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression ISO Prednisolone results in increased expression of PDLIM1 mRNA CTD PMID:17379860 NCBI chr 1:259,308,326...259,357,006
Ensembl chr 1:259,308,296...259,357,056
JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Prednisolone results in increased expression of PER1 mRNA; Prednisolone results in increased expression of PER1 protein CTD PMID:16269518 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Per2 period circadian regulator 2 decreases expression ISO Prednisolone results in decreased expression of PER2 mRNA CTD PMID:16269518 NCBI chr 9:98,555,154...98,597,362
Ensembl chr 9:98,555,169...98,597,359
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Prednisolone results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha decreases expression ISO Prednisolone results in decreased expression of PILRA mRNA CTD PMID:19192274 NCBI chr12:21,412,598...21,418,621
Ensembl chr12:21,412,538...21,420,169
JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Prednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:64,882,024...64,919,714
Ensembl chr11:64,882,288...64,919,579
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Prednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA] CTD PMID:20573295 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plcl1 phospholipase C-like 1 increases expression ISO Prednisolone results in increased expression of PLCL1 mRNA CTD PMID:24356939 NCBI chr 9:62,016,112...62,349,244
Ensembl chr 9:62,291,405...62,349,309
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Prednisolone results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions
EXP Prednisolone results in decreased expression of POMC protein; Prednisolone results in decreased expression of POMC protein modified form
sairei-to inhibits the reaction [Prednisolone results in decreased expression of POMC protein modified form]
CTD PMID:9625448, PMID:14694204 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP Prednisolone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein] CTD PMID:18577381 NCBI chr 1:87,224,683...87,232,842
Ensembl chr 1:87,224,677...87,232,848
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein increases expression ISO Prednisolone results in increased expression of PRELP mRNA CTD PMID:19192274 NCBI chr13:50,749,526...50,773,934
Ensembl chr13:50,749,514...50,761,355
JBrowse link
G Prlr prolactin receptor multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of PRLR mRNA] CTD PMID:21149847 NCBI chr 2:60,131,410...60,325,686
Ensembl chr 2:60,131,776...60,325,692
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Prednisolone results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rdh16 retinol dehydrogenase 16 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of RDH2 mRNA] CTD PMID:21149847 NCBI chr 7:71,058,150...71,072,685
Ensembl chr 7:70,980,422...71,072,689
JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions
decreases expression
EXP
ISO
Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of RGS4 mRNA]
Prednisolone results in decreased expression of RGS4 mRNA
CTD PMID:19192274, PMID:21149847 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]; Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA] CTD PMID:18391481 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Prednisolone results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Prednisolone results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:147,246,032...147,270,892
Ensembl chr 5:147,246,037...147,270,957
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Prednisolone results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Scg2 secretogranin II multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of SCG2 mRNA] CTD PMID:21149847 NCBI chr 9:85,237,460...85,243,024
Ensembl chr 9:85,237,458...85,243,001
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of SLC22A8 mRNA] CTD PMID:21149847 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Prednisolone results in decreased expression of SLC43A3 mRNA CTD PMID:19192274 NCBI chr 3:72,328,912...72,351,039
Ensembl chr 3:72,329,967...72,351,111
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
decreases expression
ISO Prednisolone results in increased expression of SLC7A11 mRNA
Prednisolone results in decreased expression of SLC7A11 mRNA
CTD PMID:19192274, PMID:24356939 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Slc7a8 solute carrier family 7 member 8 increases expression ISO Prednisolone results in increased expression of SLC7A8 mRNA CTD PMID:19192274 NCBI chr15:33,369,245...33,428,942
Ensembl chr15:33,369,216...33,428,973
JBrowse link
G Sms spermine synthase decreases expression ISO Prednisolone results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:40,363,646...40,415,110
Ensembl chr  X:40,363,646...40,415,109
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Prednisolone results in decreased expression of SOD2 mRNA CTD PMID:19192274 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO Prednisolone results in decreased expression of SOX9 mRNA CTD PMID:17379860 NCBI chr10:101,288,528...101,294,030
Ensembl chr10:101,288,489...101,293,379
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 decreases expression ISO Prednisolone results in decreased expression of SRSF7 mRNA CTD PMID:21621594 NCBI chr 6:2,879,312...2,886,505
Ensembl chr 6:2,880,518...2,886,465
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Prednisolone results in increased expression of SRXN1 mRNA CTD PMID:24356939 NCBI chr 3:147,608,850...147,614,410
Ensembl chr 3:147,609,095...147,632,801
JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Prednisolone results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Sts steroid sulfatase increases expression ISO Prednisolone results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tafa5 TAFA chemokine like family member 5 increases expression ISO Prednisolone results in increased expression of TAFA5 mRNA CTD PMID:21621594 NCBI chr 7:128,500,009...128,728,834
Ensembl chr 7:128,500,011...128,728,928
JBrowse link
G Tat tyrosine aminotransferase multiple interactions
increases activity
increases expression
EXP
ISO
(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased activity of TAT protein]; (3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased expression of TAT mRNA] CTD PMID:9259316, PMID:14694204, PMID:15784656 NCBI chr19:41,675,639...41,686,195
Ensembl chr19:41,675,355...41,686,229
JBrowse link
G Tex261 testis expressed 261 decreases expression ISO Prednisolone results in decreased expression of TEX261 mRNA CTD PMID:21621594 NCBI chr 4:115,446,830...115,454,035
Ensembl chr 4:115,448,708...115,453,659
JBrowse link
G Tf transferrin increases expression ISO Prednisolone results in increased expression of TF protein CTD PMID:3404815 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 decreases expression ISO Prednisolone results in decreased expression of TFPI2 mRNA CTD PMID:17379860 NCBI chr 4:28,947,951...28,953,261
Ensembl chr 4:28,947,965...28,953,067
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO
EXP
Prednisolone results in decreased expression of TGFB1 protein
pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
CTD PMID:11728950, PMID:28921394 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Prednisolone results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA] CTD PMID:28921394 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Prednisolone results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
decreases expression
ISO
EXP
Prednisolone results in increased expression of TNF mRNA
Prednisolone inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]
[pirfenidone co-treated with Prednisolone] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Prednisolone results in decreased expression of TNF mRNA
CTD PMID:11043609, PMID:19233868, PMID:20054000, PMID:22119283, PMID:28921394 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Prednisolone results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:135,890,869...135,903,647
Ensembl chr 6:135,890,931...135,903,647
JBrowse link
G Trim63 tripartite motif containing 63 increases expression ISO Prednisolone results in increased expression of TRIM63 mRNA CTD PMID:20065017 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Prednisolone results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Prednisolone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO Prednisolone results in increased expression of VLDLR mRNA CTD PMID:24356939 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
JBrowse link
6alpha-methylprednisolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases secretion
ISO ABCB1 gene polymorphism affects the susceptibility to [Methotrexate co-treated with Methylprednisolone]; ABCB1 protein results in increased susceptibility to [Methotrexate co-treated with Methylprednisolone]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]
Methylprednisolone results in increased expression of ABCB1 mRNA; Methylprednisolone results in increased expression of ABCB1 protein
CTD PMID:16932953, PMID:22079615, PMID:22464980 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Methylprednisolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:15365089 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Methylprednisolone results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:97,355,881...97,367,455
Ensembl chr 9:97,355,924...97,367,445
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Methylprednisolone results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP Methylprednisolone results in decreased phosphorylation of AKT1 protein
naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]
CTD PMID:15187100, PMID:30878453 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases secretion
EXP Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Methylprednisolone results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:138,704,124...138,707,221
Ensembl chr 7:138,704,126...138,707,221
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Methylprednisolone results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:118,946,267...119,131,202
Ensembl chr 4:118,946,268...119,131,202
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Methylprednisolone results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:64,929,682...65,007,872
Ensembl chr 9:64,929,721...65,007,870
JBrowse link
G Ar androgen receptor multiple interactions ISO Methylprednisolone binds to and results in decreased activity of AR protein; Methylprednisolone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Methylprednisolone results in decreased expression of ASNS mRNA CTD PMID:19192274 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX protein] CTD PMID:17570061, PMID:26093215 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:17570061 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Methylprednisolone results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:96,551,424...96,559,527
Ensembl chr 8:96,551,245...96,559,483
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases secretion
multiple interactions
EXP Methylprednisolone results in decreased secretion of BGLAP protein
[Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein]
CTD PMID:30291735 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Methylprednisolone results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:19,938,781...19,942,353
Ensembl chr16:19,938,784...19,942,353
JBrowse link
G Capn2 calpain 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein] CTD PMID:17570061 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17570061 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]]
Methylprednisolone results in increased activity of CAT protein
CTD PMID:1942778, PMID:30291735 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Methylprednisolone results in decreased expression of CCL20 mRNA; Methylprednisolone results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Methylprednisolone results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Methylprednisolone results in increased expression of CCN2 mRNA CTD PMID:19192274 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Methylprednisolone results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:160,207,969...160,219,316
Ensembl chr 3:160,207,913...160,219,331
JBrowse link
G Clgn calmegin decreases expression ISO Methylprednisolone results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:24,545,257...24,578,527
Ensembl chr19:24,545,318...24,576,798
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]
Methylprednisolone results in increased expression of COL1A1 mRNA
CTD PMID:19192274, PMID:26093215 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA] CTD PMID:1762292 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 NCBI chr 1:215,541,570...215,553,446
Ensembl chr 1:215,541,542...215,553,451
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Methylprednisolone results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Methylprednisolone results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of DDIT4 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of DDIT4 protein]
CTD PMID:21931329 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddx58 DEXD/H-box helicase 58 decreases expression ISO Methylprednisolone results in decreased expression of DDX58 mRNA CTD PMID:19192274 NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Methylprednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 NCBI chr 6:114,475,156...114,489,443
Ensembl chr 6:114,476,142...114,476,723
JBrowse link
G Dmd dystrophin multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:51,149,358...53,519,271
Ensembl chr  X:51,286,737...53,519,259
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:7756592 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA] CTD PMID:7756592 NCBI chr15:88,004,775...88,036,354
Ensembl chr15:88,006,977...88,036,354
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Methylprednisolone results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:113,202,382...113,294,993
Ensembl chr14:113,202,419...113,295,014
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Methylprednisolone binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G F8 coagulation factor VIII increases expression ISO Methylprednisolone results in increased expression of F8 protein CTD PMID:20405515 NCBI chr18:367,862...399,242
Ensembl chr18:367,862...399,242
JBrowse link
G Fbln1 fibulin 1 increases expression ISO Methylprednisolone results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:126,096,793...126,176,468
Ensembl chr 7:126,096,793...126,176,468
JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of FBXO32 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FBXO32 protein]
CTD PMID:21931329 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fcer2 Fc fragment of IgE receptor II multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein] CTD PMID:11997017 NCBI chr12:2,233,772...2,245,324
Ensembl chr12:2,233,778...2,245,324
JBrowse link
G Foxo1 forkhead box O1 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of FOXO1 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]
CTD PMID:21931329 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Methylprednisolone results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Methylprednisolone results in decreased expression of GFAP protein CTD PMID:18509235 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Methylprednisolone results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:29,604,607...29,751,174
Ensembl chr  X:29,607,075...29,648,403
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] CTD PMID:30891624 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity
EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein
Methylprednisolone results in increased activity of GPX1 protein
CTD PMID:1942778 NCBI chr 8:117,117,430...117,118,528
Ensembl chr 8:117,117,430...117,118,522
JBrowse link
G Gsdme gasdermin E decreases expression ISO Methylprednisolone results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:79,934,075...79,999,678
Ensembl chr 4:79,934,887...79,989,572
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Methylprednisolone results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:88,606,851...88,649,424
Ensembl chr 4:88,607,518...88,649,216
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO Methylprednisolone results in decreased expression of HILPDA mRNA CTD PMID:19192274 NCBI chr 4:56,547,600...56,550,584
Ensembl chr 4:56,549,739...56,549,993
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA] CTD PMID:26093215 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Methylprednisolone results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
decreases activity
ISO [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with ramosetron] results in decreased activity of HTR3A protein
Methylprednisolone results in decreased activity of HTR3A protein
CTD PMID:15329590 NCBI chr 8:53,211,436...53,223,878
Ensembl chr 8:53,211,438...53,223,804
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Methylprednisolone results in increased expression of ID3 mRNA CTD PMID:19192274 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Methylprednisolone results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:127,327,959...127,334,430
Ensembl chr 6:127,327,959...127,334,428
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Methylprednisolone results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:89,358,376...89,366,628
Ensembl chr10:89,358,376...89,366,626
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Methylprednisolone results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:256,897,765...256,915,591
Ensembl chr 2:256,897,772...256,915,569
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Methylprednisolone results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:256,948,722...256,979,573
Ensembl chr 2:256,964,860...256,978,668
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Methylprednisolone results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Methylprednisolone results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
JBrowse link
G Il10 interleukin 10 increases expression ISO Methylprednisolone results in increased expression of IL10 protein CTD PMID:28557239 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA] CTD PMID:26093215 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Methylprednisolone results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Methylprednisolone results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]
Methylprednisolone results in decreased expression of IL4 protein
CTD PMID:7988651, PMID:11997017 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein] CTD PMID:11997017 NCBI chr 1:196,942,343...196,967,221
Ensembl chr 1:196,942,364...196,967,220
JBrowse link
G Il5 interleukin 5 decreases expression ISO Methylprednisolone results in decreased expression of IL5 protein CTD PMID:7988651 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]
Methylprednisolone results in decreased expression of IL6 mRNA; Methylprednisolone results in decreased expression of IL6 protein
CTD PMID:19192274, PMID:26093215 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Methylprednisolone results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Methylprednisolone results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:173,624,862...173,629,124
Ensembl chr 5:173,624,310...173,626,248
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Methylprednisolone results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:140,602,553...140,608,892
Ensembl chr 1:140,601,791...140,608,946
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein] CTD PMID:11997017 NCBI chr 5:119,982,503...120,091,452
Ensembl chr 5:119,982,943...120,083,904
JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:1762292 NCBI chr 6:50,528,796...50,596,593
Ensembl chr 6:50,528,823...50,596,079
JBrowse link
G Lamb2 laminin subunit beta 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:1762292 NCBI chr 8:117,268,335...117,280,517
Ensembl chr 8:117,268,337...117,280,517
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Methylprednisolone results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:112,031,614...112,073,187
Ensembl chr13:112,031,594...112,073,186
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Methylprednisolone results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:116,355,426...116,359,862
Ensembl chr 7:116,355,698...116,359,862
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
EXP cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased expression of MAPK1 protein modified form]; cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased phosphorylation of MAPK1 protein] CTD PMID:12904460 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Methylprednisolone results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:42,966,140...42,971,838
Ensembl chr20:42,966,140...42,971,838
JBrowse link
G Mbp myelin basic protein decreases expression ISO Methylprednisolone results in decreased expression of MBP protein CTD PMID:18509235 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Methylprednisolone results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:44,747,467...44,854,628
Ensembl chr 4:44,774,741...44,852,665
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Methylprednisolone results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Methylprednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:5,594,717...5,616,494
Ensembl chr 8:5,606,592...5,616,493
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MPO protein]
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]
Methylprednisolone results in decreased expression of MPO protein
CTD PMID:26093215, PMID:28557239, PMID:30891624 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA] CTD PMID:26093215 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Mx2 MX dynamin like GTPase 2 decreases expression ISO Methylprednisolone results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:38,035,306...38,066,185
Ensembl chr11:38,035,450...38,059,950
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Methylprednisolone results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:70,821,904...70,824,085
Ensembl chr 7:70,821,957...70,824,085
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA] CTD PMID:26093215 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of NFKB1 mRNA] CTD PMID:26093215 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nid2 nidogen 2 increases expression ISO Methylprednisolone results in increased expression of NID2 mRNA CTD PMID:19192274 NCBI chr15:4,893,999...4,951,893
Ensembl chr15:4,894,213...4,951,917
JBrowse link
G Nmb neuromedin B decreases expression ISO Methylprednisolone results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22422321 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Methylprednisolone results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Methylprednisolone results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:41,200,680...41,211,393
Ensembl chr12:41,200,718...41,211,909
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Methylprednisolone results in decreased expression of OAS3 mRNA CTD PMID:19192274 NCBI chr12:41,313,081...41,368,217
Ensembl chr12:41,316,764...41,336,562
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Methylprednisolone results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:47,444,138...47,456,680
Ensembl chr12:47,444,104...47,456,894
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Methylprednisolone results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:64,882,024...64,919,714
Ensembl chr11:64,882,288...64,919,579
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA] CTD PMID:20573295 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Methylprednisolone results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:124,690,214...124,765,499
Ensembl chr 5:124,690,214...124,765,498
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein increases expression ISO Methylprednisolone results in increased expression of PRELP mRNA CTD PMID:19192274 NCBI chr13:50,749,526...50,773,934
Ensembl chr13:50,749,514...50,761,355
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Methylprednisolone results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form] CTD PMID:26930420 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Ren renin increases activity
multiple interactions
EXP Methylprednisolone results in increased activity of REN protein
Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]
CTD PMID:235222, PMID:6277579 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Methylprednisolone results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr13:88,054,817...88,061,108
Ensembl chr13:88,054,817...88,061,108
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Methylprednisolone results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Methylprednisolone results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:147,246,032...147,270,892
Ensembl chr 5:147,246,037...147,270,957
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Methylprednisolone results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Methylprednisolone results in decreased expression of SLC43A3 mRNA CTD PMID:19192274 NCBI chr 3:72,328,912...72,351,039
Ensembl chr 3:72,329,967...72,351,111
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Methylprednisolone results in decreased expression of SLC7A11 mRNA CTD PMID:19192274 NCBI chr 2:139,453,774...139,528,479
Ensembl chr 2:139,453,774...139,528,162
JBrowse link
G Sms spermine synthase decreases expression ISO Methylprednisolone results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:40,363,646...40,415,110
Ensembl chr  X:40,363,646...40,415,109
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
increases activity
EXP
ISO
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of SOD2 protein
Methylprednisolone results in decreased expression of SOD2 mRNA
Methylprednisolone results in increased activity of SOD2 protein
CTD PMID:1942778, PMID:19192274 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Methylprednisolone results in decreased expression of STAT1 mRNA CTD PMID:19192274 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Methylprednisolone results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:54,340,649...54,457,753
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein] CTD PMID:11997017 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Sts steroid sulfatase increases expression ISO Methylprednisolone results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA] CTD PMID:26093215 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Methylprednisolone results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Methylprednisolone results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:182,840,171...182,846,061
Ensembl chr 2:182,840,727...182,846,061
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TNF mRNA]
Methylprednisolone results in decreased expression of TNF protein
CTD PMID:8384958, PMID:26093215, PMID:28557239 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Methylprednisolone results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:135,890,869...135,903,647
Ensembl chr 6:135,890,931...135,903,647
JBrowse link
G Trim63 tripartite motif containing 63 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of TRIM63 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of TRIM63 protein]
CTD PMID:21931329 NCBI chr 5:152,533,362...152,547,138
Ensembl chr 5:152,533,349...152,547,179
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Methylprednisolone results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Vwf von Willebrand factor decreases expression
increases expression
ISO Methylprednisolone results in decreased expression of VWF protein
Methylprednisolone results in increased expression of VWF protein
CTD PMID:7491699, PMID:20405515 NCBI chr 4:158,085,059...158,219,525
Ensembl chr 4:158,088,505...158,219,523
JBrowse link
alclometasone dipropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO alclometasone dipropionate results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO alclometasone dipropionate results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO alclometasone dipropionate results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO alclometasone dipropionate results in decreased expression of CSF2 protein CTD PMID:11407316 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ifng interferon gamma decreases expression ISO alclometasone dipropionate results in decreased expression of IFNG protein CTD PMID:11407316 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il2 interleukin 2 decreases expression ISO alclometasone dipropionate results in decreased expression of IL2 protein CTD PMID:11407316 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il3 interleukin 3 decreases expression ISO alclometasone dipropionate results in decreased expression of IL3 protein CTD PMID:11407316 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4 interleukin 4 decreases expression ISO alclometasone dipropionate results in decreased expression of IL4 protein CTD PMID:11407316 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 decreases expression ISO alclometasone dipropionate results in decreased expression of IL5 protein CTD PMID:11407316 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO alclometasone dipropionate results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
beclomethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases secretion
ISO Beclomethasone inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]
Beclomethasone results in increased expression of ABCB1 mRNA; Beclomethasone results in increased expression of ABCB1 protein
CTD PMID:15370884, PMID:16442095, PMID:22464980 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Beclomethasone results in increased expression of ABCB4 mRNA CTD PMID:15370884 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Beclomethasone results in increased expression of ABCC1 mRNA CTD PMID:15370884 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
ISO Beclomethasone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Beclomethasone results in increased activity of ABCG2 protein
CTD PMID:15365089, PMID:16442095 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases activity ISO Beclomethasone results in decreased activity of ACP5 protein CTD PMID:8429434 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Beclomethasone results in increased expression of ADRB2 mRNA CTD PMID:9032216, PMID:15679717 NCBI chr18:57,513,792...57,515,834
Ensembl chr18:57,513,793...57,515,834
JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases expression ISO Beclomethasone results in decreased expression of BDKRB1 mRNA CTD PMID:18039523 NCBI chr 6:129,437,423...129,441,553
Ensembl chr 6:129,438,158...129,440,574
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO Beclomethasone results in decreased expression of BGLAP protein CTD PMID:7746775, PMID:9232087, PMID:9544892 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Casp9 caspase 9 increases activity ISO Beclomethasone results in increased activity of CASP9 protein CTD PMID:11734450 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase increases expression ISO Beclomethasone results in increased expression of CAT protein CTD PMID:10445599 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein] CTD PMID:17988555 NCBI chr10:69,434,965...69,439,566
Ensembl chr10:69,434,941...69,439,575
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Beclomethasone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Beclomethasone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Beclomethasone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CCL5 protein; [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CCL5 protein; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
Beclomethasone results in decreased expression of CCL5 mRNA; Beclomethasone results in decreased expression of CCL5 protein
CTD PMID:8534483, PMID:10903220, PMID:14643170, PMID:15679717 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]; Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases secretion
increases activity
ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CSF2 protein; [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CSF2 protein; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of CSF2 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of CSF2 protein]; Beclomethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Beclomethasone results in decreased secretion of CSF2 protein
Beclomethasone results in increased activity of CSF2 protein
CTD PMID:7545059, PMID:10460758, PMID:10868704, PMID:11167953, PMID:11730731, PMID:15679717 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Beclomethasone results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Beclomethasone results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:82,595,211...82,610,350
Ensembl chr 1:82,595,211...82,610,350
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
increases expression
ISO 1-aminobenzotriazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Mifepristone inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Paraoxon inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Physostigmine inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:12538830, PMID:23512537, PMID:24555085 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP Beclomethasone inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:75,160,690...75,171,774
Ensembl chr10:75,160,690...75,171,774
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig decreases expression EXP Beclomethasone results in decreased expression of FCER1G protein CTD PMID:1834581 NCBI chr13:89,601,894...89,606,326
Ensembl chr13:89,601,896...89,606,326
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases activity
ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Albuterol promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein] CTD PMID:18076728 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] CTD PMID:18076728 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Beclomethasone results in decreased expression of FOS protein CTD PMID:9797757 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 increases activity
increases expression
multiple interactions
ISO Beclomethasone results in increased activity of GGT5 protein
Beclomethasone results in increased expression of GGT5 mRNA
[Beclomethasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4
CTD PMID:11447392 NCBI chr20:13,988,444...14,001,296 JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases metabolic processing ISO HSD11B2 protein results in increased metabolism of Beclomethasone CTD PMID:16549198 NCBI chr19:37,476,083...37,481,326
Ensembl chr19:37,476,095...37,481,307
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Beclomethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:9150321 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Beclomethasone results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions
increases activity
ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 protein]
Beclomethasone inhibits the reaction [OVAL protein results in increased expression of IL13 protein]
Beclomethasone results in increased activity of IL13 protein
CTD PMID:17988555, PMID:29986831 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases secretion
decreases expression
ISO Beclomethasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Beclomethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Beclomethasone results in decreased secretion of IL1B protein
Beclomethasone results in decreased expression of IL1B protein
CTD PMID:7545059, PMID:9176529, PMID:9371735, PMID:10460758, PMID:15337628 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Beclomethasone results in decreased expression of IL1RN protein CTD PMID:11015126 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Beclomethasone results in decreased expression of IL2RA protein CTD PMID:8111605, PMID:9314351 NCBI chr17:70,500,672...70,547,929
Ensembl chr17:70,499,083...70,548,071
JBrowse link
G Il3 interleukin 3 multiple interactions ISO Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL3 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL3 protein] CTD PMID:11167953 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]; Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]
Beclomethasone results in decreased expression of IL4 protein
CTD PMID:7988651, PMID:18076728 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression
ISO Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL5 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL5 protein]
Beclomethasone results in decreased expression of IL5 protein
CTD PMID:7988651, PMID:10813552, PMID:11167953 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 protein] CTD PMID:17988555 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Ltf lactotransferrin multiple interactions
decreases secretion
ISO Beclomethasone inhibits the reaction [methylcholine results in increased secretion of LTF protein]
Beclomethasone results in decreased secretion of LTF protein
CTD PMID:11112886 NCBI chr 8:119,290,416...119,313,261
Ensembl chr 8:119,290,416...119,313,261
JBrowse link
G Mefv MEFV innate immuity regulator, pyrin increases response to substance ISO MEFV mutant form results in increased susceptibility to Beclomethasone CTD PMID:20828792 NCBI chr10:12,045,813...12,056,229
Ensembl chr10:12,046,541...12,056,311
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Beclomethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein] CTD PMID:10455257 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO Beclomethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
Beclomethasone results in decreased expression of MMP9 protein
CTD PMID:10452757, PMID:10455257 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Beclomethasone results in decreased expression of NOS2 protein CTD PMID:12668791 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Beclomethasone results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects localization
increases expression
affects binding
multiple interactions
increases activity
ISO
EXP
Beclomethasone affects the localization of NR3C1 protein
Beclomethasone results in increased expression of NR3C1 mRNA
Beclomethasone binds to NR3C1 protein
[Beclomethasone co-treated with Albuterol] affects the localization of NR3C1 protein; [Beclomethasone co-treated with Formoterol Fumarate] affects the localization of NR3C1 protein; Beclomethasone affects the localization of and results in increased activity of NR3C1 protein; Beclomethasone binds to and results in increased activity of NR3C1 protein
Beclomethasone results in increased activity of NR3C1 protein
CTD PMID:16814, PMID:2207292, PMID:15362971, PMID:15679717, PMID:15860753, PMID:15862954, PMID:16507850, PMID:21543282, PMID:24555085 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Beclomethasone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:64,882,024...64,919,714
Ensembl chr11:64,882,288...64,919,579
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases activity
multiple interactions
ISO Beclomethasone results in decreased activity of PLA2G4A protein
Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA]
CTD PMID:15337628, PMID:20573295 NCBI chr13:67,062,252...67,206,688
Ensembl chr13:66,988,937...67,206,693
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP Beclomethasone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein] CTD PMID:18577381 NCBI chr 1:87,224,683...87,232,842
Ensembl chr 1:87,224,677...87,232,848
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]; Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA] CTD PMID:18391481 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rnase2 ribonuclease A family member 2 decreases expression ISO Beclomethasone results in decreased expression of RNASE2 protein CTD PMID:12166584 NCBI chr15:28,154,482...28,155,291
Ensembl chr15:28,154,482...28,155,291
JBrowse link
G Rnase3 ribonuclease A family member 3 multiple interactions
decreases expression
ISO [Salmeterol Xinafoate co-treated with Beclomethasone] affects the reaction [Allergens results in increased expression of RNASE3 protein]; Beclomethasone affects the reaction [Allergens results in increased expression of RNASE3 protein]
Beclomethasone results in decreased expression of RNASE3 protein
CTD PMID:1443864, PMID:10513351, PMID:10573242, PMID:12166584, PMID:12587966, PMID:15144908 NCBI chr15:28,216,744...28,217,614
Ensembl chr15:28,216,744...28,217,614
JBrowse link
G Sele selectin E multiple interactions ISO Beclomethasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA] CTD PMID:9371735 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Beclomethasone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] CTD PMID:18076728 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Beclomethasone results in increased expression of TIMP1 protein CTD PMID:10452757 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Beclomethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Beclomethasone results in decreased secretion of TNF protein
CTD PMID:8937731, PMID:9150321, PMID:9819297, PMID:10100995, PMID:10903220, PMID:14643170 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Beclomethasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Beclomethasone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        xenobiotic 18380
          prednisolone 231
            6-methylprednisolone + 126
            alclometasone 0
            alclometasone dipropionate 10
            beclomethasone + 58
            prednisolone phosphate 0
            prednisolone-16-carboxylic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      ketone 16140
                                        oxo steroid 9275
                                          3-oxo steroid 8805
                                            3-oxo-Delta(4) steroid 7934
                                              progesterone 2707
                                                Delta(1)-progesterone 236
                                                  prednisolone 231
                                                    6-methylprednisolone + 126
                                                    alclometasone 0
                                                    alclometasone dipropionate 10
                                                    beclomethasone + 58
                                                    prednisolone phosphate 0
                                                    prednisolone-16-carboxylic acid + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.