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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prednisolone
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Accession:CHEBI:8378 term browser browse the term
Definition:A glucocorticoid that is prednisone in which the oxo group at position 11 has been reduced to the corresponding beta-hydroxy group. It is a drug metabolite of prednisone.
Synonyms:exact_synonym: 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione
 related_synonym: (11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione;   1,4-pregnadiene-3,20-dione-11beta,17alpha,21-triol;   3,20-dioxo-11beta,17alpha,21-trihydroxy-1,4-pregnadiene;   Delta(1)-dehydrocortisol;   Delta(1)-dehydrohydrocortisone;   Delta(1)-hydrocortisone;   Formula=C21H28O5;   InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1;   InChIKey=OIGNJSKKLXVSLS-VWUMJDOOSA-N;   SMILES=[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(=O)CO;   hydroretrocortine;   metacortandralone;   prednisolona;   prednisolonum
 xref: Beilstein:1354103;   CAS:50-24-8;   DrugBank:DB00860;   Drug_Central:2245;   HMDB:HMDB0014998;   KEGG:C07369;   KEGG:D00472
 xref_mesh: MESH:D011239
 xref: PMID:11294518;   PMID:23625982;   PMID:24392764;   Reaxys:1354103;   VSDB:1848;   Wikipedia:Prednisolone



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prednisolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Prednisolone results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO Prednisolone results in increased expression of ACSL1 mRNA CTD PMID:17379860 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Prednisolone results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Ahr aryl hydrocarbon receptor increases activity ISO Prednisolone results in increased activity of AHR protein CTD PMID:30203046 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of AKR1B7 mRNA] CTD PMID:21149847 NCBI chr 4:63,053,560...63,100,934
Ensembl chr 4:63,076,800...63,089,502
JBrowse link
G Alb albumin increases expression
multiple interactions
decreases secretion
ISO
EXP
Prednisolone results in increased expression of ALB protein
montelukast inhibits the reaction [Prednisolone results in decreased secretion of ALB protein]
CTD PMID:3404815 PMID:30276927 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Prednisolone results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Prednisolone results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Prednisolone results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G Ar androgen receptor multiple interactions
increases expression
ISO Prednisolone binds to and results in decreased activity of AR protein; Prednisolone binds to and results in increased activity of AR protein; Prednisolone binds to and results in increased activity of AR protein mutant form
[Phenytoin co-treated with Prednisolone] results in increased expression of AR protein
Prednisolone results in increased expression of AR mRNA; Prednisolone results in increased expression of AR protein
CTD PMID:11956172 PMID:19490052 PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arhgap45 Rho GTPase activating protein 45 decreases expression ISO Prednisolone results in decreased expression of ARHGAP45 mRNA CTD PMID:21621594 NCBI chr 7:9,674,873...9,690,286
Ensembl chr 7:9,674,897...9,690,268
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like increases expression ISO Prednisolone results in increased expression of ARNTL mRNA CTD PMID:16269518 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Arrdc3 arrestin domain containing 3 increases expression ISO Prednisolone results in increased expression of ARRDC3 mRNA CTD PMID:24356939 NCBI chr 2:11,137,443...11,149,978
Ensembl chr 2:11,137,460...11,149,978
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Prednisolone results in decreased expression of ASNS mRNA CTD PMID:19192274 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Prednisolone results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Prednisolone results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions
EXP Prednisolone results in increased expression of CASP3 protein
montelukast inhibits the reaction [Prednisolone results in increased expression of CASP3 protein]
CTD PMID:30276927 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase decreases activity
multiple interactions
EXP Prednisolone results in decreased activity of CAT protein
[Prednisolone co-treated with pirfenidone] inhibits the reaction [Paraquat results in decreased activity of CAT protein]; montelukast inhibits the reaction [Prednisolone results in decreased activity of CAT protein]
CTD PMID:28921394 PMID:30276927 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbll1 Cbl proto-oncogene like 1 decreases expression ISO Prednisolone results in decreased expression of CBLL1 mRNA CTD PMID:21621594 NCBI chr 6:48,071,190...48,086,174
Ensembl chr 6:48,071,190...48,086,444
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL11 mRNA] CTD PMID:23133493 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO Prednisolone results in decreased expression of CCL2 protein
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCL2 mRNA]
CTD PMID:20116850 PMID:23133493 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Prednisolone results in decreased expression of CCL20 mRNA; Prednisolone results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Prednisolone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Prednisolone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Prednisolone results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Prednisolone results in increased expression of CCN2 mRNA CTD PMID:19192274 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Prednisolone results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Prednisolone results in increased expression of CCNG2 mRNA CTD PMID:24356939 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccr3 C-C motif chemokine receptor 3 multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of CCR3 mRNA] CTD PMID:23133493 NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
JBrowse link
G Cd34 CD34 molecule multiple interactions ISO [Melphalan co-treated with Prednisolone] results in decreased expression of CD34 protein CTD PMID:10618687 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cd84 CD84 molecule increases expression ISO Prednisolone results in increased expression of CD84 mRNA CTD PMID:24356939 NCBI chr13:84,327,580...84,367,153
Ensembl chr13:84,327,553...84,362,076
JBrowse link
G Clgn calmegin decreases expression ISO Prednisolone results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Prednisolone results in increased expression of COL1A1 mRNA CTD PMID:19192274 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Crh corticotropin releasing hormone decreases expression
multiple interactions
EXP Prednisolone results in decreased expression of CRH protein
sairei-to inhibits the reaction [Prednisolone results in decreased expression of CRH protein]
CTD PMID:9625448 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crim1 cysteine rich transmembrane BMP regulator 1 increases expression ISO Prednisolone results in increased expression of CRIM1 mRNA CTD PMID:24356939 NCBI chr 6:16,695,864...16,870,264
Ensembl chr 6:16,697,829...16,870,259
JBrowse link
G Cry1 cryptochrome circadian regulator 1 decreases expression ISO Prednisolone results in decreased expression of CRY1 mRNA CTD PMID:16269518 NCBI chr 7:18,529,823...18,594,092
Ensembl chr 7:18,529,823...18,594,091
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Prednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Prednisolone results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Prednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO Prednisolone results in decreased expression of CXCR2 protein CTD PMID:15804745 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Prednisolone results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of CYP2C19 mRNA] CTD PMID:21149847 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Prednisolone results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO Prednisolone results in increased expression of CYP3A4 mRNA CTD PMID:12673034 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dbp D-box binding PAR bZIP transcription factor decreases expression ISO Prednisolone results in decreased expression of DBP mRNA CTD PMID:16269518 NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745
JBrowse link
G Ddx58 DEXD/H-box helicase 58 decreases expression ISO Prednisolone results in decreased expression of DDX58 mRNA CTD PMID:19192274 NCBI chr 5:55,321,229...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Prednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Prednisolone results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018
JBrowse link
G Fbln1 fibulin 1 increases expression ISO Prednisolone results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases expression ISO Prednisolone results in increased expression of FMO2 mRNA CTD PMID:21621594 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Prednisolone results in decreased expression of GBP1 mRNA CTD PMID:19192274 PMID:21621594 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,517,398...231,529,600
JBrowse link
G Gdf5 growth differentiation factor 5 decreases expression ISO Prednisolone results in decreased expression of GDF5 mRNA CTD PMID:18830904 NCBI chr 3:144,454,306...144,458,757
Ensembl chr 3:144,454,338...144,458,612
JBrowse link
G Gjb1 gap junction protein, beta 1 increases expression ISO Prednisolone results in increased expression of GJB1 mRNA CTD PMID:21621594 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gm2a GM2 ganglioside activator increases expression ISO Prednisolone results in increased expression of GM2A mRNA CTD PMID:17379860 NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757
JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Prednisolone results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:28,057,788...28,204,409
Ensembl chr  X:28,059,450...28,204,211
JBrowse link
G Gsdme gasdermin E decreases expression ISO Prednisolone results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Prednisolone results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Prednisolone results in increased expression of HMGCS1 mRNA CTD PMID:24356939 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase multiple interactions ISO Prednisolone results in increased expression of and results in increased activity of HPGD protein CTD PMID:15680906 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Prednisolone results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases metabolic processing ISO HSD11B2 protein results in increased metabolism of Prednisolone CTD PMID:16549198 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Prednisolone results in increased expression of ID3 mRNA CTD PMID:19192274 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Prednisolone results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Prednisolone results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Prednisolone results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Prednisolone results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Prednisolone results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
ISO
EXP
Prednisolone results in decreased expression of IFNG protein
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG mRNA]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IFNG protein]
Prednisolone results in decreased expression of IFNG mRNA
CTD PMID:11043609 PMID:15821026 PMID:23133493 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 decreases response to substance
increases expression
ISO Prednisolone results in decreased susceptibility to IGF1 protein
Prednisolone results in increased expression of IGF1 protein
CTD PMID:16079165 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Ighe immunoglobulin heavy constant epsilon decreases expression ISO Prednisolone results in decreased expression of IGHE protein CTD PMID:15821026
G Il10 interleukin 10 decreases expression
decreases expression
decreases secretion
ISO Prednisolone results in decreased expression of IL10 protein
prednisolone decreases expression of IL10 protein in LPS-stimulated human PBMC
Prednisolone results in decreased secretion of IL10 protein
CTD
RGD
PMID:15821026 PMID:28003376 PMID:10493164 RGD:40903016 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12b interleukin 12B decreases secretion ISO Prednisolone results in decreased secretion of IL12B protein CTD PMID:28003376 NCBI chr10:28,888,832...28,903,796
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL13 protein] CTD PMID:23133493 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL17A mRNA] CTD PMID:23133493 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL18 protein] CTD PMID:16442096 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
decreases secretion
ISO
EXP
Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL1B protein]
prednisolone decreases expression of IL1b mRNA and protein in LPS-stimulated human PBMC
Prednisolone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
Prednisolone results in decreased secretion of IL1B protein
Prednisolone results in decreased expression of IL1B mRNA
Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IL1B protein]
CTD
RGD
PMID:9259316 PMID:16442096 PMID:17379860 PMID:22119283 PMID:10493164 RGD:40903016 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Prednisolone results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2 interleukin 2 decreases expression ISO Prednisolone results in decreased expression of IL2 protein CTD PMID:15821026 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Prednisolone results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 mRNA]; Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL4 protein]; Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL4 protein]
Prednisolone results in decreased expression of IL4 protein
CTD PMID:15821026 PMID:16442096 PMID:23133493 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases expression
multiple interactions
ISO Prednisolone results in decreased expression of IL5 protein
Prednisolone inhibits the reaction [Dinitrochlorobenzene results in increased expression of IL5 mRNA]
CTD PMID:15821026 PMID:23133493 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
ISO
EXP
Prednisolone inhibits the reaction [Amiodarone results in increased secretion of IL6 protein]
prednisolone decreases expression of IL6 mRNA and protein in LPS-stimulated human PBMC
Prednisolone results in decreased expression of IL6 mRNA; Prednisolone results in decreased expression of IL6 protein
Prednisolone inhibits the reaction [Picryl Chloride results in increased expression of IL6 protein]
CTD
RGD
PMID:11043609 PMID:11288978 PMID:16442096 PMID:19192274 PMID:10493164 RGD:40903016 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Prednisolone results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Prednisolone results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Prednisolone results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Klhl24 kelch-like family member 24 increases expression ISO Prednisolone results in increased expression of KLHL24 mRNA CTD PMID:24356939 NCBI chr11:80,843,621...80,877,693
Ensembl chr11:80,846,755...80,877,636
JBrowse link
G Kmt2a lysine methyltransferase 2A decreases response to substance ISO KMT2A gene mutant form results in decreased susceptibility to Prednisolone CTD PMID:14712291 NCBI chr 8:45,116,771...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Krt8 keratin 8 increases expression ISO Prednisolone results in increased expression of KRT8 mRNA CTD PMID:21621594 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Prednisolone results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Lcn2 lipocalin 2 decreases secretion ISO Prednisolone results in decreased secretion of LCN2 protein CTD PMID:28003376 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Ltf lactotransferrin decreases expression ISO Prednisolone results in decreased expression of LTF mRNA CTD PMID:21621594 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Prednisolone results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
JBrowse link
G Ly96 lymphocyte antigen 96 decreases expression ISO Prednisolone results in decreased expression of LY96 mRNA CTD PMID:17379860 NCBI chr 5:2,582,233...2,612,357
Ensembl chr 5:2,582,254...2,612,386
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Prednisolone results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Prednisolone results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Prednisolone results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Prednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA]]; Prednisolone inhibits the reaction [Paraquat results in increased expression of MMP2 mRNA] CTD PMID:28921394 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of and results in increased cleavage of MMP9 protein] CTD PMID:22119283 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO
EXP
Prednisolone inhibits the reaction [Picryl Chloride results in increased activity of MPO protein]
Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein]
CTD PMID:16442096 PMID:22119283 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Muc16 mucin 16, cell surface associated decreases expression ISO Prednisolone results in decreased expression of MUC16 protein CTD PMID:12169874 NCBI chr 8:16,164,531...16,323,126 JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO Prednisolone results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Prednisolone results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Prednisolone results in increased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nid2 nidogen 2 increases expression ISO Prednisolone results in increased expression of NID2 mRNA CTD PMID:19192274 NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843
JBrowse link
G Nmb neuromedin B decreases expression ISO Prednisolone results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP Prednisolone results in increased expression of NOS2 protein
montelukast inhibits the reaction [Prednisolone results in increased expression of NOS2 protein]
CTD PMID:30276927 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 decreases expression ISO Prednisolone results in decreased expression of NR1D1 mRNA CTD PMID:16269518 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects response to substance
increases activity
affects binding
multiple interactions
ISO NR3C1 protein alternative form affects the susceptibility to Prednisolone
Prednisolone results in increased activity of NR3C1 protein
Prednisolone binds to NR3C1 protein
NR3C1 protein alternative form inhibits the reaction [Prednisolone results in increased activity of NR3C1 protein alternative form]; Prednisolone binds to and results in increased activity of NR3C1 protein
CTD PMID:11956172 PMID:14694204 PMID:15362971 PMID:15704223 PMID:15705660 More... NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Prednisolone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Prednisolone results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Prednisolone results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Prednisolone results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Olfml2b olfactomedin-like 2B increases expression ISO Prednisolone results in increased expression of OLFML2B mRNA CTD PMID:19192274 NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO Prednisolone results in increased expression of PCK1 mRNA CTD PMID:20065017 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pdcd4 programmed cell death 4 increases expression ISO Prednisolone results in increased expression of PDCD4 mRNA CTD PMID:24356939 NCBI chr 1:252,921,342...252,944,278
Ensembl chr 1:252,921,392...252,944,275
JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression ISO Prednisolone results in increased expression of PDLIM1 mRNA CTD PMID:17379860 NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
JBrowse link
G Per1 period circadian regulator 1 increases expression ISO Prednisolone results in increased expression of PER1 mRNA; Prednisolone results in increased expression of PER1 protein CTD PMID:16269518 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Per2 period circadian regulator 2 decreases expression ISO Prednisolone results in decreased expression of PER2 mRNA CTD PMID:16269518 NCBI chr 9:92,007,289...92,049,551
Ensembl chr 9:92,007,296...92,049,459
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Prednisolone results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha decreases expression ISO Prednisolone results in decreased expression of PILRA mRNA CTD PMID:19192274
G Pla1a phospholipase A1 member A multiple interactions ISO Prednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:62,320,117...62,357,779
Ensembl chr11:62,320,493...62,357,779
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Prednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA] CTD PMID:20573295 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plcl1 phospholipase C-like 1 increases expression ISO Prednisolone results in increased expression of PLCL1 mRNA CTD PMID:24356939 NCBI chr 9:56,901,573...57,238,782
Ensembl chr 9:56,901,534...57,238,782
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Prednisolone results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
JBrowse link
G Pomc proopiomelanocortin decreases expression
multiple interactions
EXP Prednisolone results in decreased expression of POMC protein; Prednisolone results in decreased expression of POMC protein modified form
sairei-to inhibits the reaction [Prednisolone results in decreased expression of POMC protein modified form]
CTD PMID:9625448 PMID:14694204 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP Prednisolone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein] CTD PMID:18577381 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein increases expression ISO Prednisolone results in increased expression of PRELP mRNA CTD PMID:19192274 NCBI chr13:45,368,407...45,391,480
Ensembl chr13:45,370,533...45,380,270
JBrowse link
G Prlr prolactin receptor multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of PRLR mRNA] CTD PMID:21149847 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Prednisolone results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rdh16 retinol dehydrogenase 16 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of RDH2 mRNA] CTD PMID:21149847 NCBI chr 7:63,616,724...63,624,120
Ensembl chr 7:63,597,536...63,624,124
JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions
decreases expression
EXP
ISO
Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of RGS4 mRNA]
Prednisolone results in decreased expression of RGS4 mRNA
CTD PMID:19192274 PMID:21149847 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP Prednisolone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]; Prednisolone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA] CTD PMID:18391481 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Prednisolone results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Prednisolone results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:141,406,085...141,431,380
Ensembl chr 5:141,406,118...141,431,380
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Prednisolone results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G Scg2 secretogranin II multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in increased expression of SCG2 mRNA] CTD PMID:21149847 NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions EXP Prednisolone inhibits the reaction [Freund's Adjuvant results in decreased expression of SLC22A8 mRNA] CTD PMID:21149847 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Prednisolone results in decreased expression of SLC43A3 mRNA CTD PMID:19192274 NCBI chr 3:70,008,160...70,030,324
Ensembl chr 3:70,009,313...70,029,749
JBrowse link
G Slc7a11 solute carrier family 7 member 11 increases expression
decreases expression
ISO Prednisolone results in increased expression of SLC7A11 mRNA
Prednisolone results in decreased expression of SLC7A11 mRNA
CTD PMID:19192274 PMID:24356939 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Slc7a8 solute carrier family 7 member 8 increases expression ISO Prednisolone results in increased expression of SLC7A8 mRNA CTD PMID:19192274 NCBI chr15:28,183,013...28,242,717
Ensembl chr15:28,183,015...28,242,717
JBrowse link
G Sms spermine synthase decreases expression ISO Prednisolone results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Prednisolone results in decreased expression of SOD2 mRNA CTD PMID:19192274 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sox9 SRY-box transcription factor 9 decreases expression ISO Prednisolone results in decreased expression of SOX9 mRNA CTD PMID:17379860 NCBI chr10:97,806,485...97,811,994
Ensembl chr10:97,806,485...97,811,994
JBrowse link
G Srsf7 serine and arginine rich splicing factor 7 decreases expression ISO Prednisolone results in decreased expression of SRSF7 mRNA CTD PMID:21621594 NCBI chr 6:14,811,775...14,818,968
Ensembl chr 6:14,811,808...14,818,965
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO Prednisolone results in increased expression of SRXN1 mRNA CTD PMID:24356939 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Prednisolone results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:49,472,660...49,588,540 JBrowse link
G Sts steroid sulfatase increases expression ISO Prednisolone results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Tafa5 TAFA chemokine like family member 5 increases expression ISO Prednisolone results in increased expression of TAFA5 mRNA CTD PMID:21621594 NCBI chr 7:118,613,731...118,835,016
Ensembl chr 7:118,613,889...118,834,353
JBrowse link
G Tat tyrosine aminotransferase multiple interactions
increases activity
increases expression
EXP
ISO
(3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased activity of TAT protein]; (3b,5b,7a,12a)-7,12-dihydroxy-3-(2-((4-((11b,17b)-17-hydroxy-3-oxo-17-prop-1-ynylestra-4,9-dien-11-yl) phenyl)(methyl)amino)ethoxy)cholan-24-oic acid inhibits the reaction [Prednisolone results in increased expression of TAT mRNA] CTD PMID:9259316 PMID:14694204 PMID:15784656 NCBI chr19:37,947,153...37,957,717
Ensembl chr19:37,947,112...37,958,031
JBrowse link
G Tex261 testis expressed 261 decreases expression ISO Prednisolone results in decreased expression of TEX261 mRNA CTD PMID:21621594 NCBI chr 4:116,253,547...116,260,730
Ensembl chr 4:116,244,600...116,260,253
JBrowse link
G Tf transferrin increases expression ISO Prednisolone results in increased expression of TF protein CTD PMID:3404815 NCBI chr 8:103,789,780...103,816,487
Ensembl chr 8:103,767,995...103,816,511
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 decreases expression ISO Prednisolone results in decreased expression of TFPI2 mRNA CTD PMID:17379860 NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions
ISO
EXP
Prednisolone results in decreased expression of TGFB1 protein
pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TGFB1 mRNA]
CTD PMID:11728950 PMID:28921394 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Prednisolone results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP pirfenidone promotes the reaction [Prednisolone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA]]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TIMP1 mRNA] CTD PMID:28921394 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Prednisolone results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnf tumor necrosis factor increases expression
decreases expression
multiple interactions
ISO
EXP
Prednisolone results in increased expression of TNF mRNA
prednisolone decreases expression of TNFa mRNA and protein in LPS-stimulated human PBMC
Prednisolone inhibits the reaction [[Lipopolysaccharides co-treated with Galactosamine] results in increased expression of TNF protein]
[pirfenidone co-treated with Prednisolone] inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Paraquat results in increased expression of TNF mRNA]; Prednisolone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of TNF protein]
Prednisolone results in decreased expression of TNF mRNA
CTD
RGD
PMID:11043609 PMID:19233868 PMID:20054000 PMID:22119283 PMID:28921394 More... RGD:40903016 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Prednisolone results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
JBrowse link
G Trim63 tripartite motif containing 63 increases expression ISO Prednisolone results in increased expression of TRIM63 mRNA CTD PMID:20065017 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Prednisolone results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Prednisolone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vldlr very low density lipoprotein receptor increases expression ISO Prednisolone results in increased expression of VLDLR mRNA CTD PMID:24356939 NCBI chr 1:224,813,539...224,850,400
Ensembl chr 1:224,814,377...224,845,920
JBrowse link
6alpha-methylprednisolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases secretion
ISO ABCB1 gene polymorphism affects the susceptibility to [Methotrexate co-treated with Methylprednisolone]; ABCB1 protein results in increased susceptibility to [Methotrexate co-treated with Methylprednisolone]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Methylprednisolone]
Methylprednisolone results in increased expression of ABCB1 mRNA; Methylprednisolone results in increased expression of ABCB1 protein
CTD PMID:16932953 PMID:22079615 PMID:22464980 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Methylprednisolone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] CTD PMID:15365089 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Methylprednisolone results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Methylprednisolone results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions
EXP Methylprednisolone results in decreased phosphorylation of AKT1 protein
naringin inhibits the reaction [Methylprednisolone results in decreased phosphorylation of AKT1 protein]
CTD PMID:15187100 PMID:30878453 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions
increases secretion
EXP Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in increased secretion of ALPL protein]] CTD PMID:30291735 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Methylprednisolone results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Methylprednisolone results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Methylprednisolone results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G Ar androgen receptor multiple interactions ISO Methylprednisolone binds to and results in decreased activity of AR protein; Methylprednisolone binds to and results in increased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO Methylprednisolone results in decreased expression of ASNS mRNA CTD PMID:19192274 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BAX protein] CTD PMID:17570061 PMID:26093215 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 mRNA]; Methylprednisolone inhibits the reaction [Hydrogen Peroxide affects the expression of BCL2 protein] CTD PMID:17570061 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Methylprednisolone results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases secretion
multiple interactions
EXP Methylprednisolone results in decreased secretion of BGLAP protein
[Nebivolol co-treated with Alendronate] inhibits the reaction [Methylprednisolone results in decreased secretion of BGLAP protein]
CTD PMID:30291735 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Methylprednisolone results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Capn2 calpain 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased expression of CAPN2 protein] CTD PMID:17570061 NCBI chr13:94,150,244...94,200,969
Ensembl chr13:94,150,240...94,200,969
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Methylprednisolone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17570061 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions
decreases activity
increases activity
EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of CAT protein; Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]; Nebivolol promotes the reaction [Alendronate inhibits the reaction [Methylprednisolone results in decreased activity of CAT protein]]
Methylprednisolone results in increased activity of CAT protein
CTD PMID:1942778 PMID:30291735 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Methylprednisolone results in decreased expression of CCL20 mRNA; Methylprednisolone results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Methylprednisolone results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO Methylprednisolone results in increased expression of CCN2 mRNA CTD PMID:19192274 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Methylprednisolone results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636
JBrowse link
G Clgn calmegin decreases expression ISO Methylprednisolone results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
increases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]
Methylprednisolone results in increased expression of COL1A1 mRNA
CTD PMID:19192274 PMID:26093215 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of COL4A1 mRNA] CTD PMID:1762292 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Methylprednisolone inhibits the reaction [Isoproterenol results in increased expression of CTSD mRNA] CTD PMID:894732 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Methylprednisolone results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Methylprednisolone results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Methylprednisolone results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases expression
increases activity
ISO Methylprednisolone results in decreased expression of CYP3A4 mRNA
Methylprednisolone results in increased activity of CYP3A4 protein
CTD PMID:15964336 PMID:16837568 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of DDIT4 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of DDIT4 protein]
CTD PMID:21931329 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddx58 DEXD/H-box helicase 58 decreases expression ISO Methylprednisolone results in decreased expression of DDX58 mRNA CTD PMID:19192274 NCBI chr 5:55,321,229...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Dio2 iodothyronine deiodinase 2 increases expression ISO Methylprednisolone results in increased expression of DIO2 mRNA CTD PMID:19192274 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dmd dystrophin multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr  X:47,272,324...49,504,219
Ensembl chr  X:47,272,331...49,504,207
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDN1 mRNA] CTD PMID:7756592 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of EDNRB mRNA] CTD PMID:7756592 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Methylprednisolone results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Methylprednisolone binds to and results in increased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G F8 coagulation factor VIII increases expression ISO Methylprednisolone results in increased expression of F8 protein CTD PMID:20405515 NCBI chr18:140,848...172,330
Ensembl chr18:140,955...171,857
JBrowse link
G Fbln1 fibulin 1 increases expression ISO Methylprednisolone results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
JBrowse link
G Fbxo32 F-box protein 32 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of FBXO32 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FBXO32 protein]
CTD PMID:21931329 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Fcer2 Fc fragment of IgE receptor II multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein] CTD PMID:11997017 NCBI chr12:1,742,809...1,754,476
Ensembl chr12:1,742,815...1,754,476
JBrowse link
G Foxo1 forkhead box O1 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of FOXO1 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of FOXO1 protein]
CTD PMID:21931329 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Methylprednisolone results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,517,398...231,529,600
JBrowse link
G Gfap glial fibrillary acidic protein decreases expression ISO Methylprednisolone results in decreased expression of GFAP protein CTD PMID:18509235 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Methylprednisolone results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:28,057,788...28,204,409
Ensembl chr  X:28,059,450...28,204,211
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased expression of GPT protein] CTD PMID:30891624 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases activity
EXP [Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of GPX1 protein
Methylprednisolone results in increased activity of GPX1 protein
CTD PMID:1942778 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gsdme gasdermin E decreases expression ISO Methylprednisolone results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Methylprednisolone results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO Methylprednisolone results in decreased expression of HILPDA mRNA CTD PMID:19192274 NCBI chr 4:57,871,076...57,875,206 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of HMOX1 mRNA] CTD PMID:26093215 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Methylprednisolone results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Htr3a 5-hydroxytryptamine receptor 3A multiple interactions
decreases activity
ISO [Methylprednisolone co-treated with Metoclopramide] results in decreased activity of HTR3A protein; [Methylprednisolone co-treated with ramosetron] results in decreased activity of HTR3A protein
Methylprednisolone results in decreased activity of HTR3A protein
CTD PMID:15329590 NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Methylprednisolone results in increased expression of ID3 mRNA CTD PMID:19192274 NCBI chr 5:148,372,784...148,374,353
Ensembl chr 5:148,372,762...148,374,349
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Methylprednisolone results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Methylprednisolone results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Methylprednisolone results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Methylprednisolone results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Methylprednisolone results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Methylprednisolone results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
JBrowse link
G Il10 interleukin 10 increases expression ISO Methylprednisolone results in increased expression of IL10 protein CTD PMID:28557239 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL1B mRNA] CTD PMID:26093215 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Methylprednisolone results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Methylprednisolone results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of FCER2 protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein]
Methylprednisolone results in decreased expression of IL4 protein
CTD PMID:7988651 PMID:11997017 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R mRNA]; Methylprednisolone inhibits the reaction [IL4 protein results in increased expression of IL4R protein]; Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of IL4R protein] CTD PMID:11997017 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il5 interleukin 5 decreases expression ISO Methylprednisolone results in decreased expression of IL5 protein CTD PMID:7988651 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of IL6 mRNA]
Methylprednisolone results in decreased expression of IL6 mRNA; Methylprednisolone results in decreased expression of IL6 protein
CTD PMID:19192274 PMID:26093215 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Methylprednisolone results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Methylprednisolone results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Methylprednisolone results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Jak1 Janus kinase 1 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein results in increased phosphorylation of JAK1 protein] CTD PMID:11997017 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB1 mRNA] CTD PMID:1762292 NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
JBrowse link
G Lamb2 laminin subunit beta 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of LAMB2 mRNA] CTD PMID:1762292 NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Methylprednisolone results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Methylprednisolone results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases expression
decreases phosphorylation
EXP cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased expression of MAPK1 protein modified form]; cobaltous chloride inhibits the reaction [Methylprednisolone results in decreased phosphorylation of MAPK1 protein] CTD PMID:12904460 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Methylprednisolone results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
JBrowse link
G Mbp myelin basic protein decreases expression ISO Methylprednisolone results in decreased expression of MBP protein CTD PMID:18509235 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Methylprednisolone results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Methylprednisolone results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp12 matrix metallopeptidase 12 decreases expression ISO Methylprednisolone results in decreased expression of MMP12 mRNA CTD PMID:19192274 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MPO protein]
[Polymyxin B co-treated with Methylprednisolone] inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]; Methylprednisolone inhibits the reaction [Alpha-Amanitin results in increased activity of MPO protein]
Methylprednisolone results in decreased expression of MPO protein
CTD PMID:26093215 PMID:28557239 PMID:30891624 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of MUC5AC mRNA] CTD PMID:26093215 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO Methylprednisolone results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Methylprednisolone results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in decreased expression of NFE2L2 mRNA] CTD PMID:26093215 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of NFKB1 mRNA] CTD PMID:26093215 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nid2 nidogen 2 increases expression ISO Methylprednisolone results in increased expression of NID2 mRNA CTD PMID:19192274 NCBI chr15:4,458,082...4,513,808
Ensembl chr15:4,458,084...4,513,843
JBrowse link
G Nmb neuromedin B decreases expression ISO Methylprednisolone results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:22422321 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Methylprednisolone results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Methylprednisolone results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Oas3 2'-5'-oligoadenylate synthetase 3 decreases expression ISO Methylprednisolone results in decreased expression of OAS3 mRNA CTD PMID:19192274 NCBI chr12:35,779,028...35,802,781
Ensembl chr12:35,779,022...35,802,781
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Methylprednisolone results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Methylprednisolone results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:62,320,117...62,357,779
Ensembl chr11:62,320,493...62,357,779
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions ISO Methylprednisolone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA] CTD PMID:20573295 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Methylprednisolone results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
JBrowse link
G Prelp proline and arginine rich end leucine rich repeat protein increases expression ISO Methylprednisolone results in increased expression of PRELP mRNA CTD PMID:19192274 NCBI chr13:45,368,407...45,391,480
Ensembl chr13:45,370,533...45,380,270
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Methylprednisolone results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form] CTD PMID:26930420 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin increases activity
multiple interactions
EXP Methylprednisolone results in increased activity of REN protein
Sodium Chloride inhibits the reaction [Methylprednisolone results in increased activity of REN protein]
CTD PMID:235222 PMID:6277579 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Methylprednisolone results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Methylprednisolone results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Methylprednisolone results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:141,406,085...141,431,380
Ensembl chr 5:141,406,118...141,431,380
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Methylprednisolone results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Methylprednisolone inhibits the reaction [DMD gene mutant form results in increased expression of SIRT1 mRNA] CTD PMID:26930420 NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Slc43a3 solute carrier family 43, member 3 decreases expression ISO Methylprednisolone results in decreased expression of SLC43A3 mRNA CTD PMID:19192274 NCBI chr 3:70,008,160...70,030,324
Ensembl chr 3:70,009,313...70,029,749
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Methylprednisolone results in decreased expression of SLC7A11 mRNA CTD PMID:19192274 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sms spermine synthase decreases expression ISO Methylprednisolone results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
increases activity
EXP
ISO
[Methylprednisolone co-treated with Puromycin Aminonucleoside] results in increased activity of SOD2 protein
Methylprednisolone results in decreased expression of SOD2 mRNA
Methylprednisolone results in increased activity of SOD2 protein
CTD PMID:1942778 PMID:19192274 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Methylprednisolone results in decreased expression of STAT1 mRNA CTD PMID:19192274 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat4 signal transducer and activator of transcription 4 decreases expression ISO Methylprednisolone results in decreased expression of STAT4 mRNA CTD PMID:19192274 NCBI chr 9:49,472,660...49,588,540 JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO Methylprednisolone inhibits the reaction [IL4 protein promotes the reaction [STAT6 protein binds to FCER2 promoter]]; Methylprednisolone inhibits the reaction [IL4 protein results in increased activity of and results in increased phosphorylation of STAT6 protein] CTD PMID:11997017 NCBI chr 7:63,480,229...63,497,551
Ensembl chr 7:63,479,642...63,498,495
JBrowse link
G Sts steroid sulfatase increases expression ISO Methylprednisolone results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TGFB1 mRNA] CTD PMID:26093215 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Methylprednisolone results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Methylprednisolone results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
EXP
ISO
Methylprednisolone inhibits the reaction [Bleomycin results in increased expression of TNF mRNA]; Methylprednisolone inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TNF mRNA]
[Cyclophosphamide co-treated with Methylprednisolone] inhibits the reaction [Paraquat results in increased expression of TNF protein]
Methylprednisolone results in decreased expression of TNF protein
CTD PMID:8384958 PMID:26093215 PMID:28557239 PMID:33737140 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Methylprednisolone results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
JBrowse link
G Trim63 tripartite motif containing 63 increases expression
multiple interactions
EXP Methylprednisolone results in increased expression of TRIM63 protein
Testosterone inhibits the reaction [Methylprednisolone results in increased expression of TRIM63 protein]
CTD PMID:21931329 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Methylprednisolone results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Vwf von Willebrand factor decreases expression
increases expression
ISO Methylprednisolone results in decreased expression of VWF protein
Methylprednisolone results in increased expression of VWF protein
CTD PMID:7491699 PMID:20405515 NCBI chr 4:158,360,152...158,491,539
Ensembl chr 4:158,360,152...158,491,539
JBrowse link
alclometasone dipropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO alclometasone dipropionate results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO alclometasone dipropionate results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO alclometasone dipropionate results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Csf2 colony stimulating factor 2 decreases expression ISO alclometasone dipropionate results in decreased expression of CSF2 protein CTD PMID:11407316 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ifng interferon gamma decreases expression ISO alclometasone dipropionate results in decreased expression of IFNG protein CTD PMID:11407316 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il2 interleukin 2 decreases expression ISO alclometasone dipropionate results in decreased expression of IL2 protein CTD PMID:11407316 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 decreases expression ISO alclometasone dipropionate results in decreased expression of IL3 protein CTD PMID:11407316 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 decreases expression ISO alclometasone dipropionate results in decreased expression of IL4 protein CTD PMID:11407316 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases expression ISO alclometasone dipropionate results in decreased expression of IL5 protein CTD PMID:11407316 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO alclometasone dipropionate results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
beclomethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
increases secretion
ISO Beclomethasone inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]; Beclomethasone inhibits the reaction [ABCB1 protein results in increased export of fluorexon]; Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]; valspodar inhibits the reaction [ABCB1 protein results in increased secretion of Beclomethasone]
Beclomethasone results in increased expression of ABCB1 mRNA; Beclomethasone results in increased expression of ABCB1 protein
CTD PMID:15370884 PMID:16442095 PMID:22464980 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO Beclomethasone results in increased expression of ABCB4 mRNA CTD PMID:15370884 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO Beclomethasone results in increased expression of ABCC1 mRNA CTD PMID:15370884 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity
ISO Beclomethasone inhibits the reaction [ABCG2 protein affects the transport of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine]; Beclomethasone inhibits the reaction [ABCG2 protein results in increased export of Mitoxantrone]
Beclomethasone results in increased activity of ABCG2 protein
CTD PMID:15365089 PMID:16442095 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant decreases activity ISO Beclomethasone results in decreased activity of ACP5 protein CTD PMID:8429434 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Adrb2 adrenoceptor beta 2 increases expression ISO Beclomethasone results in increased expression of ADRB2 mRNA CTD PMID:9032216 PMID:15679717 NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512
JBrowse link
G Bdkrb1 bradykinin receptor B1 decreases expression ISO Beclomethasone results in decreased expression of BDKRB1 mRNA CTD PMID:18039523 NCBI chr 6:124,510,827...124,514,475
Ensembl chr 6:124,510,870...124,513,747
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO Beclomethasone results in decreased expression of BGLAP protein CTD PMID:7746775 PMID:9232087 PMID:9544892 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Casp9 caspase 9 increases activity ISO Beclomethasone results in increased activity of CASP9 protein CTD PMID:11734450 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases expression ISO Beclomethasone results in increased expression of CAT protein CTD PMID:10445599 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein] CTD PMID:17988555 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Beclomethasone results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Beclomethasone results in increased expression of CCL3 protein CTD PMID:20116850 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO Beclomethasone results in increased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions
decreases expression
ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CCL5 protein; [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CCL5 protein; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]
Beclomethasone results in decreased expression of CCL5 mRNA; Beclomethasone results in decreased expression of CCL5 protein
CTD PMID:8534483 PMID:10903220 PMID:14643170 PMID:15679717 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]; Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]] CTD PMID:18076728 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions
decreases secretion
increases activity
ISO [Beclomethasone co-treated with Albuterol] results in decreased secretion of CSF2 protein; [Beclomethasone co-treated with Formoterol Fumarate] results in decreased secretion of CSF2 protein; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of CSF2 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of CSF2 protein]; Beclomethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]
Beclomethasone results in decreased secretion of CSF2 protein
Beclomethasone results in increased activity of CSF2 protein
CTD PMID:7545059 PMID:10460758 PMID:10868704 PMID:11167953 PMID:11730731 More... NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 decreases secretion ISO Beclomethasone results in decreased secretion of CXCL10 protein CTD PMID:17996064 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 decreases expression ISO Beclomethasone results in decreased expression of CYP2S1 mRNA CTD PMID:22155357 NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
increases expression
ISO 1-aminobenzotriazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Ketoconazole inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Mifepristone inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Paraoxon inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA]; Physostigmine inhibits the reaction [Beclomethasone results in increased expression of CYP3A5 mRNA] CTD PMID:12538830 PMID:23512537 PMID:24555085 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Epx eosinophil peroxidase multiple interactions EXP Beclomethasone inhibits the reaction [sephadex results in increased expression of EPX protein] CTD PMID:10850854 NCBI chr10:72,666,865...72,677,952
Ensembl chr10:72,666,865...72,677,952
JBrowse link
G Fcer1g Fc fragment of IgE receptor Ig decreases expression EXP Beclomethasone results in decreased expression of FCER1G protein CTD PMID:1834581 NCBI chr13:83,649,447...83,654,215
Ensembl chr13:83,649,449...83,671,443
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions
decreases activity
ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Albuterol promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of CD44 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Formoterol Fumarate promotes the reaction [Beclomethasone results in decreased activity of FGF2 protein] CTD PMID:18076728 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Beclomethasone co-treated with Albuterol] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein]; [Beclomethasone co-treated with Formoterol Fumarate] inhibits the reaction [FGF2 protein results in increased secretion of FN1 protein] CTD PMID:18076728 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO Beclomethasone results in decreased expression of FOS protein CTD PMID:9797757 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Ggt5 gamma-glutamyltransferase 5 increases activity
increases expression
multiple interactions
ISO Beclomethasone results in increased activity of GGT5 protein
Beclomethasone results in increased expression of GGT5 mRNA
[Beclomethasone results in increased activity of GGT5 protein] which results in increased metabolism of Leukotriene C4
CTD PMID:11447392 NCBI chr20:13,043,255...13,071,523 JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases metabolic processing ISO HSD11B2 protein results in increased metabolism of Beclomethasone CTD PMID:16549198 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Beclomethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:9150321 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il10 interleukin 10 decreases secretion ISO Beclomethasone results in decreased secretion of IL10 protein CTD PMID:9819297 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 multiple interactions
increases activity
ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of CCL11 protein]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 protein]
Beclomethasone inhibits the reaction [OVAL protein results in increased expression of IL13 protein]
Beclomethasone results in increased activity of IL13 protein
CTD PMID:17988555 PMID:29986831 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases secretion
decreases expression
ISO Beclomethasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA]; Beclomethasone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]; Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Beclomethasone results in decreased secretion of IL1B protein
Beclomethasone results in decreased expression of IL1B protein
CTD PMID:7545059 PMID:9176529 PMID:9371735 PMID:10460758 PMID:15337628 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Beclomethasone results in decreased expression of IL1RN protein CTD PMID:11015126 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il2ra interleukin 2 receptor subunit alpha decreases expression ISO Beclomethasone results in decreased expression of IL2RA protein CTD PMID:8111605 PMID:9314351 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697
JBrowse link
G Il3 interleukin 3 multiple interactions ISO Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL3 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL3 protein] CTD PMID:11167953 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 multiple interactions
decreases expression
ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]; Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [IL4 protein results in decreased expression of CD44 protein]]
Beclomethasone results in decreased expression of IL4 protein
CTD PMID:7988651 PMID:18076728 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 multiple interactions
decreases expression
ISO Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL5 mRNA]; Beclomethasone inhibits the reaction [Antigens, Dermatophagoides results in increased secretion of IL5 protein]
Beclomethasone results in decreased expression of IL5 protein
CTD PMID:7988651 PMID:10813552 PMID:11167953 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 mRNA]; Beclomethasone inhibits the reaction [IL13 protein results in increased expression of IL6 protein] CTD PMID:17988555 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ltf lactotransferrin multiple interactions
decreases secretion
ISO Beclomethasone inhibits the reaction [methylcholine results in increased secretion of LTF protein]
Beclomethasone results in decreased secretion of LTF protein
CTD PMID:11112886 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795
JBrowse link
G Mefv MEFV innate immuity regulator, pyrin increases response to substance ISO MEFV mutant form results in increased susceptibility to Beclomethasone CTD PMID:20828792 NCBI chr10:11,786,948...11,796,977
Ensembl chr10:11,787,422...11,796,973
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Beclomethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP2 protein] CTD PMID:10455257 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO Beclomethasone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]
Beclomethasone results in decreased expression of MMP9 protein
CTD PMID:10452757 PMID:10455257 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO Beclomethasone results in decreased expression of NOS2 protein CTD PMID:12668791 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Beclomethasone results in increased activity of NR1I2 protein CTD PMID:21068194 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects localization
increases expression
affects binding
multiple interactions
increases activity
ISO
EXP
Beclomethasone affects the localization of NR3C1 protein
Beclomethasone results in increased expression of NR3C1 mRNA
Beclomethasone binds to NR3C1 protein
[Beclomethasone co-treated with Albuterol] affects the localization of NR3C1 protein; [Beclomethasone co-treated with Formoterol Fumarate] affects the localization of NR3C1 protein; Beclomethasone affects the localization of and results in increased activity of NR3C1 protein; Beclomethasone binds to and results in increased activity of NR3C1 protein
Beclomethasone results in increased activity of NR3C1 protein
CTD PMID:16814 PMID:2207292 PMID:15362971 PMID:15679717 PMID:15860753 More... NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases activity ISO Beclomethasone results in increased activity of NR3C2 protein CTD PMID:15362971 NCBI chr19:30,715,648...31,059,885
Ensembl chr19:30,715,648...31,059,885
JBrowse link
G Pla1a phospholipase A1 member A multiple interactions ISO Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA1A mRNA] CTD PMID:20573295 NCBI chr11:62,320,117...62,357,779
Ensembl chr11:62,320,493...62,357,779
JBrowse link
G Pla2g4a phospholipase A2 group IVA decreases activity
multiple interactions
ISO Beclomethasone results in decreased activity of PLA2G4A protein
Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of PLA2G4A mRNA]
CTD PMID:15337628 PMID:20573295 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Ppp1r14a protein phosphatase 1, regulatory (inhibitor) subunit 14A multiple interactions EXP Beclomethasone inhibits the reaction [Acetylcholine results in increased phosphorylation of PPP1R14A protein] CTD PMID:18577381 NCBI chr 1:84,583,127...84,590,743
Ensembl chr 1:84,586,627...84,590,671
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP Beclomethasone inhibits the reaction [[[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein] which results in increased susceptibility to Acetylcholine]; Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of and results in increased activity of RHOA protein]; Beclomethasone inhibits the reaction [[Antigens, Bacterial co-treated with Allergens] results in increased expression of RHOA mRNA] CTD PMID:18391481 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rnase2 ribonuclease A family member 2 decreases expression ISO Beclomethasone results in decreased expression of RNASE2 protein CTD PMID:12166584 NCBI chr15:24,449,618...24,450,427
Ensembl chr15:24,449,611...24,450,479
JBrowse link
G Rnase3 ribonuclease A family member 3 multiple interactions
decreases expression
ISO [Salmeterol Xinafoate co-treated with Beclomethasone] affects the reaction [Allergens results in increased expression of RNASE3 protein]; Beclomethasone affects the reaction [Allergens results in increased expression of RNASE3 protein]
Beclomethasone results in decreased expression of RNASE3 protein
CTD PMID:1443864 PMID:10513351 PMID:10573242 PMID:12166584 PMID:12587966 More... NCBI chr15:24,511,894...24,512,764
Ensembl chr15:24,511,891...24,512,790
JBrowse link
G Sele selectin E multiple interactions ISO Beclomethasone inhibits the reaction [IL1B protein results in increased expression of SELE mRNA] CTD PMID:9371735 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Beclomethasone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions ISO Albuterol promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]]; Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]; Formoterol Fumarate promotes the reaction [Beclomethasone inhibits the reaction [FGF2 protein results in decreased expression of THY1 protein]] CTD PMID:18076728 NCBI chr 8:44,389,495...44,394,688
Ensembl chr 8:44,389,513...44,394,659
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO Beclomethasone results in increased expression of TIMP1 protein CTD PMID:10452757 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases secretion
ISO Beclomethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Beclomethasone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CCL5 protein]; Beclomethasone inhibits the reaction [TNF protein results in increased secretion of CXCL8 protein]
Beclomethasone results in decreased secretion of TNF protein
CTD PMID:8937731 PMID:9150321 PMID:9819297 PMID:10100995 PMID:10903220 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Beclomethasone inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:10100995 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Beclomethasone results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        xenobiotic 18446
          prednisolone 232
            6-methylprednisolone + 127
            alclometasone 0
            alclometasone dipropionate 10
            beclomethasone + 58
            prednisolone phosphate 0
            prednisolone succinate 0
            prednisolone-16-carboxylic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic group 18739
                              organic divalent group 18730
                                organodiyl group 18730
                                  carbonyl group 18678
                                    carbonyl compound 18678
                                      ketone 16926
                                        oxo steroid 9722
                                          3-oxo steroid 9280
                                            3-oxo-Delta(4) steroid 8423
                                              progesterone 2716
                                                Delta(1)-progesterone 238
                                                  prednisolone 232
                                                    6-methylprednisolone + 127
                                                    alclometasone 0
                                                    alclometasone dipropionate 10
                                                    beclomethasone + 58
                                                    prednisolone phosphate 0
                                                    prednisolone succinate 0
                                                    prednisolone-16-carboxylic acid + 0
paths to the root