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Accession:CHEBI:83766 term browser browse the term
Definition:A member of the class of N-acylpiperazines obtained by formal condensation of the carboxy group of 2-fluoro-5-[(4-oxo-3,4-dihydrophthalazin-1-yl)methyl]benzoic acid with the free amino group of N-(cyclpropylcarbonyl)piperazine; used to treat advanced ovarian cancer.
Synonyms:exact_synonym: 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one
 related_synonym: AZD-2281;   AZD2281;   Formula=C24H23FN4O3;   InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30);   InChIKey=FDLYAMZZIXQODN-UHFFFAOYSA-N;   KU59436;   Lynparza;   SMILES=Fc1ccc(Cc2n[nH]c(=O)c3ccccc23)cc1C(=O)N1CCN(CC1)C(=O)C1CC1
 xref: CAS:763113-22-0 "ChemIDplus";   CAS:763113-22-0 "KEGG DRUG";   Drug_Central:4907 "DrugCentral";   KEGG:D09730;   LINCS:LSM-1145
 xref_mesh: MESH:C531550
 xref: PDBeChem:09L;   PMID:18800822 "SUBMITTER";   PMID:22454224 "Europe PMC";   PMID:24038812 "Europe PMC";   PMID:24356813 "Europe PMC";   PMID:24534203 "Europe PMC";   PMID:24577941 "Europe PMC";   PMID:24631446 "Europe PMC";   PMID:24694947 "Europe PMC";   PMID:24700236 "Europe PMC";   PMID:24817481 "Europe PMC";   PMID:24826054 "Europe PMC";   PMID:24827126 "Europe PMC";   PMID:25025963 "Europe PMC";   PMID:25072752 "Europe PMC";   PMID:25139258 "Europe PMC";   PMID:25218906 "Europe PMC";   PMID:25275045 "Europe PMC";   PMID:25404465 "Europe PMC";   PMID:25483710 "Europe PMC";   PMID:25531448 "Europe PMC";   PMID:25566684 "Europe PMC";   PMID:25573533 "Europe PMC";   Reaxys:12051534 "Reaxys";   Wikipedia:Olaparib

show annotations for term's descendants       view all columns           Sort by:
olaparib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bap1 Brca1 associated protein 1 JBrowse link 16 7,336,685 7,345,511 RGD:6480464
G Brca1 BRCA1, DNA repair associated JBrowse link 10 89,394,821 89,455,093 RGD:6480464
G Brca2 BRCA2, DNA repair associated JBrowse link 12 503,660 544,754 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:6480464
G Fh fumarate hydratase JBrowse link 13 93,651,486 93,677,371 RGD:6480464
G H2ax H2A.X variant histone JBrowse link 8 48,665,652 48,666,981 RGD:6480464
G Mlh1 mutL homolog 1 JBrowse link 8 119,486,655 119,523,716 RGD:6480464
G Msh2 mutS homolog 2 JBrowse link 6 11,215,951 11,274,916 RGD:6480464
G Msh3 mutS homolog 3 JBrowse link 2 21,790,048 21,931,791 RGD:6480464
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:6480464
G Sdhb succinate dehydrogenase complex iron sulfur subunit B JBrowse link 5 159,484,378 159,505,063 RGD:6480464
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      biological role 19604
        biochemical role 19133
          apoptosis inducer 10823
            olaparib 13
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic molecule 19337
                              organic cyclic compound 19089
                                carbocyclic compound 17514
                                  benzenoid aromatic compound 17036
                                    benzenes 16751
                                      fluorobenzenes 1620
                                        monofluorobenzenes 1287
                                          olaparib 13
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.