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ONTOLOGY REPORT - ANNOTATIONS


Term:prazosin
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Accession:CHEBI:8364 term browser browse the term
Definition:A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Synonyms:exact_synonym: 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
 related_synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine;   2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline;   Formula=C19H21N5O4;   InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);   InChIKey=IENZQIKPVFGBNW-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1;   prazosina;   prazosine;   prazosinum
 xref: Beilstein:768345 "Beilstein";   CAS:19216-56-9 "ChemIDplus";   CAS:19216-56-9 "KEGG COMPOUND";   DrugBank:DB00457;   Drug_Central:4209 "DrugCentral";   HMDB:HMDB0014600;   KEGG:C07368;   KEGG:D08411;   LINCS:LSM-3079
 xref_mesh: MESH:D011224
 xref: PMID:20825390 "Europe PMC";   Patent:GB1156973;   Patent:NL7206067;   Patent:US3511836;   Reaxys:768345 "Reaxys";   Wikipedia:Prazosin


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prazosin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCB1 ATP binding cassette subfamily B member 1 JBrowse link 7 87,503,017 87,713,323 RGD:6480464
G ABCG2 ATP binding cassette subfamily G member 2 (Junior blood group) JBrowse link 4 88,090,264 88,231,626 RGD:6480464
G ACTA1 actin alpha 1, skeletal muscle JBrowse link 1 229,431,245 229,434,094 RGD:6480464
G ADORA1 adenosine A1 receptor JBrowse link 1 203,127,705 203,167,405 RGD:6480464
G ADORA2A adenosine A2a receptor JBrowse link 22 24,423,597 24,442,360 RGD:6480464
G ADORA3 adenosine A3 receptor JBrowse link 1 111,499,429 111,503,633 RGD:6480464
G ADRA1A adrenoceptor alpha 1A JBrowse link 8 26,738,113 26,870,994 RGD:6480464
G ADRA1B adrenoceptor alpha 1B JBrowse link 5 159,916,482 159,989,205 RGD:6480464
G ADRA1D adrenoceptor alpha 1D JBrowse link 20 4,220,630 4,249,287 RGD:6480464
G ADRA2A adrenoceptor alpha 2A JBrowse link 10 111,077,029 111,080,907 RGD:6480464
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 JBrowse link 12 110,281,247 110,351,093 RGD:6480464
G AVP arginine vasopressin JBrowse link 20 3,082,556 3,093,521 RGD:6480464
G CASP8 caspase 8 JBrowse link 2 201,233,443 201,287,711 RGD:6480464
G CASP9 caspase 9 JBrowse link 1 15,491,401 15,524,912 RGD:6480464
G CCL5 C-C motif chemokine ligand 5 JBrowse link 17 35,871,491 35,880,360 RGD:6480464
G CREB1 cAMP responsive element binding protein 1 JBrowse link 2 207,529,943 207,605,988 RGD:6480464
G CXCL8 C-X-C motif chemokine ligand 8 JBrowse link 4 73,740,569 73,743,716 RGD:6480464
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 JBrowse link 15 74,719,542 74,725,528 RGD:6480464
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 JBrowse link 15 74,748,845 74,756,607 RGD:6480464
G EDN1 endothelin 1 JBrowse link 6 12,256,463 12,297,194 RGD:6480464
G FN1 fibronectin 1 JBrowse link 2 215,360,440 215,436,167 RGD:6480464
G FOS Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 14 75,278,828 75,282,230 RGD:6480464
G G6PD glucose-6-phosphate dehydrogenase JBrowse link X 154,531,390 154,547,569 RGD:6480464
G GCLC glutamate-cysteine ligase catalytic subunit JBrowse link 6 53,497,341 53,545,101 RGD:6480464
G HMOX1 heme oxygenase 1 JBrowse link 22 35,381,096 35,394,207 RGD:6480464
G IGF1 insulin like growth factor 1 JBrowse link 12 102,395,860 102,481,839 RGD:6480464
G JUN Jun proto-oncogene, AP-1 transcription factor subunit JBrowse link 1 58,780,791 58,784,047 RGD:6480464
G LHB luteinizing hormone subunit beta JBrowse link 19 49,015,980 49,017,090 RGD:6480464
G LPL lipoprotein lipase JBrowse link 8 19,939,253 19,967,259 RGD:6480464
G MAPK1 mitogen-activated protein kinase 1 JBrowse link 22 21,759,657 21,867,680 RGD:6480464
G MAPK3 mitogen-activated protein kinase 3 JBrowse link 16 30,114,105 30,123,309 RGD:6480464
G MMP2 matrix metallopeptidase 2 JBrowse link 16 55,478,830 55,506,691 RGD:6480464
G MYH6 myosin heavy chain 6 JBrowse link 14 23,381,990 23,408,277 RGD:6480464
G MYH7 myosin heavy chain 7 JBrowse link 14 23,412,740 23,435,677 RGD:6480464
G NCF1 neutrophil cytosolic factor 1 JBrowse link 7 74,773,962 74,789,376 RGD:6480464
G NFE2L2 nuclear factor, erythroid 2 like 2 JBrowse link 2 177,230,303 177,265,131 RGD:6480464
G NOS2 nitric oxide synthase 2 JBrowse link 17 27,756,766 27,800,529 RGD:6480464
G NPPA natriuretic peptide A JBrowse link 1 11,845,709 11,847,783 RGD:6480464
G NPY neuropeptide Y JBrowse link 7 24,284,190 24,291,862 RGD:6480464
G OXT oxytocin/neurophysin I prepropeptide JBrowse link 20 3,068,871 3,072,517 RGD:6480464
G PLCB1 phospholipase C beta 1 JBrowse link 20 8,132,266 8,884,900 RGD:6480464
G PLCB3 phospholipase C beta 3 JBrowse link 11 64,251,530 64,269,452 RGD:6480464
G PLCD1 phospholipase C delta 1 JBrowse link 3 38,007,496 38,029,642 RGD:6480464
G PLCG1 phospholipase C gamma 1 JBrowse link 20 41,137,519 41,177,626 RGD:6480464
G PPARGC1A PPARG coactivator 1 alpha JBrowse link 4 23,792,021 24,472,905 RGD:6480464
G REN renin JBrowse link 1 204,154,819 204,166,337 RGD:6480464
G RPS6KB1 ribosomal protein S6 kinase B1 JBrowse link 17 59,893,046 59,950,574 RGD:6480464
G RPS6KB2 ribosomal protein S6 kinase B2 JBrowse link 11 67,428,475 67,435,408 RGD:6480464
G SHC1 SHC adaptor protein 1 JBrowse link 1 154,962,298 154,974,492 RGD:6480464
G SLC22A1 solute carrier family 22 member 1 JBrowse link 6 160,121,808 160,160,590 RGD:6480464
G SLC22A2 solute carrier family 22 member 2 JBrowse link 6 160,216,755 160,258,821 RGD:6480464
G SLC22A3 solute carrier family 22 member 3 JBrowse link 6 160,348,378 160,454,982 RGD:6480464
G SPN sialophorin JBrowse link 16 29,662,950 29,670,876 RGD:6480464
G TGFB1 transforming growth factor beta 1 JBrowse link 19 41,330,323 41,353,922 RGD:6480464
G TGFB2 transforming growth factor beta 2 JBrowse link 1 218,345,284 218,444,619 RGD:6480464
G TGFB3 transforming growth factor beta 3 JBrowse link 14 75,958,061 75,983,011 RGD:6480464
G TIMP2 TIMP metallopeptidase inhibitor 2 JBrowse link 17 78,852,977 78,925,387 RGD:6480464
G TNFSF11 TNF superfamily member 11 JBrowse link 13 42,562,736 42,608,013 RGD:6480464
G TYR tyrosinase JBrowse link 11 89,177,565 89,295,759 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 23677
    role 23565
      application 22946
        pharmaceutical 22484
          drug 22484
            cardiovascular drug 7688
              antihypertensive agent 1689
                prazosin 59
                  prazosin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 23677
    subatomic particle 23624
      composite particle 23624
        hadron 23624
          baryon 23624
            nucleon 23624
              atomic nucleus 23624
                atom 23624
                  main group element atom 23441
                    p-block element atom 23441
                      carbon group element atom 23142
                        carbon atom 23118
                          organic molecular entity 23118
                            organic group 21814
                              organic divalent group 21784
                                organodiyl group 21784
                                  carbonyl group 21756
                                    carbonyl compound 21756
                                      carboxylic acid 20776
                                        carboacyl group 18718
                                          univalent carboacyl group 18718
                                            carbamoyl group 18038
                                              carboxamide 18038
                                                monocarboxylic acid amide 14124
                                                  prazosin 59
                                                    prazosin hydrochloride 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.