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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prazosin
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Accession:CHEBI:8364 term browser browse the term
Definition:A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Synonyms:exact_synonym: 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
 related_synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine;   2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline;   Formula=C19H21N5O4;   InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);   InChIKey=IENZQIKPVFGBNW-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1;   prazosina;   prazosine;   prazosinum
 xref: Beilstein:768345;   CAS:19216-56-9;   DrugBank:DB00457;   Drug_Central:4209;   HMDB:HMDB0014600;   KEGG:C07368;   KEGG:D08411;   LINCS:LSM-3079
 xref_mesh: MESH:D011224
 xref: PMID:20825390;   Patent:GB1156973;   Patent:NL7206067;   Patent:US3511836;   Reaxys:768345;   Wikipedia:Prazosin



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prazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
affects transport
ISO ABCB1A protein affects the susceptibility to Prazosin
ABCB1A protein affects the transport of Prazosin
ABCB1 protein affects the transport of Prazosin
CTD PMID:15502009 PMID:15616150 PMID:18322075 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Prazosin CTD PMID:15502009 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases export
affects transport
ISO 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Prazosin]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of Prazosin]
6-OH-BDE-47 inhibits the reaction [ABCG2 protein results in increased export of Prazosin]
ABCG2 protein affects the transport of Prazosin
CTD PMID:18322075 PMID:19056916 PMID:28031414 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA] CTD PMID:17592507 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein] CTD PMID:19966059 NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein] CTD PMID:19966059 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Adora3 adenosine A3 receptor multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein] CTD PMID:19966059 NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
affects binding
increases expression
decreases activity
ISO
EXP
1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1A protein]; alfuzosin inhibits the reaction [Prazosin binds to ADRA1A protein]; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1A protein]; Norepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]; Prazosin binds to and results in decreased activity of ADRA1A protein; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]; xylometazoline inhibits the reaction [ADRA1A protein binds to Prazosin]
ADRA1A protein binds to Prazosin; Prazosin binds to ADRA1A protein
Prazosin results in increased expression of ADRA1A mRNA; Prazosin results in increased expression of ADRA1A protein
Prazosin binds to and affects the activity of ADRA1A protein; Prazosin binds to and results in decreased activity of ADRA1A protein; Prazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]
Prazosin results in decreased activity of ADRA1A protein
CTD PMID:6310690 PMID:7536677 PMID:8183249 PMID:8196478 PMID:9639061 More... NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
increases expression
affects binding
ISO
EXP
1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1B protein]; Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1B protein]; Norepinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1B protein binds to Prazosin]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein]; xylometazoline inhibits the reaction [ADRA1B protein binds to Prazosin]
Prazosin results in increased expression of ADRA1B protein
Prazosin binds to and affects the activity of ADRA1B protein
ADRA1B protein binds to Prazosin; Prazosin binds to ADRA1B protein
CTD PMID:8183249 PMID:9639061 PMID:11934817 PMID:11937776 PMID:20030735 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions
affects binding
ISO
EXP
1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1D protein]; Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1D protein]; Norepinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1D protein binds to Prazosin]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein]; xylometazoline inhibits the reaction [ADRA1D protein binds to Prazosin]
ADRA1D protein binds to Prazosin; Prazosin binds to ADRA1D protein
Prazosin binds to and affects the activity of ADRA1D protein
CTD PMID:8183249 PMID:9294627 PMID:9639061 PMID:11937776 PMID:15493479 More... NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP
Prazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]
Prazosin binds to and results in decreased activity of ADRA2A protein
CTD PMID:8397342 PMID:10742289 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA] CTD PMID:11577024 PMID:17592507 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Avp arginine vasopressin increases expression EXP Prazosin results in increased expression of AVP protein CTD PMID:1791990 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Casp8 caspase 8 increases activity ISO Prazosin results in increased activity of CASP8 protein CTD PMID:26449523 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Prazosin results in increased activity of CASP9 protein CTD PMID:26449523 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Prazosin inhibits the reaction [Norepinephrine results in increased secretion of CCL5 protein] CTD PMID:16782692 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] CTD PMID:15522277 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
Prazosin results in increased expression of CYP1A1 mRNA
CTD PMID:15627480 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein] CTD PMID:16510159 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Prazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein] CTD PMID:12513686 PMID:15007106 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Norepinephrine co-treated with Prazosin] results in decreased expression of FN1 protein CTD PMID:11821714 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
Prazosin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein]
Prazosin inhibits the reaction [Amphetamine results in increased expression of FOS protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]
CTD PMID:12560108 PMID:12955385 PMID:19225867 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]; Prazosin inhibits the reaction [norfenefrine results in increased activity of G6PD protein] CTD PMID:1378361 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Prazosin inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA] CTD PMID:18071297 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Prazosin inhibits the reaction [Acetaminophen results in increased expression of HMOX1 mRNA] CTD PMID:18071297 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP Prazosin inhibits the reaction [IGF1 protein results in decreased susceptibility to Norepinephrine] CTD PMID:17184500 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA] CTD PMID:19225867 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein] CTD PMID:3953791 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA] CTD PMID:9032464 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
affects activity
ISO
EXP
Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
Prazosin affects the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
Prazosin affects the activity of MAPK1 protein
CTD PMID:11693273 PMID:11804996 PMID:11880281 PMID:12513686 PMID:17306214 More... NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects activity
multiple interactions
EXP
ISO
Prazosin affects the activity of MAPK3 protein
Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CTD PMID:11693273 PMID:11804996 PMID:11880281 PMID:12513686 PMID:17306214 More... NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA] CTD PMID:15326086 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA] CTD PMID:11577024 PMID:17592507 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:11577024 PMID:17592507 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Prazosin inhibits the reaction [Cocaine results in increased phosphorylation of NCF1 protein] CTD PMID:15936005 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases activity ISO Prazosin results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Prazosin inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 protein]
CTD PMID:15753950 PMID:19439816 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Prazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:12513686 PMID:15240149 PMID:16714034 PMID:17592507 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Npy neuropeptide Y multiple interactions EXP [Prazosin co-treated with SCH 23390] inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein] CTD PMID:21989786 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide increases expression EXP Prazosin results in increased expression of OXT protein CTD PMID:1791990 NCBI chr 3:117,782,650...117,783,490
Ensembl chr 3:117,782,650...117,783,490
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein] CTD PMID:16714034 PMID:19225867 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
G Plcb3 phospholipase C beta 3 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein] CTD PMID:16714034 PMID:19225867 NCBI chr 1:204,143,257...204,160,384
Ensembl chr 1:204,144,956...204,160,228
JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein] CTD PMID:16714034 PMID:19225867 NCBI chr 8:118,795,196...118,818,186
Ensembl chr 8:118,795,201...118,818,186
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein] CTD PMID:16714034 PMID:19225867 NCBI chr 3:149,385,587...149,416,330
Ensembl chr 3:149,385,587...149,416,330
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA] CTD PMID:16513826 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ren renin decreases activity
increases activity
multiple interactions
increases transport
ISO
EXP
Prazosin results in decreased activity of REN protein
Prazosin results in increased activity of REN protein
Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein]
CTD PMID:3539430 PMID:6173514 PMID:6258839 PMID:7023672 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein] CTD PMID:12720544 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein] CTD PMID:12720544 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions
ISO Prazosin results in decreased activity of SLC22A1 protein
Prazosin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:12110607 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Prazosin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases activity
ISO Prazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Prazosin results in decreased activity of SLC22A3 protein
CTD PMID:12110607 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Spn sialophorin decreases response to substance ISO SPN protein results in decreased susceptibility to Prazosin CTD PMID:18711009 NCBI chr 1:181,746,937...181,759,564
Ensembl chr 1:181,746,429...181,759,628
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB1 mRNA] CTD PMID:15326086 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB2 mRNA] CTD PMID:15326086 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB3 mRNA] CTD PMID:15326086 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA] CTD PMID:15326086 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA] CTD PMID:17306214 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tyr tyrosinase multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein] CTD PMID:15278367 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20056
    role 20008
      application 19745
        pharmaceutical 19618
          drug 19618
            cardiovascular drug 7726
              antihypertensive agent 1877
                prazosin 59
                  prazosin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20056
    subatomic particle 20054
      composite particle 20054
        hadron 20054
          baryon 20054
            nucleon 20054
              atomic nucleus 20054
                atom 20054
                  main group element atom 19956
                    p-block element atom 19956
                      carbon group element atom 19882
                        carbon atom 19875
                          organic molecular entity 19875
                            organic group 18961
                              organic divalent group 18947
                                organodiyl group 18947
                                  carbonyl group 18900
                                    carbonyl compound 18900
                                      carboxylic acid 18594
                                        carboacyl group 17706
                                          univalent carboacyl group 17706
                                            carbamoyl group 17546
                                              carboxamide 17546
                                                monocarboxylic acid amide 15515
                                                  prazosin 59
                                                    prazosin hydrochloride 0
paths to the root