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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:prazosin
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Accession:CHEBI:8364 term browser browse the term
Definition:A member of the class of piperazines that is piperazine substituted by a furan-2-ylcarbonyl group and a 4-amino-6,7-dimethoxyquinazolin-2-yl group at positions 1 and 4 respectively.
Synonyms:exact_synonym: 2-[4-(2-furoyl)piperazin-1-yl]-6,7-dimethoxyquinazolin-4-amine
 related_synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine;   2-(4-(2-Furoyl)piperazin-1-yl)-4-amino-6,7-dimethoxyquinazoline;   Formula=C19H21N5O4;   InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);   InChIKey=IENZQIKPVFGBNW-UHFFFAOYSA-N;   SMILES=COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1;   prazosina;   prazosine;   prazosinum
 xref: Beilstein:768345;   CAS:19216-56-9;   DrugBank:DB00457;   Drug_Central:4209;   HMDB:HMDB0014600;   KEGG:C07368;   KEGG:D08411;   LINCS:LSM-3079
 xref_mesh: MESH:D011224
 xref: PMID:20825390;   Patent:GB1156973;   Patent:NL7206067;   Patent:US3511836;   Reaxys:768345;   Wikipedia:Prazosin


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prazosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance
affects transport
ISO ABCB1A protein affects the susceptibility to Prazosin
ABCB1A protein affects the transport of Prazosin
ABCB1 protein affects the transport of Prazosin
CTD PMID:15502009, PMID:15616150, PMID:18322075 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Prazosin CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases export
affects transport
ISO 3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester inhibits the reaction [ABCG2 protein results in increased export of Prazosin]; Elacridar inhibits the reaction [ABCG2 protein results in increased export of Prazosin]
6-OH-BDE-47 inhibits the reaction [ABCG2 protein results in increased export of Prazosin]
ABCG2 protein affects the transport of Prazosin
CTD PMID:18322075, PMID:19056916, PMID:28031414 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ACTA1 mRNA] CTD PMID:17592507 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Adora1 adenosine A1 receptor multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA1 protein] CTD PMID:19966059 NCBI chr13:51,042,111...51,076,913
Ensembl chr13:51,042,248...51,076,852
JBrowse link
G Adora2a adenosine A2a receptor multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA2A protein] CTD PMID:19966059 NCBI chr20:14,265,251...14,282,873
Ensembl chr20:14,265,252...14,282,873
JBrowse link
G Adora3 adenosine A3 receptor multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of ADORA3 protein] CTD PMID:19966059 NCBI chr 2:208,336,909...208,379,217
Ensembl chr 2:208,373,154...208,376,803
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions
affects binding
increases expression
decreases activity
ISO
EXP
1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1A protein]; alfuzosin inhibits the reaction [Prazosin binds to ADRA1A protein]; Epinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1A protein]; Norepinephrine inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1A protein binds to Prazosin]; Oxymetazoline inhibits the reaction [Prazosin binds to ADRA1A protein]; Prazosin binds to and results in decreased activity of ADRA1A protein; Prazosin inhibits the reaction [[Phenylephrine results in increased activity of ADRA1A protein] which results in decreased transport of Potassium]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]; xylometazoline inhibits the reaction [ADRA1A protein binds to Prazosin]
ADRA1A protein binds to Prazosin; Prazosin binds to ADRA1A protein
Prazosin results in increased expression of ADRA1A mRNA; Prazosin results in increased expression of ADRA1A protein
Prazosin binds to and affects the activity of ADRA1A protein; Prazosin binds to and results in decreased activity of ADRA1A protein; Prazosin inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]; Prazosin inhibits the reaction [Norepinephrine results in increased activity of ADRA1A protein]
Prazosin results in decreased activity of ADRA1A protein
CTD PMID:6310690, PMID:7536677, PMID:8183249, PMID:8196478, PMID:9639061, PMID:10416824, PMID:11693201, PMID:11934817, PMID:11937776, PMID:12560108, PMID:15365637, PMID:15550506, PMID:15627480, PMID:15951348, PMID:16545797, PMID:20030735 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions
increases expression
affects binding
ISO
EXP
1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1B protein]; Epinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1B protein]; Norepinephrine inhibits the reaction [ADRA1B protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1B protein binds to Prazosin]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein]; xylometazoline inhibits the reaction [ADRA1B protein binds to Prazosin]
Prazosin results in increased expression of ADRA1B protein
Prazosin binds to and affects the activity of ADRA1B protein
ADRA1B protein binds to Prazosin; Prazosin binds to ADRA1B protein
CTD PMID:8183249, PMID:9639061, PMID:11934817, PMID:11937776, PMID:20030735 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions
affects binding
ISO
EXP
1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol inhibits the reaction [Prazosin binds to ADRA1D protein]; Epinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Ketanserin inhibits the reaction [Prazosin binds to ADRA1D protein]; Norepinephrine inhibits the reaction [ADRA1D protein binds to Prazosin]; Oxymetazoline inhibits the reaction [ADRA1D protein binds to Prazosin]; sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein]; xylometazoline inhibits the reaction [ADRA1D protein binds to Prazosin]
ADRA1D protein binds to Prazosin; Prazosin binds to ADRA1D protein
Prazosin binds to and affects the activity of ADRA1D protein
CTD PMID:8183249, PMID:9294627, PMID:9639061, PMID:11937776, PMID:15493479, PMID:20030735 NCBI chr 3:124,129,558...124,145,566
Ensembl chr 3:124,129,558...124,145,566
JBrowse link
G Adra2a adrenoceptor alpha 2A multiple interactions ISO
EXP
Prazosin inhibits the reaction [Norepinephrine binds to and results in increased activity of ADRA2A protein]; Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Brimonidine Tartrate binds to and results in increased activity of ADRA2A protein]]
Prazosin binds to and results in decreased activity of ADRA2A protein
CTD PMID:8397342, PMID:10742289 NCBI chr 1:274,766,283...274,769,083
Ensembl chr 1:274,766,283...274,769,081
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in decreased expression of ATP2A2 mRNA] CTD PMID:11577024, PMID:17592507 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Avp arginine vasopressin increases expression EXP Prazosin results in increased expression of AVP protein CTD PMID:1791990 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Casp8 caspase 8 increases activity ISO Prazosin results in increased activity of CASP8 protein CTD PMID:26449523 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases activity ISO Prazosin results in increased activity of CASP9 protein CTD PMID:26449523 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Prazosin inhibits the reaction [Norepinephrine results in increased secretion of CCL5 protein] CTD PMID:16782692 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of CREB1 protein] CTD PMID:15522277 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
Prazosin results in increased expression of CYP1A1 mRNA
CTD PMID:15627480 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]; Prazosin promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 protein] CTD PMID:16510159 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP Prazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of EDN1 protein] CTD PMID:12513686, PMID:15007106 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [Norepinephrine co-treated with Prazosin] results in decreased expression of FN1 protein CTD PMID:11821714 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO
EXP
Prazosin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased expression of FOS protein]
Prazosin inhibits the reaction [Amphetamine results in increased expression of FOS protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of FOS mRNA]
CTD PMID:12560108, PMID:12955385, PMID:19225867 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased activity of G6PD protein]; Prazosin inhibits the reaction [norfenefrine results in increased activity of G6PD protein] CTD PMID:1378361 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Prazosin inhibits the reaction [Acetaminophen results in increased expression of GCLC mRNA] CTD PMID:18071297 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Prazosin inhibits the reaction [Acetaminophen results in increased expression of HMOX1 mRNA] CTD PMID:18071297 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP Prazosin inhibits the reaction [IGF1 protein results in decreased susceptibility to Norepinephrine] CTD PMID:17184500 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of JUN mRNA] CTD PMID:19225867 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in decreased secretion of and results in decreased expression of LHB protein] CTD PMID:3953791 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lpl lipoprotein lipase multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of LPL mRNA] CTD PMID:9032464 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
affects activity
ISO
EXP
Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
Prazosin affects the reaction [Norepinephrine results in increased activity of and results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK1 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK1 protein]
Prazosin affects the activity of MAPK1 protein
CTD PMID:11693273, PMID:11804996, PMID:11880281, PMID:12513686, PMID:17306214, PMID:18445782, PMID:20434527 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects activity
multiple interactions
EXP
ISO
Prazosin affects the activity of MAPK3 protein
Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
Prazosin inhibits the reaction [[Norepinephrine co-treated with Propranolol] results in increased phosphorylation of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased activity of MAPK3 protein]; Prazosin inhibits the reaction [Phenylephrine results in increased phosphorylation of MAPK3 protein]
CTD PMID:11693273, PMID:11804996, PMID:11880281, PMID:12513686, PMID:17306214, PMID:18445782 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of MMP2 mRNA] CTD PMID:15326086 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in decreased expression of MYH6 mRNA] CTD PMID:11577024, PMID:17592507 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA] CTD PMID:11577024, PMID:17592507 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP Prazosin inhibits the reaction [Cocaine results in increased phosphorylation of NCF1 protein] CTD PMID:15936005 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases activity ISO Prazosin results in decreased activity of NFE2L2 protein CTD PMID:30203046 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
Prazosin inhibits the reaction [carvedilol inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [carvedilol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Dopamine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Epinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitrites]]; Prazosin inhibits the reaction [Norepinephrine inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NOS2 protein]
CTD PMID:15753950, PMID:19439816 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Prazosin inhibits the reaction [EDN1 protein results in increased expression of NPPA protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]; Prazosin inhibits the reaction [Phenylephrine results in increased expression of NPPA protein] CTD PMID:12513686, PMID:15240149, PMID:16714034, PMID:17592507 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y multiple interactions EXP [Prazosin co-treated with SCH 23390] inhibits the reaction [Phenylpropanolamine results in decreased expression of NPY protein] CTD PMID:21989786 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Oxt oxytocin/neurophysin I prepropeptide increases expression EXP Prazosin results in increased expression of OXT protein CTD PMID:1791990 NCBI chr 3:123,106,694...123,107,534
Ensembl chr 3:123,106,694...123,107,534
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB1 protein] CTD PMID:16714034, PMID:19225867 NCBI chr 3:127,721,244...128,419,565
Ensembl chr 3:128,155,069...128,419,545
JBrowse link
G Plcb3 phospholipase C beta 3 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCB3 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCB3 protein] CTD PMID:16714034, PMID:19225867 NCBI chr 1:222,207,887...222,224,993
Ensembl chr 1:222,209,575...222,224,910
JBrowse link
G Plcd1 phospholipase C, delta 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCD1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCD1 protein] CTD PMID:16714034, PMID:19225867 NCBI chr 8:127,753,514...127,782,070
Ensembl chr 8:127,753,539...127,782,070
JBrowse link
G Plcg1 phospholipase C, gamma 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of and results in increased activity of PLCG1 protein]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 mRNA]; Prazosin inhibits the reaction [Norepinephrine results in increased expression of PLCG1 protein] CTD PMID:16714034, PMID:19225867 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions ISO [Propranolol co-treated with Prazosin] inhibits the reaction [Norepinephrine results in increased expression of PPARGC1A mRNA] CTD PMID:16513826 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ren renin decreases activity
increases activity
multiple interactions
increases transport
ISO
EXP
Prazosin results in decreased activity of REN protein
Prazosin results in increased activity of REN protein
Propranolol inhibits the reaction [Prazosin results in increased transport of REN protein]
CTD PMID:3539430, PMID:6173514, PMID:6258839, PMID:7023672 NCBI chr13:50,502,724...50,513,953
Ensembl chr13:50,502,724...50,514,151
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein] CTD PMID:12720544 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased activity of RPS6KB2 protein] CTD PMID:12720544 NCBI chr 1:219,406,201...219,412,888
Ensembl chr 1:219,406,202...219,412,888
JBrowse link
G Shc1 SHC adaptor protein 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased phosphorylation of SHC1 protein alternative form] CTD PMID:19168439 NCBI chr 2:188,745,503...188,757,066
Ensembl chr 2:188,745,503...188,757,066
JBrowse link
G Slc22a1 solute carrier family 22 member 1 decreases activity
multiple interactions
ISO Prazosin results in decreased activity of SLC22A1 protein
Prazosin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:12110607 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Prazosin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases activity
ISO Prazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Prazosin results in decreased activity of SLC22A3 protein
CTD PMID:12110607 NCBI chr 1:48,433,079...48,521,261
Ensembl chr 1:48,433,079...48,521,256
JBrowse link
G Spn sialophorin decreases response to substance ISO SPN protein results in decreased susceptibility to Prazosin CTD PMID:18711009 NCBI chr 1:198,572,999...198,585,664
Ensembl chr 1:198,572,999...198,577,226
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB1 mRNA] CTD PMID:15326086 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB2 mRNA] CTD PMID:15326086 NCBI chr13:105,039,639...105,142,010
Ensembl chr13:105,039,853...105,141,030
JBrowse link
G Tgfb3 transforming growth factor, beta 3 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TGFB3 mRNA] CTD PMID:15326086 NCBI chr 6:109,913,757...109,936,217
Ensembl chr 6:109,913,757...109,935,533
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Prazosin inhibits the reaction [Norepinephrine results in increased expression of TIMP2 mRNA] CTD PMID:15326086 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Prazosin inhibits the reaction [Phenylephrine results in increased expression of TNFSF11 mRNA] CTD PMID:17306214 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tyr tyrosinase multiple interactions EXP Prazosin inhibits the reaction [Phenylephrine results in increased activity of TYR protein] CTD PMID:15278367 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      application 19420
        pharmaceutical 19293
          drug 19293
            cardiovascular drug 7618
              antihypertensive agent 1677
                prazosin 59
                  prazosin hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic group 18527
                              organic divalent group 18520
                                organodiyl group 18520
                                  carbonyl group 18427
                                    carbonyl compound 18427
                                      carboxylic acid 18108
                                        carboacyl group 17369
                                          univalent carboacyl group 17369
                                            carbamoyl group 17156
                                              carboxamide 17156
                                                monocarboxylic acid amide 14573
                                                  prazosin 59
                                                    prazosin hydrochloride 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.