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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:3,5-diethoxycarbonyl-1,4-dihydrocollidine
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Accession:CHEBI:83605 term browser browse the term
Definition:A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5.
Synonyms:exact_synonym: diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: 3,5-bis(ethoxycarbonyl)-1,4-dihydrocollidine;   DDC;   Formula=C14H21NO4;   InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3;   InChIKey=CDVAIHNNWWJFJW-UHFFFAOYSA-N;   SMILES=CCOC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCC;   dicarbethoxydihydrocollidine
 alt_id: MESH:C530773
 xref: CAS:632-93-9
 xref_mesh: MESH:D003997
 xref: PMID:21843714;   Reaxys:227619


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3,5-diethoxycarbonyl-1,4-dihydrocollidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ABCB1A mRNA CTD PMID:8707270 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCB4 ATP binding cassette subfamily B member 4 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ABCB4 mRNA CTD PMID:8707270 NCBI chr 7:87,365,896...87,476,027
Ensembl chr 7:87,401,696...87,480,435 		JBrowse link
G ACADS acyl-CoA dehydrogenase short chain decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of ACADS mRNA CTD PMID:20512997 NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008 		JBrowse link
G ACTA2 actin alpha 2, smooth muscle multiple interactions ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ACTA2 protein] CTD PMID:37544346 NCBI chr10:88,935,074...88,991,337
Ensembl chr10:88,935,074...88,991,339 		JBrowse link
G AFP alpha fetoprotein increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]		 CTD PMID:18098314 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174 		JBrowse link
G ALB albumin increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of ALB protein CTD PMID:17585168 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482 		JBrowse link
G CASP1 caspase 1 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CASP1 protein
fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CASP1 protein]		 CTD PMID:37544346 NCBI chr11:105,025,443...105,036,686
Ensembl chr11:105,025,397...105,035,250 		JBrowse link
G CD44 CD44 molecule (IN blood group) increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA]		 CTD PMID:27052460 NCBI chr11:35,139,171...35,232,402
Ensembl chr11:35,138,882...35,232,402 		JBrowse link
G CPT2 carnitine palmitoyltransferase 2 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of CPT2 mRNA CTD PMID:20512997 NCBI chr 1:53,196,824...53,214,197
Ensembl chr 1:53,196,792...53,214,197 		JBrowse link
G CSF2 colony stimulating factor 2 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of CSF2 protein CTD PMID:30825315 NCBI chr 5:132,073,789...132,076,170
Ensembl chr 5:132,073,789...132,076,170 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions
decreases expression
decreases response to substance		 ISO CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein]; CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of CTNNB1 protein
CTNNB1 protein results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine		 CTD PMID:23620592 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CYP2B10 mRNA CTD PMID:21826054 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398 		JBrowse link
G DNMT1 DNA methyltransferase 1 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of DNMT1 mRNA CTD PMID:18098314 NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286 		JBrowse link
G DNMT3A DNA methyltransferase 3 alpha increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]		 CTD PMID:18098314 NCBI chr 2:25,227,874...25,342,590
Ensembl chr 2:25,227,855...25,342,590 		JBrowse link
G EEF2 eukaryotic translation elongation factor 2 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EEF2 mRNA CTD PMID:20512997 NCBI chr19:3,976,056...3,985,463
Ensembl chr19:3,976,056...3,985,463 		JBrowse link
G EPCAM epithelial cell adhesion molecule increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein
GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]		 CTD PMID:21826054 PMID:27052460 NCBI chr 2:47,369,311...47,387,020
Ensembl chr 2:47,345,158...47,387,601 		JBrowse link
G FABP3 fatty acid binding protein 3 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of FABP3 mRNA CTD PMID:20512997 NCBI chr 1:31,359,588...31,373,076
Ensembl chr 1:31,365,253...31,376,850 		JBrowse link
G FOXO3 forkhead box O3 multiple interactions
affects localization		 ISO CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein] CTD PMID:23620592 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774 		JBrowse link
G GJA1 gap junction protein alpha 1 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA]		 CTD PMID:27052460 NCBI chr 6:121,435,646...121,449,727
Ensembl chr 6:121,435,595...121,449,727 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GOT1 protein
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GOT1 protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GOT1 protein]		 CTD PMID:38104874 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624 		JBrowse link
G GPT glutamic--pyruvic transaminase increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein
cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GPT protein]		 CTD PMID:37544346 PMID:38104874 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased phosphorylation of and results in decreased activity of GSK3B protein CTD PMID:20512997 NCBI chr 3:119,821,321...120,094,447
Ensembl chr 3:119,821,321...120,094,994 		JBrowse link
G GSTM2 glutathione S-transferase mu 2 increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA]		 CTD PMID:18098314 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551 		JBrowse link
G HDAC7 histone deacetylase 7 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of HDAC7 mRNA CTD PMID:18098314 NCBI chr12:47,782,722...47,821,344
Ensembl chr12:47,782,722...47,833,132 		JBrowse link
G HDAC9 histone deacetylase 9 increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA]		 CTD PMID:18098314 NCBI chr 7:18,086,825...19,002,416
Ensembl chr 7:18,086,949...19,002,416 		JBrowse link
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of HIF1A protein		 CTD PMID:38104874 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259 		JBrowse link
G IFNG interferon gamma multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IFNG protein CTD PMID:30825315 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL12A interleukin 12A multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12A protein CTD PMID:30825315 NCBI chr 3:159,988,835...159,996,019
Ensembl chr 3:159,988,835...159,996,019 		JBrowse link
G IL12B interleukin 12B multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12B protein CTD PMID:30825315 NCBI chr 5:159,314,780...159,330,487
Ensembl chr 5:159,314,780...159,330,863 		JBrowse link
G IL17A interleukin 17A multiple interactions
increases expression		 ISO NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL17A protein] CTD PMID:30825315 NCBI chr 6:52,186,375...52,190,638
Ensembl chr 6:52,186,375...52,190,638 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases secretion
increases expression		 ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL1B protein; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL1B protein]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B protein]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL1B protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B protein		 CTD PMID:30825315 PMID:37544346 PMID:38104874 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL1RN interleukin 1 receptor antagonist increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1RN mRNA
NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1RN mRNA]		 CTD PMID:30825315 NCBI chr 2:113,099,360...113,134,014
Ensembl chr 2:113,099,315...113,134,016 		JBrowse link
G IL3 interleukin 3 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL3 protein CTD PMID:30825315 NCBI chr 5:132,060,655...132,063,204
Ensembl chr 5:132,060,655...132,063,204 		JBrowse link
G IL5 interleukin 5 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL5 protein CTD PMID:30825315 NCBI chr 5:132,541,445...132,556,815
Ensembl chr 5:132,541,445...132,556,838 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases secretion
increases expression		 ISO cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL6 protein]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of IL6 protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein		 CTD PMID:27052460 PMID:37544346 PMID:38104874 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G IL6ST interleukin 6 cytokine family signal transducer increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein]		 CTD PMID:27052460 NCBI chr 5:55,935,095...55,994,963
Ensembl chr 5:55,935,095...55,995,022 		JBrowse link
G INS-IGF2 INS-IGF2 readthrough multiple interactions ISO [3,5-diethoxycarbonyl-1,4-dihydrocollidine co-treated with Allylisopropylacetamide] results in increased expression of INS1 protein CTD PMID:21889565 NCBI chr11:2,129,117...2,161,209
Ensembl chr11:2,132,538...2,161,209 		JBrowse link
G KAT2B lysine acetyltransferase 2B decreases expression ISO Dicarbethoxydihydrocollidine results in decreased expression of KAT2B mRNA CTD PMID:18098314 NCBI chr 3:20,040,446...20,154,404
Ensembl chr 3:20,040,446...20,154,404 		JBrowse link
G KEAP1 kelch like ECH associated protein 1 affects response to substance
multiple interactions
decreases response to substance		 ISO KEAP1 gene affects the susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
KEAP1 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]
KEAP1 gene mutant form results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine		 CTD PMID:30215777 PMID:30825315 NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558 		JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KIT mRNA
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KIT mRNA]		 CTD PMID:27052460 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783 		JBrowse link
G KLF6 KLF transcription factor 6 increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]		 CTD PMID:18098314 NCBI chr10:3,775,996...3,785,209
Ensembl chr10:3,775,996...3,785,281 		JBrowse link
G KRT18 keratin 18 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT18 mRNA CTD PMID:10751352 NCBI chr12:52,948,855...52,952,906
Ensembl chr12:52,948,871...52,952,906 		JBrowse link
G KRT19 keratin 19 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein; Dicarbethoxydihydrocollidine results in increased expression of KRT19 protein
GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]; KEAP1 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]		 CTD PMID:17585168 PMID:27052460 PMID:30825315 NCBI chr17:41,523,617...41,528,308
Ensembl chr17:41,523,617...41,528,308 		JBrowse link
G KRT8 keratin 8 increases expression
decreases response to substance		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT8 mRNA
KRT8 protein results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine		 CTD PMID:10751352 NCBI chr12:52,897,191...52,949,860
Ensembl chr12:52,897,187...52,949,954 		JBrowse link
G LEP leptin decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of LEP protein CTD PMID:20512997 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G MAPT microtubule associated protein tau increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA alternative form; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT protein CTD PMID:10051481 NCBI chr17:45,894,554...46,028,334
Ensembl chr17:45,894,527...46,028,334 		JBrowse link
G MAT2A methionine adenosyltransferase 2A increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of MAT2A mRNA CTD PMID:18098314 NCBI chr 2:85,539,168...85,545,281
Ensembl chr 2:85,539,168...85,545,281 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYD88 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYD88 protein
fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYD88 mRNA]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYD88 protein]		 CTD PMID:37544346 NCBI chr 3:38,138,661...38,143,022
Ensembl chr 3:38,138,552...38,143,024 		JBrowse link
G MYH7 myosin heavy chain 7 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYH7 mRNA CTD PMID:20512997 NCBI chr14:23,412,740...23,435,660
Ensembl chr14:23,412,740...23,435,660 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases response to substance
multiple interactions		 ISO NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
[NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of CSF2 protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IFNG protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12A protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12B protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL1B protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL3 protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL5 protein; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL17A protein]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1RN mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]		 CTD PMID:30825315 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions
increases expression		 ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NFKB1 mRNA] CTD PMID:37544346 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKB2 nuclear factor kappa B subunit 2 multiple interactions
increases expression		 ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NFKB2 mRNA] CTD PMID:37544346 NCBI chr10:102,394,110...102,402,529
Ensembl chr10:102,394,110...102,402,524 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NLRP3 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NLRP3 protein
fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NLRP3 mRNA]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NLRP3 protein]		 CTD PMID:37544346 NCBI chr 1:247,416,077...247,448,817
Ensembl chr 1:247,416,156...247,449,108 		JBrowse link
G NPPB natriuretic peptide B increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NPPB mRNA CTD PMID:20512997 NCBI chr 1:11,857,464...11,858,945
Ensembl chr 1:11,857,464...11,858,945 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 multiple interactions
affects response to substance		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased activity of and affects the localization of NR1I3 protein
NR1I3 protein affects the susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine		 CTD PMID:21826054 NCBI chr 1:161,229,669...161,238,203
Ensembl chr 1:161,229,666...161,238,244 		JBrowse link
G PKM pyruvate kinase M1/2 multiple interactions
increases expression		 ISO GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein] CTD PMID:27052460 NCBI chr15:72,199,029...72,231,591
Ensembl chr15:72,199,029...72,231,819 		JBrowse link
G PROM1 prominin 1 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of PROM1 protein CTD PMID:17585168 NCBI chr 4:15,968,228...16,084,023
Ensembl chr 4:15,963,076...16,084,378 		JBrowse link
G PYCARD PYD and CARD domain containing multiple interactions
increases expression		 ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PYCARD protein] CTD PMID:37544346 NCBI chr16:31,201,486...31,202,760
Ensembl chr16:31,201,486...31,203,450 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased phosphorylation of RELA protein] CTD PMID:37544346 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G SGK1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein
CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein]		 CTD PMID:23620592 NCBI chr 6:134,169,256...134,318,112
Ensembl chr 6:134,169,248...134,318,112 		JBrowse link
G SIRT3 sirtuin 3 decreases expression ISO Dicarbethoxydihydrocollidine results in decreased expression of SIRT3 mRNA CTD PMID:18098314 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931 		JBrowse link
G SLC2A1 solute carrier family 2 member 1 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A1 mRNA CTD PMID:20512997 NCBI chr 1:42,925,353...42,958,868
Ensembl chr 1:42,925,353...42,958,893 		JBrowse link
G SLC2A4 solute carrier family 2 member 4 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A4 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A4 protein CTD PMID:20512997 NCBI chr17:7,281,718...7,288,257
Ensembl chr17:7,281,718...7,288,257 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
increases expression		 ISO cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of STAT3 protein		 CTD PMID:38104874 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G SULT2B1 sulfotransferase family 2B member 1 increases expression
multiple interactions		 ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SULT2B1 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SULT2B1 protein
SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 22-hydroxycholesterol]; SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 24,25-epoxycholesterol]; SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 25-hydroxycholesterol]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KIT mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of THY1 mRNA]		 CTD PMID:27052460 NCBI chr19:48,552,172...48,599,427
Ensembl chr19:48,552,172...48,599,425 		JBrowse link
G TACSTD2 tumor associated calcium signal transducer 2 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TACSTD2 mRNA CTD PMID:21826054 NCBI chr 1:58,575,433...58,577,252
Ensembl chr 1:58,575,433...58,577,252 		JBrowse link
G THY1 Thy-1 cell surface antigen multiple interactions
increases expression		 ISO SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of THY1 mRNA] CTD PMID:27052460 NCBI chr11:119,415,476...119,424,985
Ensembl chr11:119,415,476...119,424,985 		JBrowse link
G TLR4 toll like receptor 4 multiple interactions
increases expression		 ISO fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TLR4 mRNA]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TLR4 protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TLR4 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TLR4 protein		 CTD PMID:37544346 NCBI chr 9:117,704,403...117,724,735
Ensembl chr 9:117,704,175...117,724,735 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
increases expression		 ISO cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF protein]; cucurbitacin B inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of TNF protein]; fuzheng huayu inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF protein]; Ursodeoxycholic Acid inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased secretion of TNF protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF protein		 CTD PMID:30825315 PMID:37544346 PMID:38104874 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G UBD ubiquitin D increases expression
multiple interactions		 ISO Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA]		 CTD PMID:18098314 NCBI chr 6:29,555,515...29,559,732
Ensembl chr 6:29,555,515...29,559,732 		JBrowse link
G UCP3 uncoupling protein 3 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 protein CTD PMID:20512997 NCBI chr11:74,000,277...74,009,085
Ensembl chr11:74,000,277...74,009,085 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        aetiopathogenetic role 24592
          hepatotoxic agent 16792
            hepatic steatosis inducing agent 2602
              3,5-diethoxycarbonyl-1,4-dihydrocollidine 71
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      chalcogen 24917
                        oxygen atom 24817
                          oxygen molecular entity 24806
                            hydroxides 24049
                              organic hydroxy compound 22060
                                alcohol 16612
                                  primary alcohol 15330
                                    ethanols 9063
                                      ethanol 9073
                                        ethyl ester 4288
                                          3,5-diethoxycarbonyl-1,4-dihydrocollidine 71
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