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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:3,5-diethoxycarbonyl-1,4-dihydrocollidine
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Accession:CHEBI:83605 term browser browse the term
Definition:A dihydropyridine that is 2,4,6-trimethyl-1,4-dihydropyridine substituted by ethoxycarbonyl groups at positions 3 and 5.
Synonyms:exact_synonym: diethyl 2,4,6-trimethyl-1,4-dihydropyridine-3,5-dicarboxylate
 related_synonym: 3,5-bis(ethoxycarbonyl)-1,4-dihydrocollidine;   DDC;   Formula=C14H21NO4;   InChI=1S/C14H21NO4/c1-6-18-13(16)11-8(3)12(14(17)19-7-2)10(5)15-9(11)4/h8,15H,6-7H2,1-5H3;   InChIKey=CDVAIHNNWWJFJW-UHFFFAOYSA-N;   SMILES=CCOC(=O)C1=C(C)NC(C)=C(C1C)C(=O)OCC;   dicarbethoxydihydrocollidine
 alt_id: MESH:C530773
 xref: CAS:632-93-9
 xref_mesh: MESH:D003997
 xref: PMID:21843714;   Reaxys:227619


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3,5-diethoxycarbonyl-1,4-dihydrocollidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ABCB1A mRNA CTD PMID:8707270 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of ABCB4 mRNA CTD PMID:8707270 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Acads acyl-CoA dehydrogenase short chain decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of ACADS mRNA CTD PMID:20512997 NCBI chr12:47,254,503...47,263,747
Ensembl chr12:47,254,484...47,263,747
JBrowse link
G Afp alpha-fetoprotein increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of AFP mRNA]
CTD PMID:18098314 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Alb albumin increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of ALB protein CTD PMID:17585168 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA]
CTD PMID:27052460 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of CPT2 mRNA CTD PMID:20512997 NCBI chr 5:127,505,646...127,523,016
Ensembl chr 5:127,505,614...127,523,089
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of CSF2 protein CTD PMID:30825315 NCBI chr10:39,602,089...39,604,070
Ensembl chr10:39,602,089...39,604,070
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
decreases response to substance
ISO CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein]; CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein]
3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of CTNNB1 protein
CTNNB1 protein results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
CTD PMID:23620592 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CYP2B10 mRNA CTD PMID:21826054 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Dnmt1 DNA methyltransferase 1 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of DNMT1 mRNA CTD PMID:18098314 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of DNMT3A mRNA]
CTD PMID:18098314 NCBI chr 6:28,205,375...28,346,052
Ensembl chr 6:28,235,695...28,340,577
JBrowse link
G Eef2 eukaryotic translation elongation factor 2 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EEF2 mRNA CTD PMID:20512997 NCBI chr 7:11,401,501...11,406,771
Ensembl chr 7:11,401,501...11,406,771
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein
GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]
CTD PMID:21826054 PMID:27052460 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
JBrowse link
G Fabp3 fatty acid binding protein 3 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of FABP3 mRNA CTD PMID:20512997 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Foxo3 forkhead box O3 multiple interactions
affects localization
ISO CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine affects the localization of FOXO3 protein] CTD PMID:23620592 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA]
CTD PMID:27052460 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased phosphorylation of and results in decreased activity of GSK3B protein CTD PMID:20512997 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gstm2 glutathione S-transferase mu 2 increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA]
CTD PMID:18098314 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Hdac7 histone deacetylase 7 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of HDAC7 mRNA CTD PMID:18098314 NCBI chr 7:139,280,396...139,319,108
Ensembl chr 7:139,281,187...139,318,455
JBrowse link
G Hdac9 histone deacetylase 9 increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of HDAC9 mRNA]
CTD PMID:18098314 NCBI chr 6:53,487,367...54,358,694
Ensembl chr 6:53,488,883...54,059,119
JBrowse link
G Ifng interferon gamma multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IFNG protein CTD PMID:30825315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Il12a interleukin 12A multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12A protein CTD PMID:30825315 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
JBrowse link
G Il12b interleukin 12B multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12B protein CTD PMID:30825315 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il17a interleukin 17A multiple interactions
increases expression
ISO NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL17A protein] CTD PMID:30825315 NCBI chr 9:26,841,299...26,844,786
Ensembl chr 9:26,841,299...26,844,786
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL1B protein; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA] CTD PMID:30825315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression
ISO NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1RN mRNA] CTD PMID:30825315 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il3 interleukin 3 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL3 protein CTD PMID:30825315 NCBI chr10:39,620,535...39,622,973
Ensembl chr10:39,620,563...39,622,973
JBrowse link
G Il5 interleukin 5 multiple interactions ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL5 protein CTD PMID:30825315 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]
CTD PMID:27052460 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein
SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein]
CTD PMID:27052460 NCBI chr 2:44,279,199...44,319,427
Ensembl chr 2:44,289,393...44,314,944
JBrowse link
G Kat2b lysine acetyltransferase 2B decreases expression ISO Dicarbethoxydihydrocollidine results in decreased expression of KAT2B mRNA CTD PMID:18098314 NCBI chr 9:4,440,982...4,492,949 JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 affects response to substance
decreases response to substance
multiple interactions
ISO KEAP1 gene affects the susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
KEAP1 gene mutant form results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
KEAP1 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]
CTD PMID:30215777 PMID:30825315 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase multiple interactions
increases expression
ISO SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KIT mRNA] CTD PMID:27052460 NCBI chr14:35,072,131...35,149,638
Ensembl chr14:35,072,108...35,149,610
JBrowse link
G Klf6 Kruppel-like factor 6 increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of KLF6 mRNA]
CTD PMID:18098314 NCBI chr17:67,887,939...67,945,052
Ensembl chr17:67,887,939...67,945,037
JBrowse link
G Krt18 keratin 18 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT18 mRNA CTD PMID:10751352 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt19 keratin 19 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein; Dicarbethoxydihydrocollidine results in increased expression of KRT19 protein
GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]; KEAP1 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]
CTD PMID:17585168 PMID:27052460 PMID:30825315 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt8 keratin 8 increases expression
decreases response to substance
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT8 mRNA
KRT8 protein results in decreased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
CTD PMID:10751352 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Lep leptin decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of LEP protein CTD PMID:20512997 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Mapt microtubule-associated protein tau increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT mRNA alternative form; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MAPT protein CTD PMID:10051481 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mat2a methionine adenosyltransferase 2A increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of MAT2A mRNA CTD PMID:18098314 NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
JBrowse link
G Myh7 myosin heavy chain 7 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of MYH7 mRNA CTD PMID:20512997 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases response to substance
ISO [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of CSF2 protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IFNG protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12A protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL12B protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL1B protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL3 protein; [NFE2L2 gene mutant form results in increased susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine] which results in increased expression of IL5 protein; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL17A protein]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1B mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL1RN mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 mRNA]; NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA] CTD PMID:30825315 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nppb natriuretic peptide B increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of NPPB mRNA CTD PMID:20512997 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions
affects response to substance
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased activity of and affects the localization of NR1I3 protein
NR1I3 protein affects the susceptibility to 3,5-diethoxycarbonyl-1,4-dihydrocollidine
CTD PMID:21826054 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions
increases expression
ISO GW 3965 inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein] CTD PMID:27052460 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
JBrowse link
G Prom1 prominin 1 increases expression ISO Dicarbethoxydihydrocollidine results in increased expression of PROM1 protein CTD PMID:17585168 NCBI chr14:71,532,321...71,637,400
Ensembl chr14:71,533,063...71,637,417
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein
CTNNB1 mutant form inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SGK1 protein]
CTD PMID:23620592 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sirt3 sirtuin 3 decreases expression ISO Dicarbethoxydihydrocollidine results in decreased expression of SIRT3 mRNA CTD PMID:18098314 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A1 mRNA CTD PMID:20512997 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A4 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SLC2A4 protein CTD PMID:20512997 NCBI chr10:56,552,921...56,558,562
Ensembl chr10:56,552,983...56,558,487
JBrowse link
G Sult2b1 sulfotransferase family 2B member 1 increases expression
multiple interactions
ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SULT2B1 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of SULT2B1 protein
SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 22-hydroxycholesterol]; SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 24,25-epoxycholesterol]; SULT2B1 protein inhibits the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased abundance of 25-hydroxycholesterol]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of CD44 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of EPCAM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of GJA1 mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6 protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of IL6ST protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KIT mRNA]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of KRT19 protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of PKM protein]; SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of THY1 mRNA]
CTD PMID:27052460 NCBI chr 1:101,712,254...101,774,683
Ensembl chr 1:101,710,959...101,773,508
JBrowse link
G Tacstd2 tumor-associated calcium signal transducer 2 increases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TACSTD2 mRNA CTD PMID:21826054 NCBI chr 4:98,341,187...98,342,887
Ensembl chr 4:98,341,188...98,342,887
JBrowse link
G Thy1 Thy-1 cell surface antigen multiple interactions
increases expression
ISO SULT2B1 protein promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of THY1 mRNA] CTD PMID:27052460 NCBI chr 8:48,382,121...48,387,271
Ensembl chr 8:48,382,121...48,386,935
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO NFE2L2 gene mutant form promotes the reaction [3,5-diethoxycarbonyl-1,4-dihydrocollidine results in increased expression of TNF mRNA] CTD PMID:30825315 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Ubd ubiquitin D increases expression
multiple interactions
ISO Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA
S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of UBD mRNA]
CTD PMID:18098314 NCBI chr20:1,876,175...1,878,126
Ensembl chr20:1,876,173...1,897,814
JBrowse link
G Ucp3 uncoupling protein 3 decreases expression ISO 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 mRNA; 3,5-diethoxycarbonyl-1,4-dihydrocollidine results in decreased expression of UCP3 protein CTD PMID:20512997 NCBI chr 1:165,482,912...165,495,895
Ensembl chr 1:165,482,155...165,496,206
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19883
    role 19833
      biological role 19833
        aetiopathogenetic role 19017
          hepatotoxic agent 14600
            hepatic steatosis inducing agent 1991
              3,5-diethoxycarbonyl-1,4-dihydrocollidine 57
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      chalcogen 19464
                        oxygen atom 19425
                          oxygen molecular entity 19425
                            hydroxides 19147
                              organic hydroxy compound 18696
                                alcohol 15040
                                  primary alcohol 13941
                                    ethanols 8157
                                      ethanol 8157
                                        ethyl ester 3228
                                          3,5-diethoxycarbonyl-1,4-dihydrocollidine 57
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