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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pralidoxime
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Accession:CHEBI:8354 term browser browse the term
Definition:A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.
Synonyms:exact_synonym: 2-[(E)-(hydroxyimino)methyl]-1-methylpyridinium
 related_synonym: 2-PAM;   Formula=C7H9N2O;   InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1;   InChIKey=JBKPUQTUERUYQE-UHFFFAOYSA-O;   Pralidoximum;   SMILES=C[n+]1ccccc1\\C=N\\O
 xref: CAS:6735-59-7;   DrugBank:DB00733;   Drug_Central:2231;   HMDB:HMDB0014871;   KEGG:C07400;   LINCS:LSM-5708
 xref_mesh: MESH:C028797
 xref: PMID:24625936;   Reaxys:1526531;   Wikipedia:Pralidoxime



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pralidoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects binding
EXP
ISO
pralidoxime binds to and results in decreased activity of ACHE protein; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]
pralidoxime inhibits the reaction [Chlorfenvinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dicrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [ethylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [heptenophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [leptophos oxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methyl demeton results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Obidoxime Chloride results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Organophosphorus Compounds results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Phosphamidon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Soman results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime metabolite inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime metabolite inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Propoxur results in decreased activity of ACHE protein]
[Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
pralidoxime binds to ACHE protein
CTD PMID:1494302 PMID:8134223 PMID:8783813 PMID:15669039 PMID:16025528 More... NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
JBrowse link
G Bche butyrylcholinesterase multiple interactions
affects binding
EXP
ISO
pralidoxime binds to and results in decreased activity of BCHE protein
pralidoxime binds to and affects the activity of BCHE protein; pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [quinalphos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of BCHE protein]
BCHE protein binds to pralidoxime
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein; pralidoxime affects the reaction [4-nitrophenyl 2-propylmethylphosphonate results in decreased activity of BCHE protein]; pralidoxime affects the reaction [ethyl 4-nitrophenyl methylphosphonate results in decreased activity of BCHE protein]
CTD PMID:423703 PMID:16598855 PMID:17963125 PMID:18825528 PMID:20227398 More... NCBI chr 3:73,543,138...73,615,767
Ensembl chr 3:73,543,141...73,615,748
JBrowse link
G Cat catalase multiple interactions EXP [Malathion co-treated with pralidoxime] results in increased activity of CAT protein CTD PMID:21723318 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein] CTD PMID:29098328 NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
JBrowse link
G Slc22a2 solute carrier family 22 (organic cation transporter), member 2 multiple interactions ISO pralidoxime inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr17:12,803,076...12,847,376
Ensembl chr17:12,803,019...12,847,375
JBrowse link
G Tshb thyroid stimulating hormone, beta subunit multiple interactions ISO [pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] CTD PMID:15891268 NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
JBrowse link

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Path 1
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  CHEBI ontology 22279
    role 22263
      biological role 22262
        biochemical role 21480
          enzyme reactivator 13
            cholinesterase reactivator 13
              pralidoxime 6
                pralidoxime chloride 0
                pralidoxime iodide 0
                pralidoxime mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22279
    subatomic particle 22273
      composite particle 22273
        hadron 22273
          baryon 22273
            nucleon 22273
              atomic nucleus 22273
                atom 22273
                  main group element atom 22152
                    p-block element atom 22152
                      carbon group element atom 21955
                        carbon group molecular entity 21955
                          organic molecular entity 21895
                            organic ion 11674
                              organic cation 9133
                                pyridinium ion 2425
                                  pralidoxime 6
                                    pralidoxime chloride 0
                                    pralidoxime iodide 0
                                    pralidoxime mesylate 0
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