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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pralidoxime
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Accession:CHEBI:8354 term browser browse the term
Definition:A pyridinium ion that is 1-methylpyridinium substituted by a (hydroxyimino)methyl group at position 2.
Synonyms:exact_synonym: 2-[(E)-(hydroxyimino)methyl]-1-methylpyridinium
 related_synonym: Formula=C7H9N2O;   InChI=1S/C7H8N2O/c1-9-5-3-2-4-7(9)6-8-10/h2-6H,1H3/p+1;   InChIKey=JBKPUQTUERUYQE-UHFFFAOYSA-O;   Pralidoximum;   SMILES=C[n+]1ccccc1\\C=N\\O
 xref: Beilstein:1526531;   CAS:6735-59-7;   DrugBank:DB00733;   Drug_Central:2231;   HMDB:HMDB0014871;   KEGG:C07400;   LINCS:LSM-5708
 xref_mesh: MESH:C028797
 xref: PMID:24625936;   Reaxys:1526531;   Wikipedia:Pralidoxime


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pralidoxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase affects binding
multiple interactions
ISO
EXP
pralidoxime binds to ACHE protein
pralidoxime inhibits the reaction [Chlorfenvinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [cyclohexyl methylphosphonofluoridate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Diazinon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dicrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Dimethoate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [dimethoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [ethylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [heptenophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [leptophos oxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methamidophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methyl demeton results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [methylparaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Mevinphos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Monocrotophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Obidoxime Chloride results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Organophosphorus Compounds results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Phosphamidon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Soman results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein mutant form]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX binds to and results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime metabolite inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime metabolite inhibits the reaction [VX results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Carbaryl results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [Propoxur results in decreased activity of ACHE protein]
[Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of ACHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of ACHE protein; [Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein; [pralidoxime co-treated with Atropine] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [[Paraoxon co-treated with pralidoxime co-treated with Atropine] results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Sarin results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of ACHE protein]; pralidoxime promotes the reaction [[Atropine co-treated with Curcumin] inhibits the reaction [Dichlorvos results in decreased activity of ACHE protein]]
pralidoxime binds to and results in decreased activity of ACHE protein; pralidoxime inhibits the reaction [malaoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [tabun results in decreased activity of ACHE protein]
CTD PMID:1494302 PMID:8134223 PMID:8783813 PMID:15669039 PMID:16025528 PMID:16112538 PMID:16598855 PMID:17265452 PMID:17963125 PMID:18070496 PMID:18344198 PMID:18804659 PMID:19917271 PMID:20096273 PMID:20156430 PMID:20227398 PMID:20382137 PMID:20406208 PMID:20412789 PMID:20433814 PMID:20688148 PMID:20971170 PMID:21673941 PMID:21723318 PMID:21983245 PMID:22783142 PMID:22960624 PMID:22975155 PMID:23073172 PMID:23111374 PMID:23123249 PMID:23962483 PMID:25451328 PMID:25743373 PMID:26070418 PMID:26210933 PMID:26368669 PMID:26751814 PMID:27129421 PMID:27138243 PMID:27551891 PMID:29614332 PMID:29772260 PMID:29920286 PMID:31276662 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Bche butyrylcholinesterase multiple interactions
affects binding
ISO
EXP
pralidoxime binds to and results in decreased activity of BCHE protein
[Atropine co-treated with pralidoxime] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime co-treated with Atropine] results in decreased expression of BCHE protein; [Methyl Parathion co-treated with pralidoxime] results in decreased expression of BCHE protein; pralidoxime affects the reaction [4-nitrophenyl 2-propylmethylphosphonate results in decreased activity of BCHE protein]; pralidoxime affects the reaction [ethyl 4-nitrophenyl methylphosphonate results in decreased activity of BCHE protein]
BCHE protein binds to pralidoxime
pralidoxime binds to and affects the activity of BCHE protein; pralidoxime inhibits the reaction [Chlorpyrifos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Cholinesterase Inhibitors binds to and results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Isoflurophate inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Isoflurophate results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Organophosphates binds to and results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [quinalphos results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Sarin analog inhibits the reaction [BCHE protein results in increased hydrolysis of Butyrylthiocholine]]; pralidoxime inhibits the reaction [Sarin analog results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [VX analog results in decreased activity of BCHE protein]
CTD PMID:423703 PMID:16598855 PMID:17963125 PMID:18825528 PMID:20227398 PMID:21802514 PMID:22922115 PMID:24052565 PMID:26705700 PMID:27551891 PMID:29614332 PMID:29920286 PMID:31173753 PMID:32278739 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cat catalase multiple interactions ISO [Malathion co-treated with pralidoxime] results in increased activity of CAT protein CTD PMID:21723318 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Pon1 paraoxonase 1 multiple interactions EXP pralidoxime inhibits the reaction [Dichlorvos results in decreased activity of PON1 protein] CTD PMID:29098328 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO pralidoxime inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP [pralidoxime co-treated with Atropine] inhibits the reaction [methamidophos results in decreased expression of TSHB protein] CTD PMID:15891268 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19786
    role 19732
      biological role 19732
        biochemical role 19333
          enzyme reactivator 6
            cholinesterase reactivator 6
              pralidoxime 6
                pralidoxime chloride 0
                pralidoxime iodide 0
                pralidoxime mesylate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19786
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19675
                    p-block element atom 19675
                      carbon group element atom 19596
                        carbon group molecular entity 19596
                          organic molecular entity 19586
                            organic ion 8465
                              organic cation 7322
                                pyridinium ion 2407
                                  pralidoxime 6
                                    pralidoxime chloride 0
                                    pralidoxime iodide 0
                                    pralidoxime mesylate 0
paths to the root