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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-(3-(trifluoromethyl)phenyl)piperazine
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Accession:CHEBI:83536 term browser browse the term
Definition:A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.
Synonyms:related_synonym: 1-(m-trifluoromethylphenyl)piperazine;   3-trifluoromethylphenylpiperazine;   Formula=C11H13F3N2;   InChI=1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2;   InChIKey=KKIMDKMETPPURN-UHFFFAOYSA-N;   N-(alpha,alpha,alpha-trifluoro-3-tolyl)piperazine;   SMILES=C1=C(C(F)(F)F)C=CC=C1N2CCNCC2;   TFMPP
 xref: CAS:15532-75-9;   LINCS:LSM-24939
 xref_mesh: MESH:C018406
 xref: PMID:23890650;   PMID:24547667;   PMID:24810679;   PMID:24968061;   Reaxys:614217;   Wikipedia:Trifluoromethylphenylpiperazine


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1-(3-(trifluoromethyl)phenyl)piperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of ACAT2 mRNA CTD PMID:26821219 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in decreased expression of BHMT mRNA CTD PMID:26821219 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of CYP51 mRNA CTD PMID:26821219 NCBI chr 4:27,175,564...27,194,018
Ensembl chr 4:27,175,243...27,194,018
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in decreased expression of CYP8B1 mRNA CTD PMID:26821219 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [Estradiol binds to ESR1 protein] CTD PMID:23026265 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Fads1 fatty acid desaturase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FADS1 mRNA CTD PMID:26821219 NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
JBrowse link
G Fasn fatty acid synthase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FASN mRNA CTD PMID:26821219 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FDFT1 mRNA CTD PMID:26821219 NCBI chr15:46,339,248...46,367,302
Ensembl chr15:46,339,249...46,367,302
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FDPS mRNA CTD PMID:26821219 NCBI chr 2:188,403,595...188,413,219
Ensembl chr 2:188,392,858...188,413,219
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:26344803 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:26344803 NCBI chr10:27,973,694...28,193,072
Ensembl chr10:27,973,681...28,187,565
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:26344803 NCBI chr10:27,090,913...27,179,786
Ensembl chr10:27,092,827...27,179,900
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of GPNMB mRNA CTD PMID:26821219 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCR mRNA CTD PMID:26821219 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCS1 mRNA CTD PMID:26821219 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of IDI1 mRNA CTD PMID:26821219 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of MSMO1 mRNA CTD PMID:26821219 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of PCSK9 mRNA CTD PMID:26821219 NCBI chr 5:126,031,368...126,053,726
Ensembl chr 5:126,031,368...126,053,726
JBrowse link
G Pgr progesterone receptor increases expression ISO 1-(3-trifluoromethylphenyl)piperazine results in increased expression of PGR mRNA CTD PMID:23026265 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Rragd Ras-related GTP binding D increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of RRAGD mRNA CTD PMID:26821219 NCBI chr 5:48,224,994...48,260,691
Ensembl chr 5:48,224,994...48,260,685
JBrowse link
G Sqle squalene epoxidase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of SQLE mRNA CTD PMID:26821219 NCBI chr 7:99,609,929...99,624,803
Ensembl chr 7:99,609,191...99,624,732
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 1-(3-trifluoromethylphenyl)piperazine results in increased expression of TFF1 mRNA CTD PMID:23026265 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link

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Path 1
Term Annotations click to browse term
  CHEBI ontology 19767
    role 19714
      biological role 19714
        xenobiotic 18392
          1-(3-(trifluoromethyl)phenyl)piperazine 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    main group molecular entity 19657
                      s-block molecular entity 19421
                        hydrogen molecular entity 19414
                          hydrides 18754
                            organic hydride 18358
                              organic fundamental parent 18358
                                hydrocarbon 18075
                                  halohydrocarbon 14045
                                    haloalkane 11690
                                      fluoroalkane 7166
                                        fluoromethanes 6354
                                          tetrafluoromethane 6354
                                            trifluoromethyl group 6354
                                              (trifluoromethyl)benzenes 6354
                                                1-(3-(trifluoromethyl)phenyl)piperazine 22
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