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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:1-(3-(trifluoromethyl)phenyl)piperazine
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Accession:CHEBI:83536 term browser browse the term
Definition:A N-arylpiperazine that is piperazine substituted by a 3-(trifluoromethyl)phenyl group at position 1. A serotonergic agonist used as a recreational drug.
Synonyms:related_synonym: 1-(m-trifluoromethylphenyl)piperazine;   3-trifluoromethylphenylpiperazine;   Formula=C11H13F3N2;   InChI=1S/C11H13F3N2/c12-11(13,14)9-2-1-3-10(8-9)16-6-4-15-5-7-16/h1-3,8,15H,4-7H2;   InChIKey=KKIMDKMETPPURN-UHFFFAOYSA-N;   N-(alpha,alpha,alpha-trifluoro-3-tolyl)piperazine;   SMILES=C1=C(C(F)(F)F)C=CC=C1N2CCNCC2;   TFMPP
 xref: CAS:15532-75-9;   LINCS:LSM-24939
 xref_mesh: MESH:C018406
 xref: PMID:23890650;   PMID:24547667;   PMID:24810679;   PMID:24968061;   Reaxys:614217;   Wikipedia:Trifluoromethylphenylpiperazine



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1-(3-(trifluoromethyl)phenyl)piperazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of ACAT2 mRNA CTD PMID:26821219 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in decreased expression of BHMT mRNA CTD PMID:26821219 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of CYP51 mRNA CTD PMID:26821219 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 decreases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in decreased expression of CYP8B1 mRNA CTD PMID:26821219 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [Estradiol binds to ESR1 protein] CTD PMID:23026265 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fads1 fatty acid desaturase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FADS1 mRNA CTD PMID:26821219 NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734
JBrowse link
G Fasn fatty acid synthase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FASN mRNA CTD PMID:26821219 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FDFT1 mRNA CTD PMID:26821219 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fdps farnesyl diphosphate synthase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of FDPS mRNA CTD PMID:26821219 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:26344803 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:26344803 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO 1-(3-trifluoromethylphenyl)piperazine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:26344803 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of GPNMB mRNA CTD PMID:26821219 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCR mRNA CTD PMID:26821219 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of HMGCS1 mRNA CTD PMID:26821219 NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of IDI1 mRNA CTD PMID:26821219 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of MSMO1 mRNA CTD PMID:26821219 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Pcsk9 proprotein convertase subtilisin/kexin type 9 increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of PCSK9 mRNA CTD PMID:26821219 NCBI chr 5:121,211,278...121,233,688
Ensembl chr 5:121,211,278...121,233,688
JBrowse link
G Pgr progesterone receptor increases expression ISO 1-(3-trifluoromethylphenyl)piperazine results in increased expression of PGR mRNA CTD PMID:23026265 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Rragd Ras-related GTP binding D increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of RRAGD mRNA CTD PMID:26821219 NCBI chr 5:47,373,902...47,409,369
Ensembl chr 5:47,373,463...47,409,356
JBrowse link
G Sqle squalene epoxidase increases expression EXP 1-(3-trifluoromethylphenyl)piperazine results in increased expression of SQLE mRNA CTD PMID:26821219 NCBI chr 7:90,867,973...90,883,623
Ensembl chr 7:90,868,011...90,883,618
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 1-(3-trifluoromethylphenyl)piperazine results in increased expression of TFF1 mRNA CTD PMID:23026265 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19703
    role 19678
      biological role 19677
        xenobiotic 18588
          1-(3-(trifluoromethyl)phenyl)piperazine 22
            LY-165163 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19703
    subatomic particle 19702
      composite particle 19702
        hadron 19702
          baryon 19702
            nucleon 19702
              atomic nucleus 19702
                atom 19702
                  main group element atom 19651
                    main group molecular entity 19651
                      s-block molecular entity 19500
                        hydrogen molecular entity 19493
                          hydrides 18963
                            organic hydride 18575
                              organic fundamental parent 18575
                                hydrocarbon 18340
                                  halohydrocarbon 15362
                                    haloalkane 12092
                                      fluoroalkane 7755
                                        fluoromethanes 6700
                                          tetrafluoromethane 6700
                                            trifluoromethyl group 6700
                                              (trifluoromethyl)benzenes 6700
                                                1-(3-(trifluoromethyl)phenyl)piperazine 22
                                                  LY-165163 0
paths to the root