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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:diazoxon
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Accession:CHEBI:83533 term browser browse the term
Definition:An organic phosphate that is diethyl hydrogen phosphate in which the hydrogen of the hydroxy group has been replaced by a 6-methyl-2-(propan-2-yl)pyrimidin-4-yl group. It is a metabolite of the pesticide diazinon.
Synonyms:exact_synonym: diethyl 6-methyl-2-(propan-2-yl)pyrimidin-4-yl phosphate
 related_synonym: Formula=C12H21N2O4P;   InChI=1S/C12H21N2O4P/c1-6-16-19(15,17-7-2)18-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3;   InChIKey=VBLJFQYCTRKKKF-UHFFFAOYSA-N;   Oxodiazinon;   SMILES=CCOP(=O)(OCC)Oc1cc(C)nc(n1)C(C)C;   diethyl 2-isopropyl-6-methylpyrimidin-4-ylphosphate
 xref: CAS:962-58-3
 xref_mesh: MESH:C000912
 xref: PMID:24342266;   PMID:24418454;   PMID:24561003;   PMID:24573775;   Reaxys:273789


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diazoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
increases activity
multiple interactions		 ISO
EXP		 diazoxon results in decreased activity of ACHE protein
diazoxon metabolite results in increased activity of ACHE protein
[[Chlorine co-treated with Diazinon] results in increased abundance of diazoxon] which results in decreased activity of ACHE protein		 CTD PMID:16978018 PMID:25562544 PMID:30978295 PMID:33037899 PMID:33497710 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Alb albumin affects binding
increases hydrolysis
multiple interactions
decreases response to substance		 ISO diazoxon binds to ALB protein
ALB protein results in increased hydrolysis of diazoxon
ALB protein results in decreased susceptibility to [diazoxon results in decreased activity of BCHE protein]
ALB protein results in decreased susceptibility to diazoxon		 CTD PMID:15525694 PMID:20211614 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 ISO
EXP		 ALB protein results in decreased susceptibility to [diazoxon results in decreased activity of BCHE protein] CTD PMID:20211614 PMID:33497710 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Cat catalase increases activity EXP diazoxon results in increased activity of CAT protein CTD PMID:25562544 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Cnr1 cannabinoid receptor 1 decreases activity
multiple interactions		 ISO diazoxon results in decreased activity of CNR1 protein
diazoxon inhibits the reaction [CP 55244 binds to CNR1 protein]		 CTD PMID:12243867 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO diazoxon results in increased expression of IL1B mRNA CTD PMID:30978295 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO diazoxon results in decreased activity of NCEH1 protein CTD PMID:16449251 PMID:16978018 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588 		JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression ISO diazoxon results in increased expression of PDGFA mRNA CTD PMID:30978295 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497 		JBrowse link
G Pon1 paraoxonase 1 affects hydrolysis
decreases hydrolysis
affects metabolic processing
multiple interactions
decreases response to substance
increases hydrolysis
increases response to substance		 ISO PON1 gene polymorphism affects the hydrolysis of diazoxon
PON1 gene polymorphism results in decreased hydrolysis of diazoxon
PON1 protein affects the metabolism of diazoxon; PON1 protein polymorphism affects the metabolism of diazoxon
PON1 protein polymorphism affects the reaction [PON1 protein results in increased hydrolysis of diazoxon]
PON1 protein polymorphism results in decreased susceptibility to diazoxon; PON1 protein results in decreased susceptibility to diazoxon
PON1 affects the susceptibility to [diazoxon co-treated with malaoxon]
PON1 protein polymorphism results in increased hydrolysis of diazoxon; PON1 protein results in increased hydrolysis of diazoxon
PON1 gene mutant form results in increased susceptibility to diazoxon		 CTD PMID:10898114 PMID:11022865 PMID:12563177 PMID:15924216 PMID:19071155 More... NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Tnf tumor necrosis factor increases expression ISO diazoxon results in increased expression of TNF mRNA CTD PMID:30978295 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO diazoxon metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19811
    role 19818
      application 19630
        NMR chemical shift reference compound 17936
          phosphoric acid 11417
            phosphoric acid derivative 11226
              organic phosphate 11225
                diazoxon 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      chalcogen 19515
                        oxygen atom 19520
                          oxygen molecular entity 19490
                            hydroxides 19300
                              oxoacid 18725
                                pnictogen oxoacid 13221
                                  phosphorus oxoacid 12413
                                    phosphoric acids 11427
                                      phosphoric acid 11417
                                        phosphoric acid derivative 11226
                                          phosphate 11225
                                            organic phosphate 11225
                                              diazoxon 11
paths to the root