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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diazoxon
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Accession:CHEBI:83533 term browser browse the term
Definition:An organic phosphate that is diethyl hydrogen phosphate in which the hydrogen of the hydroxy group has been replaced by a 6-methyl-2-(propan-2-yl)pyrimidin-4-yl group. It is a metabolite of the pesticide diazinon.
Synonyms:exact_synonym: diethyl 6-methyl-2-(propan-2-yl)pyrimidin-4-yl phosphate
 related_synonym: Formula=C12H21N2O4P;   InChI=1S/C12H21N2O4P/c1-6-16-19(15,17-7-2)18-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3;   InChIKey=VBLJFQYCTRKKKF-UHFFFAOYSA-N;   Oxodiazinon;   SMILES=CCOP(=O)(OCC)Oc1cc(C)nc(n1)C(C)C;   diethyl 2-isopropyl-6-methylpyrimidin-4-ylphosphate
 xref: CAS:962-58-3
 xref_mesh: MESH:C000912
 xref: PMID:24342266;   PMID:24418454;   PMID:24561003;   PMID:24573775;   Reaxys:273789



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diazoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity
increases activity
multiple interactions
ISO
EXP
diazoxon results in decreased activity of ACHE protein
diazoxon metabolite results in increased activity of ACHE protein
[[Chlorine co-treated with Diazinon] results in increased abundance of diazoxon] which results in decreased activity of ACHE protein
CTD PMID:16978018 PMID:25562544 PMID:30978295 PMID:33037899 PMID:33497710 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Alb albumin affects binding
increases hydrolysis
multiple interactions
decreases response to substance
ISO diazoxon binds to ALB protein
ALB protein results in increased hydrolysis of diazoxon
ALB protein results in decreased susceptibility to [diazoxon results in decreased activity of BCHE protein]
ALB protein results in decreased susceptibility to diazoxon
CTD PMID:15525694 PMID:20211614 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity
ISO
EXP
ALB protein results in decreased susceptibility to [diazoxon results in decreased activity of BCHE protein] CTD PMID:20211614 PMID:33497710 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Cat catalase increases activity EXP diazoxon results in increased activity of CAT protein CTD PMID:25562544 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases activity
multiple interactions
ISO diazoxon results in decreased activity of CNR1 protein
diazoxon inhibits the reaction [CP 55244 binds to CNR1 protein]
CTD PMID:12243867 NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099
JBrowse link
G Il1b interleukin 1 beta increases expression ISO diazoxon results in increased expression of IL1B mRNA CTD PMID:30978295 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO diazoxon results in decreased activity of NCEH1 protein CTD PMID:16449251 PMID:16978018 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588
JBrowse link
G Pdgfa platelet derived growth factor subunit A increases expression ISO diazoxon results in increased expression of PDGFA mRNA CTD PMID:30978295 NCBI chr12:15,645,549...15,667,056
Ensembl chr12:15,645,541...15,666,497
JBrowse link
G Pon1 paraoxonase 1 affects hydrolysis
decreases hydrolysis
affects metabolic processing
multiple interactions
decreases response to substance
increases hydrolysis
increases response to substance
ISO PON1 gene polymorphism affects the hydrolysis of diazoxon
PON1 gene polymorphism results in decreased hydrolysis of diazoxon
PON1 protein affects the metabolism of diazoxon; PON1 protein polymorphism affects the metabolism of diazoxon
PON1 protein polymorphism affects the reaction [PON1 protein results in increased hydrolysis of diazoxon]
PON1 protein polymorphism results in decreased susceptibility to diazoxon; PON1 protein results in decreased susceptibility to diazoxon
PON1 affects the susceptibility to [diazoxon co-treated with malaoxon]
PON1 protein polymorphism results in increased hydrolysis of diazoxon; PON1 protein results in increased hydrolysis of diazoxon
PON1 gene mutant form results in increased susceptibility to diazoxon
CTD PMID:10898114 PMID:11022865 PMID:12563177 PMID:15924216 PMID:19071155 More... NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Tnf tumor necrosis factor increases expression ISO diazoxon results in increased expression of TNF mRNA CTD PMID:30978295 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 affects activity ISO diazoxon metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19905
    role 19881
      application 19716
        NMR chemical shift reference compound 17973
          phosphoric acid 11432
            phosphoric acid derivative 11240
              organic phosphate 11239
                diazoxon 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 19905
    subatomic particle 19903
      composite particle 19903
        hadron 19903
          baryon 19903
            nucleon 19903
              atomic nucleus 19903
                atom 19903
                  main group element atom 19853
                    p-block element atom 19853
                      chalcogen 19598
                        oxygen atom 19572
                          oxygen molecular entity 19572
                            hydroxides 19375
                              oxoacid 18772
                                pnictogen oxoacid 13194
                                  phosphorus oxoacid 12436
                                    phosphoric acids 11432
                                      phosphoric acid 11432
                                        phosphoric acid derivative 11240
                                          phosphate 11239
                                            organic phosphate 11239
                                              diazoxon 11
paths to the root