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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:diazoxon
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Accession:CHEBI:83533 term browser browse the term
Definition:An organic phosphate that is diethyl hydrogen phosphate in which the hydrogen of the hydroxy group has been replaced by a 6-methyl-2-(propan-2-yl)pyrimidin-4-yl group. It is a metabolite of the pesticide diazinon.
Synonyms:exact_synonym: diethyl 6-methyl-2-(propan-2-yl)pyrimidin-4-yl phosphate
 related_synonym: Formula=C12H21N2O4P;   InChI=1S/C12H21N2O4P/c1-6-16-19(15,17-7-2)18-11-8-10(5)13-12(14-11)9(3)4/h8-9H,6-7H2,1-5H3;   InChIKey=VBLJFQYCTRKKKF-UHFFFAOYSA-N;   Oxodiazinon;   SMILES=CCOP(=O)(OCC)Oc1cc(C)nc(n1)C(C)C;   diethyl 2-isopropyl-6-methylpyrimidin-4-ylphosphate
 xref: CAS:962-58-3
 xref_mesh: MESH:C000912
 xref: PMID:24342266;   PMID:24418454;   PMID:24561003;   PMID:24573775;   Reaxys:273789


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diazoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP
diazoxon results in decreased activity of ACHE protein CTD PMID:16978018, PMID:25562544 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Alb albumin affects binding
decreases response to substance
multiple interactions
increases hydrolysis
ISO diazoxon binds to ALB protein
ALB protein results in decreased susceptibility to diazoxon
ALB protein results in decreased susceptibility to [diazoxon results in decreased activity of BCHE protein]
ALB protein results in increased hydrolysis of diazoxon
CTD PMID:15525694, PMID:20211614 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO ALB protein results in decreased susceptibility to [diazoxon results in decreased activity of BCHE protein] CTD PMID:20211614 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395
JBrowse link
G Cat catalase increases activity EXP diazoxon results in increased activity of CAT protein CTD PMID:25562544 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cnr1 cannabinoid receptor 1 decreases activity
multiple interactions
ISO diazoxon results in decreased activity of CNR1 protein
diazoxon inhibits the reaction [CP 55244 binds to CNR1 protein]
CTD PMID:12243867 NCBI chr 5:49,307,584...49,333,064
Ensembl chr 5:49,311,030...49,333,056
JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 decreases activity ISO diazoxon results in decreased activity of NCEH1 protein CTD PMID:16449251, PMID:16978018 NCBI chr 2:112,868,834...112,932,622
Ensembl chr 2:112,868,707...112,934,953
JBrowse link
G Pon1 paraoxonase 1 affects hydrolysis
increases response to substance
increases hydrolysis
multiple interactions
decreases response to substance
affects metabolic processing
decreases hydrolysis
ISO PON1 gene polymorphism affects the hydrolysis of diazoxon
PON1 gene mutant form results in increased susceptibility to diazoxon
PON1 protein polymorphism results in increased hydrolysis of diazoxon; PON1 protein results in increased hydrolysis of diazoxon
PON1 affects the susceptibility to [diazoxon co-treated with malaoxon]
PON1 protein polymorphism results in decreased susceptibility to diazoxon; PON1 protein results in decreased susceptibility to diazoxon
PON1 protein polymorphism affects the reaction [PON1 protein results in increased hydrolysis of diazoxon]
PON1 protein affects the metabolism of diazoxon; PON1 protein polymorphism affects the metabolism of diazoxon
PON1 gene polymorphism results in decreased hydrolysis of diazoxon
CTD PMID:10898114, PMID:11022865, PMID:12563177, PMID:15924216, PMID:19071155, PMID:19371602, PMID:19446239, PMID:20221869, PMID:20981111, PMID:23123254 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        solvent 16456
          phosphoric acid 7794
            phosphoric acid derivative 7473
              organic phosphate 7472
                diazoxon 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      chalcogen 19360
                        oxygen atom 19321
                          oxygen molecular entity 19321
                            hydroxides 19066
                              oxoacid 18192
                                pnictogen oxoacid 10144
                                  phosphorus oxoacid 9032
                                    phosphoric acids 7794
                                      phosphoric acid 7794
                                        phosphoric acid derivative 7473
                                          phosphate 7473
                                            organic phosphate 7472
                                              diazoxon 7
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