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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:moclobemide
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Accession:CHEBI:83531 term browser browse the term
Definition:A member of the class of benzamides that is benzamide substituted by a chloro group at position 4 and a 2-(morpholin-4-yl)ethyl group at the nitrogen atom. It acts as a reversible monoamine oxidase inhibitor and is used in the treatment of depression.
Synonyms:exact_synonym: 4-chloro-N-[2-(morpholin-4-yl)ethyl]benzamide
 related_synonym: Formula=C13H17ClN2O2;   InChI=1S/C13H17ClN2O2/c14-12-3-1-11(2-4-12)13(17)15-5-6-16-7-9-18-10-8-16/h1-4H,5-10H2,(H,15,17);   InChIKey=YHXISWVBGDMDLQ-UHFFFAOYSA-N;   SMILES=Clc1ccc(cc1)C(=O)NCCN1CCOCC1;   moclobemida;   moclobemidum
 xref: CAS:71320-77-9;   DrugBank:DB01171;   Drug_Central:1825;   HMDB:HMDB0015302;   KEGG:D02561;   LINCS:LSM-5247
 xref_mesh: MESH:D020912
 xref: PMID:23616181;   PMID:24859491;   PMID:24863864;   PMID:25335956;   Reaxys:530974



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moclobemide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing ISO CYP2C19 protein results in increased metabolism of Moclobemide CTD PMID:12464242 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G Maoa monoamine oxidase A decreases activity
multiple interactions
ISO
EXP
Moclobemide results in decreased activity of MAOA protein
Moclobemide inhibits the reaction [MAOA protein results in decreased amination of Serotonin]
CTD PMID:15178694 PMID:15545290 PMID:21923181 PMID:23943324 PMID:26721607 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
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Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      biological role 19892
        xenobiotic 18778
          moclobemide 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic group 18995
                              organic divalent group 18969
                                organodiyl group 18969
                                  carbonyl group 18922
                                    carbonyl compound 18922
                                      carboxylic acid 18646
                                        carboacyl group 17727
                                          univalent carboacyl group 17727
                                            carbamoyl group 17575
                                              carboxamide 17575
                                                monocarboxylic acid amide 15699
                                                  arenecarboxamide 8255
                                                    benzamides 8255
                                                      moclobemide 2
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