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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:neotame
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Accession:CHEBI:83503 term browser browse the term
Definition:A dipeptide composed of N-(3,3-dimethylbutyl)-L-aspartic acid and methyl L-phenylalanate units joined by a peptide linkage.
Synonyms:exact_synonym: methyl N-(3,3-dimethylbutyl)-L-alpha-aspartyl-L-phenylalaninate
 related_synonym: Formula=C20H30N2O5;   InChI=1S/C20H30N2O5/c1-20(2,3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9,15-16,21H,10-13H2,1-4H3,(H,22,25)(H,23,24)/t15-,16-/m0/s1;   InChIKey=HLIAVLHNDJUHFG-HOTGVXAUSA-N;   N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine methyl ester;   SMILES=COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NCCC(C)(C)C
 xref: CAS:165450-17-9;   HMDB:HMDB0034566
 xref_mesh: MESH:C404525
 xref: PMID:23595253;   PMID:24612793;   PMID:25216979;   Reaxys:8352678;   Wikipedia:Neotame


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neotame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tas1r2 taste 1 receptor member 2 affects binding
multiple interactions		 ISO neotame binds to [TAS1R2 protein binds to TAS1R3 protein]; neotame binds to TAS1R2 protein
neotame binds to and results in increased activity of TAS1R2 protein; neotame results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]		 CTD PMID:15353592 PMID:17168764 PMID:20173092 NCBI chr 5:151,909,617...151,925,760
Ensembl chr 5:151,830,701...151,925,345 		JBrowse link
G Tas1r3 taste 1 receptor member 3 affects binding
multiple interactions		 ISO neotame binds to [TAS1R2 protein binds to TAS1R3 protein]
neotame results in increased activity of [TAS1R2 protein binds to TAS1R3 protein]		 CTD PMID:17168764 PMID:20173092 NCBI chr 5:166,468,703...166,472,759
Ensembl chr 5:166,469,589...166,472,742 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        xenobiotic 18763
          neotame 2
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbon oxoacid 18687
                                    carboxylic acid 18684
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17579
                                            carboxamide 17579
                                              peptide 11439
                                                oligopeptide 1350
                                                  dipeptide 414
                                                    neotame 2
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