CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: perfluorohexanoic acid
Accession: CHEBI:83492
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Definition: A monocarboxylic acid that is perfluorinated hexanoic acid.
Synonyms: exact_synonym: undecafluorohexanoic acid
related_synonym: 2,2,3,3,4,4,5,5,6,6,6-undecafluorohexanoic acid; Formula=C6HF11O2; InChI=1S/C6HF11O2/c7-2(8,1(18)19)3(9,10)4(11,12)5(13,14)6(15,16)17/h(H,18,19); InChIKey=PXUULQAPEKKVAH-UHFFFAOYSA-N; SMILES=OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
alt_id: MESH:C479228
xref: CAS:307-24-4
xref_mesh: MESH:C479228
xref: PMID:24113473; PMID:24158108; PMID:24768527; PMID:25377447; Reaxys:1805852
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Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
perfluorohexanoic acid results in increased expression of ABCA1 mRNA
CTD
PMID:35337807
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Acot1
acyl-CoA thioesterase 1
increases expression
EXP
perfluorohexanoic acid results in increased expression of ACOT1 mRNA
CTD
PMID:19407336
NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163
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Acot2
acyl-CoA thioesterase 2
increases expression
ISO
perfluorohexanoic acid results in increased expression of ACOT2 mRNA
CTD
PMID:35337807
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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Acox1
acyl-CoA oxidase 1
increases expression
ISO
perfluorohexanoic acid results in increased expression of ACOX1 mRNA
CTD
PMID:36435305
NCBI chr10:101,406,197...101,431,252
Ensembl chr10:101,406,197...101,431,232
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Acsl1
acyl-CoA synthetase long-chain family member 1
increases expression
ISO
perfluorohexanoic acid results in increased expression of ACSL1 mRNA
CTD
PMID:23567314
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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Angptl4
angiopoietin-like 4
increases expression
ISO
perfluorohexanoic acid results in increased expression of ANGPTL4 mRNA
CTD
PMID:23567314
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Apoa2
apolipoprotein A2
increases expression
ISO
perfluorohexanoic acid results in increased expression of APOA2 mRNA
CTD
PMID:23567314
NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
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Apoa4
apolipoprotein A4
increases expression
EXP
perfluorohexanoic acid results in increased expression of APOA4 mRNA
CTD
PMID:22071372
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
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Apoa5
apolipoprotein A5
increases expression
ISO
perfluorohexanoic acid results in increased expression of APOA5 mRNA
CTD
PMID:23567314
NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
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Ar
androgen receptor
multiple interactions
ISO
perfluorohexanoic acid promotes the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD
PMID:29601859
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Ccnd1
cyclin D1
decreases expression
ISO
perfluorohexanoic acid results in decreased expression of CCND1 mRNA
CTD
PMID:23567314
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cd36
CD36 molecule
increases expression
ISO
perfluorohexanoic acid results in increased expression of CD36 mRNA
CTD
PMID:36435305
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cpt1a
carnitine palmitoyltransferase 1A
increases expression
ISO
perfluorohexanoic acid results in increased expression of CPT1A mRNA
CTD
PMID:23567314
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Cpt1b
carnitine palmitoyltransferase 1B
increases expression
ISO
perfluorohexanoic acid results in increased expression of CPT1B mRNA
CTD
PMID:23567314
NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
perfluorohexanoic acid results in increased expression of CYP2B6 mRNA
CTD
PMID:23567314 PMID:35337807
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
increases expression
EXP
perfluorohexanoic acid results in increased expression of CYP4A1 mRNA
CTD
PMID:19407336
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
perfluorohexanoic acid results in decreased expression of CYP7A1 mRNA
CTD
PMID:23567314
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
increases expression
ISO
perfluorohexanoic acid results in increased expression of EHHADH mRNA
CTD
PMID:23567314 PMID:35337807 PMID:36435305
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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Fabp1
fatty acid binding protein 1
increases expression
ISO
perfluorohexanoic acid results in increased expression of FABP1 mRNA
CTD
PMID:23567314 PMID:36435305
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fasn
fatty acid synthase
increases expression
ISO
perfluorohexanoic acid results in increased expression of FASN mRNA
CTD
PMID:35337807
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fdft1
farnesyl diphosphate farnesyl transferase 1
increases expression
EXP
perfluorohexanoic acid results in increased expression of FDFT1 mRNA
CTD
PMID:22071372
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
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Flg
filaggrin
increases expression
ISO
perfluorohexanoic acid results in increased expression of FLG mRNA
CTD
PMID:36435305
NCBI chr 2:178,884,793...178,912,986
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Gpam
glycerol-3-phosphate acyltransferase, mitochondrial
increases expression
ISO
perfluorohexanoic acid results in increased expression of GPAM mRNA
CTD
PMID:35337807
NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
increases expression decreases expression
ISO EXP
perfluorohexanoic acid results in increased expression of HADHA mRNA perfluorohexanoic acid results in decreased expression of HADHA mRNA
CTD
PMID:22071372 PMID:23567314
NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
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Hadhb
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
increases expression
EXP
perfluorohexanoic acid results in increased expression of HADHB mRNA
CTD
PMID:22071372
NCBI chr 6:26,153,572...26,187,668
Ensembl chr 6:26,153,578...26,184,869
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Hhex
hematopoietically expressed homeobox
increases expression
EXP
perfluorohexanoic acid results in increased expression of HHEX mRNA
CTD
PMID:22071372
NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
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Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
increases expression
ISO
perfluorohexanoic acid results in increased expression of HMGCS1 mRNA
CTD
PMID:35337807
NCBI chr 2:51,649,368...51,667,100
Ensembl chr 2:51,649,497...51,667,100
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Loricrin
loricrin cornified envelope precursor protein
increases expression
ISO
perfluorohexanoic acid results in increased expression of LORICRIN mRNA
CTD
PMID:36435305
NCBI chr 2:177,558,062...177,560,960
Ensembl chr 2:177,558,252...177,559,807
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Mbl2
mannose binding lectin 2
increases expression
ISO
perfluorohexanoic acid results in increased expression of MBL2 mRNA
CTD
PMID:23567314
NCBI chr 1:228,016,439...228,024,736
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Mogat1
monoacylglycerol O-acyltransferase 1
increases expression
ISO
perfluorohexanoic acid results in increased expression of MOGAT1 mRNA
CTD
PMID:23567314
NCBI chr 9:79,980,963...79,988,513
Ensembl chr 9:79,956,649...79,988,513
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Mttp
microsomal triglyceride transfer protein
increases expression
ISO
perfluorohexanoic acid results in increased expression of MTTP mRNA
CTD
PMID:35337807
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression
ISO
perfluorohexanoic acid results in increased expression of NFE2L2 mRNA
CTD
PMID:35337807
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nos2
nitric oxide synthase 2
increases expression
ISO
perfluorohexanoic acid results in increased expression of NOS2 mRNA
CTD
PMID:23567314
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity increases expression
ISO
perfluorohexanoic acid results in increased activity of NR1I2 protein perfluorohexanoic acid results in increased expression of NR1I2 mRNA
CTD
PMID:28115241 PMID:35337807
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression
ISO
perfluorohexanoic acid results in increased expression of NR1I3 mRNA
CTD
PMID:35337807
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Pax8
paired box 8
increases expression
EXP
perfluorohexanoic acid results in increased expression of PAX8 mRNA
CTD
PMID:22071372
NCBI chr 3:7,185,721...7,242,363
Ensembl chr 3:7,185,723...7,242,363
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Pck2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
increases expression
ISO
perfluorohexanoic acid results in increased expression of PCK2 mRNA
CTD
PMID:35337807
NCBI chr15:29,027,891...29,036,729
Ensembl chr15:29,027,894...29,037,283
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Pdk4
pyruvate dehydrogenase kinase 4
increases expression
ISO
perfluorohexanoic acid results in increased expression of PDK4 mRNA
CTD
PMID:23567314
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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Plin2
perilipin 2
increases expression
ISO
perfluorohexanoic acid results in increased expression of PLIN2 mRNA
CTD
PMID:23567314
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Por
cytochrome p450 oxidoreductase
increases expression
ISO
perfluorohexanoic acid results in increased expression of POR mRNA
CTD
PMID:23567314
NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
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Ppara
peroxisome proliferator activated receptor alpha
increases activity increases expression multiple interactions affects binding decreases expression
ISO
perfluorohexanoic acid results in increased activity of PPARA protein perfluorohexanoic acid results in increased expression of PPARA mRNA [perfluorooctanoic acid co-treated with perfluorohexanoic acid] results in increased expression of PPARA mRNA perfluorohexanoic acid binds to PPARA protein perfluorohexanoic acid results in decreased expression of PPARA mRNA
CTD
PMID:23391484 PMID:24374136 PMID:28857218 PMID:35337807 PMID:35752307 PMID:36435305 More...
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Ppard
peroxisome proliferator-activated receptor delta
increases expression decreases expression
ISO
perfluorohexanoic acid results in increased expression of PPARD mRNA perfluorohexanoic acid results in decreased expression of PPARD mRNA
CTD
PMID:23567314 PMID:36435305
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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Pparg
peroxisome proliferator-activated receptor gamma
increases activity affects binding
ISO EXP
perfluorohexanoic acid results in increased activity of PPARG protein perfluorohexanoic acid binds to PPARG protein
CTD
PMID:23391484 PMID:35752307
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ptpn11
protein tyrosine phosphatase, non-receptor type 11
multiple interactions
ISO
perfluorohexanoic acid binds to and results in decreased activity of PTPN11 protein
CTD
PMID:27572461
NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
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S100a8
S100 calcium binding protein A8
increases expression
ISO
perfluorohexanoic acid results in increased expression of S100A8 mRNA
CTD
PMID:36435305
NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
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Scd
stearoyl-CoA desaturase
increases expression
ISO
perfluorohexanoic acid results in increased expression of SCD mRNA
CTD
PMID:23567314 PMID:35337807
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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Slc22a12
solute carrier family 22 member 12
affects uptake
ISO
SLC22A12 protein affects the uptake of perfluorohexanoic acid
CTD
PMID:35835357
NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555
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Slc22a6
solute carrier family 22 member 6
multiple interactions
EXP
perfluorohexanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid]
CTD
PMID:19915082
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc25a34
solute carrier family 25, member 34
increases expression
ISO
perfluorohexanoic acid results in increased expression of SLC25A34 mRNA
CTD
PMID:23567314
NCBI chr 5:153,932,081...153,936,854
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Sod1
superoxide dismutase 1
increases expression
ISO
perfluorohexanoic acid results in increased expression of SOD1 mRNA
CTD
PMID:35337807
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Srebf1
sterol regulatory element binding transcription factor 1
increases expression
ISO
perfluorohexanoic acid results in increased expression of SREBF1 mRNA
CTD
PMID:35337807
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Sult2a1
sulfotransferase family 2A member 1
increases expression
ISO
perfluorohexanoic acid results in increased expression of SULT2A1 mRNA
CTD
PMID:35337807
NCBI chr 1:75,451,178...75,508,113
Ensembl chr 1:74,911,100...75,508,134
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Ttr
transthyretin
multiple interactions
ISO
perfluorohexanoic acid affects the reaction [Thyroxine binds to TTR protein]
CTD
PMID:27528273
NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
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Txnip
thioredoxin interacting protein
increases expression
ISO
perfluorohexanoic acid results in increased expression of TXNIP mRNA
CTD
PMID:23567314
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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