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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:perfluorohexanoic acid
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Accession:CHEBI:83492 term browser browse the term
Definition:A monocarboxylic acid that is perfluorinated hexanoic acid.
Synonyms:exact_synonym: undecafluorohexanoic acid
 related_synonym: 2,2,3,3,4,4,5,5,6,6,6-undecafluorohexanoic acid;   Formula=C6HF11O2;   InChI=1S/C6HF11O2/c7-2(8,1(18)19)3(9,10)4(11,12)5(13,14)6(15,16)17/h(H,18,19);   InChIKey=PXUULQAPEKKVAH-UHFFFAOYSA-N;   SMILES=OC(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F
 alt_id: MESH:C479228
 xref: CAS:307-24-4
 xref_mesh: MESH:C479228
 xref: PMID:24113473;   PMID:24158108;   PMID:24768527;   PMID:25377447;   Reaxys:1805852


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perfluorohexanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acot1 acyl-CoA thioesterase 1 increases expression EXP perfluorohexanoic acid results in increased expression of ACOT1 mRNA CTD PMID:19407336 NCBI chr 6:103,636,173...103,644,167 JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 increases expression ISO perfluorohexanoic acid results in increased expression of ACSL1 mRNA CTD PMID:23567314 NCBI chr16:45,755,246...45,821,541 JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO perfluorohexanoic acid results in increased expression of ANGPTL4 mRNA CTD PMID:23567314 NCBI chr 7:14,550,288...14,557,797 JBrowse link
G Apoa2 apolipoprotein A2 increases expression ISO perfluorohexanoic acid results in increased expression of APOA2 mRNA CTD PMID:23567314 NCBI chr13:83,644,460...83,646,358 JBrowse link
G Apoa4 apolipoprotein A4 increases expression EXP perfluorohexanoic acid results in increased expression of APOA4 mRNA CTD PMID:22071372 NCBI chr 8:46,539,083...46,541,464 JBrowse link
G Apoa5 apolipoprotein A5 increases expression ISO perfluorohexanoic acid results in increased expression of APOA5 mRNA CTD PMID:23567314 NCBI chr 8:46,561,180...46,563,818 JBrowse link
G Ar androgen receptor multiple interactions ISO perfluorohexanoic acid promotes the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:29601859 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO perfluorohexanoic acid results in decreased expression of CCND1 mRNA CTD PMID:23567314 NCBI chr 1:200,089,002...200,098,524 JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A increases expression ISO perfluorohexanoic acid results in increased expression of CPT1A mRNA CTD PMID:23567314 NCBI chr 1:200,564,634...200,627,059 JBrowse link
G Cpt1b carnitine palmitoyltransferase 1B increases expression ISO perfluorohexanoic acid results in increased expression of CPT1B mRNA CTD PMID:23567314 NCBI chr 7:120,491,354...120,500,833 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO perfluorohexanoic acid results in increased expression of CYP2B6 mRNA CTD PMID:23567314 NCBI chr 1:81,652,762...81,732,153 JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP perfluorohexanoic acid results in increased expression of CYP4A1 mRNA CTD PMID:19407336 NCBI chr 5:129,123,323...129,137,464 JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 decreases expression ISO perfluorohexanoic acid results in decreased expression of CYP7A1 mRNA CTD PMID:23567314 NCBI chr 5:19,376,979...19,386,676 JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase increases expression ISO perfluorohexanoic acid results in increased expression of EHHADH mRNA CTD PMID:23567314 NCBI chr11:79,241,927...79,275,173 JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO perfluorohexanoic acid results in increased expression of FABP1 mRNA CTD PMID:23567314 NCBI chr 4:103,191,015...103,194,791 JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP perfluorohexanoic acid results in increased expression of FDFT1 mRNA CTD PMID:22071372 NCBI chr15:37,412,143...37,440,198 JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha increases expression
decreases expression
ISO
EXP
perfluorohexanoic acid results in increased expression of HADHA mRNA
perfluorohexanoic acid results in decreased expression of HADHA mRNA
CTD PMID:22071372 PMID:23567314 NCBI chr 6:26,187,969...26,227,605 JBrowse link
G Hadhb hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta increases expression EXP perfluorohexanoic acid results in increased expression of HADHB mRNA CTD PMID:22071372 NCBI chr 6:26,153,572...26,187,668 JBrowse link
G Hhex hematopoietically expressed homeobox increases expression EXP perfluorohexanoic acid results in increased expression of HHEX mRNA CTD PMID:22071372 NCBI chr 1:235,190,455...235,196,042 JBrowse link
G Mbl2 mannose binding lectin 2 increases expression ISO perfluorohexanoic acid results in increased expression of MBL2 mRNA CTD PMID:23567314 NCBI chr 1:228,016,439...228,024,736 JBrowse link
G Mogat1 monoacylglycerol O-acyltransferase 1 increases expression ISO perfluorohexanoic acid results in increased expression of MOGAT1 mRNA CTD PMID:23567314 NCBI chr 9:79,980,963...79,988,513 JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO perfluorohexanoic acid results in increased expression of NOS2 mRNA CTD PMID:23567314 NCBI chr10:63,815,308...63,851,208 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO perfluorohexanoic acid results in increased activity of NR1I2 protein CTD PMID:28115241 NCBI chr11:62,460,213...62,496,665 JBrowse link
G Pax8 paired box 8 increases expression EXP perfluorohexanoic acid results in increased expression of PAX8 mRNA CTD PMID:22071372 NCBI chr 3:7,185,721...7,242,363 JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression ISO perfluorohexanoic acid results in increased expression of PDK4 mRNA CTD PMID:23567314 NCBI chr 4:33,591,796...33,601,798 JBrowse link
G Plin2 perilipin 2 increases expression ISO perfluorohexanoic acid results in increased expression of PLIN2 mRNA CTD PMID:23567314 NCBI chr 5:101,156,643...101,211,738 JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO perfluorohexanoic acid results in increased expression of POR mRNA CTD PMID:23567314 NCBI chr12:20,951,058...20,999,198 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha increases activity
multiple interactions
increases expression
ISO perfluorohexanoic acid results in increased activity of PPARA protein
[perfluorooctanoic acid co-treated with perfluorohexanoic acid] results in increased expression of PPARA mRNA
perfluorohexanoic acid results in increased expression of PPARA mRNA
CTD PMID:23391484 PMID:24374136 PMID:28857218 NCBI chr 7:116,832,405...116,900,878 JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO perfluorohexanoic acid results in increased expression of PPARD mRNA CTD PMID:23567314 NCBI chr20:6,298,785...6,363,970 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity ISO perfluorohexanoic acid results in increased activity of PPARG protein CTD PMID:23391484 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 multiple interactions ISO perfluorohexanoic acid binds to and results in decreased activity of PTPN11 protein CTD PMID:27572461 NCBI chr12:35,365,436...35,424,925 JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO perfluorohexanoic acid results in increased expression of SCD mRNA CTD PMID:23567314 NCBI chr 1:243,269,745...243,282,878 JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP perfluorohexanoic acid inhibits the reaction [SLC22A6 protein results in increased import of p-Aminohippuric Acid] CTD PMID:19915082 NCBI chr 1:205,522,579...205,531,179 JBrowse link
G Slc25a34 solute carrier family 25, member 34 increases expression ISO perfluorohexanoic acid results in increased expression of SLC25A34 mRNA CTD PMID:23567314 NCBI chr 5:153,932,081...153,936,854 JBrowse link
G Ttr transthyretin multiple interactions ISO perfluorohexanoic acid affects the reaction [Thyroxine binds to TTR protein] CTD PMID:27528273 NCBI chr18:11,941,791...11,951,008 JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO perfluorohexanoic acid results in increased expression of TXNIP mRNA CTD PMID:23567314 NCBI chr 2:184,093,079...184,096,882 JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19762
    role 19708
      biological role 19708
        xenobiotic 18395
          perfluorohexanoic acid 36
Path 2
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  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic group 18611
                              organic divalent group 18602
                                organodiyl group 18602
                                  carbonyl group 18519
                                    carbonyl compound 18519
                                      carboxylic acid 18195
                                        monocarboxylic acid 17594
                                          fatty acid 16001
                                            saturated fatty acid 15976
                                              straight-chain saturated fatty acid 15433
                                                hexanoic acid 73
                                                  perfluorohexanoic acid 36
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